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Omicron variant better at evading protection: study – CTV News

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The new Omicron variant may have a greater ability than other strains of the virus to escape immune protection from antibodies produced by previous COVID-19 infection, and potentially vaccines.

That’s according to a new, peer-reviewed study published on Saturday in the journal Emerging Microbes & Infection.

The Omicron variant has caused global panic prompting many countries, including Canada, to impose more stringent travel rules.

Experts say the Omicron variant is unusual because it has a high number of mutations in two key areas of the virus’ spike protein.

Dozens of cases of the variant have been detected across Canada.

The researchers said their study showed test tube samples of the Omicron variant “exceeded” all other COVID-19 variants in its ability to evade the protection gained from previous infection or vaccination.

Youchun Wang, senior research fellow from the National Institutes for Food and Drug Control in China, said the research supports recent findings in South Africa that suggest Omicron finds it “easy to evade immunity.”

“We found the large number of mutations of the Omicron variant did cause significant changes of neutralization sensitivity against people who had already had COVID,” Wang said in a press release.

“However, the average ED50 (protection level) against Omicron is still higher than the baseline, which indicated there is still some protection effect can be observed,” Wang continued.

Wang, the vice chairman of the Medical Microbiology and Immunology of the Chinese Medical Association, cautioned that because antibody protection from either vaccination or previous infection decreases over a period of six months, the variant “may be able to escape immunity even better.”

The study suggests that while a third dose of a COVID-19 vaccine “can significantly boost immunity,” the protection it provides from Omicron “may be compromised.”

“In addition, it needs to be re-evaluated whether the therapeutic monoclonal antibodies can still be effective against the Omicron variant,” the study reads.

“More laboratory and the real-world studies are needed to understand whether Omicron can escape from the vaccine elicited immunity to cause more severe disease and death.”

In order to conduct the study, researchers looked at 28 serum samples from patients who were recovering from the original COVID-19 strain, known as SARS-CoV-2.

These were tested against test-tube or in-vitro samples of Omicron and other strains deemed “variants of concern” by the World Health Organization, including Alpha, Beta, Gamma and Delta.

Researchers also tested samples of variants of interest Lambda and Mu.

Wang said the study “verifies the enhanced immune escape” of the Omicron variant, “which sounds the alarm to the world and has important implications for the public health planning and the development of matching strategies.”

However, the team of researchers say more research is needed to better understand the variant, and said real-world studies, not just in-vitro, must be conducted.

The authors said research to determine whether the Omicron variant can “escape from the vaccine elicited immunity to cause more severe disease and death,” must also be conducted.

“It needs to be re-evaluated whether the antibodies can still be effective against the Omicron variant,” the authors wrote in the paper.

“The exact impact to human protection may be influenced by more factors such as the infectivity of Omicron variant relative to other variants to human populations and the viral fitness of Omicron once the humans are infected,” the study reads.

The authors call for “more population studies,” saying research into the level of immune protection and symptoms among people infected with Omicron are needed “to fully establish the global impact of Omicron to the control of [the] COVID-19 pandemic.” 

VACCINE DATA SO FAR

Meanwhile on Saturday, researchers in Israel said they found a three-shot course of the Pfizer/BioNTech COVID-19 vaccine provided significant protection against the Omicron variant.

The study released Saturday, was conducted by the Sheba Medical Center and the Health Ministry’s Central Virology Laboratory.

Researchers compared the blood of 20 people who had received two vaccine doses five to six months earlier to 20 individuals who received a booster a month before.

The study found people who received the second dose five or six months ago did “not have neutralization ability against Omicron.”

“They do have some against the Delta (strain,)” Gili Regev-Yochay, director of the Infectious Diseases Unit at Sheba told reporters.

“The good news is that with the booster dose it increases about a hundredfold,” she said. “There is a significant protection of the booster dose. It is lower than the neutralization ability against the Delta, about four times lower.”

What’s more, on Wednesday, Pfizer released preliminary data that suggests two doses may not be protective enough to prevent an Omicron COVID-19 infection.

However, the company said that a booster dose increased by 25-fold an individual’s level of antibodies against the Omicron variant.

Pfizer’s findings are preliminary though, meaning they have not yet been peer-reviewed.

With files from CTV News’ Nicole Bogart and Reuters 

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Bad traffic, changed plans: Toronto braces for uncertainty of its Taylor Swift Era

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TORONTO – Will Taylor Swift bring chaos or do we all need to calm down?

It’s a question many Torontonians are asking this week as the city braces for the arrival of Swifties, the massive fan base of one of the world’s biggest pop stars.

Hundreds of thousands are expected to descend on the downtown core for the singer’s six concerts which kick off Thursday at the Rogers Centre and run until Nov. 23.

And while their arrival will be a boon to tourism dollars — the city estimates more than $282 million in economic impact — some worry it could worsen Toronto’s gridlock by clogging streets that already come to a standstill during rush hour.

Swift’s shows are set to collide with sports events at the nearby Scotiabank Arena, including a Raptors game on Friday and a Leafs game on Saturday.

Some residents and local businesses have already adjusted their plans to avoid the area and its planned road closures.

Aahil Dayani says he and some friends intended to throw a birthday bash for one of their pals until they realized it would overlap with the concerts.

“Something as simple as getting together and having dinner is now thrown out the window,” he said.

Dayani says the group rescheduled the gathering for after Swift leaves town. In the meantime, he plans to hunker down at his Toronto residence.

“Her coming into town has kind of changed up my social life,” he added.

“We’re pretty much just not doing anything.”

Max Sinclair, chief executive and founder of A.I. technology firm Ecomtent, suggested his employees avoid the company’s downtown offices on concert days, saying he doesn’t see the point in forcing people to endure potential traffic jams.

“It’s going to be less productive for us, and it’s going to be just a pain for everyone, so it’s easier to avoid it,” Sinclair said.

“We’re a hybrid company, so we can be flexible. It just makes sense.”

Swift’s concerts are the latest pop culture moment to draw attention to Toronto’s notoriously disastrous daily commute.

In June, One Direction singer Niall Horan uploaded a social media video of himself walking through traffic to reach the venue for his concert.

“Traffic’s too bad in Toronto, so we’re walking to the venue,” he wrote in the post.

Toronto Transit Commission spokesperson Stuart Green says the public agency has been working for more than a year on plans to ease the pressure of so many Swifties in one confined area.

“We are preparing for something that would be akin to maybe the Beatles coming in the ‘60s,” he said.

Dozens of buses and streetcars have been added to transit routes around the stadium, and the TTC has consulted the city on potential emergency scenarios.

Green will be part of a command centre operated by the City of Toronto and staffed by Toronto police leaders, emergency services and others who have handled massive gatherings including the Raptors’ NBA championship parade in 2019.

“There may be some who will say we’re over-preparing, and that’s fair,” Green said.

“But we know based on what’s happened in other places, better to be over-prepared than under-prepared.”

Metrolinx, the agency for Ontario’s GO Transit system, has also added extra trips and extended hours in some regions to accommodate fans looking to travel home.

A day before Swift’s first performance, the city began clearing out tents belonging to homeless people near the venue. The city said two people were offered space in a shelter.

“As the area around Rogers Centre is expected to receive a high volume of foot traffic in the coming days, this area has been prioritized for outreach work to ensure the safety of individuals in encampments, other residents, businesses and visitors — as is standard for large-scale events,” city spokesperson Russell Baker said in a statement.

Homeless advocate Diana Chan McNally questioned whether money and optics were behind the measure.

“People (in the area) are already in close proximity to concerts, sports games, and other events that generate massive amounts of traffic — that’s nothing new,” she said in a statement.

“If people were offered and willingly accepted a shelter space, free of coercion, I support that fully — that’s how it should happen.”

This report by The Canadian Press was first published Nov. 13, 2024.



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‘It’s literally incredible’: Swifties line up for merch ahead of Toronto concerts

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TORONTO – Hundreds of Taylor Swift fans lined up outside the gates of Toronto’s Rogers Centre Wednesday, with hopes of snagging some of the pop star’s merchandise on the eve of the first of her six sold-out shows in the city.

Swift is slated to perform at the venue from Thursday to Saturday, and the following week from Nov. 21 to Nov. 23, with concert merchandise available for sale on some non-show days.

Swifties were all smiles as they left the merch shop, their arms full of sweaters and posters bearing pictures of the star and her Eras Tour logo.

Among them was Zoe Haronitis, 22, who said she waited in line for about two hours to get $300 worth of merchandise, including some apparel for her friends.

Haronitis endured the autumn cold and the hefty price tag even though she hasn’t secured a concert ticket. She said she’s hunting down a resale ticket and plans to spend up to $600.

“I haven’t really budgeted anything,” Haronitis said. “I don’t care how much money I spent. That was kind of my mindset.”

The megastar’s merchandise costs up to $115 for a sweater, and $30 for tote bags and other accessories.

Rachel Renwick, 28, also waited a couple of hours in line for merchandise, but only spent about $70 after learning that a coveted blue sweater and a crewneck had been snatched up by other eager fans before she got to the shop. She had been prepared to spend much more, she said.

“The two prized items sold out. I think a lot more damage would have been done,” Renwick said, adding she’s still determined to buy a sweater at a later date.

Renwick estimated she’s spent about $500 in total on “all-things Eras Tour,” including her concert outfit and merchandise.

The long queue for Swift merch is just a snapshot of what the city will see in the coming days. It’s estimated that up to 500,000 visitors from outside Toronto will be in town during the concert period.

Tens of thousands more are also expected to attend Taylgate’24, an unofficial Swiftie fan event scheduled to be held at the nearby Metro Toronto Convention Centre.

Meanwhile, Destination Toronto has said it anticipates the economic impact of the Eras Tour could grow to $282 million as the money continues to circulate.

But for fans like Haronitis, the experience in Toronto comes down to the Swiftie community. Knowing that Swift is going to be in the city for six shows and seeing hundreds gather just for merchandise is “awesome,” she said.

Even though Haronitis hasn’t officially bought her ticket yet, she said she’s excited to see the megastar.

“It’s literally incredible.”

This report by The Canadian Press was first published Nov. 13, 2024.

The Canadian Press. All rights reserved.



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Via Rail seeks judicial review on CN’s speed restrictions

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OTTAWA – Via Rail is asking for a judicial review on the reasons why Canadian National Railway Co. has imposed speed restrictions on its new passenger trains.

The Crown corporation says it is seeking the review from the Federal Court after many attempts at dialogue with the company did not yield valid reasoning for the change.

It says the restrictions imposed last month are causing daily delays on Via Rail’s Québec City-Windsor corridor, affecting thousands of passengers and damaging Via Rail’s reputation with travellers.

CN says in a statement that it imposed the restrictions at rail crossings given the industry’s experience and known risks associated with similar trains.

The company says Via has asked the courts to weigh in even though Via has agreed to buy the equipment needed to permanently fix the issues.

Via said in October that no incidents at level crossings have been reported in the two years since it put 16 Siemens Venture trains into operation.

This report by The Canadian Press was first published Nov. 13, 2024.

Companies in this story: (TSX:CN)

The Canadian Press. All rights reserved.



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