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Oncology nurses should be routinely tested for SARS-CoV-2, warn researchers – News-Medical.Net

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Researchers from the NHS Foundation Trust, University of Cambridge and Cambridge Clinical Laboratories have warned that until a vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) becomes available, antigen and antibody testing should be carried out among oncology nurses as part of routine patient care.

The team’s study of 434 patient-facing oncology staff who worked during the peak of the coronavirus disease 2019 (COVD-19) pandemic in the UK, found that the highest seroprevalence rate for SARS-CoV-2 was among nurses.

David Favara and colleagues say that current UK guidelines recommend that all patients receiving systemic anticancer therapy should be tested for SARS-CoV-2 by PCR (polymerase chain reaction) before starting treatment, with further testing considered at intervals during treatment.

The guidance regarding healthcare workers, on the other hand, only recommends testing in the broadest sense, says the team.

“We propose that there should be a focus on routinely testing oncology nursing staff for both SARS-CoV-2 antigen and antibodies until an effective vaccine comes available,” write the researchers.

A pre-print version of the paper is available on the server medRxiv*, while the article undergoes peer review.

Summary of relationship between role, previous symptoms and antibody results (June 2020 sample collection). All participants were nasopharyngeal swab SARSCOV-2 PCR negative at time of SARS-COV-2 antibody testing.

Cancer patients may be at greater risk of contracting SARS-CoV-2

Since the first cases of SARS-CoV-2 were first identified in Wuhan, China, late last year, the virus has now infected more than 31 million people globally and caused more than 961,000 deaths. Despite researchers’ intense efforts to develop therapies, no effective antiviral treatments or vaccines have yet been developed.

Cancer patients may be at a greater risk of contracting SARS-CoV-2 owing to the multiple hospital visits they need to attend for diagnosis, treatment, and follow-up.

Recent studies have suggested that while anticancer therapy does not increase the mortality risk among cancer patients infected with SARS-CoV-2, it may increase the risk of severe complications following infection.

Guidance is therefore needed to safeguard both patients and oncology staff, say Favara and colleagues.

However, data regarding oncology-specific SARS-CoV-2 infection and immunity rates in the UK are lacking, and the risk of transmission among staff who care for cancer patients is not known.

“To date, no large study has specifically reported and tracked patient-facing oncology staff SARS-CoV-2 exposure,” say Favara and team.

What did the current study involve?

Favara and colleagues recruited 434 patient-facing oncology staff who worked during the peak of the COVID-19 pandemic at three secondary care NHS Foundation Trust hospitals in the UK, namely the Queen Elizabeth Hospital, Peterborough City Hospital, and Cambridge University Hospitals.

Summary of Relationship between day 1 and day 28 positive antibody results (by SARS-CoV-2 antigen target).

Summary of Relationship between day 1 and day 28 positive antibody results (by SARS-CoV-2 antigen target).

Staff members had nasopharyngeal swabs tested for SARS-CoV-2 by PCR in June 2020 (day 1 samples) and again in July (day 28 samples). They also had their blood tested for SARS-CoV-2-specific antibodies (at the same points) using a laboratory Luminex-based assay and a rapid point-of-care (POC) assay.  

Of the 434 participants involved in the study, 58.3% were nurses, 21.2% were doctors, 10.4% were radiographers, and 10.1% were administrators. The overall median age of the study population was 40 years and 82% were female.

Prior to June, 26.3% of participants reported having symptoms indicating potential SARS-CoV-2 infection, and 1.4% had tested positive for infection by PCR.

What did the study find?

On day 1 and day 28 of testing, all participants tested negative for SARS-CoV-2 by PCR.

The Luminex-based assay identified 18.4% of participants as SARS-CoV-2 seropositive on day 1, 42.5% of whom also tested seropositive by PCO.

Luminex-based seropositivity rates were higher among nurses (21.3%) and doctors (17.4%), compared with among administration staff (13.6%) and radiographers (8.9%).

Of 400 participants who also underwent testing on day 28 in July, 13.3% tested seropositive by Luminex, 92·5% of whom had previously tested positive, and 7·5% of whom were newly positive.

Of all the staff groups tested, the seroprevalence rate was highest among nurses, at 16.5%.

“The daily interactions of nurses with multiple patients at close quarters will undoubtedly contribute to these stark statistics,” say Favara and colleagues.

Of the participants who tested seropositive on day 1, 32.5% became seronegative by day 28, suggesting that SARS-CoV-2 antibody seropositivity declines over time.

Nurses should be tested regularly as part of routine patient care

The researchers say that until a vaccine becomes available, the high prevalence of SARS-CoV-2 seropositivity in oncology nurses, along with the high rate of decline in seropositivity over 4 weeks supports regular antigen and antibody testing in this staff group as part of routine patient care.

“This study sets the first seropositivity baseline for UK oncology staff and provides new information to consider incorporating into international guidance on safeguarding patients,” say Favara and team. “We propose that there should be a focus on routinely testing oncology nursing staff for both SARS-CoV-2 antigen and antibodies until an effective vaccine comes available.”

The researchers suggest that since seropositivity can fluctuate within 4 weeks, testing should be carried out at least once a month. Ideally, weekly PCR-testing with fortnightly serology would be performed.

“Increasing availability of lower-cost, high sensitivity, and specificity SARS-CoV-2 testing methods should make this targeted approach viable, would help protect patients and staff and enable containment and tracking of new, asymptomatic infections,” they conclude.

*Important Notice

medRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information.

Journal reference:

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Here’s how Helene and other storms dumped a whopping 40 trillion gallons of rain on the South

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More than 40 trillion gallons of rain drenched the Southeast United States in the last week from Hurricane Helene and a run-of-the-mill rainstorm that sloshed in ahead of it — an unheard of amount of water that has stunned experts.

That’s enough to fill the Dallas Cowboys’ stadium 51,000 times, or Lake Tahoe just once. If it was concentrated just on the state of North Carolina that much water would be 3.5 feet deep (more than 1 meter). It’s enough to fill more than 60 million Olympic-size swimming pools.

“That’s an astronomical amount of precipitation,” said Ed Clark, head of the National Oceanic and Atmospheric Administration’s National Water Center in Tuscaloosa, Alabama. “I have not seen something in my 25 years of working at the weather service that is this geographically large of an extent and the sheer volume of water that fell from the sky.”

The flood damage from the rain is apocalyptic, meteorologists said. More than 100 people are dead, according to officials.

Private meteorologist Ryan Maue, a former NOAA chief scientist, calculated the amount of rain, using precipitation measurements made in 2.5-mile-by-2.5 mile grids as measured by satellites and ground observations. He came up with 40 trillion gallons through Sunday for the eastern United States, with 20 trillion gallons of that hitting just Georgia, Tennessee, the Carolinas and Florida from Hurricane Helene.

Clark did the calculations independently and said the 40 trillion gallon figure (151 trillion liters) is about right and, if anything, conservative. Maue said maybe 1 to 2 trillion more gallons of rain had fallen, much if it in Virginia, since his calculations.

Clark, who spends much of his work on issues of shrinking western water supplies, said to put the amount of rain in perspective, it’s more than twice the combined amount of water stored by two key Colorado River basin reservoirs: Lake Powell and Lake Mead.

Several meteorologists said this was a combination of two, maybe three storm systems. Before Helene struck, rain had fallen heavily for days because a low pressure system had “cut off” from the jet stream — which moves weather systems along west to east — and stalled over the Southeast. That funneled plenty of warm water from the Gulf of Mexico. And a storm that fell just short of named status parked along North Carolina’s Atlantic coast, dumping as much as 20 inches of rain, said North Carolina state climatologist Kathie Dello.

Then add Helene, one of the largest storms in the last couple decades and one that held plenty of rain because it was young and moved fast before it hit the Appalachians, said University of Albany hurricane expert Kristen Corbosiero.

“It was not just a perfect storm, but it was a combination of multiple storms that that led to the enormous amount of rain,” Maue said. “That collected at high elevation, we’re talking 3,000 to 6000 feet. And when you drop trillions of gallons on a mountain, that has to go down.”

The fact that these storms hit the mountains made everything worse, and not just because of runoff. The interaction between the mountains and the storm systems wrings more moisture out of the air, Clark, Maue and Corbosiero said.

North Carolina weather officials said their top measurement total was 31.33 inches in the tiny town of Busick. Mount Mitchell also got more than 2 feet of rainfall.

Before 2017’s Hurricane Harvey, “I said to our colleagues, you know, I never thought in my career that we would measure rainfall in feet,” Clark said. “And after Harvey, Florence, the more isolated events in eastern Kentucky, portions of South Dakota. We’re seeing events year in and year out where we are measuring rainfall in feet.”

Storms are getting wetter as the climate change s, said Corbosiero and Dello. A basic law of physics says the air holds nearly 4% more moisture for every degree Fahrenheit warmer (7% for every degree Celsius) and the world has warmed more than 2 degrees (1.2 degrees Celsius) since pre-industrial times.

Corbosiero said meteorologists are vigorously debating how much of Helene is due to worsening climate change and how much is random.

For Dello, the “fingerprints of climate change” were clear.

“We’ve seen tropical storm impacts in western North Carolina. But these storms are wetter and these storms are warmer. And there would have been a time when a tropical storm would have been heading toward North Carolina and would have caused some rain and some damage, but not apocalyptic destruction. ”

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Follow AP’s climate coverage at https://apnews.com/hub/climate

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Follow Seth Borenstein on Twitter at @borenbears

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Associated Press climate and environmental coverage receives support from several private foundations. See more about AP’s climate initiative here. The AP is solely responsible for all content.

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‘Big Sam’: Paleontologists unearth giant skull of Pachyrhinosaurus in Alberta

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It’s a dinosaur that roamed Alberta’s badlands more than 70 million years ago, sporting a big, bumpy, bony head the size of a baby elephant.

On Wednesday, paleontologists near Grande Prairie pulled its 272-kilogram skull from the ground.

They call it “Big Sam.”

The adult Pachyrhinosaurus is the second plant-eating dinosaur to be unearthed from a dense bonebed belonging to a herd that died together on the edge of a valley that now sits 450 kilometres northwest of Edmonton.

It didn’t die alone.

“We have hundreds of juvenile bones in the bonebed, so we know that there are many babies and some adults among all of the big adults,” Emily Bamforth, a paleontologist with the nearby Philip J. Currie Dinosaur Museum, said in an interview on the way to the dig site.

She described the horned Pachyrhinosaurus as “the smaller, older cousin of the triceratops.”

“This species of dinosaur is endemic to the Grand Prairie area, so it’s found here and nowhere else in the world. They are … kind of about the size of an Indian elephant and a rhino,” she added.

The head alone, she said, is about the size of a baby elephant.

The discovery was a long time coming.

The bonebed was first discovered by a high school teacher out for a walk about 50 years ago. It took the teacher a decade to get anyone from southern Alberta to come to take a look.

“At the time, sort of in the ’70s and ’80s, paleontology in northern Alberta was virtually unknown,” said Bamforth.

When paleontogists eventually got to the site, Bamforth said, they learned “it’s actually one of the densest dinosaur bonebeds in North America.”

“It contains about 100 to 300 bones per square metre,” she said.

Paleontologists have been at the site sporadically ever since, combing through bones belonging to turtles, dinosaurs and lizards. Sixteen years ago, they discovered a large skull of an approximately 30-year-old Pachyrhinosaurus, which is now at the museum.

About a year ago, they found the second adult: Big Sam.

Bamforth said both dinosaurs are believed to have been the elders in the herd.

“Their distinguishing feature is that, instead of having a horn on their nose like a triceratops, they had this big, bony bump called a boss. And they have big, bony bumps over their eyes as well,” she said.

“It makes them look a little strange. It’s the one dinosaur that if you find it, it’s the only possible thing it can be.”

The genders of the two adults are unknown.

Bamforth said the extraction was difficult because Big Sam was intertwined in a cluster of about 300 other bones.

The skull was found upside down, “as if the animal was lying on its back,” but was well preserved, she said.

She said the excavation process involved putting plaster on the skull and wooden planks around if for stability. From there, it was lifted out — very carefully — with a crane, and was to be shipped on a trolley to the museum for study.

“I have extracted skulls in the past. This is probably the biggest one I’ve ever done though,” said Bamforth.

“It’s pretty exciting.”

This report by The Canadian Press was first published Sept. 25, 2024.

The Canadian Press. All rights reserved.

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The ancient jar smashed by a 4-year-old is back on display at an Israeli museum after repair

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TEL AVIV, Israel (AP) — A rare Bronze-Era jar accidentally smashed by a 4-year-old visiting a museum was back on display Wednesday after restoration experts were able to carefully piece the artifact back together.

Last month, a family from northern Israel was visiting the museum when their youngest son tipped over the jar, which smashed into pieces.

Alex Geller, the boy’s father, said his son — the youngest of three — is exceptionally curious, and that the moment he heard the crash, “please let that not be my child” was the first thought that raced through his head.

The jar has been on display at the Hecht Museum in Haifa for 35 years. It was one of the only containers of its size and from that period still complete when it was discovered.

The Bronze Age jar is one of many artifacts exhibited out in the open, part of the Hecht Museum’s vision of letting visitors explore history without glass barriers, said Inbal Rivlin, the director of the museum, which is associated with Haifa University in northern Israel.

It was likely used to hold wine or oil, and dates back to between 2200 and 1500 B.C.

Rivlin and the museum decided to turn the moment, which captured international attention, into a teaching moment, inviting the Geller family back for a special visit and hands-on activity to illustrate the restoration process.

Rivlin added that the incident provided a welcome distraction from the ongoing war in Gaza. “Well, he’s just a kid. So I think that somehow it touches the heart of the people in Israel and around the world,“ said Rivlin.

Roee Shafir, a restoration expert at the museum, said the repairs would be fairly simple, as the pieces were from a single, complete jar. Archaeologists often face the more daunting task of sifting through piles of shards from multiple objects and trying to piece them together.

Experts used 3D technology, hi-resolution videos, and special glue to painstakingly reconstruct the large jar.

Less than two weeks after it broke, the jar went back on display at the museum. The gluing process left small hairline cracks, and a few pieces are missing, but the jar’s impressive size remains.

The only noticeable difference in the exhibit was a new sign reading “please don’t touch.”

The Canadian Press. All rights reserved.

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