Connect with us

Business

Ottawa announces deals with two international companies for COVID-19 vaccines – The Globe and Mail

Published

on


Nurse Kath Olmstead, right, gives volunteer Melissa Harting, of Harpersville, N.Y., an injection as the world’s biggest study of a possible COVID-19 vaccine, developed by the National Institutes of Health and Moderna Inc., gets underway, on July 27, 2020, in Binghamton, N.Y.

Hans Pennink/The Associated Press

Ottawa has struck deals with two international drug companies to purchase their candidate COVID-19 vaccines for distribution in Canada, federal officials said on Wednesday.

Details of the agreements reached with Moderna and Pfizer Inc., including the cost of the vaccines, have not been disclosed, but Public Service and Procurement Canada Minister Anita Anand said that millions of doses have been ordered from the two companies for delivery in 2021. She added similar arrangements were being sought with other suppliers, with options to increase orders based on need.

“We are working on all possible fronts and diversifying our vaccine supply chain,” Ms. Anand said.

Story continues below advertisement

Though the terms of each agreement vary, both vaccines will ultimately require Health Canada regulatory approval. This will depend, in part, on how they perform in clinical trials over the coming months.

Ottawa frees up $3.3-billion for provincial efforts to mitigate COVID-19 spread

Ottawa agrees to explore ‘wearable’ COVID-19 device after concerns from Ontario construction union

During a news conference in Toronto, Ms. Anand said parallel efforts were under way to boost supplies of needles, syringes and alcohol swabs as part of “preparing Canada for mass vaccination” against COVID-19.

At the same briefing, Navdeep Bains, the Minister for Innovation, Science and Economic Development, said his department has formed a vaccine task force to provide the federal government with expert advice on which vaccines to prioritize for purchase on the global market and which Canadian-made vaccines to support with additional funding and production capacity to enable them to advance to clinical trials.

“Priority number one is to make sure that we have safe and effective vaccines for all Canadians,” Mr. Bains said. “Long term, we also want to build a strong industrial base for [Canada’s] life sciences sector.”

The widespread distribution of a successful vaccine is widely regard as the only viable solution to the COVID-19 pandemic.

Among the nearly 200 COVID-19 vaccines in development worldwide, about 30 have advanced to human testing. As of this week, six have now reached Phase 3 clinical trials designed to measure vaccine efficacy by administering doses to thousands or tens of thousands of individuals and tracking their rates of infection over time. Among the six are the two vaccines that Canada has so far arranged to purchase.

The vaccine developed by Moderna, a Massachusetts-based biotech company, yielded promising results in an early study published last month in the New England Journal of Medicine.

Story continues below advertisement

Pfizer’s vaccine was developed jointly with BioNTech, a company based in Germany. That partnership has already stuck similar deals to supply its vaccine to Japan, the United States and Britain.

BioNTech confirmed that part of the manufacturing of the Canadian order would take place in Canada.

The federal announcement also included $56-million for Ottawa company Variation Biotechnologies Inc. and $3-million for Nova Scotia based IMV Inc. to support clinical trials of two made-in-Canada vaccine candidates. Earlier this year the federal government provided funding to Medicago, a Quebec company that last month launched Canada’s first clinical COVID-19 vaccine trial.

As of Wednesday, 133 out of 180 volunteers have been injected with the Medicago vaccine as part of a Phase 1 trial, which is primarily a safety test of the vaccine.

The multiple investments are a reflection of a broader awareness that ultimately several vaccines could be needed to defeat the COVID-19 pandemic on a global scale, said Alex Romanovschi, medical director for GSK Canada, which has partnered with Medicago on its trial.

“At the end of the day … no one company will be able to cover the entire world,” Dr. Romanovschi said.

Story continues below advertisement

The federal government has inked deals with both Pfizer and Moderna to get access to millions of doses of their experimental COVID-19 vaccine candidates. Procurement Minister Anita Anand says the vaccines must still finish human trials and be determined safe and effective against COVID-19. If Health Canada approves them, she says, the deals would ensure Canadians are among the first in line for doses next year. The Canadian Press

While several international vaccines are further ahead in testing than the leading Canadian candidates, experts have argued that Canada should complement its international purchases with efforts to accelerate vaccine development and production capacity at home at a time when it’s not clear which vaccines will ultimately work best.

Prioritizing among domestic vaccine projects, as well as potential international partnerships, is part of the mandate of the 12-member vaccine task force, which began its work in early June.

“We’re making investments that are needed now to be sure that something works out,” said Joanne Langley, a professor of pediatrics and community health and epidemiology at Dalhousie University in Halifax.

Mark Lievonen, a former president of Sanofi Pasteur Ltd. who is co-chairing the task force with Dr. Langley, said he is leading a subcommittee that is looking specifically at manufacturing challenges that vaccines makers will face in Canada.

Canadian participation in vaccine production could become crucial if international shipments are delayed at their country of origin because of demand at home or for other reasons.

A hint of the problems that can arise when relying on international sources is evident in the continued holdup of the delivery of a vaccine from CanSino Biologics – a Chinese company that has partnered with Canada’s National Research Council – for a clinical trial in Halifax. That trial was to have started two months ago but the vaccine has so far not been released by Chinese customs.

Story continues below advertisement

Mr. Bains declined to speculate on the cause of the delay but said the issue underscored the need to keep many options open.

Despite this outlook, not every COVID-19 vaccine candidate in Canada has managed to attract federal funding.

On Wednesday, Providence Therapeutics released results from preclincial tests of its mRNA vaccine candidate that is based on the same technology as the Moderna and Pfizer candidates. The company is now seeking support to move ahead with clinical trials.

Brad Sorenson, the company’s chief executive officer, said that the results show the vaccine has the potential to be as good or better than international competitors.

“The question is, does Canada want to be a buyer or a seller?” he said.

Sign up for the Coronavirus Update newsletter to read the day’s essential coronavirus news, features and explainers written by Globe reporters and editors.

Let’s block ads! (Why?)



Source link

Business

Shopify fires 2 employees for stealing customer data from up to 200 merchants – CBC.ca

Published

on


Shopify says it has terminated two “rogue” employees who were involved in a scheme to steal customer information from some of the company’s merchants.

The Ottawa-based technology company says fewer than 200 merchants were included in the breach, but that an unknown number of customers of those merchants may have had their information stolen.

The information stolen includes basic things such as names and email addresses, as well as data about what products they purchased, but did not include financial information such as credit card or banking details.

“We immediately terminated these individuals’ access to our Shopify network and referred the incident to law enforcement,” the company said.

“We are currently working with the FBI and other international agencies in their investigation of these criminal acts. While we do not have evidence of the data being utilized, we are in the early stages of the investigation and will be updating affected merchants as relevant.”

The company stressed that the breach was not the result of some sort of technical vulnerability, and that the vast majority of the company’s one million merchants and the customers who shop from them online were not affected. Any affected merchants have been notified.

“We don’t take these events lightly at Shopify,” the company said. “We have zero tolerance for platform abuse and will take action to preserve the confidence of our community and the integrity of our product.”

Shares in the company fell 1.6 per cent on Tuesday in extended trading on a down day for markets overall.

The company’s shares have more than doubled in value this year, as the company is one of numerous tech names whose business has boomed during the pandemic because of higher demand for online services.

Let’s block ads! (Why?)



Source link

Continue Reading

Business

Huawei Has Sufficient Inventory of Communications Equipment – Yahoo Finance

Published

on


TipRanks

3 “Strong Buy” Stocks That Are Flirting With a Bottom

In the investing game, it’s not only about what you buy; it’s about when you buy it. One of the most common pieces of advice thrown around the Street, “buy low” is touted as a tried-and-true tactic.Sure, the strategy seems simple. Stock prices naturally fluctuate on the basis of several factors like earnings results and the macro environment, amongst others, with investors trying to time the market and determine when stocks have hit a bottom. In practice, however, executing on this strategy is no easy task.On top of this, given the volatility that has ruled the markets over the last few weeks, how are investors supposed to gauge when a name is flirting with a bottom? That’s where the Wall Street pros come in.These expert stock pickers have identified three compelling tickers whose current share prices land close to their 52-week lows. Noting that each is set to take back off on an upward trajectory, the analysts see an attractive entry point. Using TipRanks’ database, we found out that the analyst consensus has rated all three a Strong Buy, with major upside potential also on tap.Progenity (PROG)Offering clear and actionable genetic results, Progenity specializes in providing testing services. The company started trading on Nasdaq in June and saw its shares tumbling 44% since then. With shares changing hands for $8.11, several members of the Street recommend pulling the trigger before it heats up.Piper Sandler analyst Steven Mah points out that even against the backdrop of COVID-19, PROG managed to deliver with its Q2 2020 performance. “We are encouraged by the recovery in late Q2 2020 with 75,000 accessioned tests (~79,000 in Q1 2020), driven by noninvasive prenatal testing (NIPT) and carrier screening,” the analyst noted. Expounding on this, Mah stated, “Progenity did not provide guidance, but June test volumes of ~28,000 were strong (Q1 2020 monthly average was ~26,000) which we believe showcases the durability of its reproductive tests and the success that Progenity has in co-marketing and attaching carrier screening to the more essential NIPT. Of note, despite the pandemic disruptions, Progenity was able to maintain its leading pre-COVID test turnaround times.”Additionally, health insurer Aetna is temporarily extending coverage of average-risk NIPT until year-end as a result of the pandemic, with the American College of Obstetricians and Gynecologists (ACOG) also expected to endorse average-risk in the future given its clinical utility, in Mah’s opinion.Reflecting another positive, the fourth generation NIPT (single-molecule counting assay) test was able to measure fetal fraction, a key milestone according to Mah, and will continue to be developed into 2021. As the technology could potentially be applied to DNA, RNA, epigenetic markers and proteins for additional clinical applications such as oncology, the analyst is looking forward to the completion of the preeclampsia verification in Q4 2020 and a possible 2H21 launch. “We believe preeclampsia (~2.3 billion serviceable market) is a major differentiator for Progenity, allowing them to cross-sell across the full-continuum of reproductive testing,” the analyst added.If that wasn’t enough, PROG signed its first GI Precision Medicine partnership agreement with a top-20 Pharma company in August. The Oral Biotherapeutic Delivery System (OBDS), an ingestible drug and device combination designed to precisely deliver biologics systemically through a needle-free liquid jet injection into the submucosal tissues of the small intestine, is set to be utilized as part of the collaboration. Mah commented, “We believe Progenity can sign additional Pharma deals and look forward to the newsflow coming out on this front.”To sum it all up, Mah said, “We believe Progenity shares are undervalued given the robust recovery in the core testing business and multiple upcoming growth catalysts.”To this end, Mah rates PROG an Overweight (i.e. Buy) along with a $17 price target. Should his thesis play out, a twelve-month gain of 105% could potentially be in the cards. (To watch Mah’s track record, click here)Are other analysts in agreement? They are. Only Buy ratings, 4, in fact, have been issued in the last three months. Therefore, the message is clear: PROG is a Strong Buy. Given the $13.33 average price target, shares could climb 60% higher in the next year. (See PROG stock analysis on TipRanks)Tactile Systems Technology (TCMD)Developing at-home therapy devices, Tactile Systems Technology wants to provide new treatments for lymphedema, which occurs when the lymphatic system is impaired, disrupting normal transport of fluid within the body, and chronic venous insufficiency. Down 52% year-to-date, its $32.67 share price lands close to its $29.47 52-week low. Thus, with business trends improving, the Street is pounding the table.Writing for Canaccord, analyst Cecilia Furlong acknowledges that the pandemic has hampered the company, with COVID-19 weighing on both volumes and sales. In the second half of March, volumes were down 50% compared to the first half of the month, and TCMD’s patient volumes in April and May remained challenged. That being said, trends started to improve at the end of May.“Going forward, given the vast majority of TCMD’s clinician customers practice in outpatient or office-based settings, we remain positive on TCMD’s ability to demonstrate better insulation against COVID impacts and likely experience a greater bounce-back relative to overall med-tech volume trends, with TCMD further benefitting from its expanding using of technology to remotely engage with clinicians and support patients,” Furlong explained.The analyst added, “Furthermore, recent trends among some providers to prescribe Flexitouch (an advanced intermittent pneumatic compression device to self-manage lymphedema and nonhealing venous leg ulcers) earlier along the therapy process, as a means to reduce in-person contact, could provide upside near term, as well as potentially transition to a longer-term tailwind.”On top of this, Furlong is also optimistic about new CEO Dan Reuvers and the reprioritization of the company’s investment and market development efforts. TCMD will shift focus away from its acquired Airwear product line, with it redirecting investments toward its Flexitouch and Entre (a pneumatic compression device used to assist in the home management of chronic swelling and venous ulcers associated with lymphedema and chronic venous insufficiency) products.“Given significant under-penetration in the lymphedema/phlebolymphedema market targeted by Flexitouch alongside the large patient population with limited treatment options today targeted by the firm’s Head & Neck platform, we view the combination of education and clinical data as key to further developing and penetrating these markets… Going forward, we expect management to continue to compile a broad base of clinical data to support reimbursement and drive broad adoption,” Furlong commented.All of this prompted Furlong to keep a Buy rating and $62 price target on the stock. This target conveys her confidence in TCMD’s ability to soar 90% in the next year. (To watch Furlong’s track record, click here)In general, other analysts are on the same page. With 3 Buy ratings and 1 Hold, the word on the Street is that TCMD is a Strong Buy. The $62.33 average price target brings the upside potential to 91%. (See TCMD stock analysis on TipRanks)uniQure N.V. (QURE)Last but not least we have uniQure, which delivers curative gene therapies that could potentially transform the lives of patients. Even though shares have fallen 44% year-to-date to $40, not much higher than its 52-week low of $36.20, multiple analysts still have high hopes.Representing SVB Leerink, 5-star analyst Joseph Schwartz acknowledges that shares struggled after news broke of its collaboration and licensing agreement with CSL Behring for AMT-061, QURE’s gene therapy for Hemophilia B, he argues the “shareholder base turnover is likely now complete as investors and QURE shift focus to next-in-line AMT-130, its AAV5 gene therapy for Huntington’s Disease (HD).”Schwartz further added, “With the M&A premium now out of the stock, we see the QURE’s current level as an attractive buying opportunity for those investors interested in the company’s up and coming CNS gene therapies, internal manufacturing, and robust intellectual property and knowhow.”Looking more closely at the agreement with CSL Behring, QURE will be tasked with the completion of the pivotal Phase 3 HOPE-B trial as well as the manufacturing process validation and manufacturing supply of AMT-061.According to management, 26-week Factor IX (FIX) data from all 54 patients enrolled in the trial remains on track, and topline data from the pivotal trial is still slated to read out by YE20. It should be mentioned that in a Phase 2b dose-confirmation study, QURE reported 41% FIX activity out to one year. Additionally, Schwartz points out that with HOPE-B progressing as planned, QURE has continued its manufacturing process validation work ahead of the anticipated BLA/MAA submissions in the U.S. and EU in 2021.On top of this, as part of the deal, QURE is eligible to receive more than $2 billion including a $450 million upfront cash payment, $1.6 billion in regulatory and commercial milestones and double-digit royalties ranging up to the low-twenties percentage of net product sales.“With a strengthened cash position, QURE is well funded to rapidly advance CNS assets including AMT-130 (AAV5 gene therapy for Huntington’s Disease (HD)) and AMT-150 (AAV gene therapy for Spinocerebellar Ataxia Type 3/SCA3)…We continue to believe that as QURE’s CNS pipeline assets mature, the company could once again be an attractive partner to larger biopharma companies that have recently acquired many publicly traded gene therapy platforms with substantial manufacturing capabilities,” Schwartz noted.Everything that QURE has going for it convinced Schwartz to reiterate an Outperform (i.e. Buy) rating. Along with the call, he attached a $67 price target, suggesting 68% upside potential from current levels. (To watch Schwartz’s track record, click here)What does the rest of the Street have to say? 9 Buys and 3 Holds have been issued in the last three months, so the consensus rating is a Strong Buy. In addition, the $69.89 average price target indicates 75% upside potential. (See QURE stock analysis on TipRanks)To find good ideas for beaten-down stocks trading at attractive valuations, visit TipRanks’ Best Stocks to Buy, a newly launched tool that unites all of TipRanks’ equity insights.Disclaimer: The opinions expressed in this article are solely those of the featured analysts. The content is intended to be used for informational purposes only. It is very important to do your own analysis before making any investment.

Let’s block ads! (Why?)



Source link

Continue Reading

Business

Tesla’s Battery Day Letdown Risks $320 Billion Stock Gain – Yahoo Canada Finance

Published

on


Tesla’s Battery Day Letdown Risks $320 Billion Stock Gain

(Bloomberg) — Tesla Inc.’s highly anticipated “Battery Day” fell short of expectations that helped fuel its $320 billion surge in market value this year, with Elon Musk outlining grandiose goals that will take time to pull off.

The chief executive officer laid out a plan Tuesday to build a $25,000 car and cut battery costs in half over the next three years. Analysts said while the technology and manufacturing innovations outlined were impressive, Tesla’s valuation already reflected its ability to disrupt and that investors may be let down by the lack of surprises at the much-hyped event.

“With the Battery Day in the rearview, we think there is a lack of upcoming catalysts and are cautious about demand given the recessionary environment,” Robert W. Baird’s Ben Kallo wrote in a Wednesday report naming Tesla a bearish “fresh pick.”

That was echoed by Patrick Hummel, an analyst at UBS with a “neutral” rating on the stock, who said in a research note Tesla’s leadership in battery technology and costs is fully valued into the stock. “Given the high expectations into the event, we think the market will initially respond negatively to the relatively long timelines of the innovations and the lack of granularity,” he wrote.

Tesla shares fell 5.4% to $401.19 as of 9:50 a.m. in New York. The stock has soared about 400% this year.

Musk, 49, said Tesla wants to eventually produce 20 million cars a year. He described a series of innovations that include using dry-electrode technology and making the battery a structural element of the car. Those incremental and longer-term advances belied expectations for a blockbuster leap forward, which Musk himself played up in the weeks leading up to the event.

“The challenge with the stock is that everything they are talking about is three years away,” said Gene Munster, managing director of Loup Ventures. “I think traditional auto is in an even tighter spot, but Tesla investors want this tomorrow.”

Vertical-integration improvements — from making its own battery cells on a pilot line at its factory in Fremont, California, to owning rights to a lithium clay deposit in Nevada — are designed to allow Tesla to cut costs and offer a cheap car as soon as 2023.

“This has always been our dream from the very beginning,” Musk said at the event showcasing Tesla’s battery technology. “In about three years from now, we are confident we can make a compelling $25,000 electric vehicle that is also fully autonomous.”

Halving Battery Costs

Musk, 49, is teasing prospects for a cheaper mystery model without ever having really delivered on the $35,000 price point he had long promised for the Model 3. Three years after Tesla started taking orders for the car in early 2016, the CEO announced plans to close most of Tesla’s stores as a cost-saving measure, allowing him to offer the car at that cost. He backtracked 10 days later, and the cheapest Model 3 available now is $37,990.

Making a truly mass-market electric car and boosting Tesla’s current annual production to 20 million cars will require vastly more batteries than are currently being produced from a handful of suppliers around the world. So Musk plans to expand global capacity by manufacturing battery cells in-house to supplement what it can buy.

“Today’s batteries can’t scale fast enough,” said Musk, who is driven in part by the need to find sustainable energy sources. “There’s a clear path to success but a ton of work to do.” Musk said the gasoline-powered internal-combustion engine will one day be obsolete.

Musk described an “incredible series of innovations with varying levels of difficulty,” said Venkat Viswanathan, a battery expert at Carnegie Mellon University. While battery-manufacturing advances are feasible and deliverable in the three-year time frame, Viswanathan thinks that chemistry developments will take a longer.

If the planned innovations pay off, vehicle range could increase 54%, cost could decrease 56% and investment in gigafactories could decline 69%, said Andrew Baglino, Tesla’s senior vice president for powertrain and energy engineering.

BloombergNEF estimates Tesla’s pack prices were $128/kWh in 2019. A 56% cost reduction would bring prices down to $56/kWh. In addition to the pilot line for battery-cell production in Fremont, and Musk said the company also will make cells at the factory that is under construction in Berlin.

Battery Cell ‘Leap’

Most global automakers have shied away from making their own battery cells, citing the high investment costs and their lack of expertise in an industry dominated mostly by Asian electronics manufactures such as Panasonic Corp. and LG Chem Ltd.

Musk said in a tweet Monday that Tesla will need to start producing its own battery cells to support its various products, even as it ramps up purchases from outside suppliers. He wrote that the company expects significant shortages of cells in 2022 and beyond unless it ramps up output of its own.

“I’m really surprised that they’re taking that leap themselves,” said Tony Posawatz, a consultant who led development of General Motors Co.’s plug-in hybrid Chevrolet Volt and now sits on the board of Lucid Motors Inc., a Tesla rival. “I think this is going to be a bit harder than what they think, and I don’t think we’ll see a lot of volume out of that for quite some time.”

Tesla’s most important and long-standing partner on batteries is Osaka-based Panasonic, but it also has smaller-scale agreements with Contemporary Amperex Technology Co., or CATL, in China’s Fujian province and South Korea’s LG Chem.

Read more: LG Chem, Panasonic Slide as Tesla Looks to Lower Battery Costs

The highly technical Battery Day presentation included several nuggets of news that were overshadowed by the talk of cathodes and electrolytes. One example: The “Plaid” version of the Model S sedan — with a range of 520 miles — is now available to order, though the vehicle isn’t expected to go on sales until late 2021.

Tuesday’s three-hour event began with the annual shareholder meeting, held outside to allow for social distancing. Shareholders sat in Tesla cars in a parking lot, beeping loudly instead of cheering as Musk spoke.

Investors voted to re-elect Musk and chairman Robyn Denholm to the board and voted against resolutions that would have required more transparency about human rights in the supply chain and the use of arbitration with employees. One shareholder resolution, which requires Tesla to adopt a simple majority vote, did pass.

Musk told shareholders he expects to see deliveries grow on the order of 30% to 40% this year, reaffirming Tesla’s forecast at a time when automakers are struggling to recover from the coronavirus pandemic. “While the rest of the industry has gone down, Tesla has gone up,” he said.

Tesla has said it anticipates delivering 500,000 vehicles in 2020, up about 36% from 2019. In July, the electric-car maker said achieving that goal would be “more difficult” due to a pandemic-related production shutdown early in the year. Global sales are projected to drop about 17% this year to 75 million from 90 million last year, according to research firm LMC Automotive.

(Updates with additional analyst comment in fourth paragraph and opening shares in fifth paragraph.)

<p class="canvas-atom canvas-text Mb(1.0em) Mb(0)–sm Mt(0.8em)–sm" type="text" content="For more articles like this, please visit us at bloomberg.com” data-reactid=”55″>For more articles like this, please visit us at bloomberg.com

<p class="canvas-atom canvas-text Mb(1.0em) Mb(0)–sm Mt(0.8em)–sm" type="text" content="Subscribe now to stay ahead with the most trusted business news source.” data-reactid=”56″>Subscribe now to stay ahead with the most trusted business news source.

©2020 Bloomberg L.P.

Let’s block ads! (Why?)



Source link

Continue Reading

Trending