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Ottawa Hospital researchers join global COVID-19 fight: 'We're all looking at what we can do to make a difference' – Ottawa Sun

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Scientists at the Ottawa Hospital Research Institute have joined the global race to prevent and treat COVID-19, the disease caused by the novel coronavirus.

Scientists at the Ottawa Hospital Research Institute have joined the global race to prevent and treat COVID-19, the disease caused by the novel coronavirus.

The research institute has launched more than a dozen COVID-19 research projects, many of them in partnership with other scientists in Canada around the world.

“Like everyone else, we’re all looking at what we can do to make a difference,” said Dr. Duncan Stewart, executive vice-president of research at The Ottawa Hospital. “For scientists who have expertise and technologies that are relevant, this is a fantastic opportunity to try to develop something that could help in the prevention, detection or treatment of this disease.


Dr. Duncan Stewart of the Ottawa Hospital Research Institute is focusing his work on COVID-19 research.

“We’re preparing for what we think will be an overwhelming number of these patients in our intensive care units,” he said Thursday, “and we want to be able to offer them as much as we can.”

Among the research institute’s initiatives:

° Infectious disease researchers are creating a local registry of COVID-19 patients to track disease patterns and the effectiveness of different treatments.

Confirmed COVID-19 cases in Ontario

° Dr. Carolina Ilkow and other immunotherapy experts who work with cancer-fighting viruses have launched a project aimed at using the same technology to develop a COVID-19 vaccine; they want to combine tiny bits of the coronavirus’ genetic material with one of these viruses — they don’t harm people — to magnify the immune system’s response to it.

° Dr. Stewart and a team of researchers are working to launch a clinical trial that tests the ability of multipurpose adult stem cells, mesenchymal stromal cells (MSCs), to treat the most severe cases of COVID-19.

“We’re learning every day more about COVID-19: It’s a very interesting and unique virus,” said Stewart, a professor at the University of Ottawa.

In earlier research, Stewart explored how MSCs can be used to control the immune system’s runaway response during sepsis, a life-threatening condition caused by the body’s reaction to a serious infection. Patients infected with COVID-19 can develop a similar condition, Acute Respiratory Distress Syndrome (ARDS), also triggered by an exaggerated immune response. In ARDS, the lungs flood with fluid because of acute injury, Stewart said, leading to severe shortness of breath.

“COVID-19 likes the lung, it targets the lung,” he said.

Ontario: Total deaths from COVID-19

Stewart believes that MSCs can be deployed to modulate the immune system’s response to COVID-19. MSCs are involved in repairing damaged tissues in the body and their interaction with the immune system, he said, “appears to be part of their natural healing abilities.”

He hopes to launch a new clinical trial within weeks.

Dr. Carolina Ilkow said the research team in which she’s involved wants to repurpose the cancer-killing viruses they’ve studied for years to target COVID-19. They intend to use these oncolytic viruses as a vehicle to program the body’s immune system to identify and destroy the coronavirus.

“These viruses are really good at expressing information, at educating new systems,” she said.

The team hopes to develop a vaccine that can go into clinical testing by the end of the year.

Meanwhile, Canada’s national blood agency announced Thursday that it is part of a research group seeking approval for a national clinical trial that uses blood plasma drawn from recovered COVID-19 patients to treat people who are ill with the disease.

The Ottawa Hospital will be one of the lead sites in that clinical trial, along with hospitals in Hamilton and Toronto, if it’s approved by Health Canada. 

China, South Korea and Singapore have all used plasma from recovered patients to treat those with COVID-19, and there’s some evidence that it can help.

Plasma is a key blood component that contains antibodies, clotting agents and proteins; it makes up more than half of the overall content of the blood.

Confirmed COVID-19 cases in Ottawa

People who have recovered from COVID-19 carry disease antibodies in their plasma to shield them against another infection. Researchers hope those same antibodies can be deployed to treat others with the disease.

As part of the clinical trial, plasma will be collected from volunteer blood donors in Canada who have fully recovered from COVID-19, said Dr. Dana Devine, chief scientist at Canadian Blood Services, which is headquartered in Ottawa. The agency will contact potential donors from among the country’s recovered COVID-19 patients.

It’s expected to take several months to complete the national clinical trial.

The Ottawa-based research initiatives were unveiled Thursday as scientists in Australia launched animal testing of two potential coronavirus vaccines.

Developed by Oxford University and Inovio Pharmaceuticals Inc., the vaccines have been cleared for animal testing by the World Health Organization. Australia’s national science agency will conduct those tests, which represent a critical stage in the development of a potential vaccine. It normally takes at least a year or two to reach that stage.

The tests are expected to take three months to complete, according to Australia’s Commonwealth Scientific and Industrial Research Organization.

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Here is how to prepare your online accounts for when you die

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LONDON (AP) — Most people have accumulated a pile of data — selfies, emails, videos and more — on their social media and digital accounts over their lifetimes. What happens to it when we die?

It’s wise to draft a will spelling out who inherits your physical assets after you’re gone, but don’t forget to take care of your digital estate too. Friends and family might treasure files and posts you’ve left behind, but they could get lost in digital purgatory after you pass away unless you take some simple steps.

Here’s how you can prepare your digital life for your survivors:

Apple

The iPhone maker lets you nominate a “ legacy contact ” who can access your Apple account’s data after you die. The company says it’s a secure way to give trusted people access to photos, files and messages. To set it up you’ll need an Apple device with a fairly recent operating system — iPhones and iPads need iOS or iPadOS 15.2 and MacBooks needs macOS Monterey 12.1.

For iPhones, go to settings, tap Sign-in & Security and then Legacy Contact. You can name one or more people, and they don’t need an Apple ID or device.

You’ll have to share an access key with your contact. It can be a digital version sent electronically, or you can print a copy or save it as a screenshot or PDF.

Take note that there are some types of files you won’t be able to pass on — including digital rights-protected music, movies and passwords stored in Apple’s password manager. Legacy contacts can only access a deceased user’s account for three years before Apple deletes the account.

Google

Google takes a different approach with its Inactive Account Manager, which allows you to share your data with someone if it notices that you’ve stopped using your account.

When setting it up, you need to decide how long Google should wait — from three to 18 months — before considering your account inactive. Once that time is up, Google can notify up to 10 people.

You can write a message informing them you’ve stopped using the account, and, optionally, include a link to download your data. You can choose what types of data they can access — including emails, photos, calendar entries and YouTube videos.

There’s also an option to automatically delete your account after three months of inactivity, so your contacts will have to download any data before that deadline.

Facebook and Instagram

Some social media platforms can preserve accounts for people who have died so that friends and family can honor their memories.

When users of Facebook or Instagram die, parent company Meta says it can memorialize the account if it gets a “valid request” from a friend or family member. Requests can be submitted through an online form.

The social media company strongly recommends Facebook users add a legacy contact to look after their memorial accounts. Legacy contacts can do things like respond to new friend requests and update pinned posts, but they can’t read private messages or remove or alter previous posts. You can only choose one person, who also has to have a Facebook account.

You can also ask Facebook or Instagram to delete a deceased user’s account if you’re a close family member or an executor. You’ll need to send in documents like a death certificate.

TikTok

The video-sharing platform says that if a user has died, people can submit a request to memorialize the account through the settings menu. Go to the Report a Problem section, then Account and profile, then Manage account, where you can report a deceased user.

Once an account has been memorialized, it will be labeled “Remembering.” No one will be able to log into the account, which prevents anyone from editing the profile or using the account to post new content or send messages.

X

It’s not possible to nominate a legacy contact on Elon Musk’s social media site. But family members or an authorized person can submit a request to deactivate a deceased user’s account.

Passwords

Besides the major online services, you’ll probably have dozens if not hundreds of other digital accounts that your survivors might need to access. You could just write all your login credentials down in a notebook and put it somewhere safe. But making a physical copy presents its own vulnerabilities. What if you lose track of it? What if someone finds it?

Instead, consider a password manager that has an emergency access feature. Password managers are digital vaults that you can use to store all your credentials. Some, like Keeper,Bitwarden and NordPass, allow users to nominate one or more trusted contacts who can access their keys in case of an emergency such as a death.

But there are a few catches: Those contacts also need to use the same password manager and you might have to pay for the service.

___

Is there a tech challenge you need help figuring out? Write to us at onetechtip@ap.org with your questions.

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Google’s partnership with AI startup Anthropic faces a UK competition investigation

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LONDON (AP) — Britain’s competition watchdog said Thursday it’s opening a formal investigation into Google’s partnership with artificial intelligence startup Anthropic.

The Competition and Markets Authority said it has “sufficient information” to launch an initial probe after it sought input earlier this year on whether the deal would stifle competition.

The CMA has until Dec. 19 to decide whether to approve the deal or escalate its investigation.

“Google is committed to building the most open and innovative AI ecosystem in the world,” the company said. “Anthropic is free to use multiple cloud providers and does, and we don’t demand exclusive tech rights.”

San Francisco-based Anthropic was founded in 2021 by siblings Dario and Daniela Amodei, who previously worked at ChatGPT maker OpenAI. The company has focused on increasing the safety and reliability of AI models. Google reportedly agreed last year to make a multibillion-dollar investment in Anthropic, which has a popular chatbot named Claude.

Anthropic said it’s cooperating with the regulator and will provide “the complete picture about Google’s investment and our commercial collaboration.”

“We are an independent company and none of our strategic partnerships or investor relationships diminish the independence of our corporate governance or our freedom to partner with others,” it said in a statement.

The U.K. regulator has been scrutinizing a raft of AI deals as investment money floods into the industry to capitalize on the artificial intelligence boom. Last month it cleared Anthropic’s $4 billion deal with Amazon and it has also signed off on Microsoft’s deals with two other AI startups, Inflection and Mistral.

The Canadian Press. All rights reserved.

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Kuwait bans ‘Call of Duty: Black Ops 6’ video game, likely over it featuring Saddam Hussein in 1990s

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DUBAI, United Arab Emirates (AP) — The tiny Mideast nation of Kuwait has banned the release of the video game “Call of Duty: Black Ops 6,” which features the late Iraqi dictator Saddam Hussein and is set in part in the 1990s Gulf War.

Kuwait has not publicly acknowledged banning the game, which is a tentpole product for the Microsoft-owned developer Activision and is set to be released on Friday worldwide. However, it comes as Kuwait still wrestles with the aftermath of the invasion and as video game makers more broadly deal with addressing historical and cultural issues in their work.

The video game, a first-person shooter, follows CIA operators fighting at times in the United States and also in the Middle East. Game-play trailers for the game show burning oilfields, a painful reminder for Kuwaitis who saw Iraqis set fire to the fields, causing vast ecological and economic damage. Iraqi troops damaged or set fire to over 700 wells.

There also are images of Saddam and Iraq’s old three-star flag in the footage released by developers ahead of the game’s launch. The game’s multiplayer section, a popular feature of the series, includes what appears to be a desert shootout in Kuwait called Scud after the Soviet missiles Saddam fired in the war. Another is called Babylon, after the ancient city in Iraq.

Activision acknowledged in a statement that the game “has not been approved for release in Kuwait,” but did not elaborate.

“All pre-orders in Kuwait will be cancelled and refunded to the original point of purchase,” the company said. “We remain hopeful that local authorities will reconsider, and allow players in Kuwait to enjoy this all-new experience in the Black Ops series.”

Kuwait’s Media Ministry did not respond to requests for comment from The Associated Press over the decision.

“Call of Duty,” which first began in 2003 as a first-person shooter set in World War II, has expanded into an empire worth billions of dollars now owned by Microsoft. But it also has been controversial as its gameplay entered the realm of geopolitics. China and Russia both banned chapters in the franchise. In 2009, an entry in the gaming franchise allowed players to take part in a militant attack at a Russian airport, killing civilians.

But there have been other games recently that won praise for their handling of the Mideast. Ubisoft’s “Assassin’s Creed: Mirage” published last year won praise for its portrayal of Baghdad during the Islamic Golden Age in the 9th century.

The Canadian Press. All rights reserved.

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