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Paralyzed woman speaks via AI brain implant for 1st time after stroke 18 years ago

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Ann Johnson was just 30 years old when she experienced a life-altering stroke in 2005 that left her paralyzed and unable to speak. At the time, she was a math and P.E. teacher at Luther College in Regina, had an eight-year-old stepson and had just welcomed a baby girl into the world.

“Overnight, everything was taken from me,” she wrote, according to a post from Luther College.

The stroke left her with locked-in syndrome (LIS), a rare neurological disorder that can cause full paralysis except for the muscles that control eye movement, the National Institutes of Health writes.

Johnson, now 47, described her experience with LIS in a paper she wrote for a psychology class in 2020, painstakingly typed letter by letter.

“You’re fully cognizant, you have full sensation, all five senses work, but you are locked inside a body where no muscles work,” she wrote. “I learned to breathe on my own again, I now have full neck movement, my laugh returned, I can cry and read and over the years my smile has returned, and I am able to wink and say a few words.”

A year later, in 2021, Johnson learned of a research study that had the potential to change her life. She was selected as one of eight participants for the clinical trial, offered by the departments of neurology and neurosurgery at the University of California, San Francisco (UCSF), and was the only Canadian.

“I always knew that my injury was rare, and living in Regina was remote. My kids were young when my stroke happened, and I knew participating in a study would mean leaving them. So, I waited until this summer to volunteer – my kids are now 25 and 17,” she writes.

Now, the results of Johnson’s work with a team of U.S. neurologists and computer scientists have come to fruition.

A study published in Nature on Wednesday revealed that Johnson is the first person in the world to speak out loud via decoded brain signals.

An implant that rests on her brain records her neurological activity while an artificial intelligence (AI) model translates those signals into words. In real time, that decoded text is synthesized into speech, spoken out loud by a digital avatar that can even generate Johnson’s facial expressions.


Ann Johnson sits in front of a digital avatar, through which she can speak out loud via a brain-compter interface.


Noah Berger/UCSF

The system can translate Johnson’s brain activity into text at a rate of nearly 80 words per minute, much faster than the 14 words per minute she can achieve typing out words with her current communication device, which tracks her eye movements.

The breakthrough was demonstrated in a video released by UCSF, in which Johnson speaks to her husband for the first time using her own voice, which the AI model can mimic thanks to a recording of Johnson taken on her wedding day.

“How are you feeling about the Blue Jays today?” her husband Bill asks, wearing a cap from the Toronto baseball team.

“Anything is possible,” she responds via the avatar.

Johnson’s husband jokes that she doesn’t seem very confident in the Jays.

“You are right about that,” she says, smiling.

Ann Johnson working with researchers on a technology that allows her to speak via brain signals after a stroke left her paralyzed.

Ann Johnson working with researchers on a technology that allows her to speak via brain signals after a stroke left her paralyzed.


Noah Berger/UCSF

The research team behind the technology, known as a brain-computer interface, hopes it can secure approval from U.S. regulators to make this system accessible to the public.

“Our goal is to restore a full, embodied way of communicating, which is the most natural way for us to talk with others,” says Edward Chang, chair of neurological surgery at UCSF and one of the lead authors of the study. “These advancements bring us much closer to making this a real solution for patients.”

So, how did they do it?

The team surgically implanted a paper-thin grid of 253 electrodes onto the surface of Johnson’s brain, covering the areas that are important for speech.

“The electrodes intercepted the brain signals that, if not for the stroke, would have gone to muscles in Ann’s lips, tongue, jaw and larynx, as well as her face,” a news release from UCSF reads.

Those brain signals get transferred into a port that is screwed onto the outside of Johnson’s head. From there, a cable that plugs into the port can be hooked up to a bank of computers that decode the signals into text and synthesize the text into speech.


Animation of the brain implant Ann Johnson received that allows her to speak via a digital avatar.


Noah Berger/UCSF

The AI model doesn’t exactly decode Johnson’s thoughts, but interprets how Johnson’s brain would move her face to make sounds — a process that also allows the AI to generate her facial expressions and emotions.

The AI translates these muscle signals into the building blocks of speech: components called phonemes.

“These are the sub-units of speech that form spoken words in the same way that letters form written words. ‘Hello,’ for example, contains four phonemes: ‘HH,’ ‘AH,’ ‘L’ and ‘OW,’” according to the UCSF release.

“Using this approach, the computer only needed to learn 39 phonemes to decipher any word in English. This both enhanced the system’s accuracy and made it three times faster.”

Over the course of many weeks, Johnson worked with the research team to train the AI to “recognize her unique brain signals for speech.”

They did this by repeating phrases from a bank of 1,024 words over and over again until the AI learned to recognize Johnson’s brain activity associated with each phoneme.

“The accuracy, speed and vocabulary are crucial,” said Sean Metzger, who developed the AI decoder with Alex Silva, both graduate students in the joint bioengineering program at UC Berkeley and UCSF. “It’s what gives Ann the potential, in time, to communicate almost as fast as we do, and to have much more naturalistic and normal conversations.”


Ann Johnson, 47, can speak out loud again for the first time after she was paralyzed in a stroke that happened in 2005.


Noah Berger/UCSF

Johnson is still getting used to hearing her old voice again, generated by the AI. The model was trained on a recording of a speech Johnson gave on her wedding day, allowing her digital avatar to sound similar to how she spoke before the stroke.

“My brain feels funny when it hears my synthesized voice,” she told UCSF. “It’s like hearing an old friend.

“My daughter was one when I had my injury, it’s like she doesn’t know Ann.… She has no idea what Ann sounds like.”

Her daughter only knows the British-accented voice of her current communication device.

More on Science and Tech

Another bonus of the brain-computer interface is that Johnson can control the facial movements of her digital avatar, making its jaw open, lips protrude and tongue go up and down if she wishes. She can also simulate facial expressions for happiness, sadness and surprise.

“When Ann first used this system to speak and move the avatar’s face in tandem, I knew that this was going to be something that would have a real impact,” said Kaylo Littlejohn, a graduate student working with the research team.

The next steps for the researchers will be to develop a wireless version of the system that wouldn’t require Johnson to be physically hooked up to computers. Currently, she’s wired in with cables that plug into the port on the top of her head.

“Giving people like Ann the ability to freely control their own computers and phones with this technology would have profound effects on their independence and social interactions,” said study co-author David Moses, a professor in neurological surgery.


A researcher plugs a wire into a port that is screwed into Ann Johnson’s head, which is connected to the grid of electrodes resting on her brain.


Noah Berger/UCSF

Johnson says being part of a brain-computer interface study has given her “a sense of purpose.”

“I feel like I am contributing to society. It feels like I have a job again. It’s amazing I have lived this long; this study has allowed me to really live while I’m still alive!”

Johnson was inspired to become a trauma counsellor after hearing about the Humboldt Broncos bus crash that claimed the lives of 16 young hockey players in 2018. With the help of this AI interface, and the freedom and ease of communication it allows, she hopes that dream will soon become a reality.

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Health Canada approves updated Moderna COVID-19 vaccine

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TORONTO – Health Canada has authorized Moderna’s updated COVID-19 vaccine that protects against currently circulating variants of the virus.

The mRNA vaccine, called Spikevax, has been reformulated to target the KP.2 subvariant of Omicron.

It will replace the previous version of the vaccine that was released a year ago, which targeted the XBB.1.5 subvariant of Omicron.

Health Canada recently asked provinces and territories to get rid of their older COVID-19 vaccines to ensure the most current vaccine will be used during this fall’s respiratory virus season.

Health Canada is also reviewing two other updated COVID-19 vaccines but has not yet authorized them.

They are Pfizer’s Comirnaty, which is also an mRNA vaccine, as well as Novavax’s protein-based vaccine.

This report by The Canadian Press was first published Sept. 17, 2024.

Canadian Press health coverage receives support through a partnership with the Canadian Medical Association. CP is solely responsible for this content.

The Canadian Press. All rights reserved.

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These people say they got listeria after drinking recalled plant-based milks

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TORONTO – Sanniah Jabeen holds a sonogram of the unborn baby she lost after contracting listeria last December. Beneath, it says “love at first sight.”

Jabeen says she believes she and her baby were poisoned by a listeria outbreak linked to some plant-based milks and wants answers. An investigation continues into the recall declared July 8 of several Silk and Great Value plant-based beverages.

“I don’t even have the words. I’m still processing that,” Jabeen says of her loss. She was 18 weeks pregnant when she went into preterm labour.

The first infection linked to the recall was traced back to August 2023. One year later on Aug. 12, 2024, the Public Health Agency of Canada said three people had died and 20 were infected.

The number of cases is likely much higher, says Lawrence Goodridge, Canada Research Chair in foodborne pathogen dynamics at the University of Guelph: “For every person known, generally speaking, there’s typically 20 to 25 or maybe 30 people that are unknown.”

The case count has remained unchanged over the last month, but the Public Health Agency of Canada says it won’t declare the outbreak over until early October because of listeria’s 70-day incubation period and the reporting delays that accompany it.

Danone Canada’s head of communications said in an email Wednesday that the company is still investigating the “root cause” of the outbreak, which has been linked to a production line at a Pickering, Ont., packaging facility.

Pregnant people, adults over 60, and those with weakened immune systems are most at risk of becoming sick with severe listeriosis. If the infection spreads to an unborn baby, Health Canada says it can cause miscarriage, stillbirth, premature birth or life-threatening illness in a newborn.

The Canadian Press spoke to 10 people, from the parents of a toddler to an 89-year-old senior, who say they became sick with listeria after drinking from cartons of plant-based milk stamped with the recalled product code. Here’s a look at some of their experiences.

Sanniah Jabeen, 32, Toronto

Jabeen says she regularly drank Silk oat and almond milk in smoothies while pregnant, and began vomiting seven times a day and shivering at night in December 2023. She had “the worst headache of (her) life” when she went to the emergency room on Dec. 15.

“I just wasn’t functioning like a normal human being,” Jabeen says.

Told she was dehydrated, Jabeen was given fluids and a blood test and sent home. Four days later, she returned to hospital.

“They told me that since you’re 18 weeks, there’s nothing you can do to save your baby,” says Jabeen, who moved to Toronto from Pakistan five years ago.

Jabeen later learned she had listeriosis and an autopsy revealed her baby was infected, too.

“It broke my heart to read that report because I was just imagining my baby drinking poisoned amniotic fluid inside of me. The womb is a place where your baby is supposed to be the safest,” Jabeen said.

Jabeen’s case is likely not included in PHAC’s count. Jabeen says she was called by Health Canada and asked what dairy and fresh produce she ate – foods more commonly associated with listeria – but not asked about plant-based beverages.

She’s pregnant again, and is due in several months. At first, she was scared to eat, not knowing what caused the infection during her last pregnancy.

“Ever since I learned about the almond, oat milk situation, I’ve been feeling a bit better knowing that it wasn’t something that I did. It was something else that caused it. It wasn’t my fault,” Jabeen said.

She’s since joined a proposed class action lawsuit launched by LPC Avocates against the manufacturers and sellers of Silk and Great Value plant-based beverages. The lawsuit has not yet been certified by a judge.

Natalie Grant and her seven year-old daughter, Bowmanville, Ont.

Natalie Grant says she was in a hospital waiting room when she saw a television news report about the recall. She wondered if the dark chocolate almond milk her daughter drank daily was contaminated.

She had brought the girl to hospital because she was vomiting every half hour, constantly on the toilet with diarrhea, and had severe pain in her abdomen.

“I’m definitely thinking that this is a pretty solid chance that she’s got listeria at this point because I knew she had all the symptoms,” Grant says of seeing the news report.

Once her daughter could hold fluids, they went home and Grant cross-checked the recalled product code – 7825 – with the one on her carton. They matched.

“I called the emerg and I said I’m pretty confident she’s been exposed,” Grant said. She was told to return to the hospital if her daughter’s symptoms worsened. An hour and a half later, her fever spiked, the vomiting returned, her face flushed and her energy plummeted.

Grant says they were sent to a hospital in Ajax, Ont. and stayed two weeks while her daughter received antibiotics four times a day until she was discharged July 23.

“Knowing that my little one was just so affected and how it affected us as a family alone, there’s a bitterness left behind,” Grant said. She’s also joined the proposed class action.

Thelma Feldman, 89, Toronto

Thelma Feldman says she regularly taught yoga to friends in her condo building before getting sickened by listeria on July 2. Now, she has a walker and her body aches. She has headaches and digestive problems.

“I’m kind of depressed,” she says.

“It’s caused me a lot of physical and emotional pain.”

Much of the early days of her illness are a blur. She knows she boarded an ambulance with profuse diarrhea on July 2 and spent five days at North York General Hospital. Afterwards, she remembers Health Canada officials entering her apartment and removing Silk almond milk from her fridge, and volunteers from a community organization giving her sponge baths.

“At my age, 89, I’m not a kid anymore and healing takes longer,” Feldman says.

“I don’t even feel like being with people. I just sit at home.”

Jasmine Jiles and three-year-old Max, Kahnawake Mohawk Territory, Que.

Jasmine Jiles says her three-year-old son Max came down with flu-like symptoms and cradled his ears in what she interpreted as a sign of pain, like the one pounding in her own head, around early July.

When Jiles heard about the recall soon after, she called Danone Canada, the plant-based milk manufacturer, to find out if their Silk coconut milk was in the contaminated batch. It was, she says.

“My son is very small, he’s very young, so I asked what we do in terms of overall monitoring and she said someone from the company would get in touch within 24 to 48 hours,” Jiles says from a First Nations reserve near Montreal.

“I never got a call back. I never got an email”

At home, her son’s fever broke after three days, but gas pains stuck with him, she says. It took a couple weeks for him to get back to normal.

“In hindsight, I should have taken him (to the hospital) but we just tried to see if we could nurse him at home because wait times are pretty extreme,” Jiles says, “and I don’t have child care at the moment.”

Joseph Desmond, 50, Sydney, N.S.

Joseph Desmond says he suffered a seizure and fell off his sofa on July 9. He went to the emergency room, where they ran an electroencephalogram (EEG) test, and then returned home. Within hours, he had a second seizure and went back to hospital.

His third seizure happened the next morning while walking to the nurse’s station.

In severe cases of listeriosis, bacteria can spread to the central nervous system and cause seizures, according to Health Canada.

“The last two months have really been a nightmare,” says Desmond, who has joined the proposed lawsuit.

When he returned home from the hospital, his daughter took a carton of Silk dark chocolate almond milk out of the fridge and asked if he had heard about the recall. By that point, Desmond says he was on his second two-litre carton after finishing the first in June.

“It was pretty scary. Terrifying. I honestly thought I was going to die.”

Cheryl McCombe, 63, Haliburton, Ont.

The morning after suffering a second episode of vomiting, feverish sweats and diarrhea in the middle of the night in early July, Cheryl McCombe scrolled through the news on her phone and came across the recall.

A few years earlier, McCombe says she started drinking plant-based milks because it seemed like a healthier choice to splash in her morning coffee. On June 30, she bought two cartons of Silk cashew almond milk.

“It was on the (recall) list. I thought, ‘Oh my God, I got listeria,’” McCombe says. She called her doctor’s office and visited an urgent care clinic hoping to get tested and confirm her suspicion, but she says, “I was basically shut down at the door.”

Public Health Ontario does not recommend listeria testing for infected individuals with mild symptoms unless they are at risk of developing severe illness, such as people who are immunocompromised, elderly, pregnant or newborn.

“No wonder they couldn’t connect the dots,” she adds, referencing that it took close to a year for public health officials to find the source of the outbreak.

“I am a woman in my 60s and sometimes these signs are of, you know, when you’re vomiting and things like that, it can be a sign in women of a bigger issue,” McCombe says. She was seeking confirmation that wasn’t the case.

Disappointed, with her stomach still feeling off, she says she decided to boost her gut health with probiotics. After a couple weeks she started to feel like herself.

But since then, McCombe says, “I’m back on Kawartha Dairy cream in my coffee.”

This report by The Canadian Press was first published Sept. 16, 2024.

Canadian Press health coverage receives support through a partnership with the Canadian Medical Association. CP is solely responsible for this content.

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B.C. mayors seek ‘immediate action’ from federal government on mental health crisis

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VANCOUVER – Mayors and other leaders from several British Columbia communities say the provincial and federal governments need to take “immediate action” to tackle mental health and public safety issues that have reached crisis levels.

Vancouver Mayor Ken Sim says it’s become “abundantly clear” that mental health and addiction issues and public safety have caused crises that are “gripping” Vancouver, and he and other politicians, First Nations leaders and law enforcement officials are pleading for federal and provincial help.

In a letter to Prime Minister Justin Trudeau and Premier David Eby, mayors say there are “three critical fronts” that require action including “mandatory care” for people with severe mental health and addiction issues.

The letter says senior governments also need to bring in “meaningful bail reform” for repeat offenders, and the federal government must improve policing at Metro Vancouver ports to stop illicit drugs from coming in and stolen vehicles from being exported.

Sim says the “current system” has failed British Columbians, and the number of people dealing with severe mental health and addiction issues due to lack of proper care has “reached a critical point.”

Vancouver Police Chief Adam Palmer says repeat violent offenders are too often released on bail due to a “revolving door of justice,” and a new approach is needed to deal with mentally ill people who “pose a serious and immediate danger to themselves and others.”

This report by The Canadian Press was first published Sept. 16, 2024

The Canadian Press. All rights reserved.

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