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Recovered Patients May Still Be Infectious. And More Info Straight from Science Journals – TheTyee.ca

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With misinformation and deliberate disinformation running almost as rampant as the virus that causes COVID-19, we thought it would be best to go to the source for the latest insights. Compiled by veteran medical journalist Brian Owens, Hakai Magazine in partnership with The Tyee regularly presents this roundup of some of the newest science on the COVID-19 pandemic, straight from the scientific journals.

Masks may help prevent infected people from spreading the coronavirus that causes COVID-19

Surgical facemasks may be helpful in limiting the spread of coronaviruses from people who are infected. Masks were shown to significantly reduce the detection of influenza virus in respiratory droplets, and seasonal coronaviruses in aerosols. It is important to note, however, that the study did not examine SARS-CoV-2, the cause of COVID-19, specifically, and does not address whether masks work in the opposite direction: by preventing infections in the wearer.

Nature Medicine, April 3, 2020

Keep taking heart and kidney medication

Recently we highlighted a study that suggested that drugs commonly used to treat chronic heart and kidney diseases may increase the risk of complications from COVID-19. This study was based on animal experiments that showed that those drugs increased the number of ACE2 receptors in the animal. The coronavirus that causes COVID-19 uses ACE2 cells to enter the body.

Now, a group of researchers has completed a detailed review of more than 60 studies and concluded that none reported an increase in ACE2 levels in humans caused by these same drugs. They recommend patients currently taking these medications continue to do so without interruption.

Mayo Clinic Proceedings, March 30, 2020

Patients may still be infectious even after they recover

Two studies of patients who had recovered from COVID-19 found that they may still be infectious even after symptoms have disappeared. One study looked at people who had mild infections and found that half of them continued to test positive for up to eight days after their symptoms disappeared. The other study found that the virus could still be detected in a patient’s mucous and feces even after they had tested negative on two consecutive throat swabs. The researchers recommend that if you were quarantined at home with mild symptoms, you should extend your quarantine for another two weeks even after you feel better.

American Journal of Respiratory and Critical Care Medicine, March 23, 2020

Annals of Internal Medicine, March 30, 2020

Patients shed the virus at high rates early in infection

Scientists in Germany have found that shedding of SARS-CoV-2 in the upper respiratory tract occurs most efficiently early on, when patients still have mild symptoms. They could detect the infectious form of the virus in the throat and lungs until day eight of symptoms, and viral RNA in mucus from the lungs after the symptoms were gone. They did not detect the virus in blood or urine, and did not find the infectious form in feces, despite high levels of viral RNA.

Nature, April 1, 2020

Potential vaccine shows promise in mice

A potential vaccine against SARS-CoV-2, developed at the University of Pittsburgh, has been tested in mice. The vaccine was found to produce antibodies specific to the virus at quantities thought to be sufficient to neutralize the virus. The vaccine uses lab-made pieces of viral protein to trigger an immune response — the same way that current flu vaccines work. It is delivered using a microneedle array, a fingertip-sized patch of 400 tiny needles made of sugar that goes on like a Band-Aid and delivers the vaccine into the skin. The researchers expect to start trials in humans within a few months.

eBioMedicine, April 2, 2020

Potential treatment drug identified by University of British Columbia scientists

A drug that has already been tested against lung disease could potentially be a useful treatment for COVID-19. The drug, called human recombinant soluble angiotensin-converting enzyme 2, blocks the ACE2 receptor that the virus uses to enter cells. In cell cultures, hrsACE2 reduced viral growth by a factor of 1,000 to 5,000.

Cell, April 2, 2020

What affects adherence to quarantine?

A person’s compliance with quarantine rules during infectious disease outbreaks can vary from as little as zero per cent up to 92.8 per cent, according to a review of existing research. The factors that have the biggest effect of adherence are the knowledge people had about the disease and quarantine procedure, social norms, perceived benefits of quarantine and perceived risk of the disease, as well as practical issues such as running out of supplies or the financial consequences of being out of work. Public health officials should take these factors into account to improve adherence, the researchers say.

Public Health, March 30, 2020

No evidence for or against ibuprofen

Despite speculation that non-steroidal anti-inflammatory drugs such as ibuprofen might make things worse for some COVID-19 patients, a review of existing research found no evidence either for or against the use of NSAIDs for COVID-19. The researchers also found that other types of drugs such as TNF blockers and JAK inhibitors, used to treat arthritis or other forms of inflammation, were safe to use, and there is some evidence that corticosteroids may be helpful if used in the early acute phase of infection, but the evidence is not conclusive. Health authorities that had previously warned against the use of NSAIDs have since backed off that claim.

eCancerMedicalScience, March 30, 2020

Structure of the virus’s receptor binding domain

Two groups of scientists have determined the structure of SARS-CoV-2’s receptor binding domain, the protein that allows it to attach to human cells. They found that it was nearly identical to the one on SARS-CoV (the original SARS virus), but with a few changes that allow it to bind more effectively. The research helps us understand the evolutionary history of the virus and will help guide the development of treatments and vaccines.

Nature, March 30, 2020

Nature, March 30, 2020  [Tyee]

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What’s the greatest holiday gift: lips, hair, skin? Give the gift of great skin this holiday season

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Give the gift of great skin this holiday season

Skinstitut Holiday Gift Kits take the stress out of gifting

Toronto, October 31, 2024 – Beauty gifts are at the top of holiday wish lists this year, and Laser Clinics Canada, a leader in advanced beauty treatments and skincare, is taking the pressure out of seasonal shopping. Today, Laser Clincs Canada announces the arrival of its 2024 Holiday Gift Kits, courtesy of Skinstitut, the exclusive skincare line of Laser Clinics Group.

In time for the busy shopping season, the limited-edition Holiday Gifts Kits are available in Laser Clinics locations in the GTA and Ottawa. Clinics are conveniently located in popular shopping centers, including Hillcrest Mall, Square One, CF Sherway Gardens, Scarborough Town Centre, Rideau Centre, Union Station and CF Markville. These limited-edition Kits are available on a first come, first served basis.

“These kits combine our best-selling products, bundled to address the most relevant skin concerns we’re seeing among our clients,” says Christina Ho, Senior Brand & LAM Manager at Laser Clinics Canada. “With several price points available, the kits offer excellent value and suit a variety of gift-giving needs, from those new to cosmeceuticals to those looking to level up their skincare routine. What’s more, these kits are priced with a savings of up to 33 per cent so gift givers can save during the holiday season.

There are two kits to select from, each designed to address key skin concerns and each with a unique theme — Brightening Basics and Hydration Heroes.

Brightening Basics is a mix of everyday essentials for glowing skin for all skin types. The bundle comes in a sleek pink, reusable case and includes three full-sized products: 200ml gentle cleanser, 50ml Moisture Defence (normal skin) and 30ml1% Hyaluronic Complex Serum. The Brightening Basics kit is available at $129, a saving of 33 per cent.

Hydration Heroes is a mix of hydration essentials and active heroes that cater to a wide variety of clients. A perfect stocking stuffer, this bundle includes four deluxe products: Moisture 15 15 ml Defence for normal skin, 10 ml 1% Hyaluronic Complex Serum, 10 ml Retinol Serum and 50 ml Expert Squalane Cleansing Oil. The kit retails at $59.

In addition to the 2024 Holiday Gifts Kits, gift givers can easily add a Laser Clinic Canada gift card to the mix. Offering flexibility, recipients can choose from a wide range of treatments offered by Laser Clinics Canada, or they can expand their collection of exclusive Skinstitut products.

 

Brightening Basics 2024 Holiday Gift Kit by Skinstitut, available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

Hydration Heroes 2024 Holiday Gift Kit by Skinstitut – available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

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Here is how to prepare your online accounts for when you die

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LONDON (AP) — Most people have accumulated a pile of data — selfies, emails, videos and more — on their social media and digital accounts over their lifetimes. What happens to it when we die?

It’s wise to draft a will spelling out who inherits your physical assets after you’re gone, but don’t forget to take care of your digital estate too. Friends and family might treasure files and posts you’ve left behind, but they could get lost in digital purgatory after you pass away unless you take some simple steps.

Here’s how you can prepare your digital life for your survivors:

Apple

The iPhone maker lets you nominate a “ legacy contact ” who can access your Apple account’s data after you die. The company says it’s a secure way to give trusted people access to photos, files and messages. To set it up you’ll need an Apple device with a fairly recent operating system — iPhones and iPads need iOS or iPadOS 15.2 and MacBooks needs macOS Monterey 12.1.

For iPhones, go to settings, tap Sign-in & Security and then Legacy Contact. You can name one or more people, and they don’t need an Apple ID or device.

You’ll have to share an access key with your contact. It can be a digital version sent electronically, or you can print a copy or save it as a screenshot or PDF.

Take note that there are some types of files you won’t be able to pass on — including digital rights-protected music, movies and passwords stored in Apple’s password manager. Legacy contacts can only access a deceased user’s account for three years before Apple deletes the account.

Google

Google takes a different approach with its Inactive Account Manager, which allows you to share your data with someone if it notices that you’ve stopped using your account.

When setting it up, you need to decide how long Google should wait — from three to 18 months — before considering your account inactive. Once that time is up, Google can notify up to 10 people.

You can write a message informing them you’ve stopped using the account, and, optionally, include a link to download your data. You can choose what types of data they can access — including emails, photos, calendar entries and YouTube videos.

There’s also an option to automatically delete your account after three months of inactivity, so your contacts will have to download any data before that deadline.

Facebook and Instagram

Some social media platforms can preserve accounts for people who have died so that friends and family can honor their memories.

When users of Facebook or Instagram die, parent company Meta says it can memorialize the account if it gets a “valid request” from a friend or family member. Requests can be submitted through an online form.

The social media company strongly recommends Facebook users add a legacy contact to look after their memorial accounts. Legacy contacts can do things like respond to new friend requests and update pinned posts, but they can’t read private messages or remove or alter previous posts. You can only choose one person, who also has to have a Facebook account.

You can also ask Facebook or Instagram to delete a deceased user’s account if you’re a close family member or an executor. You’ll need to send in documents like a death certificate.

TikTok

The video-sharing platform says that if a user has died, people can submit a request to memorialize the account through the settings menu. Go to the Report a Problem section, then Account and profile, then Manage account, where you can report a deceased user.

Once an account has been memorialized, it will be labeled “Remembering.” No one will be able to log into the account, which prevents anyone from editing the profile or using the account to post new content or send messages.

X

It’s not possible to nominate a legacy contact on Elon Musk’s social media site. But family members or an authorized person can submit a request to deactivate a deceased user’s account.

Passwords

Besides the major online services, you’ll probably have dozens if not hundreds of other digital accounts that your survivors might need to access. You could just write all your login credentials down in a notebook and put it somewhere safe. But making a physical copy presents its own vulnerabilities. What if you lose track of it? What if someone finds it?

Instead, consider a password manager that has an emergency access feature. Password managers are digital vaults that you can use to store all your credentials. Some, like Keeper,Bitwarden and NordPass, allow users to nominate one or more trusted contacts who can access their keys in case of an emergency such as a death.

But there are a few catches: Those contacts also need to use the same password manager and you might have to pay for the service.

___

Is there a tech challenge you need help figuring out? Write to us at onetechtip@ap.org with your questions.

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Pediatric group says doctors should regularly screen kids for reading difficulties

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The Canadian Paediatric Society says doctors should regularly screen children for reading difficulties and dyslexia, calling low literacy a “serious public health concern” that can increase the risk of other problems including anxiety, low self-esteem and behavioural issues, with lifelong consequences.

New guidance issued Wednesday says family doctors, nurses, pediatricians and other medical professionals who care for school-aged kids are in a unique position to help struggling readers access educational and specialty supports, noting that identifying problems early couldhelp kids sooner — when it’s more effective — as well as reveal other possible learning or developmental issues.

The 10 recommendations include regular screening for kids aged four to seven, especially if they belong to groups at higher risk of low literacy, including newcomers to Canada, racialized Canadians and Indigenous Peoples. The society says this can be done in a two-to-three-minute office-based assessment.

Other tips encourage doctors to look for conditions often seen among poor readers such as attention-deficit hyperactivity disorder; to advocate for early literacy training for pediatric and family medicine residents; to liaise with schools on behalf of families seeking help; and to push provincial and territorial education ministries to integrate evidence-based phonics instruction into curriculums, starting in kindergarten.

Dr. Scott McLeod, one of the authors and chair of the society’s mental health and developmental disabilities committee, said a key goal is to catch kids who may be falling through the cracks and to better connect families to resources, including quicker targeted help from schools.

“Collaboration in this area is so key because we need to move away from the silos of: everything educational must exist within the educational portfolio,” McLeod said in an interview from Calgary, where he is a developmental pediatrician at Alberta Children’s Hospital.

“Reading, yes, it’s education, but it’s also health because we know that literacy impacts health. So I think that a statement like this opens the window to say: Yes, parents can come to their health-care provider to get advice, get recommendations, hopefully start a collaboration with school teachers.”

McLeod noted that pediatricians already look for signs of low literacy in young children by way of a commonly used tool known as the Rourke Baby Record, which offers a checklist of key topics, such as nutrition and developmental benchmarks, to cover in a well-child appointment.

But he said questions about reading could be “a standing item” in checkups and he hoped the society’s statement to medical professionals who care for children “enhances their confidence in being a strong advocate for the child” while spurring partnerships with others involved in a child’s life such as teachers and psychologists.

The guidance said pediatricians also play a key role in detecting and monitoring conditions that often coexist with difficulty reading such as attention-deficit hyperactivity disorder, but McLeod noted that getting such specific diagnoses typically involves a referral to a specialist, during which time a child continues to struggle.

He also acknowledged that some schools can be slow to act without a specific diagnosis from a specialist, and even then a child may end up on a wait list for school interventions.

“Evidence-based reading instruction shouldn’t have to wait for some of that access to specialized assessments to occur,” he said.

“My hope is that (by) having an existing statement or document written by the Canadian Paediatric Society … we’re able to skip a few steps or have some of the early interventions present,” he said.

McLeod added that obtaining specific assessments from medical specialists is “definitely beneficial and advantageous” to know where a child is at, “but having that sort of clear, thorough assessment shouldn’t be a barrier to intervention starting.”

McLeod said the society was partly spurred to act by 2022’s “Right to Read Inquiry Report” from the Ontario Human Rights Commission, which made 157 recommendations to address inequities related to reading instruction in that province.

He called the new guidelines “a big reminder” to pediatric providers, family doctors, school teachers and psychologists of the importance of literacy.

“Early identification of reading difficulty can truly change the trajectory of a child’s life.”

This report by The Canadian Press was first published Oct. 23, 2024.

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