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Studies: Promising Cognitive and Imaging Results in Alzheimer’s and pre-dementia Patients

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Posit Science

SAN FRANCISCO, Nov. 21, 2023 (GLOBE NEWSWIRE) — A pair of articles in the Journal of Alzheimer’s Disease (JAD) from researchers, who conducted a pilot study for the treatment of pre-dementia and early Alzheimer’s using a precision medicine protocol (often called ReCode), shows a number of breakthrough results in both cognitive and imaging measures. The protocol personalizes treatment for each user to better fit their respective conditions and includes the brain training program BrainHQ from Posit Science, which continually adjusts to meet the needs of each user.

A review article, in a prior issue of JAD, explaining the dynamic nature of the protocol showed 25 participants had significant improvement, from before to after treatment, on a standard global cognition measure, the Montreal Cognitive Assessment (MoCA), and on a computerized assessment battery, CNS-Vital Signs. A follow-on imaging report in the current issue of JAD showed that these benefits were accompanied by declines in white matter and grey matter that were more similar to the declines typically seen in healthy older adults than the steeper declines typically seen in those with dementia.

Overall, the researchers saw significant and widespread improvement in cognitive performance as measured by MoCA scores, which improved in 76% of patients and CNS-Vital Signs scores, which improved in 84% of patients. They also saw physical brain improvements in the imaging results that showed a trend toward renormalization to results typically seen in healthy older adults. While the imaging results appear to correspond with the cognitive assessment results, due to the small sample size and correction for multiple comparisons, the imaging results were not significant.

The authors of this single-arm study indicate that its findings support conducting a larger, randomized controlled clinical trial, which has already commenced at six different sites.

“These are promising and exciting results,” said Dr. Henry Mahncke, CEO of Posit Science. “They build on the findings in the multimodal FINGER Study in which diet, exercise, and brain training interventions were deployed, as well as the findings of the Lancet Commission that there are a dozen lifestyle interventions that can significantly reduce dementia risk. Notably, precision medicine makes a further advance by personalizing the protocol to each user based on their test results.”

In 2017, the ACTIVE Study published results on the impact of various types of brain training on the incidence of dementia over a 10-year period, and they found a significant reduction of 29% in the intervention group using a BrainHQ speed of processing exercise for 10-18 hours, and of up to 48% in people who trained a total of 14-18 hours. In 2020, Australian researchers using a multimodal approach of BrainHQ training, diet advice, and exercise advice, reported a significant reduction in Alzheimer’s risk among pre-dementia patients after an 8-week intervention.

Last month, researchers at the Institute for Systems Biology found that patients who received lifestyle coaching (including BrainHQ) derived cognitive benefit not generally seen in studies of Alzheimer’s drugs.

Last year, the National Institutes of Health made a grant to Posit Science to develop, with the YMCA of San Francisco and dementia experts at the University of California, San Francisco, a curriculum for community-based dementia prevention classes. Those classes have now rolled out in various YMCA locations across the San Francisco Bay Area.

BrainHQ exercises have also been used in many of the multimodal Worldwide FINGER studies, which have begun reporting results.

BrainHQ has shown benefits in hundreds of studies. Such benefits include gains in cognition (attention, speed, memory, decision-making), in quality of life (depressive symptoms, confidence and control, health-related quality of life) and in real-world activities (health outcomes, balance, driving, hearing). BrainHQ is offered, without charge, by leading national and 5-star Medicare Advantage plans and by leading medical centers, clinics, and communities. Consumers can try a BrainHQ exercise for free daily at https://www.brainhq.com.

CONTACT: Contact: media@brainhq.com

 

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How many Nova Scotians are on the doctor wait-list? Number hit 160,000 in June

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HALIFAX – The Nova Scotia government says it could be months before it reveals how many people are on the wait-list for a family doctor.

The head of the province’s health authority told reporters Wednesday that the government won’t release updated data until the 160,000 people who were on the wait-list in June are contacted to verify whether they still need primary care.

Karen Oldfield said Nova Scotia Health is working on validating the primary care wait-list data before posting new numbers, and that work may take a matter of months. The most recent public wait-list figures are from June 1, when 160,234 people, or about 16 per cent of the population, were on it.

“It’s going to take time to make 160,000 calls,” Oldfield said. “We are not talking weeks, we are talking months.”

The interim CEO and president of Nova Scotia Health said people on the list are being asked where they live, whether they still need a family doctor, and to give an update on their health.

A spokesperson with the province’s Health Department says the government and its health authority are “working hard” to turn the wait-list registry into a useful tool, adding that the data will be shared once it is validated.

Nova Scotia’s NDP are calling on Premier Tim Houston to immediately release statistics on how many people are looking for a family doctor. On Tuesday, the NDP introduced a bill that would require the health minister to make the number public every month.

“It is unacceptable for the list to be more than three months out of date,” NDP Leader Claudia Chender said Tuesday.

Chender said releasing this data regularly is vital so Nova Scotians can track the government’s progress on its main 2021 campaign promise: fixing health care.

The number of people in need of a family doctor has more than doubled between the 2021 summer election campaign and June 2024. Since September 2021 about 300 doctors have been added to the provincial health system, the Health Department said.

“We’ll know if Tim Houston is keeping his 2021 election promise to fix health care when Nova Scotians are attached to primary care,” Chender said.

This report by The Canadian Press was first published Sept. 11, 2024.

The Canadian Press. All rights reserved.

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Newfoundland and Labrador monitoring rise in whooping cough cases: medical officer

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ST. JOHN’S, N.L. – Newfoundland and Labrador‘s chief medical officer is monitoring the rise of whooping cough infections across the province as cases of the highly contagious disease continue to grow across Canada.

Dr. Janice Fitzgerald says that so far this year, the province has recorded 230 confirmed cases of the vaccine-preventable respiratory tract infection, also known as pertussis.

Late last month, Quebec reported more than 11,000 cases during the same time period, while Ontario counted 470 cases, well above the five-year average of 98. In Quebec, the majority of patients are between the ages of 10 and 14.

Meanwhile, New Brunswick has declared a whooping cough outbreak across the province. A total of 141 cases were reported by last month, exceeding the five-year average of 34.

The disease can lead to severe complications among vulnerable populations including infants, who are at the highest risk of suffering from complications like pneumonia and seizures. Symptoms may start with a runny nose, mild fever and cough, then progress to severe coughing accompanied by a distinctive “whooping” sound during inhalation.

“The public, especially pregnant people and those in close contact with infants, are encouraged to be aware of symptoms related to pertussis and to ensure vaccinations are up to date,” Newfoundland and Labrador’s Health Department said in a statement.

Whooping cough can be treated with antibiotics, but vaccination is the most effective way to control the spread of the disease. As a result, the province has expanded immunization efforts this school year. While booster doses are already offered in Grade 9, the vaccine is now being offered to Grade 8 students as well.

Public health officials say whooping cough is a cyclical disease that increases every two to five or six years.

Meanwhile, New Brunswick’s acting chief medical officer of health expects the current case count to get worse before tapering off.

A rise in whooping cough cases has also been reported in the United States and elsewhere. The Pan American Health Organization issued an alert in July encouraging countries to ramp up their surveillance and vaccination coverage.

This report by The Canadian Press was first published Sept. 10, 2024.

The Canadian Press. All rights reserved.

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Bizarre Sunlight Loophole Melts Belly Fat Fast!

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