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Vaccine Development Threatened as COVID-19 Infections Decline – PJ Media

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A COVID-19 vaccine developed by Oxford University has generated significant interest. Both the United States and the United Kingdom have ordered large numbers of doses in anticipation of successful human trials. The development cycle for this particular vaccine was shortened because it has already been tested in primates with good results.

President Trump announced Operation Warp Speed, which is aimed at expediting the development and approval of an effective vaccine. This includes upending the traditional production of them. Top vaccine candidates will be manufactured in advance of demonstrating effectiveness so they will be available more quickly.

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The Oxford vaccine is one of these candidates and AstraZeneca has struck a deal to produce the vaccine in advance of the conclusion of the human trial. This effort has been backed by $1 billion in U.S. taxpayer money. The goal is to produce 300 million doses by November of 2020.

Not Enough COVID-19

However, Oxford researchers are now warning of an obstacle in the trial process. As new cases of COVID-19 are declining, they worry the data will not meet the hurdles to prove effectiveness. They are now placing the odds of a successful trial at 50%. Professor Adrian Hill is sounding the alarm:

The stakes could hardly be higher. If proven effective, the ZD1222 vaccine would allow people to leave their homes and go back to work, and the shattered global economy to rebuild. But Hill, director of the university’s Jenner Institute, revealed his team now faced a major problem, throwing the September deadline into doubt.

“It is a race, yes. But it’s not a race against the other guys. It’s a race against the virus disappearing, and against time,” he said. “At the moment, there’s a 50 per cent chance that we get no result at all.”

The professor went on to explain that the trial has recruited 10,000 individuals to take the vaccine. He would expect fewer than 50 to contract COVID-19. If fewer than 20 do, Hill says the results will be useless, putting the trial in jeopardy.

“We’re in the bizarre position of wanting COVID to stay, at least for a little while. But cases are declining.”

Bizarre no doubt, given we were all assured cases would explode as lockdown restrictions were lifted.

The Vaccine Conundrum

This also places residents in some areas of the United States in quite a conundrum. State and local leaders like Mayor Eric Garcetti of Los Angeles and Governor Tom Wolfe of Pennsylvania have said that their citizens cannot return to normal until we have an effective vaccine.

However, according to Professor Hill, we can’t have an effective vaccine unless the virus is spreading at a rate sufficient to infect a statistically significant portion of the test group. It appears we have slowed the spread to such a degree it may deprive us of the vaccine so many are desperately relying on.

Protect the Vulnerable

This is just another reason to loosen lockdown restrictions. In order to test vaccines, the virus needs to circulate. In order for it to circulate people need to be moving around in public. Clearly to get to this point quickly and safely a few things need to happen. This approach should be bolstered by the CDC’s mortality data revisions.

As our health experts have often said, we need to learn to do two things at once. The data shows COVID-19 is most severe in the elderly with pre-existing conditions. Data shows the experience in nursing homes and assisted living facilities is particularly devastating. The public health system must figure out how to scrupulously protect these residents through aggressive sentinel testing and protective measures.

Let COVID-19 Circulate

The virus is least likely to be severe and result in death for people under 50. This is the vast majority of the school and working-age population. Let these people get back to their normal lives taking care to advise those with pre-existing conditions associated with severe or fatal outcomes on how they can protect themselves.

Doctors and clinicians should focus their efforts on information sharing and educating the public on symptoms and treatments aimed at mitigating the most serious disease in the under-50 cohort. There is increasing evidence this is due to an immune system overreaction called a cytokine storm.

Treatment protocols for this condition, such as the one developed by the ICU team at Cedars Sinai Providence, should be widely shared and refined. The FDA should be giving Emergency Use Authorizations for the drugs involved in this treatment as well as the antivirals and other drugs it has been applied to.

Finally, silent hypoxia, or lack of oxygen in the blood, seems to be an early indicator of severe disease in COVID-19. Patients who test positive for the virus should be encouraged to purchase or be loaned a pulse oximeter to continuously monitor this level and given instructions on what level indicates they should seek medical attention immediately.

The idea of herd immunity appears harder to obtain than originally thought given the original infection rate or R0 that was calculated. Sweden, which chose to pursue this model, only has an antibody rate of 7.3% in Stockholm as of the end of April. This is well below the expectation of 60% forecasted originally. This information also presents a hurdle to vaccine development. It is spreading more slowly than assumed.

Allowing the virus to circulate among the population least likely to suffer fatal outcomes is critical to the successful development of a vaccine. A successful vaccine, should one be developed, will allow our high-risk population to confidently return to a normal life. If we don’t move to do this quickly and safely, we only delay the development of the best preventative tool we have.

Editor’s Note: Want to support PJ Media so we can keep telling the truth about China and the virus they unleashed on the world? Join PJ Media VIP and use the promo code WUHAN to get 25% off your VIP membership.

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What’s the greatest holiday gift: lips, hair, skin? Give the gift of great skin this holiday season

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Give the gift of great skin this holiday season

Skinstitut Holiday Gift Kits take the stress out of gifting

Toronto, October 31, 2024 – Beauty gifts are at the top of holiday wish lists this year, and Laser Clinics Canada, a leader in advanced beauty treatments and skincare, is taking the pressure out of seasonal shopping. Today, Laser Clincs Canada announces the arrival of its 2024 Holiday Gift Kits, courtesy of Skinstitut, the exclusive skincare line of Laser Clinics Group.

In time for the busy shopping season, the limited-edition Holiday Gifts Kits are available in Laser Clinics locations in the GTA and Ottawa. Clinics are conveniently located in popular shopping centers, including Hillcrest Mall, Square One, CF Sherway Gardens, Scarborough Town Centre, Rideau Centre, Union Station and CF Markville. These limited-edition Kits are available on a first come, first served basis.

“These kits combine our best-selling products, bundled to address the most relevant skin concerns we’re seeing among our clients,” says Christina Ho, Senior Brand & LAM Manager at Laser Clinics Canada. “With several price points available, the kits offer excellent value and suit a variety of gift-giving needs, from those new to cosmeceuticals to those looking to level up their skincare routine. What’s more, these kits are priced with a savings of up to 33 per cent so gift givers can save during the holiday season.

There are two kits to select from, each designed to address key skin concerns and each with a unique theme — Brightening Basics and Hydration Heroes.

Brightening Basics is a mix of everyday essentials for glowing skin for all skin types. The bundle comes in a sleek pink, reusable case and includes three full-sized products: 200ml gentle cleanser, 50ml Moisture Defence (normal skin) and 30ml1% Hyaluronic Complex Serum. The Brightening Basics kit is available at $129, a saving of 33 per cent.

Hydration Heroes is a mix of hydration essentials and active heroes that cater to a wide variety of clients. A perfect stocking stuffer, this bundle includes four deluxe products: Moisture 15 15 ml Defence for normal skin, 10 ml 1% Hyaluronic Complex Serum, 10 ml Retinol Serum and 50 ml Expert Squalane Cleansing Oil. The kit retails at $59.

In addition to the 2024 Holiday Gifts Kits, gift givers can easily add a Laser Clinic Canada gift card to the mix. Offering flexibility, recipients can choose from a wide range of treatments offered by Laser Clinics Canada, or they can expand their collection of exclusive Skinstitut products.

 

Brightening Basics 2024 Holiday Gift Kit by Skinstitut, available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

Hydration Heroes 2024 Holiday Gift Kit by Skinstitut – available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

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Here is how to prepare your online accounts for when you die

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LONDON (AP) — Most people have accumulated a pile of data — selfies, emails, videos and more — on their social media and digital accounts over their lifetimes. What happens to it when we die?

It’s wise to draft a will spelling out who inherits your physical assets after you’re gone, but don’t forget to take care of your digital estate too. Friends and family might treasure files and posts you’ve left behind, but they could get lost in digital purgatory after you pass away unless you take some simple steps.

Here’s how you can prepare your digital life for your survivors:

Apple

The iPhone maker lets you nominate a “ legacy contact ” who can access your Apple account’s data after you die. The company says it’s a secure way to give trusted people access to photos, files and messages. To set it up you’ll need an Apple device with a fairly recent operating system — iPhones and iPads need iOS or iPadOS 15.2 and MacBooks needs macOS Monterey 12.1.

For iPhones, go to settings, tap Sign-in & Security and then Legacy Contact. You can name one or more people, and they don’t need an Apple ID or device.

You’ll have to share an access key with your contact. It can be a digital version sent electronically, or you can print a copy or save it as a screenshot or PDF.

Take note that there are some types of files you won’t be able to pass on — including digital rights-protected music, movies and passwords stored in Apple’s password manager. Legacy contacts can only access a deceased user’s account for three years before Apple deletes the account.

Google

Google takes a different approach with its Inactive Account Manager, which allows you to share your data with someone if it notices that you’ve stopped using your account.

When setting it up, you need to decide how long Google should wait — from three to 18 months — before considering your account inactive. Once that time is up, Google can notify up to 10 people.

You can write a message informing them you’ve stopped using the account, and, optionally, include a link to download your data. You can choose what types of data they can access — including emails, photos, calendar entries and YouTube videos.

There’s also an option to automatically delete your account after three months of inactivity, so your contacts will have to download any data before that deadline.

Facebook and Instagram

Some social media platforms can preserve accounts for people who have died so that friends and family can honor their memories.

When users of Facebook or Instagram die, parent company Meta says it can memorialize the account if it gets a “valid request” from a friend or family member. Requests can be submitted through an online form.

The social media company strongly recommends Facebook users add a legacy contact to look after their memorial accounts. Legacy contacts can do things like respond to new friend requests and update pinned posts, but they can’t read private messages or remove or alter previous posts. You can only choose one person, who also has to have a Facebook account.

You can also ask Facebook or Instagram to delete a deceased user’s account if you’re a close family member or an executor. You’ll need to send in documents like a death certificate.

TikTok

The video-sharing platform says that if a user has died, people can submit a request to memorialize the account through the settings menu. Go to the Report a Problem section, then Account and profile, then Manage account, where you can report a deceased user.

Once an account has been memorialized, it will be labeled “Remembering.” No one will be able to log into the account, which prevents anyone from editing the profile or using the account to post new content or send messages.

X

It’s not possible to nominate a legacy contact on Elon Musk’s social media site. But family members or an authorized person can submit a request to deactivate a deceased user’s account.

Passwords

Besides the major online services, you’ll probably have dozens if not hundreds of other digital accounts that your survivors might need to access. You could just write all your login credentials down in a notebook and put it somewhere safe. But making a physical copy presents its own vulnerabilities. What if you lose track of it? What if someone finds it?

Instead, consider a password manager that has an emergency access feature. Password managers are digital vaults that you can use to store all your credentials. Some, like Keeper,Bitwarden and NordPass, allow users to nominate one or more trusted contacts who can access their keys in case of an emergency such as a death.

But there are a few catches: Those contacts also need to use the same password manager and you might have to pay for the service.

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Is there a tech challenge you need help figuring out? Write to us at onetechtip@ap.org with your questions.

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Pediatric group says doctors should regularly screen kids for reading difficulties

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The Canadian Paediatric Society says doctors should regularly screen children for reading difficulties and dyslexia, calling low literacy a “serious public health concern” that can increase the risk of other problems including anxiety, low self-esteem and behavioural issues, with lifelong consequences.

New guidance issued Wednesday says family doctors, nurses, pediatricians and other medical professionals who care for school-aged kids are in a unique position to help struggling readers access educational and specialty supports, noting that identifying problems early couldhelp kids sooner — when it’s more effective — as well as reveal other possible learning or developmental issues.

The 10 recommendations include regular screening for kids aged four to seven, especially if they belong to groups at higher risk of low literacy, including newcomers to Canada, racialized Canadians and Indigenous Peoples. The society says this can be done in a two-to-three-minute office-based assessment.

Other tips encourage doctors to look for conditions often seen among poor readers such as attention-deficit hyperactivity disorder; to advocate for early literacy training for pediatric and family medicine residents; to liaise with schools on behalf of families seeking help; and to push provincial and territorial education ministries to integrate evidence-based phonics instruction into curriculums, starting in kindergarten.

Dr. Scott McLeod, one of the authors and chair of the society’s mental health and developmental disabilities committee, said a key goal is to catch kids who may be falling through the cracks and to better connect families to resources, including quicker targeted help from schools.

“Collaboration in this area is so key because we need to move away from the silos of: everything educational must exist within the educational portfolio,” McLeod said in an interview from Calgary, where he is a developmental pediatrician at Alberta Children’s Hospital.

“Reading, yes, it’s education, but it’s also health because we know that literacy impacts health. So I think that a statement like this opens the window to say: Yes, parents can come to their health-care provider to get advice, get recommendations, hopefully start a collaboration with school teachers.”

McLeod noted that pediatricians already look for signs of low literacy in young children by way of a commonly used tool known as the Rourke Baby Record, which offers a checklist of key topics, such as nutrition and developmental benchmarks, to cover in a well-child appointment.

But he said questions about reading could be “a standing item” in checkups and he hoped the society’s statement to medical professionals who care for children “enhances their confidence in being a strong advocate for the child” while spurring partnerships with others involved in a child’s life such as teachers and psychologists.

The guidance said pediatricians also play a key role in detecting and monitoring conditions that often coexist with difficulty reading such as attention-deficit hyperactivity disorder, but McLeod noted that getting such specific diagnoses typically involves a referral to a specialist, during which time a child continues to struggle.

He also acknowledged that some schools can be slow to act without a specific diagnosis from a specialist, and even then a child may end up on a wait list for school interventions.

“Evidence-based reading instruction shouldn’t have to wait for some of that access to specialized assessments to occur,” he said.

“My hope is that (by) having an existing statement or document written by the Canadian Paediatric Society … we’re able to skip a few steps or have some of the early interventions present,” he said.

McLeod added that obtaining specific assessments from medical specialists is “definitely beneficial and advantageous” to know where a child is at, “but having that sort of clear, thorough assessment shouldn’t be a barrier to intervention starting.”

McLeod said the society was partly spurred to act by 2022’s “Right to Read Inquiry Report” from the Ontario Human Rights Commission, which made 157 recommendations to address inequities related to reading instruction in that province.

He called the new guidelines “a big reminder” to pediatric providers, family doctors, school teachers and psychologists of the importance of literacy.

“Early identification of reading difficulty can truly change the trajectory of a child’s life.”

This report by The Canadian Press was first published Oct. 23, 2024.

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