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It has been called life support of the last resort, and during the pandemic ECMO, or extracorporeal membrane oxygenation, has helped pull some critically ill patients back from the brink of death.
It has been called life support of the last resort, and during the pandemic ECMO, or extracorporeal membrane oxygenation, has helped pull some critically ill patients back from the brink of death.
But treatment with the advanced form of life support appears to come at a cost for some patients, according to a new study by Ottawa researchers.
The study, published in JAMA this week, found that survivors of ECMO had a 24 per cent higher rate of mental health diagnoses after discharge compared to other ICU survivors.
“We already knew that ICU survivors can suffer mental health impacts from the trauma of invasive treatments, living with new physical limitations and dealing with long recovery times,” said lead author Dr. Shannon Fernando, a critical care physician at Lakeridge Health and postdoctoral fellow at The Ottawa Hospital and the University of Ottawa.
“We suspected ECMO survivors would be at greater risk of mental health impacts because they are sedated and ventilated for longer and often face a more challenging recovery. But we didn’t have clear data until now.”
ECMO, which temporarily replaces the heart and lungs of patients suffering from heart or respiratory failure, is used at five centres in Ontario, including the University of Ottawa Heart Institute.
The timing of the research is particularly relevant, say researchers, because use of ECMO grew worldwide during the COVID-19 pandemic to address record numbers of patients with severe respiratory failure. At one point, Ontario had twice as many patients on ECMO as it did pre-pandemic. It has typically been used infrequently because of limits on who qualifies and would benefit from use.
“We suddenly have a lot more ECMO survivors because of COVID-19,” said Dr. Kwadwo Kyeremanteng, co-senior author and scientist and critical care doctor at The Ottawa Hospital. “We need to make sure they have the mental health support they need to recover and survive.”
Because it is so invasive, ECMO is generally used on younger patients. About 50 to 65 per cent of those who receive the treatment survive and most are alive five years later, said Fernando.
The researchers from The Ottawa Hospital, the Institut du Savoir Montfort, ICES and the University of Ottawa studied health records from all ICU survivors in Ontario between April 2010 and March 2020. They matched 642 ECMO survivors with 3,820 ICU survivors who had similar characteristics, including age, sex, mental health history severity of illness and length of stay.
Thirty seven per cent of the ECMO survivors were diagnosed with a new mental health condition, such as depression, anxiety and traumatic disorders, a 24 per cent higher rate of new mental health diagnoses than the other ICU survivors.
Fernando led earlier research that found survivors of ICU are at higher risk of suicide and self harm after discharge. He said further heightened suicide and self-harm risk was not seen in the study on ECMO patients, but the research calls for a greater focus on the mental health of patients discharged from ICU and especially those who received ECMO treatment.
“Patients will need help long after they leave the ICU.”
Fernando said he has cared for patients recovering after receiving ECMO treatment. Patients would frequently describe nightmares and recurrent thoughts that were in keeping with post-traumatic stress disorders.
“It became clear it was exceedingly common.”
Knowing that can help to reassure patients, said co-senior author Dr. Peter Tanuseputro, physician-scientist at The Ottawa Hospital and ECES and investigator at the Bruyère Research Institute.
“As care providers, we can tell our patients that its common to struggle with your mental health after an ICU admission. ICU survivors need to realize that they often face months or years of recovery and families and healthcare providers need to support them.”
The full study can be found here.
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Grande Prairie RCMP issued a warning Friday after it was revealed fentanyl linked to a deadly overdose was mixed with a chemical that doesn’t respond to naloxone treatment.
The drugs were initially seized on Feb. 28 after a fatal overdose, and this week, Health Canada reported back to Mounties that the fentanyl had been mixed with Bromazolam, which is a benzodiazepine.
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Mounties say this is the first recorded instance of Bromazolam in Alberta. The drug has previously been linked to nine fatal overdoses in New Brunswick in 2022.
The pills seized in Alberta were oval-shaped and stamped with “20” and “SS,” though Mounties say it can come in other forms.
Naloxone treatment, given in many cases of opioid toxicity, is not effective in reversing the effects of Bromazalam, Mounties said, and therefore, any fentanyl mixed with the benzodiazepine “would see a reduced effectiveness of naloxone, requiring the use of additional doses and may still result in a fatality.”
From January to November of last year, there were 1,706 opioid-related deaths in Alberta, and 57 linked to benzodiazepine, up from 1,375 and 43, respectively, in 2022.
Mounties say officers responded to about 1,100 opioid-related calls for service, last year with a third of those proving fatal. RCMP officers also used naloxone 67 times while in the field, a jump of nearly a third over the previous year.
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The Canada Food Inspection Agency will continue to refer to highly pathogenic avian influenza in cattle as HPAI in cattle, and not refer to it as bovine influenza A virus (BIAV), as suggested by the American Association of Bovine Practitioners earlier this month.
Dr. Martin Appelt, senior director for the Canadian Food Inspection Agency, in the interview below, says at this time Canada will stick with “HPAI in cattle” when referencing the disease that’s been confirmed in dairy cattle in multiple states in the U.S.
The CFIA’s naming policy is consistent with the agency’s U.S. counterparts’, as the U.S. Animal and Plant Health Inspection Service has also said it will continue referring to it as HPAI or H5N1.
Appelt explains how the CFIA is learning from the U.S. experience to-date, and how it is working with veterinarians across Canada to stay vigilant for signs of the disease in dairy and beef cattle.
As of April 19, there has not been a confirmed case of HPAI in cattle in Canada. Appelt says it’s too soon to say if an eventual positive case will significantly restrict animal movement, as is the case with positive poultry cases.
This is a major concern for the cattle industry, as beef cattle especially move north and south across the U.S. border by the thousands. Appelt says that CFIA will address an infection in each species differently in conjunction with how the disease is spread and the threat to neighbouring farms or livestock.
Currently, provincial dairy organizations have advised producers to postpone any non-essential tours of dairy barns, as a precaution, in addition to other biosecurity measures to reduce the risk of cattle contracting HPAI.
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Canada has seen a concerning rise in measles cases in the first months of 2024.
By the third week of March, the country had already recorded more than three times the number of cases as all of last year. Canada had just 12 cases of measles in 2023, up from three in 2022.
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