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World on alert for potential spread of new SARS-like virus found in China – Science Magazine

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On New Year’s Day, Wuhan health authorities closed a live animal market linked to the mysterious outbreak.

NOEL CELIS/AFP/Getty Images

Had the nightmare returned? That’s the question many were asking in the first 10 days of this year, after a new form of pneumonia emerged in Wuhan, a megacity in central China. The outbreak revived memories of severe acute respiratory syndrome (SARS), the disease that emerged in China in 2002 and sickened 8098 people in 37 countries before it was quashed in the summer of 2003. Like SARS, the Wuhan pneumonia cases were linked to a market selling myriad species of live animals, and they appear to be caused by a new member of the coronavirus family closely related to the SARS virus. And once again, China appeared to be less than forthcoming with information.

Today, global health experts are breathing a little easier. As Science went to press, only one of 42 people known to be infected had died: a 61-year-old man already suffering from abdominal tumors and chronic liver disease. (SARS had a 9.6% mortality rate.) No evidence suggests the virus easily passes between humans, which can turn a local problem into a global crisis. And Chinese researchers have now shared the sequence of six genomes of the as-yet-unnamed virus with the world.

 Scientists in other countries have used the data. The World Health Organization (WHO) plans to soon publish a diagnostic test for the new virus that was developed by Christian Drosten, a virologist at Charité University Hospital in Berlin, and other researchers based on the sequences released by China. It detects fragments from three different genes in the novel coronavirus that are also present in the SARS virus. “We wanted to use SARS as a basis because every public health laboratory has SARS RNA as a positive control so they can get started immediately,” says Drosten, noting that SARS itself has not been detected in humans in 15 years. Ralph Baric, a coronavirus researcher at the University of North Carolina, Chapel Hill, is already trying to synthesize live virus from the data so that he can study it in animals and help develop a simple-to-use antibody test.

Still, many questions remain. Researchers have not identified the animal species at the marketplace that harbored the virus. When it emerged and the true number of people infected remain a mystery. Meanwhile, a case in Thailand, reported on 13 January—in a tourist who flew from Wuhan to Bangkok—led WHO Director-General Tedros Adhanom Ghebreyesus to consult experts on outbreak responses. The patient had not visited the Wuhan market at the center of the outbreak but had been to other animal markets, WHO reported on 14 January.

The first known patient developed symptoms—which can include difficulty breathing and fever—on 8 December 2019. Officials closed the seafood market on New Year’s Day, and no new patients have been identified in Wuhan since 3 January. The virus was not found in 763 close contacts of those infected, or in health care workers, who often fall ill during outbreaks of viruses that can transmit between humans. “It is a limited outbreak,” says Xu Jianguo, who runs an infectious disease laboratory at the Chinese Center for Disease Control and Prevention and heads an evaluation committee that’s advising the Chinese government. “If no new patients appear in the next week, it might be over.”

WHO said in a 12 January statement that it was “reassured of the quality of the ongoing investigations and the response measures implemented in Wuhan, and the commitment to share information regularly.”

But others criticized the way early information came out. News that researchers had discovered a novel coronavirus came in an 8 January story in The Wall Street Journal; Xu confirmed the finding on a state-run TV station several hours later. “It’s not a good situation when The Wall Street Journal [reports] a SARS-like coronavirus before the Chinese government announces it,” Baric says. On 10 January, Jeremy Farrar, an infectious disease specialist who heads the London-based Wellcome Trust, tweeted his worry about rumors that the Chinese government did not share “critical public health information” because Chinese researchers wanted to ensure publication of their findings in high-profile journals first.

Less than 12 hours later, however, evolutionary biologist Edward Holmes of the University of Sydney published an “initial” sequence of the new coronavirus on virological.org, on behalf of a consortium led by Zhang Yong-Zhen of Fudan University in Shanghai. The next day, three groups working under China’s National Health Commission posted another five sequences of the virus, gathered from different patients, on GISAID, a database primarily used for sharing data on influenza viruses.

The six sequences differ little from each other, which evolutionary biologist Andrew Rambaut of the University of Edinburgh says is “consistent with a point source”—meaning they likely came from the same batch of infected animals at the Huanan Seafood Wholesale Market, which also sells birds, snakes, and rabbit meat. (No coronaviruses have ever been found in fish.) But the fact that cases surfaced over the course of 1 month suggests the source was more than one group of animals at one location, Farrar says: “It makes me worry that whatever the exposure was to, it went on for quite a long time.” Virologist Guan Yi of Hong Kong University agrees that the Wuhan outbreak was caused by multiple jumps from animal to human hosts “separately and independently.”

Whatever species spread the virus at the market may have picked it up from some natural reservoir. Many coronaviruses occur naturally in bats, and the new virus is closest to four bat viruses that have surface proteins capable of infecting human cells. Still, Rambaut cautions there may well be another natural host. “It’s quite similar to a bat virus in parts of its genome, but not so much in other parts,” he says.

Farrar notes that most confirmed cases to date were mild, which means that even before health officials recognized the outbreak, the virus may have infected many other people who never sought medical care. That makes it premature to conclude the pathogen doesn’t spread from human to human, he says. Nurses and doctors, too, may have been infected without anyone noticing, he adds: “With a coronavirus, I’d be very surprised if there wasn’t some limited human-to-human transmission.” So far, cases have been confirmed by detecting nucleic acid from the virus, which disappears after patients recover. Now that the virus has been isolated, researchers can also develop antibody tests that pick up signs of past infection.

Limited as the outbreak appears to date, Farrar and others still worry that travel of hundreds of millions of people for the Lunar New Year celebration on 25 January could spread the virus from Wuhan, a major transportation hub, to other cities. “With people, food and animals move,” says Farrar, who suspects that this outbreak “is not going away anytime soon.”

With reporting by Kai Kupferschmidt.

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What’s the greatest holiday gift: lips, hair, skin? Give the gift of great skin this holiday season

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Give the gift of great skin this holiday season

Skinstitut Holiday Gift Kits take the stress out of gifting

Toronto, October 31, 2024 – Beauty gifts are at the top of holiday wish lists this year, and Laser Clinics Canada, a leader in advanced beauty treatments and skincare, is taking the pressure out of seasonal shopping. Today, Laser Clincs Canada announces the arrival of its 2024 Holiday Gift Kits, courtesy of Skinstitut, the exclusive skincare line of Laser Clinics Group.

In time for the busy shopping season, the limited-edition Holiday Gifts Kits are available in Laser Clinics locations in the GTA and Ottawa. Clinics are conveniently located in popular shopping centers, including Hillcrest Mall, Square One, CF Sherway Gardens, Scarborough Town Centre, Rideau Centre, Union Station and CF Markville. These limited-edition Kits are available on a first come, first served basis.

“These kits combine our best-selling products, bundled to address the most relevant skin concerns we’re seeing among our clients,” says Christina Ho, Senior Brand & LAM Manager at Laser Clinics Canada. “With several price points available, the kits offer excellent value and suit a variety of gift-giving needs, from those new to cosmeceuticals to those looking to level up their skincare routine. What’s more, these kits are priced with a savings of up to 33 per cent so gift givers can save during the holiday season.

There are two kits to select from, each designed to address key skin concerns and each with a unique theme — Brightening Basics and Hydration Heroes.

Brightening Basics is a mix of everyday essentials for glowing skin for all skin types. The bundle comes in a sleek pink, reusable case and includes three full-sized products: 200ml gentle cleanser, 50ml Moisture Defence (normal skin) and 30ml1% Hyaluronic Complex Serum. The Brightening Basics kit is available at $129, a saving of 33 per cent.

Hydration Heroes is a mix of hydration essentials and active heroes that cater to a wide variety of clients. A perfect stocking stuffer, this bundle includes four deluxe products: Moisture 15 15 ml Defence for normal skin, 10 ml 1% Hyaluronic Complex Serum, 10 ml Retinol Serum and 50 ml Expert Squalane Cleansing Oil. The kit retails at $59.

In addition to the 2024 Holiday Gifts Kits, gift givers can easily add a Laser Clinic Canada gift card to the mix. Offering flexibility, recipients can choose from a wide range of treatments offered by Laser Clinics Canada, or they can expand their collection of exclusive Skinstitut products.

 

Brightening Basics 2024 Holiday Gift Kit by Skinstitut, available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

Hydration Heroes 2024 Holiday Gift Kit by Skinstitut – available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

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Here is how to prepare your online accounts for when you die

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LONDON (AP) — Most people have accumulated a pile of data — selfies, emails, videos and more — on their social media and digital accounts over their lifetimes. What happens to it when we die?

It’s wise to draft a will spelling out who inherits your physical assets after you’re gone, but don’t forget to take care of your digital estate too. Friends and family might treasure files and posts you’ve left behind, but they could get lost in digital purgatory after you pass away unless you take some simple steps.

Here’s how you can prepare your digital life for your survivors:

Apple

The iPhone maker lets you nominate a “ legacy contact ” who can access your Apple account’s data after you die. The company says it’s a secure way to give trusted people access to photos, files and messages. To set it up you’ll need an Apple device with a fairly recent operating system — iPhones and iPads need iOS or iPadOS 15.2 and MacBooks needs macOS Monterey 12.1.

For iPhones, go to settings, tap Sign-in & Security and then Legacy Contact. You can name one or more people, and they don’t need an Apple ID or device.

You’ll have to share an access key with your contact. It can be a digital version sent electronically, or you can print a copy or save it as a screenshot or PDF.

Take note that there are some types of files you won’t be able to pass on — including digital rights-protected music, movies and passwords stored in Apple’s password manager. Legacy contacts can only access a deceased user’s account for three years before Apple deletes the account.

Google

Google takes a different approach with its Inactive Account Manager, which allows you to share your data with someone if it notices that you’ve stopped using your account.

When setting it up, you need to decide how long Google should wait — from three to 18 months — before considering your account inactive. Once that time is up, Google can notify up to 10 people.

You can write a message informing them you’ve stopped using the account, and, optionally, include a link to download your data. You can choose what types of data they can access — including emails, photos, calendar entries and YouTube videos.

There’s also an option to automatically delete your account after three months of inactivity, so your contacts will have to download any data before that deadline.

Facebook and Instagram

Some social media platforms can preserve accounts for people who have died so that friends and family can honor their memories.

When users of Facebook or Instagram die, parent company Meta says it can memorialize the account if it gets a “valid request” from a friend or family member. Requests can be submitted through an online form.

The social media company strongly recommends Facebook users add a legacy contact to look after their memorial accounts. Legacy contacts can do things like respond to new friend requests and update pinned posts, but they can’t read private messages or remove or alter previous posts. You can only choose one person, who also has to have a Facebook account.

You can also ask Facebook or Instagram to delete a deceased user’s account if you’re a close family member or an executor. You’ll need to send in documents like a death certificate.

TikTok

The video-sharing platform says that if a user has died, people can submit a request to memorialize the account through the settings menu. Go to the Report a Problem section, then Account and profile, then Manage account, where you can report a deceased user.

Once an account has been memorialized, it will be labeled “Remembering.” No one will be able to log into the account, which prevents anyone from editing the profile or using the account to post new content or send messages.

X

It’s not possible to nominate a legacy contact on Elon Musk’s social media site. But family members or an authorized person can submit a request to deactivate a deceased user’s account.

Passwords

Besides the major online services, you’ll probably have dozens if not hundreds of other digital accounts that your survivors might need to access. You could just write all your login credentials down in a notebook and put it somewhere safe. But making a physical copy presents its own vulnerabilities. What if you lose track of it? What if someone finds it?

Instead, consider a password manager that has an emergency access feature. Password managers are digital vaults that you can use to store all your credentials. Some, like Keeper,Bitwarden and NordPass, allow users to nominate one or more trusted contacts who can access their keys in case of an emergency such as a death.

But there are a few catches: Those contacts also need to use the same password manager and you might have to pay for the service.

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Is there a tech challenge you need help figuring out? Write to us at onetechtip@ap.org with your questions.

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Pediatric group says doctors should regularly screen kids for reading difficulties

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The Canadian Paediatric Society says doctors should regularly screen children for reading difficulties and dyslexia, calling low literacy a “serious public health concern” that can increase the risk of other problems including anxiety, low self-esteem and behavioural issues, with lifelong consequences.

New guidance issued Wednesday says family doctors, nurses, pediatricians and other medical professionals who care for school-aged kids are in a unique position to help struggling readers access educational and specialty supports, noting that identifying problems early couldhelp kids sooner — when it’s more effective — as well as reveal other possible learning or developmental issues.

The 10 recommendations include regular screening for kids aged four to seven, especially if they belong to groups at higher risk of low literacy, including newcomers to Canada, racialized Canadians and Indigenous Peoples. The society says this can be done in a two-to-three-minute office-based assessment.

Other tips encourage doctors to look for conditions often seen among poor readers such as attention-deficit hyperactivity disorder; to advocate for early literacy training for pediatric and family medicine residents; to liaise with schools on behalf of families seeking help; and to push provincial and territorial education ministries to integrate evidence-based phonics instruction into curriculums, starting in kindergarten.

Dr. Scott McLeod, one of the authors and chair of the society’s mental health and developmental disabilities committee, said a key goal is to catch kids who may be falling through the cracks and to better connect families to resources, including quicker targeted help from schools.

“Collaboration in this area is so key because we need to move away from the silos of: everything educational must exist within the educational portfolio,” McLeod said in an interview from Calgary, where he is a developmental pediatrician at Alberta Children’s Hospital.

“Reading, yes, it’s education, but it’s also health because we know that literacy impacts health. So I think that a statement like this opens the window to say: Yes, parents can come to their health-care provider to get advice, get recommendations, hopefully start a collaboration with school teachers.”

McLeod noted that pediatricians already look for signs of low literacy in young children by way of a commonly used tool known as the Rourke Baby Record, which offers a checklist of key topics, such as nutrition and developmental benchmarks, to cover in a well-child appointment.

But he said questions about reading could be “a standing item” in checkups and he hoped the society’s statement to medical professionals who care for children “enhances their confidence in being a strong advocate for the child” while spurring partnerships with others involved in a child’s life such as teachers and psychologists.

The guidance said pediatricians also play a key role in detecting and monitoring conditions that often coexist with difficulty reading such as attention-deficit hyperactivity disorder, but McLeod noted that getting such specific diagnoses typically involves a referral to a specialist, during which time a child continues to struggle.

He also acknowledged that some schools can be slow to act without a specific diagnosis from a specialist, and even then a child may end up on a wait list for school interventions.

“Evidence-based reading instruction shouldn’t have to wait for some of that access to specialized assessments to occur,” he said.

“My hope is that (by) having an existing statement or document written by the Canadian Paediatric Society … we’re able to skip a few steps or have some of the early interventions present,” he said.

McLeod added that obtaining specific assessments from medical specialists is “definitely beneficial and advantageous” to know where a child is at, “but having that sort of clear, thorough assessment shouldn’t be a barrier to intervention starting.”

McLeod said the society was partly spurred to act by 2022’s “Right to Read Inquiry Report” from the Ontario Human Rights Commission, which made 157 recommendations to address inequities related to reading instruction in that province.

He called the new guidelines “a big reminder” to pediatric providers, family doctors, school teachers and psychologists of the importance of literacy.

“Early identification of reading difficulty can truly change the trajectory of a child’s life.”

This report by The Canadian Press was first published Oct. 23, 2024.

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