adplus-dvertising
Connect with us

Health

UBC biochemist wins Gairdner Award for role in COVID-19 vaccines – CTV News

Published

 on


TORONTO —
When he established his lab at the University of British Columbia in the 1980s, Pieter Cullis says he never could have fathomed that his “curiosity-based” research would eventually play a critical role in the development of vaccines that have benefited hundreds of millions of people across the globe.

The Vancouver biochemistry professor was named among the winners of the prestigious Canada Gairdner Awards for his contributions to the development of mRNA COVID-19 vaccines.

Cullis said the accolade serves as a reminder that scientific inquiry starts with a question, and even “basic” research can lead to world-changing breakthroughs.

“We just find it kind of unbelievable,” Cullis said in an interview ahead of Tuesday’s Gairdner Awards announcement. “You’re working away, you’re doing what you do, and then who could prophesize that we’d have this kind of an impact.”

Cullis and his colleagues at University of Pennsylvania, Katalin Kariko and Drew Weissman, were recognized with the Gairdner International Award for developing the foundational technology behind mRNA COVID-19 vaccines, such as those manufactured by Pfizer-BioNTech and Moderna.

Karikó and Weissman are credited with discovering how to engineer messenger RNA to teach our cells to make a protein that trains the body’s immune system to identify and fight the COVID-19 virus.

The question became how to get the mRNA into our cells without degradation. It was a problem that Cullis, co-founder of Vancouver-based biotech company Acuitas Therapeutics, had been looking into since the early days of his research on the chemical composition of cell membranes.

His lab laid the groundwork for the vaccine’s drug-delivery system, which uses tiny fat bubbles — known as lipid nanoparticles — to protect and transport mRNA into our cells.

“It’s been quite remarkable to suddenly move from a situation where we’re dealing with what was a relatively unknown therapeutic approach, to have something that is now going into billions of arms worldwide,” Cullis said.

Cullis said that COVID-19 vaccines represent the “tip of the iceberg” of the technology’s potential applications. He sees lipid nanoparticles as a promising new tool that could usher in a wave of “individualized therapies” that don’t only treat the symptoms of a disease, but target the underlying causes.

In their citation, the Gairdner jury said the discoveries that undergird mRNA COVID-19 vaccines “have the potential to revolutionize the future delivery of effective and safe vaccines, therapeutics and gene therapies.”

Cullis said the Gairdner recognition underscores the importance of supporting scientific innovation in Canada, noting that many of our brightest minds move to the U.S. in pursuit of professional opportunities.

“This is something we just have to address, that we find ways of creating industries so we keep our people in Canada,” he said. “They don’t go south because they want to leave Canada. They go south because that’s where the jobs are.”

Canadians took four of this year’s seven Gairdner Awards, which recognize some of the world’s most significant scientific discoveries impacting human health.

The other Gairdner International Award laureates were John Dick, a senior scientist at Toronto’s Princess Margaret Cancer Centre, for his discovery of leukemic stem cells in an acute myeloid leukemia patient, and Harvard University’s Stuart Orkin for his breakthrough discoveries on red blood cells that have led to new treatments for disorders such as sickle cell disease.

Zulfiqar Bhutta, a senior scientist at Toronto’s Hospital for Sick Children, took the Gairdner Global Health Award for developing evidence-based strategies to support child and maternal health in marginalized populations.

The Canada Gairdner Wightman Award, given to a Canadian researcher who has demonstrated outstanding leadership in medical science, went to McMaster University’s Deborah Cook for her multi-disciplinary research on critical care medicine.

The Gairdner Awards, which include $100,000 for each recipient, are nicknamed the “baby Nobels” because 96 Gairdner winners have gone on to receive Nobel Prizes, according to organizers.

This report by The Canadian Press was first published April 5, 2022.

Adblock test (Why?)

728x90x4

Source link

Continue Reading

Health

Canada to donate up to 200,000 vaccine doses to combat mpox outbreaks in Africa

Published

 on

 

The Canadian government says it will donate up to 200,000 vaccine doses to fight the mpox outbreak in Congo and other African countries.

It says the donated doses of Imvamune will come from Canada’s existing supply and will not affect the country’s preparedness for mpox cases in this country.

Minister of Health Mark Holland says the donation “will help to protect those in the most affected regions of Africa and will help prevent further spread of the virus.”

Dr. Madhukar Pai, Canada research chair in epidemiology and global health, says although the donation is welcome, it is a very small portion of the estimated 10 million vaccine doses needed to control the outbreak.

Vaccine donations from wealthier countries have only recently started arriving in Africa, almost a month after the World Health Organization declared the mpox outbreak a public health emergency of international concern.

A few days after the declaration in August, Global Affairs Canada announced a contribution of $1 million for mpox surveillance, diagnostic tools, research and community awareness in Africa.

On Thursday, the Africa Centres for Disease Control and Prevention said mpox is still on the rise and that testing rates are “insufficient” across the continent.

Jason Kindrachuk, Canada research chair in emerging viruses at the University of Manitoba, said donating vaccines, in addition to supporting surveillance and diagnostic tests, is “massively important.”

But Kindrachuk, who has worked on the ground in Congo during the epidemic, also said that the international response to the mpox outbreak is “better late than never (but) better never late.”

“It would have been fantastic for us globally to not be in this position by having provided doses a much, much longer time prior than when we are,” he said, noting that the outbreak of clade I mpox in Congo started in early 2023.

Clade II mpox, endemic in regions of West Africa, came to the world’s attention even earlier — in 2022 — as that strain of virus spread to other countries, including Canada.

Two doses are recommended for mpox vaccination, so the donation may only benefit 100,000 people, Pai said.

Pai questioned whether Canada is contributing enough, as the federal government hasn’t said what percentage of its mpox vaccine stockpile it is donating.

“Small donations are simply not going to help end this crisis. We need to show greater solidarity and support,” he said in an email.

“That is the biggest lesson from the COVID-19 pandemic — our collective safety is tied with that of other nations.”

This report by The Canadian Press was first published Sept. 13, 2024.

Canadian Press health coverage receives support through a partnership with the Canadian Medical Association. CP is solely responsible for this content.

The Canadian Press. All rights reserved.

Source link

Continue Reading

Health

How many Nova Scotians are on the doctor wait-list? Number hit 160,000 in June

Published

 on

 

HALIFAX – The Nova Scotia government says it could be months before it reveals how many people are on the wait-list for a family doctor.

The head of the province’s health authority told reporters Wednesday that the government won’t release updated data until the 160,000 people who were on the wait-list in June are contacted to verify whether they still need primary care.

Karen Oldfield said Nova Scotia Health is working on validating the primary care wait-list data before posting new numbers, and that work may take a matter of months. The most recent public wait-list figures are from June 1, when 160,234 people, or about 16 per cent of the population, were on it.

“It’s going to take time to make 160,000 calls,” Oldfield said. “We are not talking weeks, we are talking months.”

The interim CEO and president of Nova Scotia Health said people on the list are being asked where they live, whether they still need a family doctor, and to give an update on their health.

A spokesperson with the province’s Health Department says the government and its health authority are “working hard” to turn the wait-list registry into a useful tool, adding that the data will be shared once it is validated.

Nova Scotia’s NDP are calling on Premier Tim Houston to immediately release statistics on how many people are looking for a family doctor. On Tuesday, the NDP introduced a bill that would require the health minister to make the number public every month.

“It is unacceptable for the list to be more than three months out of date,” NDP Leader Claudia Chender said Tuesday.

Chender said releasing this data regularly is vital so Nova Scotians can track the government’s progress on its main 2021 campaign promise: fixing health care.

The number of people in need of a family doctor has more than doubled between the 2021 summer election campaign and June 2024. Since September 2021 about 300 doctors have been added to the provincial health system, the Health Department said.

“We’ll know if Tim Houston is keeping his 2021 election promise to fix health care when Nova Scotians are attached to primary care,” Chender said.

This report by The Canadian Press was first published Sept. 11, 2024.

The Canadian Press. All rights reserved.

Source link

Continue Reading

Health

Newfoundland and Labrador monitoring rise in whooping cough cases: medical officer

Published

 on

 

ST. JOHN’S, N.L. – Newfoundland and Labrador‘s chief medical officer is monitoring the rise of whooping cough infections across the province as cases of the highly contagious disease continue to grow across Canada.

Dr. Janice Fitzgerald says that so far this year, the province has recorded 230 confirmed cases of the vaccine-preventable respiratory tract infection, also known as pertussis.

Late last month, Quebec reported more than 11,000 cases during the same time period, while Ontario counted 470 cases, well above the five-year average of 98. In Quebec, the majority of patients are between the ages of 10 and 14.

Meanwhile, New Brunswick has declared a whooping cough outbreak across the province. A total of 141 cases were reported by last month, exceeding the five-year average of 34.

The disease can lead to severe complications among vulnerable populations including infants, who are at the highest risk of suffering from complications like pneumonia and seizures. Symptoms may start with a runny nose, mild fever and cough, then progress to severe coughing accompanied by a distinctive “whooping” sound during inhalation.

“The public, especially pregnant people and those in close contact with infants, are encouraged to be aware of symptoms related to pertussis and to ensure vaccinations are up to date,” Newfoundland and Labrador’s Health Department said in a statement.

Whooping cough can be treated with antibiotics, but vaccination is the most effective way to control the spread of the disease. As a result, the province has expanded immunization efforts this school year. While booster doses are already offered in Grade 9, the vaccine is now being offered to Grade 8 students as well.

Public health officials say whooping cough is a cyclical disease that increases every two to five or six years.

Meanwhile, New Brunswick’s acting chief medical officer of health expects the current case count to get worse before tapering off.

A rise in whooping cough cases has also been reported in the United States and elsewhere. The Pan American Health Organization issued an alert in July encouraging countries to ramp up their surveillance and vaccination coverage.

This report by The Canadian Press was first published Sept. 10, 2024.

The Canadian Press. All rights reserved.

Source link

Continue Reading

Trending