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Vaccination after infection may curb long COVID; desktop 'air curtains' may deflect virus particles – Reuters.com

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A nurse fills up syringes with the coronavirus disease (COVID-19) vaccines for residents who are over 50 years old and immunocompromised and are eligible to receive their second booster shots in Waterford, Michigan, U.S., April 8, 2022. REUTERS/Emily Elconin

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May 19 (Reuters) – The following is a summary of some recent studies on COVID-19. They include research that warrants further study to corroborate the findings and that has yet to be certified by peer review.

Post-infection vaccination may reduce long COVID

Vaccination after infection with SARS-CoV-2 may contribute to a reduction in the burden of long COVID symptoms, a new study suggests.

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Researchers tracked 6,729 volunteers ages 18 to 69, who got two shots of either AstraZeneca’s (AZN.L) viral vector vaccine or an mRNA vaccine from Pfizer (PFE.N)/BioNTech (22UAy.DE) or Moderna (MRNA.O) after recovering from an infection with the coronavirus and who reported long COVID symptoms of any severity at least once between February and September 2021. The odds of reporting long COVID – symptoms lasting at least 12 weeks – fell by an average of 13% after a first vaccine dose, the researchers reported on Wednesday in The BMJ. The second dose, given 12 weeks after the first, was associated with a further 9% decrease in the odds of long COVID that persisted for at least 9 weeks, on average, the researchers said. The odds of reporting long COVID severe enough to result in functional impairment were similarly reduced, researchers reported. Outcomes were similar regardless of vaccine type, interval from infection to first vaccine dose, underlying health status, or severity of COVID-19. However, the study was not designed to detect such differences, nor can it definitively prove that vaccines lower the odds of long COVID.

“Further research is required to evaluate the long-term relationship between vaccination and long COVID, in particular the impact of the Omicron variant,” which emerged after this study ended, the researchers said.

Desktop “air curtains” may deflect virus particles

When people cannot maintain a safe distance to avoid the spread of COVID-19, a newly designed desktop “air curtain” can block aerosols in exhaled air, researchers found.

Air-curtains – artificially created streams of moving air – are often used to protect patients in operating rooms. At Nagoya University in Japan, researchers tested their new desktop device by simulating a blood collection booth in which a lab technician is close to the patient. Aerosol particles blown toward the curtain “were observed to bend abruptly toward (a) suction port” without passing through the air curtain, they reported on Tuesday in AIP Advances. Even putting an arm through the air curtain did not break the flow or reduce its effectiveness, they said. A high-efficiency particulate air (HEPA) filter can be installed inside the suction port, they added.

If further testing in real-life conditions confirms the effectiveness of the system, it could “be useful as an indirect barrier not only in the medical field but also in situations where sufficient physical distance cannot be maintained, such as at the reception counter,” the researchers said.

Antacid aids in COVID-19 by helping limit inflammation

Researchers have discovered just how the antacid famotidine, commonly sold as Pepcid by a Johnson & Johnson unit, was able to help alleviate COVID-19 symptoms in clinical trials.

In studies in mice, they found that famotidine stimulates the vagus nerve, which controls the immune system and other involuntary body functions. When the vagus nerve is stimulated, it can send out signals to suppress severe immune reactions – so-called cytokine storms – in which high levels of inflammatory proteins are released into the blood too quickly. When famotidine was administered to the mice, it significantly reduced levels of inflammatory proteins in the blood and spleen and improved survival. But when the vagus nerve was cut, famotidine no longer stopped the cytokine storms, according to a report published on Monday in Molecular Medicine. The data “point to a role of the vagus nerve inflammatory reflex in suppressing cytokine storm during COVID-19,” coauthor Dr. Kevin Tracey of The Feinstein Institutes for Medical Research in Manhasset, New York, said in a statement.

Direct electrical stimulation of the vagus nerve is known to improve a variety of diseases. “Famotidine, a well-tolerated oral drug, could offer an additional method” of activating the vagus nerve to reduce inflammatory protein generation and resulting tissue damage in COVID-19 and other diseases, the researchers concluded.

Click for a Reuters graphic on vaccines in development.

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Reporting by Nancy Lapid; Editing by Bill Berkrot

Our Standards: The Thomson Reuters Trust Principles.

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Canada to donate up to 200,000 vaccine doses to combat mpox outbreaks in Africa

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The Canadian government says it will donate up to 200,000 vaccine doses to fight the mpox outbreak in Congo and other African countries.

It says the donated doses of Imvamune will come from Canada’s existing supply and will not affect the country’s preparedness for mpox cases in this country.

Minister of Health Mark Holland says the donation “will help to protect those in the most affected regions of Africa and will help prevent further spread of the virus.”

Dr. Madhukar Pai, Canada research chair in epidemiology and global health, says although the donation is welcome, it is a very small portion of the estimated 10 million vaccine doses needed to control the outbreak.

Vaccine donations from wealthier countries have only recently started arriving in Africa, almost a month after the World Health Organization declared the mpox outbreak a public health emergency of international concern.

A few days after the declaration in August, Global Affairs Canada announced a contribution of $1 million for mpox surveillance, diagnostic tools, research and community awareness in Africa.

On Thursday, the Africa Centres for Disease Control and Prevention said mpox is still on the rise and that testing rates are “insufficient” across the continent.

Jason Kindrachuk, Canada research chair in emerging viruses at the University of Manitoba, said donating vaccines, in addition to supporting surveillance and diagnostic tests, is “massively important.”

But Kindrachuk, who has worked on the ground in Congo during the epidemic, also said that the international response to the mpox outbreak is “better late than never (but) better never late.”

“It would have been fantastic for us globally to not be in this position by having provided doses a much, much longer time prior than when we are,” he said, noting that the outbreak of clade I mpox in Congo started in early 2023.

Clade II mpox, endemic in regions of West Africa, came to the world’s attention even earlier — in 2022 — as that strain of virus spread to other countries, including Canada.

Two doses are recommended for mpox vaccination, so the donation may only benefit 100,000 people, Pai said.

Pai questioned whether Canada is contributing enough, as the federal government hasn’t said what percentage of its mpox vaccine stockpile it is donating.

“Small donations are simply not going to help end this crisis. We need to show greater solidarity and support,” he said in an email.

“That is the biggest lesson from the COVID-19 pandemic — our collective safety is tied with that of other nations.”

This report by The Canadian Press was first published Sept. 13, 2024.

Canadian Press health coverage receives support through a partnership with the Canadian Medical Association. CP is solely responsible for this content.

The Canadian Press. All rights reserved.

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How many Nova Scotians are on the doctor wait-list? Number hit 160,000 in June

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HALIFAX – The Nova Scotia government says it could be months before it reveals how many people are on the wait-list for a family doctor.

The head of the province’s health authority told reporters Wednesday that the government won’t release updated data until the 160,000 people who were on the wait-list in June are contacted to verify whether they still need primary care.

Karen Oldfield said Nova Scotia Health is working on validating the primary care wait-list data before posting new numbers, and that work may take a matter of months. The most recent public wait-list figures are from June 1, when 160,234 people, or about 16 per cent of the population, were on it.

“It’s going to take time to make 160,000 calls,” Oldfield said. “We are not talking weeks, we are talking months.”

The interim CEO and president of Nova Scotia Health said people on the list are being asked where they live, whether they still need a family doctor, and to give an update on their health.

A spokesperson with the province’s Health Department says the government and its health authority are “working hard” to turn the wait-list registry into a useful tool, adding that the data will be shared once it is validated.

Nova Scotia’s NDP are calling on Premier Tim Houston to immediately release statistics on how many people are looking for a family doctor. On Tuesday, the NDP introduced a bill that would require the health minister to make the number public every month.

“It is unacceptable for the list to be more than three months out of date,” NDP Leader Claudia Chender said Tuesday.

Chender said releasing this data regularly is vital so Nova Scotians can track the government’s progress on its main 2021 campaign promise: fixing health care.

The number of people in need of a family doctor has more than doubled between the 2021 summer election campaign and June 2024. Since September 2021 about 300 doctors have been added to the provincial health system, the Health Department said.

“We’ll know if Tim Houston is keeping his 2021 election promise to fix health care when Nova Scotians are attached to primary care,” Chender said.

This report by The Canadian Press was first published Sept. 11, 2024.

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Newfoundland and Labrador monitoring rise in whooping cough cases: medical officer

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ST. JOHN’S, N.L. – Newfoundland and Labrador‘s chief medical officer is monitoring the rise of whooping cough infections across the province as cases of the highly contagious disease continue to grow across Canada.

Dr. Janice Fitzgerald says that so far this year, the province has recorded 230 confirmed cases of the vaccine-preventable respiratory tract infection, also known as pertussis.

Late last month, Quebec reported more than 11,000 cases during the same time period, while Ontario counted 470 cases, well above the five-year average of 98. In Quebec, the majority of patients are between the ages of 10 and 14.

Meanwhile, New Brunswick has declared a whooping cough outbreak across the province. A total of 141 cases were reported by last month, exceeding the five-year average of 34.

The disease can lead to severe complications among vulnerable populations including infants, who are at the highest risk of suffering from complications like pneumonia and seizures. Symptoms may start with a runny nose, mild fever and cough, then progress to severe coughing accompanied by a distinctive “whooping” sound during inhalation.

“The public, especially pregnant people and those in close contact with infants, are encouraged to be aware of symptoms related to pertussis and to ensure vaccinations are up to date,” Newfoundland and Labrador’s Health Department said in a statement.

Whooping cough can be treated with antibiotics, but vaccination is the most effective way to control the spread of the disease. As a result, the province has expanded immunization efforts this school year. While booster doses are already offered in Grade 9, the vaccine is now being offered to Grade 8 students as well.

Public health officials say whooping cough is a cyclical disease that increases every two to five or six years.

Meanwhile, New Brunswick’s acting chief medical officer of health expects the current case count to get worse before tapering off.

A rise in whooping cough cases has also been reported in the United States and elsewhere. The Pan American Health Organization issued an alert in July encouraging countries to ramp up their surveillance and vaccination coverage.

This report by The Canadian Press was first published Sept. 10, 2024.

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