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Alive inside: How do we reach 'vegetative' patients when tests show they're aware of everything – National Post



“The ominous events in the early morning hours of August 12, 1997 led to a tragedy in Lloydminster, Saskatchewan….” – from a Saskatchewan Court of Queen’s Bench ruling issued in 1998.

There was a small band playing at the Dr. Cooke Extended Care Centre’s annual Christmas party this year, and tables laden with shortbread and popcorn curls and Christmas cookies. On one side of the room sat Jeffrey Tremblay and his father, Paul. Jeff has lived at the Lloydminster facility since he was 19 years old. He turns 41 this week.

Jeff can’t move or speak. He has to be tube-fed through his stomach. He’s aware of what’s going on, Paul says, which is remarkable given doctors wrote Jeff off as being trapped in a vegetative state for 16 years. Only Jeff wasn’t vegetative. Roughly 20 per cent of people like Jeff who are assumed to be totally unconscious — no idea of who they are or where they are, unable to exhibit any “willful behaviour”  — are actually aware, lingering undetected somewhere in a state between life and nothingness.

New guidelines could help in the search to find them.

It’s not clear how much Jeff knows about the role he’s playing in what some are calling a revolution in the treatment of the catastrophically brain injured. A senseless attack sent Jeff into the unknowable world he now inhabits.

Jeffrey Tremblay and his father Paul in October 2018.

Courtesy of the Tremblay family

The assault happened after a night out at a bar with friends. Jeff, the kid with the heart of gold and a smile that could light up a room, was beaten into a coma in a fit of jealousy over a girl. His assailant, then 19, six-feet-two-inches tall and weighing 250 pounds, kicked skinny, wiry, 130-pound Jeff in the chest with enough force to propel a football 25 yards. Jeff’s heart went into arrhythmia, starving his brain of oxygen. When he arrived in emergency by ambulance, he had no pulse, no blood pressure, no “respiratory effort,” no movement. His pupils were fixed and dilated. The blow to his chest “at the critical time of the cardiac electrical cycle,” Saskatchewan Court of Queen’s Bench justice Robert Hrabinsky would write, led to “no effective circulation for many minutes.”

Jeff remained comatose for three weeks, until one day Paul, camped out around the clock in Jeff’s hospital room, looked up from his crossword puzzle and saw his son’s wide-open eyes and that great big smile, and thought, ‘Geez, he’s going to be fine.’”

He wasn’t. Jeff was awake, but doctors said his brain injury, his neurological loss, was so extensive, so diffuse he likely had no awareness whatsoever. “It’s tough to hear when a doctor says that. They want you to pull the plug,” Paul said. “I wasn’t prepared to do that.”

Paul didn’t know much about the brain back then but one day he found a story about a neuroscientist named Adrian Owen, a British-born researcher who for years had been using brain scans to reach inside the minds of people considered all but gone, unable to speak or move or signal to the outside world, “I can hear you. I’m in here.”

They want you to pull the plug

Sixteen years after his beating, Jeff was flown to London, where he was slid inside a functional magnetic resonance imaging scanner, or fMRI, which measures brain activity by detecting changes in blood oxygenation and flow, and shown a short Alfred Hitchcock movie — Bang! You’re Dead! Jeff’s brain fired off the same peaks and dips in electrical activity in the frontal and parietal regions of the brain at critical points of the movie that were uncannily identical to healthy volunteers shown the same eight-minute clip. Before then, Jeff had shown no “higher-order” signs of awareness, Owen and his team wrote in the journal PNAS in 2014, no communication in any form. The experiment suggested he was exhibiting executive processing, that he was able to engage in “complex thoughts about real-world events unfolding over time.”

Owen not only reached Jeff. The Western University scientist has used fMRI to help people once diagnosed “vegetative” follow commands, acknowledge where they are and with whom, and answer questions like, “are you in pain,” by decoding their brain activity.

Now, tests that can detect covert consciousness, not just expensive, bulky fMRI, but bedside EEG machines that use small discs on the scalp to measure brain activity, are moving a step closer to routine use. New guidelines from the American Academy of Neurology and other bodies recommend  that, where there is any ambiguity or “inconclusive” findings, brain imaging should be used to hunt for emerging signs of consciousness in the brain injured who have no recourse to speech or action — a “milestone”  development in the history of brain science, Owen and colleagues wrote in a paper, “Alive Inside,” in the journal Bioethics.

“The problem up until now has been that we develop these techniques, we put them out there, we tell people how to do them and the only patients that benefit are the people who make it into other research institutions,” Owen says. “It hasn’t been incorporated into guidelines for how one treats these patients. And that has now changed.”

Neuroscientist Adrian Owen.

Paul Mayne

Owen is pushing for the tests to be adopted even more widely, used not just months or years out from a brain injury, but at the front end in the first hours after a traumatic brain injury to help predict which patients might recover from a vegetative state, which ones might benefit from rehabilitation. Most decisions to remove life support — to pull the proverbial “plug” — occur within the first 72 hours after injury. If we can improve prognosis in that group, if we can better understand who might make some recovery, “we can perhaps save some of those lives,” Owen says.

“Maybe a different decision is right for some of those patients.”

Most remarkably, others are testing deep brain stimulation and other interventions to “re-awaken” or hasten awareness in people in minimally conscious states, even years out from their injury.

But the rapidly evolving field is also raising serious ethical challenges, about how we think about consciousness; about false hope and about the existential risks of making people more aware of an existence many would consider a living nightmare.

If someone can modulate their neural activity — communicate via signals from his or her brain — is that a sufficient, or even reliable proxy for speech? And if we find a way to communicate, what, then, do we ask them? Is there anything we can do to make you more comfortable? Is there anything you’d prefer to watch on TV? Do you wish to continue living?

“What is most tantalizing about this prospect is that it would allow a seriously brain-injured patient to express their current wishes, which may well have changed radically in the interval (sometimes decades) before they expressed any premorbid opinion,” Owen wrote this year in the journal Neuron.

“Ultimately, the morally challenging question of whether theirs is a life that is ‘worth living’ is one that could be answered by the patient using fMRI,” he said.

A PET-fMRI machine at the Brain Imaging Centre in Ottawa.

Ashley Fraser/Postmedia

Sophisticated neuroimaging is already being used to involve some “covertly aware” patients in their daily care. But fMRI is expensive, bulky and nowhere near every hospital has one. However, 20 years from now brain-computer interfaces that use electrical signals from the brain to say, manipulate a computer, or move a robotic arm, could be as common as smartphones, Owen wrote.

But this is where things get dicey, says Dr. Judy Illes, Canada Research Chair in neuroethics at the University of British Columbia.

“How reliable is the signal? How do we make sure that it’s the intent of the person, that it hasn’t been hacked and that it is reproducible?” Illes wonders.

When it comes to communicating hunger or pain, it might matter less if the signal is noisy. “It’s not good to overmedicate someone but it’s much worse to under-medicate,” Illes says.

But could the signals be used in a courtroom as a form of testimony? To redirect an inheritance from the children who don’t visit anymore, to a nurse? Enable a person to request a medically assisted death?

Individuals who we thought were in a persistent vegetative state may not be and, in some cases, certainly are not

And what good is the information that a loved one appears to have some conscious processing, if there’s little available to help them? “I think that’s where I get stuck,” Illes says.

This much is true. “The technology has advanced to the point that we must attend to the fact that individuals who we thought were in a persistent vegetative state may not be and, in some cases, certainly are not. And those numbers are bigger than we ever thought,” she says.

Today, the standard way of checking for any “residual” or preserved awareness or cognitive function in brains damaged by a stroke, cardiac arrest or bash to the head are bedside scales that use response and command-following tasks — look this way or that, squeeze my hand, move a foot, follow the tennis ball with your eyes.

However, people diagnosed as being in a vegetative state, or the much larger group known as the minimally conscious, simply can’t marshal the resources to, say, blink an eye, or move a foot on command. It’s not a muscular problem. They aren’t paralyzed. Rather, there’s a central nervous system problem, a disconnection that’s preventing them from executing any movement at all, Owen says. But their thoughts, their mental process could be intact.

These people do spontaneously move. They often grunt; they’ll open their eyes or move a hand. The problem is knowing whether that’s a conscious response or merely chance.

Except in circumstances such as complete brain death, relying on neurological exams at the beside is, in many cases, “hopelessly unreliable,” Owen says.

Images of “healthy” vs. “vegetative brains.”

Courtesy of Adrian Owen

Brain imaging takes behaviour out of the equation.

In a ground-breaking Science paper published in 2006, Owen and colleagues reported that an apparently vegetative woman showed distinct patterns of brain activity when asked, while lying inside a fMRI, to imagine herself playing tennis, or walking through the rooms of her house. The pattern of her brain activity was indistinguishable from what is seen in healthy volunteers. Owen believes she was entirely aware during the scanning procedure.

Next, working with Steven Laureys from the University of Liege, Owen showed that, of 54 patients in a vegetative or minimally conscious state, five 5 were able to “willfully modulate” their brain activity. One was able to answer yes or no to questions during functional MRI even though it remained impossible to establish any form of communication at the bedside. Then, in an experiment that made worldwide headlines, the team slid a man named Scott Routley inside an fMRI scanner and asked if he was in pain. The Sarnia, Ont. man had remained in what doctors were convinced was a vegetative state for 12 years after a police cruiser rushing to the scene of a crime slammed into his car in December 1999. Lying inside the scanner, Scott was told to imagine walking around his house if the answer was “yes” or playing tennis if the answer was “no.” “Do any parts of your body hurt right now,” Owen asked Routley. The answer was, no.

Images of “healthy” vs. “vegetative brains.”

Courtesy of Adrian Owen

Since then, Owen and his team have used imaging to ask patients if they prefer the temperature lower or higher, whether they still like watching hockey. “One of the sad truths is that they get exposed to an awful lot of whatever it is they used to like before they had a brain injury,” Owen says. “If you were a great lover of Celine Dion 20 years ago when you had your brain injury, maybe you don’t want to listen to that anymore. We can return a little autonomy to patients.”

Ironically, they’re often relatively healthy. They breathe on their own. Their hearts beat on their own. They’re not being kept alive, except, like Jeff Tremblay, they have to be fed and hydrated. There’s no “plug’ to pull. They can only die by withdrawing nutrition and hydration.

The better their responses in the fMRI scanner, the more likely they are to recover, Owen believes. And there have been some spectacular cases of recovery, including Juan Torres, to whom Owen devotes an entire chapter of his book, Into the Gray Zone. The Toronto-area man suffered a catastrophic brain injury when he was 19 years old. Today, six years out, he has re-enrolled in school. “He’s intellectually right back to where he was before,” Owen says.

But Juan is truly the exception. “People often think these people go from being in a vegetative state to being back on the golf course. That almost never happens,’ Owen says.

We’ve got patients who we know are on the edge of being able to establish communication

However, he and others are starting to think about interventions that might accelerate their return to consciousness, even a normal life. “Twenty years ago, people would say to me, ‘isn’t there some sort of surgery you could do to fix these patients?

“Well, maybe, but we didn’t know where to start. You need the basic imaging and you need to understand what’s causing the problem before you can solve the problem of how to fix people. And I think we’re getting there. We’re just at the tipping point right now,” Owen says.

Researchers are testing different drug therapies, including anti-virals as well as a sleeping pill called zolpidem that famously and transiently roused Louis Viljoen, of Johannesburg, from a vegetative state in 2006. Twenty minutes after his first dose, he opened his eyes, looked at his mother and said, “Hello mummy.” More recently, in October, British scientists floated the idea of using the psychedelic psilocybin, the active substance in magic mushrooms, the idea being the hallucinogen might increase brain complexity and brain plasticity — the brain’s ability to rewire itself, and grow new neurons.

The biggest hope, however, may rest with deep-brain stimulation, or DBS. Dr. Nicholas Schiff is a neuroscientist at Weill Cornell Medicine in New York City. Schiff was also the lead author of a breakthrough study published in Nature in 2007 involving a 38-year-old man who had spent more than five years in a minimally conscious state who can now communicate with his family, thanks to pulses of electric current to his brain.

By stimulating the central thalamus, which relays motor and sensory signals to the cerebral cortex, the part of the brain involved in consciousness, Schiff’s team was able to help the man name objects, make hand gestures and eat without a feeding tube — suggesting DBS “can promote significant late functional recovery from severe traumatic brain injury” even years after the injury occurred.

“We’ve got patients who we know are on the edge of being able to establish communication, but we don’t really know what to do for them yet,” says Schiff, adding that it’s a population of patients that has been horribly neglected for years.

“Just because we identify consciousness and awareness, it’s not enough. It’s terrible to know we can make these measurements, identify awareness and not be doing what needs to be done, which is to build a medical infrastructure to support these people.”

But how quickly should we be moving? And is there a risk of overestimating what fMRI mental imagery really means? The fact this area is so fraught with ethical challenges is precisely because we don’t know what it’s like to be in such a state, or whether a person’s mental processes are functioning at full capacity.  A signal is one thing. But what does it mean?

“I’ve always imagined a clinician entering a room and saying, ‘I have wonderful news! John is aware! We know this because he’s volitionally modulating his brain activity,” Andrew Peterson, an assistant professor at George Mason University, who works with Owen’s lab, wrote in an email.

“My gut tells me that families might not know what to do with this information. What they will want to know is whether their loved one can hear their voices, feel their touch, or if he or she is experiencing pain.” However, the tests aren’t pitch perfect. Accuracy rates range from 60 to 80 per cent.

The Tremblay family in October 2018.

Courtesy of the Tremblay family

What’s more, to truly tap into a person’s state of mind requires a rich, two-way conversation, and the current technology, whether fMRI or less cumbersome, bedside EEG machines, prevents that, Peterson said. Such deeply profound decisions as “do you wish to stop being fed or hydrated” couldn’t be handled, legally or ethically, as if it were a “yes” or “no” game of 20 Questions.

A more likely scenario is how brain imaging might influence legal fights around decisions to withdraw life support.

Consider this example, Peterson says: A person’s advance directive states, “I don’t want to live if I’m in a vegetative state.” But then brain imaging detects covert consciousness. “One family member thinks that this clearly shows that the patient is not in a vegetative state and they shouldn’t withdraw care,” Peterson said. Other family members insist any detection of “covert” consciousness is irrelevant because their son or daughter or spouse could remain in that brain state for the rest of his or her life.

And it’s mostly young people who are most likely to end up with disorders of consciousness. Young people are resilient, Peterson says. They don’t die from the initial injury. Instead, they’re left in that grey zone between consciousness and unconsciousness.

And it’s impossible to know what their interior lives might be like. Some people might be relieved to learn their loved one can hear, can process speech, that they are fully aware of everything that is going on around them. Others will be horrified, and left with gut-wrenching questions about quality of life.

My gut tells me that families might not know what to do with this information

Still, the harms associated with undetected consciousness, whether it’s unnecessary pain or prematurely withdrawing care, is just too great not to starting moving the research into practice, Peterson said. “At the very least, it seems that clinicians have an ethical duty to discuss this option with families” in appropriate cases.

Before he took his son to Owen’s London lab, “everything was a dark hole,” Paul Tremblay says. “Everything was negative, negative, negative.”

“But the more you read about it, it’s just not true.”

Jeff can’t communicate. But Paul reads his eyes, to see if he’s listening or not. He smiles when he’s happy, grimaces when he’s sad, groans when he’s in pain. When he’s really tired, like most of us Jeff doesn’t listen very much. Paul takes his son to the movies once a week. He remains in touch with Owen’s lab.

“It might not help Jeff, in the long run,” Paul said. “But I think Jeff is helping the research.”

In 1998, Jeff Tremblay’s attacker was convicted of aggravated assault.

He served eight months of a three-year prison sentence.

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2 deaths, 180 COVID-19 cases announced in Manitoba Saturday – Global News



Manitoba public health officials confirm two additional deaths in people with COVID-19 have been reported.

The deaths are a man in his 70s from Southern Health-Santé Sud and a man in his 80s from the Winnipeg health region.

Read more:
Coronavirus: Manitoba business advocates propose ‘sweet spot’ reopening strategy

The current five-day COVID-19 test positivity rate is 10.2 per cent provincially and 7 per cent in Winnipeg.

As of 9:30 a.m. Saturday, 180 new cases of the virus have been identified and the total number of lab-confirmed cases in Manitoba has risen to 27,322.

The new cases are in the following regions:

  • 10 cases in the Interlake-Eastern health region
  • 69 cases in the Northern health region
  • eight cases in the Prairie Mountain Health region
  • 10 cases in the Southern Health-Santé Sud health region
  • 83 cases in the Winnipeg health region.

The data also shows there are 2,986 active cases and 23,575 individuals who have recovered from COVID-19.

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There are 122 people in hospital with active COVID-19 as well as 161 people in hospital with COVID-19 who are no longer infectious but continue to require care, for a total of 283 hospitalizations.

Click to play video 'COVID-19 cases rising in the north'

COVID-19 cases rising in the north

COVID-19 cases rising in the north

There are 19 people being treated for COVID-19 in intensive care units, as well as 17 people with COVID-19 who are no longer infectious but continue to require critical care, for a total of 36 ICU patients.

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The total number of deaths due to COVID-19 is 761. Due to a data error, one death that had been reported earlier has been removed.

Laboratory testing numbers show 2,043 tests were completed Friday, bringing the total number of lab tests completed since early February 2020 to 450,104.

Read more:
Coronavirus: New vaccine appointments paused in Manitoba as Pfizer announces delay

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An outbreak has been declared at Lynn Lake Hospital in northwestern Manitoba. The site has been moved to Critical (red) on the Pandemic Response System.

The outbreak at Seven Oaks General Hospital, 4U4-7 in Winnipeg is now declared over.

Click to play video 'Coronavirus: Over half of Canadians think vaccine should be mandatory, Ipsos poll shows'

Coronavirus: Over half of Canadians think vaccine should be mandatory, Ipsos poll shows

Coronavirus: Over half of Canadians think vaccine should be mandatory, Ipsos poll shows

Local epidemiologist Cynthia Carr says while it has been challenging to follow health restrictions, it has made a difference.

“These restrictions and the work we have done together really does matter on the serious of levels. working together we have saved almost 2,000 lives. It might have been 1,700, 1,800 or 1,600 but the reality is it mattered,” she said.

And while our numbers remain steady for now, there are still obstacles in certain regions — particularly the North.

Read more:
Manitoba asks for feedback on COVID-19 restriction changes as 5 new deaths reported

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Carr says if the pandemic hasn’t ripped the issue of housing wide open in other areas, she doesn’t know what will.

“This is an ongoing challenge. When I go to a community and do community health assessments and I talk to leadership about health, they won’t say we need a fancy hospital, X-ray machines, etc., one of the first things will be the foundation of housing.”

She says infrastructure is absolutely related to health, and it hasn’t been attended to in our northern communities.

–With files from Anya Nazeravich

© 2021 Global News, a division of Corus Entertainment Inc.

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One of Canada's oldest seniors, at 110 years old, gets COVID-19 vaccine at Surrey care home – Cowichan Valley Citizen



JaHyung Lee, a resident at a Newton care home, received his COVID-19 vaccine at the age of 110.

Amenida Seniors Community said in a news release that residents at the facility received the first dose of their vaccines on Thursday (Jan. 14). JaHyung Lee is one of Canada’s oldest seniors to be inoculated.

The second dose of the Pfizer/BioNTech vaccine will be administered “in the coming weeks.”

“We are extremely lucky that we have received enough supplies to vaccinate all of our residents in care,” said Rosa Park, general manager at Amenida.

“As many of our seniors are elderly and require complex care, we can feel safer knowing that the virus won’t be spreading within our community.”

A reporter with the Now-Leader attended Lee’s 109th birthday in 2019. He was born on Aug. 27, 1910.

RELATED: 109th birthday party for ‘amazing’ Surrey man who still shops on his own and plays bingo, Sept. 23, 2019

Meantime, Fraser Health says it has completed 151 vaccine clinics for long-term care and assisted living in the health region.

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Latest COVID update Jan. 16: Sask. administers record-high vaccines – CKOM News Talk Sports



Saskatchewan administered its highest one-day total of COVID-19 vaccinations Friday.

The encouraging news comes as the province also reported two more COVID-related deaths and 270 new cases in its daily update Saturday.

The 2,857 vaccine doses were delivered in the following areas: Saskatoon (893), Prince Albert (857), northeast (426), southeast (285), Regina (267) and the far northwest (129). The far north-central region also administered 53 vaccines on Thursday. Friday’s information wasn’t available in the provincial update. There have now been 16,927 vaccines delivered across Saskatchewan.

An update on incoming vaccines from manufacturer Pfizer was also provided in the media release.

“Due to work to expand its European manufacturing facility, production of the Pfizer vaccine will be impacted for a few weeks,” the release stated.

“Pfizer is temporarily reducing deliveries, potentially by half, to all countries receiving vaccine manufactured at this facility.”

The province reaffirmed that vaccines will continue to be administered according to its priority sequence.

A shipment of 4,900 vaccines arrive from manufacturer Moderna on Friday. Distribution is happening in the central and southeast zones. Poor conditions on Friday delayed the shipment arriving in the far northeast zone until Saturday. Clinics are expected to begin Saturday and continue on Sunday.

Daily COVID-19 cases

The province is reporting a total of 19,985 COVID-19 cases.

Both people who tested positive for COVID-19 and died were from the Regina area. One was reported in the 60-69 age group and one was in the 80-plus age category.

The new cases are located in the Saskatoon (68), northwest (49), Regina (47), southeast (26), north-central (23) far northeast (15), northeast (13), far northwest (10), south-central (six), central-east (five) and far north-central (one) zones. Seven new cases are still pending residence information.

There were an additional 12 cases previously without a location assigned to the north-central (six), far northeast (two), far northwest (one), northwest (one), Saskatoon (one) and southwest (one) zones.

A total of 15,730 people have recovered and 4,043 cases are considered active.

The seven-day average of daily new cases is 311 (25.7 new cases per 100,000 population).

There are 199 people in hospital.

Of the 164 receiving inpatient care: 55 are in Saskatoon, 34 are in Regina, 30 are in the north-central region, 10 are in the northeast, 10 are in the southeast, 10 are in the northwest, seven are in the central-east, three are in the far northwest and one person is hospitalized in each of the far north-central, far northeast, central-west, southwest and south-central zones.

Thirty-five people are in intensive care. Patients are located in Saskatoon (17), Regina (nine), north-central (five), northwest (two), central-east (one) and south-central (one).

There were 3,071 COVID-19 tests processed Friday.

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