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Chinese researchers reveal draft genome of virus implicated in Wuhan pneumonia outbreak – Science Magazine

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Health authorities in Wuhan reported today that a 61-year old man has died from the new disease and that no new patients have been identified since 3 January.

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Scientists worried about China’s lack of transparency about a month-old outbreak of pneumonia in the city of Wuhan breathed a sigh of relief today, after a consortium of researchers published a draft genome of the newly discovered coronavirus suspected of causing the outbreak.

“Potentially really important moment in global public health-must be celebrated, everyone involved in Wuhan, in China & beyond acknowledged, thanked & get all the credit,” Jeremy Farrar, head of the Wellcome Trust in London, wrote in a tweet. “Sharing of data good for public health, great for those who did the work. Just needs those incentives & trust.”

Also this morning, Wuhan health authorities reported the first death from the new disease. The patient was a 61-year old man who frequently visited the live market in Wuhan that most cases have been linked to. He also suffered from abdominal tumors and chronic liver disease and died on Thursday. The Wuhan Health Commission said 41 people so far have been confirmed to have been infected with the new virus; no new patients have been identified since 3 January.

News about the sequence came from Edward Holmes, a virologist and evolutionary biologist at the University of Sydney in Australia, who tweeted the first notice about the availability of what he referred to as an “initial” sequence of the virus early this morning. Holmes is a member of a consortium led by Yong-Zhen Zhang of the Shanghai Public Health Clinical Center & School of Public Health that posted the sequence on an open-access site, virological.org. The consortium said it had also deposited the sequence in GenBank. In a brief note, the group said researchers were free to analyze and share the data, but asked that groups “communicate with us if you wish to publish results that use these data in a journal.”

The analyzing began immediately. Evolutionary biologist Andrew Rambaut at the University of Edinburgh calculated that the virus has a 89% similarity to a SARS-related member of the Sarbecoviruses, a subgenus within the Betacoronavirus genus.

Potentially really important moment in global public health-must be celebrated.

Jeremy Farrar, Wellcome Trust

Kevin Olival, vice-president for research of the EcoHealth Alliance in New York City, published a phylogenetic tree on Twitter and concurred that the new virus “definitely clusters” with the SARS-related coronaviruses. (Later in the day, Rambaut criticized the fact that Olival did not credit the researchers who isolated the virus and sequenced it. “This is one of the reasons why people are reticent to share data,” Rambaut wrote on Twitter. “No acknowledgement of where the data comes from or who generated it. The [phylogenetic tree] is even branded with a logo.”)

Ralph Baric, a coronavirus researcher at the University of North Carolina, notes that of the four known SARS-related bat viruses capable of infecting humans, this one is the most distant from SARS itself. After downloading the sequence last night, his lab immediately began trying to reverse-engineer a live virus from the sequence, which can be helpful to develop antibody tests and to start experiments in animal models. “If you want to have a strong public health response, you have to do this quickly,” says Baric, who leads one of the few labs in the world that can re-create coronaviruses just from their sequences. (Bureaucratic hurdles would make it difficult for China to share the virus quickly with other countries, he says.)

Baric hopes this virus’s discovery and the response to it illustrate the speed at which scientists can move by working together. “One of the things that’s sad is that the public doesn’t realize how incredibly competent the public health and the basic science community are at going from a newly discovered virus to a tremendous amount of capacity to trace and try to control its spread,” Baric says.

With reporting by Martin Enserink.

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Toronto police officers who ignore COVID-19 vaccinate mandate policy will be put on unpaid leave – CBC.ca

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Toronto police officers who aren’t fully vaccinated or haven’t disclosed their COVID-19 vaccination status by Nov. 30 will be put on indefinite unpaid leave, the service says.

Any such member, uniformed or not, will not be allowed to enter buildings until they comply with the mandatory vaccine and disclosure policy.

Those members will also not be eligible for promotions to supervisory or management positions, the service said in a news release Thursday.

“Vaccination against COVID-19 protects the health and safety of each of our members, our workplaces and the public we serve,” said Chief James Ramer.

So far, 90 per cent of the service’s members have disclosed their status, with 97 per cent of those having received one dose and 94 per cent fully vaccinated. 

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Consistent communication needed for kids COVID-19 vaccine rollout: experts – Delta-Optimist

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Kelly Grindrod remembers the confusion pharmacists felt last spring as Canada’s COVID-19 vaccine policy changed rapidly throughout the rollout, sometimes with little warning.

Shifting eligibility requirements differed across the country, booking sites were harder to navigate in some regions, and one vaccine product came to be seen as inferior to the rest, infuriating the public and vaccinators alike.

Grindrod, an associate professor at the University of Waterloo and the pharmacy lead for Waterloo Region’s vaccine rollout, hopes provinces learned lessons from Canada’s first vaccination campaign for adults.

And if a COVID-19 vaccine is soon approved for children, she said a kid’s rollout needs consistent and clear messaging.

“Communication was a real challenge,” Grindrod recalled. “(Policy) would be announced nationally and everybody on the ground had to scramble because we were all hearing it at the same time.

“Immediately the phones would go crazy in pharmacies because people were trying to make sense of it…. We need a bit more lead-in, a bit more clarity, so (vaccinators) have answers before people start calling.”

Pfizer-BioNTech asked Health Canada to authorize its COVID-19 vaccine for kids aged five-to-11 this week. The regulator is reviewing data before making a decision.

Prime Minister Justin Trudeau said Thursday that Pfizer is ready to ship millions of child doses in the event of authorization, while Public Services and Procurement Minister Anita Anand added that Canada has already procured syringes and other supplies needed to speed up the rollout.

In the United States,an advisory group with the Food and Drug Administration, which received an approval request from Pfizer earlier this month, is scheduled to meet next week. The Centers for Disease Control and Prevention is then set to discuss authorization in early November.

Grindrod said U.S. regulators, which sometimes stream meetings online, have shown “more transparency around the (decision-making) process.”

Health Canada and the National Advisory Committee on Immunization supply “fairly comprehensive” documents after they’ve made decisions, she said, but vaccinators could use a heads up “to facilitate planning.”

Logistics of the kids rollout — where children get a vaccine, how they book appointments and whether certain kids will be prioritized — are still to be determined. Ontario said Tuesday it was open to running mass vaccine clinics at schools after school hours.

Omar Khan, an immunology and infectious disease expert with the University of Toronto, said school clinics are a great way to reach more kids. Pharmacies and family doctors can also help, but proper scheduling — which includes flexibility around parents’ work hours — is needed to ensure half-empty vaccine vials aren’t tossed at the end of the day.

“Anything that reduces accessibility barriers will help distribute (vaccines) to the queue of people waiting to get vaccinated across multiple sites,” he said.

Most logistics can be ironed out once supply is determined, Grindrod said.

Pfizer’s pediatric vaccine involves a different formulation, but Grindrod said some pharmacists have asked whether they must wait for kid-specific shipments or if a diluted adult dose could serve if supply was scarce. She urged clear information as soon as possible.

Messaging around the kids vaccine in general has to be handled with more care, she said,starting with whatever NACI and Health Canada recommend after reviewing its safety and efficacy.

“We need very careful communication … because we haven’t seen the data,” she said. “There are questions that need to be answered very clearly — what is the risk of COVID to kids at the point at which vaccines become available? What are the known side effects we expect to see based on data from trials?

“And then separately, what are the unknowns?”

Science communicator Samantha Yammine noted the difficulty in maintaining consistent vaccine advice when the science on COVID-19 evolved quickly throughout the pandemic.

Policies introduced midway through the adult rollout, such as NACI’s recommendation against using AstraZeneca for second doses, seemed to contradict earlier advice. But public health messaging constantly adapts to new data, she said.

While communication was confusing at times, the country still vaccinated nearly 82 per cent of its eligible population to date.

Since parents are likely more concerned about vaccinating children than getting the jab themselves, fears should be addressed honestly and parents made to feel part of the plan, Yammine said.

That includes equipping parents with child-friendly information they may need to field youngsters’ questions about the vaccine, she added.

And kids’ comprehension level shouldn’t be underestimated.

“I’m advising people to acknowledge how great a job kids have done,” Yammine said. “Wearing masks, understanding why they have to play with friends outside, it’s been really hard on kids.

“But they’ve shown us they can be involved and they can understand complex things.”

This report by The Canadian Press was first published Oct. 21, 2021.

Melissa Couto Zuber, The Canadian Press

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Get the flu shot: Public Health – Quinte News

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Local public health officials says getting the flu shot this year is especially important to reduce the risk of illness during the COVID-19 pandemic.

Since many people are vulnerable to serious risks related to the flu, officials say everyone can help reduce the spread by getting vaccinated.

In a release, Hastings Prince Edward Public Health points out that it’s safe to get the flu vaccine at the same time as, or any time before or after the COVID-19 vaccine.

They point out influenza can be a serious disease and can lead to pneumonia or organ failure.

Statement from Hastings Prince Edward Public Health:

Getting the flu vaccine is especially important this year, to reduce your risk of illness during the COVID-19 pandemic. As many people are vulnerable to serious risks related to the flu, everyone can help reduce the spread by getting vaccinated. Your choice to get vaccinated will also help ensure critical health care resources are available to those who need them most. It’s safe to get the flu vaccine at the same time as, or any time before or after the COVID-19 vaccine, so do not delay – protect yourself with these important vaccines today!

Influenza is not caused by the viruses that cause COVID-19 or a cold. It can be a serious disease that causes some individuals to be in bed for a week or longer. It can also lead to complications such as pneumonia or organ failure. Vaccinated individuals are less likely to have severe complications and end up in the hospital – which will help ensure health care resources are available to those who need them most.

This year, residents are encouraged to seek their flu vaccination as soon as possible through their health care provider or a pharmacy. As public health resources continue to be redeployed to the COVID-19 pandemic, HPEPH is not able to offer community flu clinics to the general public this year. However, flu vaccination remains the best way to protect yourself and those you love from serious illness and complications. Getting your flu vaccine early is the best way to protect yourself from the flu, as it can take up to two weeks to build immunity. The vaccine is available to individuals over 2 years of age at local pharmacies, and everyone over 6 months of age can receive the flu vaccination from their health care provider. HPEPH is considering the feasibility of offering small flu vaccination clinics to populations who are unable to receive the vaccine through these avenues, but any such clinics are dependant on the rollout of COVID-19 vaccination and local case rates, as resources continue to be required for COVID-19 case and contact management.

“You got your COVID-19 vaccine – now it’s time to protect yourself, and those you love, from the flu,” says Dr. Ethan Toumishey, Acting Medical Officer of Health at HPEPH. “The COVID-19 vaccine has shown us how important and effective vaccines can be at reducing the severity of illness. While the COVID-19 vaccine reduces your risk of complications from COVID-19, it won’t protect you from the flu.”

To reduce the spread of illness in the community, all residents should continue public health precautions. The same measures that are helping control the spread of COVID-19 will help reduce the spread of seasonal influenza. If you have symptoms of the flu, stay home and follow testing guidance for COVID-19. Even if you are vaccinated against both the flu and COVID-19, you can still get a mild case of these illnesses and spread them to others. The same public health precautions that prevent the spread of COVID-19, will prevent the spread of the flu.

  • Stay home when you are sick
  • Get tested for COVID-19 (if advised by screening)
  • Wash your hands often
  • Cover your cough and sneeze
  • Clean frequently touched surfaces often
  • Get vaccinated.

For more information, visit https://www.ontario.ca/page/flu-facts

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