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COVID-19 prevention drug coming for immunocompromised New Brunswickers – Yahoo News Canada

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The two-shot antibody treatment Evusheld provides protection from COVID-19 for about six months. (Associated Press/Ted Warren – image credit)

A drug that could prevent immunocompromised people from developing COVID-19 will soon be available in New Brunswick.

Evusheld was approved last month by Health Canada for people aged 12 or older who are immunocompromised and unlikely to mount an adequate immune response to COVID-19 vaccination, or for whom COVID-19 vaccination is not recommended.

The antibody treatment, developed by AstraZeneca, is administered through two injections before people become infected or have had a known recent exposure to the virus.

“The introduction of this treatment is good news for some specific situations,” Department of Health spokesperson Bruce Macfarlane said in an emailed statement.

“This medication may be part of a treatment plan prescribed by physicians after a clinical assessment to a limited number of individuals.”

Unlike Paxlovid, the other COVID-19 medication currently available in New Brunswick, Evusheld is not authorized to treat COVID-19.

Evusheld is not a substitute for COVID-19 vaccination for those who are eligible either.

But for people with weakened immune systems, such as cancer, transplant or dialysis patients, those with autoimmune conditions or taking immunosuppressive medications, vaccines alone may not offer sufficient protection against COVID-19, the president of AstraZeneca Canada has said.

“The key to ending the COVID-19 pandemic is protecting as many people as possible against infection, including those who may need an additional layer of protection to prevent COVID-19 than vaccines alone can provide,” said Kiersten Combs. The approval of Evusheld, she said, is “an important step along this journey.”

Jonathan Nackstrand/AFP/Getty ImagesJonathan Nackstrand/AFP/Getty Images

Jonathan Nackstrand/AFP/Getty Images

New Brunswick recorded 15 more COVID-19 deaths in its weekly report Tuesday.

Hospitalizations because of the virus dropped by six, to 81, including 10 people in intensive care, according to the province. The regional health authorities, meanwhile, report there are a total of 123 people with COVID-19 being treated in hospital, 13 of whom require intensive care.

The number of new cases of COVID-19 dropped to 2,534, but that’s based in part on PCR (polymerase chain reaction) results, and about 2,000 fewer tests were performed April 24-30.

Limited supply

Clinical trials found Evusheld cut the risk of developing symptomatic COVID-19 by 77 per cent and the protection lasted for at least six months.

“We are expecting that the supply of this medication will be very limited in our province over the next few months while the federal government works to secure larger quantities,” Macfarlane said.

In February, AstraZeneca announced it had struck a deal with the federal government to supply 100,000 doses of Evusheld to be delivered in 2022, pending its approval in Canada.

While vaccines rely on a person’s natural immune system to develop targeted antibodies and infection-fighting cells, Evusheld contains the lab-made antibodies tixagevimab and cilgavimab, which are designed to linger in the body for months to contain the virus in case of an infection.

Common side effects, expected in one in 10 people, may include a rash or hives, or injection site reaction, such as pain, redness, itching and swelling.

Uncommon side effects, expected in one in 100 people, may include headache, chills, and redness, discomfort or soreness near the injection site.

There isn’t enough data yet to be sure Evusheld is safe for use by those pregnant or breastfeeding. Health Canada recommends those individuals discuss the potential benefits and risks with a health-care provider.

“The best defence against Omicron is vaccination and we urge everyone to ensure they get their booster dose as soon as possible,” said Macfarlane.

A total of 52 per cent of eligible New Brunswickers are now boosted after 885 more people received their COVID-19 booster shot, Public Health reported Tuesday, up from 51.9 per cent a week ago.

A total of 87.9 per cent have received two doses, up from 87.8 per cent (233 more people), and 93.1 per cent have received their first dose, unchanged again (146 more people).

Evusheld is expected to “retain neutralizing activity against Omicron subvariant BA.2, which is now the dominant variant in many communities in Canada,” Health Canada has said.

As one of the conditions of authorization, AstraZeneca must continue to provide Health Canada with information on the safety and efficacy of Evusheld, including protection against current and emerging variants of concern, as soon as it’s available.

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Canada to donate up to 200,000 vaccine doses to combat mpox outbreaks in Africa

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The Canadian government says it will donate up to 200,000 vaccine doses to fight the mpox outbreak in Congo and other African countries.

It says the donated doses of Imvamune will come from Canada’s existing supply and will not affect the country’s preparedness for mpox cases in this country.

Minister of Health Mark Holland says the donation “will help to protect those in the most affected regions of Africa and will help prevent further spread of the virus.”

Dr. Madhukar Pai, Canada research chair in epidemiology and global health, says although the donation is welcome, it is a very small portion of the estimated 10 million vaccine doses needed to control the outbreak.

Vaccine donations from wealthier countries have only recently started arriving in Africa, almost a month after the World Health Organization declared the mpox outbreak a public health emergency of international concern.

A few days after the declaration in August, Global Affairs Canada announced a contribution of $1 million for mpox surveillance, diagnostic tools, research and community awareness in Africa.

On Thursday, the Africa Centres for Disease Control and Prevention said mpox is still on the rise and that testing rates are “insufficient” across the continent.

Jason Kindrachuk, Canada research chair in emerging viruses at the University of Manitoba, said donating vaccines, in addition to supporting surveillance and diagnostic tests, is “massively important.”

But Kindrachuk, who has worked on the ground in Congo during the epidemic, also said that the international response to the mpox outbreak is “better late than never (but) better never late.”

“It would have been fantastic for us globally to not be in this position by having provided doses a much, much longer time prior than when we are,” he said, noting that the outbreak of clade I mpox in Congo started in early 2023.

Clade II mpox, endemic in regions of West Africa, came to the world’s attention even earlier — in 2022 — as that strain of virus spread to other countries, including Canada.

Two doses are recommended for mpox vaccination, so the donation may only benefit 100,000 people, Pai said.

Pai questioned whether Canada is contributing enough, as the federal government hasn’t said what percentage of its mpox vaccine stockpile it is donating.

“Small donations are simply not going to help end this crisis. We need to show greater solidarity and support,” he said in an email.

“That is the biggest lesson from the COVID-19 pandemic — our collective safety is tied with that of other nations.”

This report by The Canadian Press was first published Sept. 13, 2024.

Canadian Press health coverage receives support through a partnership with the Canadian Medical Association. CP is solely responsible for this content.

The Canadian Press. All rights reserved.

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How many Nova Scotians are on the doctor wait-list? Number hit 160,000 in June

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HALIFAX – The Nova Scotia government says it could be months before it reveals how many people are on the wait-list for a family doctor.

The head of the province’s health authority told reporters Wednesday that the government won’t release updated data until the 160,000 people who were on the wait-list in June are contacted to verify whether they still need primary care.

Karen Oldfield said Nova Scotia Health is working on validating the primary care wait-list data before posting new numbers, and that work may take a matter of months. The most recent public wait-list figures are from June 1, when 160,234 people, or about 16 per cent of the population, were on it.

“It’s going to take time to make 160,000 calls,” Oldfield said. “We are not talking weeks, we are talking months.”

The interim CEO and president of Nova Scotia Health said people on the list are being asked where they live, whether they still need a family doctor, and to give an update on their health.

A spokesperson with the province’s Health Department says the government and its health authority are “working hard” to turn the wait-list registry into a useful tool, adding that the data will be shared once it is validated.

Nova Scotia’s NDP are calling on Premier Tim Houston to immediately release statistics on how many people are looking for a family doctor. On Tuesday, the NDP introduced a bill that would require the health minister to make the number public every month.

“It is unacceptable for the list to be more than three months out of date,” NDP Leader Claudia Chender said Tuesday.

Chender said releasing this data regularly is vital so Nova Scotians can track the government’s progress on its main 2021 campaign promise: fixing health care.

The number of people in need of a family doctor has more than doubled between the 2021 summer election campaign and June 2024. Since September 2021 about 300 doctors have been added to the provincial health system, the Health Department said.

“We’ll know if Tim Houston is keeping his 2021 election promise to fix health care when Nova Scotians are attached to primary care,” Chender said.

This report by The Canadian Press was first published Sept. 11, 2024.

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Newfoundland and Labrador monitoring rise in whooping cough cases: medical officer

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ST. JOHN’S, N.L. – Newfoundland and Labrador‘s chief medical officer is monitoring the rise of whooping cough infections across the province as cases of the highly contagious disease continue to grow across Canada.

Dr. Janice Fitzgerald says that so far this year, the province has recorded 230 confirmed cases of the vaccine-preventable respiratory tract infection, also known as pertussis.

Late last month, Quebec reported more than 11,000 cases during the same time period, while Ontario counted 470 cases, well above the five-year average of 98. In Quebec, the majority of patients are between the ages of 10 and 14.

Meanwhile, New Brunswick has declared a whooping cough outbreak across the province. A total of 141 cases were reported by last month, exceeding the five-year average of 34.

The disease can lead to severe complications among vulnerable populations including infants, who are at the highest risk of suffering from complications like pneumonia and seizures. Symptoms may start with a runny nose, mild fever and cough, then progress to severe coughing accompanied by a distinctive “whooping” sound during inhalation.

“The public, especially pregnant people and those in close contact with infants, are encouraged to be aware of symptoms related to pertussis and to ensure vaccinations are up to date,” Newfoundland and Labrador’s Health Department said in a statement.

Whooping cough can be treated with antibiotics, but vaccination is the most effective way to control the spread of the disease. As a result, the province has expanded immunization efforts this school year. While booster doses are already offered in Grade 9, the vaccine is now being offered to Grade 8 students as well.

Public health officials say whooping cough is a cyclical disease that increases every two to five or six years.

Meanwhile, New Brunswick’s acting chief medical officer of health expects the current case count to get worse before tapering off.

A rise in whooping cough cases has also been reported in the United States and elsewhere. The Pan American Health Organization issued an alert in July encouraging countries to ramp up their surveillance and vaccination coverage.

This report by The Canadian Press was first published Sept. 10, 2024.

The Canadian Press. All rights reserved.

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