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Do stem cells grow better in space? Here’s what researchers say – Global News

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Researcher Dhruv Sareen’s own stem cells are now orbiting the Earth. The mission? To test whether they’ll grow better in zero gravity.

Scientists at Cedars-Sinai Medical Center in Los Angeles are trying to find new ways to produce huge batches of a type of stem cell that can generate nearly any other type of cell in the body– and potentially be used to make treatments for many diseases. The cells arrived over the weekend at the International Space Station on a supply ship.

“I don’t think I would be able to pay whatever it costs now” to take a private ride to space, Sareen said. “At least a part of me in cells can go up!”

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The experiment is the latest research project that involves shooting stem cells into space. Some, like this one, aim to overcome the terrestrial difficulty of mass producing the cells. Others explore how space travel impacts the cells in the body. And some help better understand diseases such as cancer.

“By pushing the boundaries like this, it’s knowledge and it’s science and it’s learning,” said Clive Svendsen, executive director of Cedars-Sinai’s Regenerative Medicine Institute.

Six earlier projects from the U.S., China and Italy sent up various types of stem cells– including his team’s study of the effects of microgravity on cell-level heart function, said Dr. Joseph Wu of Stanford University, who directs the Stanford Cardiovascular Institute. Wu helped coordinate a series of programs on space-based stem cell research last year.


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Swabbing for Minh, 4-year-old Montreal girl in need of life-saving donation from compatible match


Swabbing for Minh, 4-year-old Montreal girl in need of life-saving donation from compatible match

Earthly applications of much of this research may be a little ways off.

At this point, the only stem cell-based products approved by the Food and Drug Administration contain blood-forming stem cells from umbilical cord blood for patients with blood disorders such as certain cases of lymphoma. There are no approved therapies using the kind of stem cells being sent to space or others derived from them, said Jeffrey Millman, a biomedical engineering expert at Washington University in St. Louis.

But clinical trials underway involving stem cells target conditions such as macular degeneration, Parkinson’s disease and heart attack damage. And Millman is involved in research that could lead to a new approach for treating Type 1 diabetes.

Scientists see great promise in stem cells.

The gravity dilemma

That promise is tempered by a frustrating earthly problem: The planet’s gravity makes it tough to grow the vast quantities of cells necessary for future therapies that may require more than a billion per patient.

“With current technology right now, even if the FDA instantly approved any of these therapies, we don’t have the capacity to manufacture” what’s needed, Millman said.

The issue? In large bioreactors, the cells need to be stirred vigorously or they clump or fall to the bottom of the tank, Millman said. The stress can cause most cells to die.

“In zero G, there’s no force on the cells, so they can just grow in a different way,” Svendsen said.


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Increasing diversity on Canada’s stem cell registry


Increasing diversity on Canada’s stem cell registry – Jun 24, 2019

The Cedars-Sinai team has sent up what are called induced pluripotent stem cells. Many scientists consider them the perfect starting materials for all sorts of personalized, cell-based treatments. They carry a patient’s own DNA, and their versatility makes them similar to embryonic stem cells, only they are reprogrammed from adults’ skin or blood cells.

For their experiment, which is being funded by NASA, a shoebox-sized container holds bags filled with spheres of cells and all of the pumps and solutions needed to keep them alive for four weeks. The cargo will also include neural stem cells originating from Svendsen. The scientists used stem cells derived from their own white blood cells because it was easy for them to give consent.

They will run the experiment remotely with a box of cells on Earth for comparison. They’ll get the space experiment back in five weeks or so, when it returns in the same SpaceX capsule.

The work is designed to pave the way for more NASA-funded research. If they are able to figure out how to make billions of cells in orbit, Svendsen said, “the impact could be huge.”

A high-flying future

During the same cargo launch, researchers from the University of California, San Diego, sent blood stem cells to the space station, a repeat of an experiment they did last year. They want to find out if low Earth orbit induces faster aging in the cells, leading to problems that set the stage for precancerous changes. One goal is to protect astronauts’ health.

Afshin Beheshti, a researcher at NASA Ames Research Center, said scientists are just beginning to understand some of the risks of space travel.

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“There’s more unknowns in space than there are knowns,” he said. “Any new type of experiment is going to shed light on how the body responds to the space environment.”

Ultimately, Beheshti said, the research should yield more than practical, earthly solutions like new medicines. It will also help with far-off human aspirations, like living on other planets.

© 2022 The Associated Press

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Las Vegas Aces Rookie Kate Martin Suffers Ankle Injury in Game Against Chicago Sky

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Las Vegas Aces rookie Kate Martin had to be helped off the floor and taken to the locker room after suffering an apparent ankle injury in the first quarter of Tuesday night’s game against the Chicago Sky.

Late in the first quarter, Martin was pushing the ball up the court when she appeared to twist her ankle and lost her balance. The rookie was in serious pain, lying on the floor before eventually being helped off. Her entire team came out in support, and although she managed to put some pressure on the leg, she was taken to the locker room for further evaluation.

Martin returned to the team’s bench late in the second quarter but was ruled out for the remainder of the game.

“Kate Martin is awesome. Kate Martin picks up things so quickly, she’s an amazing sponge,” Aces guard Kelsey Plum said of the rookie during the preseason. “I think (coach) Becky (Hammon) nicknamed her Kate ‘Money’ Martin. I think that’s gonna stick. And when I say ‘money,’ it’s not just about scoring and stuff, she’s just in the right place at the right time. She just makes people better. And that’s what Becky values, that’s what our coaching staff values and that’s why she’s gonna be a great asset to our team.”

Las Vegas selected Martin in the second round of the 2024 WNBA Draft. She was coming off the best season of her collegiate career at Iowa, where she averaged 13.1 points, 6.8 rebounds, and 2.3 assists per game during the 2023-24 campaign. Martin’s integration into the Aces organization has been seamless, with her quickly earning the respect and admiration of her teammates and coaches.

The team and fans alike are hoping for a speedy recovery for Martin, whose contributions have been vital to the Aces’ performance this season.

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Asteroid Apophis will visit Earth in 2029, and this European satellite will be along for the ride

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The European Space Agency is fast-tracking a new mission called Ramses, which will fly to near-Earth asteroid 99942 Apophis and join the space rock in 2029 when it comes very close to our planet — closer even than the region where geosynchronous satellites sit.

Ramses is short for Rapid Apophis Mission for Space Safety and, as its name suggests, is the next phase in humanity’s efforts to learn more about near-Earth asteroids (NEOs) and how we might deflect them should one ever be discovered on a collision course with planet Earth.

In order to launch in time to rendezvous with Apophis in February 2029, scientists at the European Space Agency have been given permission to start planning Ramses even before the multinational space agency officially adopts the mission. The sanctioning and appropriation of funding for the Ramses mission will hopefully take place at ESA’s Ministerial Council meeting (involving representatives from each of ESA’s member states) in November of 2025. To arrive at Apophis in February 2029, launch would have to take place in April 2028, the agency says.

This is a big deal because large asteroids don’t come this close to Earth very often. It is thus scientifically precious that, on April 13, 2029, Apophis will pass within 19,794 miles (31,860 kilometers) of Earth. For comparison, geosynchronous orbit is 22,236 miles (35,786 km) above Earth’s surface. Such close fly-bys by asteroids hundreds of meters across (Apophis is about 1,230 feet, or 375 meters, across) only occur on average once every 5,000 to 10,000 years. Miss this one, and we’ve got a long time to wait for the next.

When Apophis was discovered in 2004, it was for a short time the most dangerous asteroid known, being classified as having the potential to impact with Earth possibly in 2029, 2036, or 2068. Should an asteroid of its size strike Earth, it could gouge out a crater several kilometers across and devastate a country with shock waves, flash heating and earth tremors. If it crashed down in the ocean, it could send a towering tsunami to devastate coastlines in multiple countries.

Over time, as our knowledge of Apophis’ orbit became more refined, however, the risk of impact  greatly went down. Radar observations of the asteroid in March of 2021 reduced the uncertainty in Apophis’ orbit from hundreds of kilometers to just a few kilometers, finally removing any lingering worries about an impact — at least for the next 100 years. (Beyond 100 years, asteroid orbits can become too unpredictable to plot with any accuracy, but there’s currently no suggestion that an impact will occur after 100 years.) So, Earth is expected to be perfectly safe in 2029 when Apophis comes through. Still, scientists want to see how Apophis responds by coming so close to Earth and entering our planet’s gravitational field.

“There is still so much we have yet to learn about asteroids but, until now, we have had to travel deep into the solar system to study them and perform experiments ourselves to interact with their surface,” said Patrick Michel, who is the Director of Research at CNRS at Observatoire de la Côte d’Azur in Nice, France, in a statement. “Nature is bringing one to us and conducting the experiment itself. All we need to do is watch as Apophis is stretched and squeezed by strong tidal forces that may trigger landslides and other disturbances and reveal new material from beneath the surface.”

The Goldstone radar’s imagery of asteroid 99942 Apophis as it made its closest approach to Earth, in March 2021. (Image credit: NASA/JPL–Caltech/NSF/AUI/GBO)

By arriving at Apophis before the asteroid’s close encounter with Earth, and sticking with it throughout the flyby and beyond, Ramses will be in prime position to conduct before-and-after surveys to see how Apophis reacts to Earth. By looking for disturbances Earth’s gravitational tidal forces trigger on the asteroid’s surface, Ramses will be able to learn about Apophis’ internal structure, density, porosity and composition, all of which are characteristics that we would need to first understand before considering how best to deflect a similar asteroid were one ever found to be on a collision course with our world.

Besides assisting in protecting Earth, learning about Apophis will give scientists further insights into how similar asteroids formed in the early solar system, and, in the process, how  planets (including Earth) formed out of the same material.

One way we already know Earth will affect Apophis is by changing its orbit. Currently, Apophis is categorized as an Aten-type asteroid, which is what we call the class of near-Earth objects that have a shorter orbit around the sun than Earth does. Apophis currently gets as far as 0.92 astronomical units (137.6 million km, or 85.5 million miles) from the sun. However, our planet will give Apophis a gravitational nudge that will enlarge its orbit to 1.1 astronomical units (164.6 million km, or 102 million miles), such that its orbital period becomes longer than Earth’s.

It will then be classed as an Apollo-type asteroid.

Ramses won’t be alone in tracking Apophis. NASA has repurposed their OSIRIS-REx mission, which returned a sample from another near-Earth asteroid, 101955 Bennu, in 2023. However, the spacecraft, renamed OSIRIS-APEX (Apophis Explorer), won’t arrive at the asteroid until April 23, 2029, ten days after the close encounter with Earth. OSIRIS-APEX will initially perform a flyby of Apophis at a distance of about 2,500 miles (4,000 km) from the object, then return in June that year to settle into orbit around Apophis for an 18-month mission.

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Furthermore, the European Space Agency still plans on launching its Hera spacecraft in October 2024 to follow-up on the DART mission to the double asteroid Didymos and Dimorphos. DART impacted the latter in a test of kinetic impactor capabilities for potentially changing a hazardous asteroid’s orbit around our planet. Hera will survey the binary asteroid system and observe the crater made by DART’s sacrifice to gain a better understanding of Dimorphos’ structure and composition post-impact, so that we can place the results in context.

The more near-Earth asteroids like Dimorphos and Apophis that we study, the greater that context becomes. Perhaps, one day, the understanding that we have gained from these missions will indeed save our planet.

 

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McMaster Astronomy grad student takes a star turn in Killarney Provincial Park

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Astronomy PhD candidate Veronika Dornan served as the astronomer in residence at Killarney Provincial Park. She’ll be back again in October when the nights are longer (and bug free). Dornan has delivered dozens of talks and shows at the W.J. McCallion Planetarium and in the community. (Photos by Veronika Dornan)

Veronika Dornan followed up the April 8 total solar eclipse with another awe-inspiring celestial moment.

This time, the astronomy PhD candidate wasn’t cheering alongside thousands of people at McMaster — she was alone with a telescope in the heart of Killarney Provincial Park just before midnight.

Dornan had the park’s telescope pointed at one of the hundreds of globular star clusters that make up the Milky Way. She was seeing light from thousands of stars that had travelled more than 10,000 years to reach the Earth.

This time there was no cheering: All she could say was a quiet “wow”.

Dornan drove five hours north to spend a week at Killarney Park as the astronomer in residence. part of an outreach program run by the park in collaboration with the Allan I. Carswell Observatory at York University.

Dornan applied because the program combines her two favourite things — astronomy and the great outdoors. While she’s a lifelong camper, hiker and canoeist, it was her first trip to Killarney.

Bruce Waters, who’s taught astronomy to the public since 1981 and co-founded Stars over Killarney, warned Dornan that once she went to the park, she wouldn’t want to go anywhere else.

The park lived up to the hype. Everywhere she looked was like a painting, something “a certain Group of Seven had already thought many times over.”

The dome telescopes at Killarney Provincial Park.

She spent her days hiking the Granite Ridge, Crack and Chikanishing trails and kayaking on George Lake.  At night, she went stargazing with campers — or at least tried to. The weather didn’t cooperate most evenings — instead of looking through the park’s two domed telescopes, Dornan improvised and gave talks in the amphitheatre beneath cloudy skies.

Dornan has delivered dozens of talks over the years in McMaster’s W.J. McCallion Planetarium and out in the community, but “it’s a bit more complicated when you’re talking about the stars while at the same time fighting for your life against swarms of bugs.”

When the campers called it a night and the clouds parted, Dornan spent hours observing the stars. “I seriously messed up my sleep schedule.”

She also gave astrophotography a try during her residency, capturing images of the Ring Nebula and the Great Hercules Cluster.

A star cluster image by Veronika Dornan

“People assume astronomers take their own photos. I needed quite a lot of guidance for how to take the images. It took a while to fiddle with the image properties, but I got my images.”

Dornan’s been invited back for another week-long residency in bug-free October, when longer nights offer more opportunities to explore and photograph the final frontier.

She’s aiming to defend her PhD thesis early next summer, then build a career that continues to combine research and outreach.

“Research leads to new discoveries which gives you exciting things to talk about. And if you’re not connecting with the public then what’s the point of doing research?”

 

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