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Do you have atopic dermatitis?

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This dry skin problem affects quality of life

Atopic dermatitis or atopic eczema is a dry skin problem that stems from the mutation of the profilaggrin gene, which is responsible for the skin barrier protection of the skin. With this mutation, there are higher chances of reacting to environmental factors, such as heat, stress, and products.  This makes the atopic skin prone to scratching, skin infection, and even changes of the skin color due to the response to inflammation. Some rashes will develop pigments as a response to continued and repeated cycle of irritation, resulting to formation of post-inflammatory hyperpigmentation. Some atopic patients, however, respond by not producing pigments in the problem area, thus forming hypopigmented lesion, which we call post-inflammatory hypopigmentation.

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These are some treatment for post inflammatory hyperpigmentation.

*Topical agents such as Hydroquinone, topical retinoid, topical corticosteroid, glycolic acid and other fruit acids, azelaic acid, L-ascorbic acid (vitamin C)

*Resurfacing laser such as Dermablate laser, Baby skin laser, and Pico ablative laser.

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*Chemical peels such as Coquille peel, Citrine peel, and Tresare peel.

Hypopigmentation due to inflammatory skin disorders and infections usually resolves by itself over weeks to months and even years, once the underlying disorder has been cleared.

Hypopigmentation can affect the quality of life and self-esteem, as patients refuse to leave their house, and feel inferior to others.

As physicians, we aim to improve pigmentary changes but also improve quality of life and self-esteem. There are a lot of convincing studies to prove that antioxidants and growth factors can help improve these cases, but patience is very important. For most patients from the beginning, we know that it will take them at least six months to have that improvement on post inflammatory hyper/hypopigmentation.

These are some of the treatments that can be done at medical clinics.

*Medical hydration via lasers and machines every two weeks

*Application of superoxide dismutase, the only antioxidant enzyme that scavenges the superoxide anion by converting this free radical to oxygen and hydrogen peroxide, thus preventing peroxynitrite production and further damage.

*Topical immunomodulators such as calcineurin inhibitors are the best option during flareups Patients can avoid steroid in the meantime to prevent steroid-induced hypopigmentation.

* Emollient moisturizer helps rebuild the skin barrier to help prevent flareups.

*Microtherapy + Growth factor + Hyaluronic acid + Neurotoxin (Refreshed micrococktail) – This special concoction aims to help augment skin color by promoting healing mechanism of injured skin, PRP releases growth factors (healing and regeneration) adhesion molecules and chemokines interacting with the local environment, promotes cell differentiation, proliferation and regeneration, while Hyaluronic acid induces remodeling of dermal extracellular matrix and reduced inflammation, which is suitable intradermal delivery, and lastly, neurotoxin which has melanin protective property.

To every skin problem, there is a solution.  One must be patient and consistent to be able to see results.  Consult your dermatologist or cosmetic surgeons for the best options for you today.

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Model With Lifestyle, Health Behavior Information Predicts CKD – The Suburban Newspaper

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TUESDAY, Jan. 31, 2023 (HealthDay News) — Self-reported lifestyle and health behavior information can predict incident chronic kidney disease (CKD), according to a study published in the January issue of the Clinical Journal of the American Society of Nephrology.

Ariana J. Noel, M.D., from the University of Ottawa in Canada, and colleagues developed and validated a survey-based prediction equation to identify individuals at risk for incident CKD. Data were obtained from 22,200 adults with an estimated glomerular filtration rate (eGFR) ≥70 mL/min/1.73 m2 who completed a comprehensive general population health survey between 2000 and 2015. Demographics, comorbidities, lifestyle factors, diet, and mood were included in prediction equations. Models with and without baseline eGFR were derived and validated externally in 15,522 participants from the U.K. Biobank. The primary outcome was new-onset CKD.

The researchers found that during a median follow-up of 4.2 years, new-onset CKD occurred in 1,981 participants (9 percent). Lifestyle factors (smoking, alcohol, physical activity) and comorbid illnesses (diabetes, hypertension, cancer) were included in the final models. For individuals with and without a baseline eGFR measure, the model was discriminating (five-year C statistic, 83.5 and 81.0, respectively) and was well calibrated. The five-year C-statistic was 78.1 and 66.0 in external validation with and without baseline eGFR, respectively, and maintained calibration.

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“Our equation demonstrated excellent discrimination and calibration, and may serve as a patient-facing tool to improve CKD awareness and education,” the authors write.

Several authors disclosed financial ties to the biopharmaceutical industry.

Abstract/Full Text (subscription or payment may be required)

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Gendered gap puts Calgary woman at increased heart disease risk: new report – Calgary Herald

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Research into heart disease has often evaded complexities of menstrual cycles and pregnancy, a new report says

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Christina Stuwe’s triple-bypass, open-heart surgery in 2018 was a life-saving procedure for the Calgary mother.

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But the need for the surgery nearly went undetected by health professionals, as tests for her irregular heartbeat came back inconclusive and she was told to come back in a year.

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It was only after Stuwe and her husband pushed for further testing, including an angiogram, that they discovered multiple blocked arteries in her heart — and the fact she unknowingly had a heart attack three years earlier.

“The way my heart was reacting really put everyone off, and they couldn’t really explain it,” Stuwe said.

“Once something was identified with my heart, it was like it was being put off even though we obviously knew something was wrong . . . If I had waited a year, who knows, I might have had another heart attack and been gone.”

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Stuwe’s experience highlights a Canadian health system that sometimes struggles to provide adequate care to women with cardiovascular disease.

Gendered gaps in medical diagnosis and care, as well as research and awareness, put women at heightened risk from both heart and brain disease, according to a report from the Heart and Stroke Foundation released Wednesday.

That report says women face different risk factors than men for heart disease due to biological differences, but that health systems historically have fallen short in considering those differences. The inequities worsen when factoring in groups including women of colour, women with low socioeconomic status and women living in rural or remote areas.

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Research has often evaded complexities of menstrual cycles, pregnancy

Heart disease is the leading cause of premature death in Canadian women, said Dr. Kara Nerenberg, a clinician-scientist at the University of Calgary Cumming School of Medicine whose work focuses on preventing heart disease and stroke in younger women.

She said in the past, much cardiovascular research specific to women has been excluded by researchers to avoid dealing with the complexities of menstrual cycles or pregnancies in their studies.

That means some treatments developed to treat heart disease that work well in men don’t work for women, Nerenberg said.

“That’s potentially because of a different biology, the hormonal changes and how it affects drug metabolism, or even just the dosing of medications,” Nerenberg said, adding women are underdiagnosed when it comes to heart disease.

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“We know that even in Alberta, women receive fewer cardiac tests and fewer cardiac medications.”

  1. Dr. Anmol Kapoor, a Cardiologist, and Founder & CEO of CardiAI, is shown in a company supplied photo. Calgary-based CardiAI is using artificial intelligence to detect the signs of heart disease more accurately and sooner than the current methods.

    Nelson: Calgary doctor pushes AI boundaries in heart disease

  2. The University of Calgary.

    U of C has widest gender pay gap among Canadian universities

  3. Dr. Paul Fedak is a cardiovascular surgeon in Calgary and a professor and head of the department of cardiac sciences and director at the Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary.

    Opinion: Our suffering health-care system can be resuscitated, but let’s make it personal

Women can experience different symptoms than men

Some conditions of pregnancy can increase risk of cardiovascular disease, Nerenberg said, underlining a need for better and more regular screenings for women.

She said health-care providers, as well as women, should be aware of different ways that heart disease presents itself between men and women.

“We do know that a lot of women will have the same symptoms of men of heart disease — chest pain, shortness of breath. But women also commonly experience different symptoms, like fatigue or different types of pain, and they may not describe it the same way as men,” she said.

“As a society as a whole, we need to put more attention to signs in our own bodies, and that’s male or female. I think too many times, we put things off because life is busy, but we have to pay attention to ourselves,” Stuwe said.

jherring@postmedia.com

Twitter: @jasonfherring

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Ultra-Processed Foods May Be Linked to Increased Risk of Cancer

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Summary: High consumption of ultra-processed foods, including soda, chips, and some white bread products, was associated with an increased risk of developing and dying from certain kinds of cancer, including brain cancer.

Source: Imperial College London

Higher consumption of ultra-processed foods may be linked to an increased risk of developing and dying from cancer, an Imperial College London-led observational study suggests.

Researchers from Imperial’s School of Public Health have produced the most comprehensive assessment to date of the association between ultra-processed foods and the risk of developing cancers.

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Ultra-processed foods are food items which have been heavily processed during their production, such as fizzy drinks, mass-produced packaged breads, many ready meals and most breakfast cereals.

Ultra-processed foods are often relatively cheap, convenient, and heavily marketed, often as healthy options. But these foods are also generally higher in salt, fat, sugar, and contain artificial additives. It is now well documented that they are linked with a range of poor health outcomes including obesity, type 2 diabetes and cardiovascular disease.

The first UK study of its kind used UK Biobank records to collect information on the diets of 200,000 middle-aged adult participants. Researchers monitored participants’ health over a 10-year period, looking at the risk of developing any cancer overall as well as the specific risk of developing 34 types of cancer. They also looked at the risk of people dying from cancer.

The study found that higher consumption of ultra-processed foods was associated with a greater risk of developing cancer overall, and specifically with ovarian and brain cancers. It was also associated with an increased risk of dying from cancer, most notably with ovarian and breast cancers.

For every 10 percent increase in ultra-processed food in a person’s diet, there was an increased incidence of 2 percent for cancer overall, and a 19 percent increase for ovarian cancer specifically.

Each 10 percent increase in ultra-processed food consumption was also associated with increased mortality for cancer overall by 6 percent, alongside a 16 percent increase for breast cancer and a 30 percent increase for ovarian cancer.

These links remained after adjusting for a range of socio-economic, behavioral and dietary factors, such as smoking status, physical activity and body mass index (BMI).

The Imperial team carried out the study, which is published in eClinicalMedicine, in collaboration with researchers from the International Agency for Research on Cancer (IARC), University of São Paulo, and NOVA University Lisbon.

Previous research from the team reported the levels of consumption of ultra-processed foods in the UK, which are the highest in Europe for both adults and children. The team also found that higher consumption of ultra-processed foods was associated with a greater risk of developing obesity and type 2 diabetes in UK adults, and a greater weight gain in UK children extending from childhood to young adulthood.

Dr. Eszter Vamos, lead senior author for the study, from Imperial College London’s School of Public Health, said, “This study adds to the growing evidence that ultra-processed foods are likely to negatively impact our health including our risk for cancer. Given the high levels of consumption in UK adults and children, this has important implications for future health outcomes.

“Although our study cannot prove causation, other available evidence shows that reducing ultra-processed foods in our diet could provide important health benefits. Further research is needed to confirm these findings and understand the best public health strategies to reduce the widespread presence and harms of ultra-processed foods in our diet.”

Dr. Kiara Chang, first author for the study, from Imperial College London’s School of Public Health, said, “The average person in the UK consumes more than half of their daily energy intake from ultra-processed foods.

“This is exceptionally high and concerning as ultra-processed foods are produced with industrially derived ingredients and often use food additives to adjust color, flavor, consistency, texture, or extend shelf life.

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The study found that higher consumption of ultra-processed foods was associated with a greater risk of developing cancer overall, and specifically with ovarian and brain cancers. Image is in the public domain

“Our bodies may not react the same way to these ultra-processed ingredients and additives as they do to fresh and nutritious minimally processed foods. However, ultra-processed foods are everywhere and highly marketed with cheap price and attractive packaging to promote consumption. This shows our food environment needs urgent reform to protect the population from ultra-processed foods.”

The World Health Organization and the United Nations’ Food and Agriculture Organization has previously recommended restricting ultra-processed foods as part of a healthy sustainable diet.

There are ongoing efforts to reduce ultra-processed food consumption around the world, with countries such as Brazil, France and Canada updating their national dietary guidelines with recommendations to limit such foods. Brazil has also banned the marketing of ultra-processed foods in schools. There are currently no similar measures to tackle ultra-processed foods in the UK.

Dr. Chang added, “We need clear front of pack warning labels for ultra-processed foods to aid consumer choices, and our sugar tax should be extended to cover ultra-processed fizzy drinks, fruit-based and milk-based drinks, as well as other ultra-processed products.

“Lower income households are particularly vulnerable to these cheap and unhealthy ultra-processed foods. Minimally processed and freshly prepared meals should be subsidized to ensure everyone has access to healthy, nutritious and affordable options.”

The researchers note that their study is observational, so does not show a causal link between ultra-processed foods and cancer due to the observational nature of the research. More work is needed in this area to establish a causal link.

About this diet and brain cancer research news

Author: Press Office
Source: Imperial College London
Contact: Press Office – Imperial College London
Image: The image is in the public domain

Original Research: The findings will appear in eClinicalMedicine

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