Study Uncovers How Covid-19 Kills, Offers Possible Ways To Stop It

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Study Uncovers How Covid-19 Kills, Offers Possible Ways To Stop It | newkerala.com Health News – New Kerala

Published

4 years ago

August 27, 2020

Harry Miller

IANS | 16 hours ago

Toronto, Aug 27 : In the fight against the novel coronavirus, researchers have made significant progress in understanding the Covid-19 virus and offered possible ways to stop the pandemic.

“While the findings need to be validated with larger groups of patients, they could have important implications for treating and studying this disease,” said study author Douglas Fraser from the Lawson Health Research Institute in Canada.

According to the study published in the journal Critical Care Explorations, a major complication occurring in most critically ill Covid-19 patients is clotting in the lung’s small blood vessels which leads to low oxygen levels in the body.

“The reason for this clotting has been unclear. Most suspect the clotting mechanisms in our blood are put into overdrive and so many clinicians have been treating with anticoagulant therapies like the drug heparin,” Fraser said.

“But we’ve uncovered an entirely different mechanism,” Fraser added.

In a first study, the team measured 1,161 plasma proteins from the blood of 30 participants 10 Covid-19 patients and 10 patients with other infections admitted to ICU, as well as 10 healthy control participants. Blood was drawn on set days of ICU admission, processed in a lab and then analysed using statistical methods and artificial intelligence.

The team noted that predicting a patient’s disease severity can help in a number of ways. It could allow for medical teams to have important conversations with family members, setting goals of care based on the patient’s health and personal wishes. In a second study, the team further analysed the blood samples from the 30 participants and found evidence to suggest that the inner linings of small blood vessels are becoming damaged and inflamed, making them a welcoming environment for platelets (small blood cells) to stick. They discovered that Covid-19 patients had elevated levels of three molecules (hyaluronic acid, syndecan-1 and P-selectin.)

The first two molecules are products broken down from small hair-like structures (the glycocalyx) which line the inside of the blood vessels. Their presence suggests the glycocalyx is being damaged with its breakdown products sent into the bloodstream. The presence of P-selectin is also significant as this molecule helps to make both platelets and the inner lining of blood vessels adhere to one another.

“The glycocalyx keeps platelets from touching the inside wall of the blood vessel and helps facilitate the production of nitric oxide, which has an important role in preventing platelets from sticking,” explained Fraser.

“We suspect the body’s immune response is producing enzymes that shear off these little hair-like structures, inflaming blood vessels and making them a welcoming environment for platelets to form clots,” Fraser said.

The team suggests that two therapies may hold promise for treating blood clots in Covid-19 patients platelet inhibitors to stop platelets from sticking and molecules to protect and restore the inner lining of blood vessels.

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April 22nd to 30th is Immunization Awareness Week – Oldies 107.7

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2 hours ago

April 24, 2024

Harry Miller

<!–April 22nd to 30th is Immunization Awareness Week | Oldies 107.7

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AHS confirms case of measles in Edmonton – CityNews Edmonton

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3 hours ago

April 24, 2024

Harry Miller

Alberta Health Services (AHS) has confirmed a case of measles in Edmonton, and is advising the public that the individual was out in public while infectious.

Measles is an extremely contagious disease that is spread easily through the air, and can only be prevented through immunization.

AHS says individuals who were in the following locations during the specified dates and times, may have been exposed to measles.

April 16
- Edmonton International Airport, international arrivals and baggage claim area — between 3:20 p.m. and 6 p.m.
April 20
- Stollery Children’s Hospital Emergency Department — between 5 a.m. to 3 p.m.
April 22
- 66^th Medical Clinic (13635 66 St NW Edmonton) — between 12:15 p.m. to 3:30 p.m.
- Pharmacy 66 (13637 66 St NW Edmonton) — between 12:15 p.m. to 3:30 p.m.
April 23
- Stollery Children’s Hospital Emergency Department — between 4:40 a.m. to 9:33 a.m.

AHS says anyone who attended those locations during those times is at risk of developing measles if they’ve not had two documented doses of measles-containing vaccine.

Those who have not had two doses, who are pregnant, under one year of age, or have a weakened immune system are at greatest risk of getting measles and should contact Health Link at 1-877-720-0707.

Symptoms

Symptoms of measles include a fever of 38.3° C or higher, cough, runny nose, and/or red eyes, a red blotchy rash that appears three to seven days after fever starts, beginning behind the ears and on the face and spreading down the body and then to the arms and legs.

If you have any of these symptoms stay home and call Health Link.

In Alberta, measles vaccine is offered, free of charge, through Alberta’s publicly funded immunization program. Children in Alberta typically receive their first dose of measles vaccine at 12 months of age, and their second dose at 18 months of age.

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U.S. tightens rules for dairy cows a day after bird flu virus fragments found in pasteurized milk samples – Toronto Star

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4 hours ago

April 24, 2024

Harry Miller

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Infected cows were already prohibited from being transported out of state, but that was based on the physical characteristics of the milk, which looks curdled when a cow is infected, or a cow has decreased lactation or low appetite, both symptoms of infection.

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