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The AstraZeneca vaccine, blood clots and VIPIT: What you need to know – CTV News

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TORONTO —
Canada’s National Advisory Committee on Immunization (NACI) has recommended pausing administration of the AstraZeneca coronavirus vaccine to those under the age of 55 due to fears of recipients getting a rare type of blood clot called vaccine-induced prothrombotic immune thrombocytopenia (VIPIT).

Several provinces, including Alberta, Manitoba, Ontario and Quebec, announced they would follow the guidance, which NACI said stems from pending investigations of VIPIT cases in Europe.

It was believed that VIPIT occurred in about one per million administered vaccines, according to the World Health Organization (WHO), but a report from the Paul Ehrlich Institute in Germany cited potential numbers closer to one in 100,000 doses.

European cases of VIPIT have been primarily reported in women under the age of 55, with a few cases in men.

VIPIT refers to a specific type of blood clot that can stem from receipt of the AstraZeneca vaccine and is different from the blood’s regular clotting mechanism or conditions like deep vein thrombosis.

“A blood clot is what you see when the blood coagulates, the platelets stop the bleeding after someone has cut themselves – it’s a response of the body to injury,” said clinical researcher and Toronto physician Dr. Iris Gorfinkel in a telephone interview with CTVNews.ca Monday. “It’s really common and it’s necessary.”

“But what happens from certain disease states, and that’s one of the concerns around the AstraZeneca vaccine, is whether it will cause the blood to clot that’s not in a good way, but in a bad way that actually causes…a blood clot to develop in an area and block the blood vessel, and that blood vessel will no longer bring oxygen and nutrients to the area it’s supposed to,” Gorfinkel explained.

VIPIT symptoms usually occur between four and 20 days after vaccination and include persistent and severe headaches, seizures, blurred vision, shortness of breath, chest or abdominal pain and redness in a limb, according to an advisory issued from the Ontario COVID-19 Science Advisory Table.

The advisory states that VIPIT is very rare and it’s not known if certain patients are more likely to get the condition.

At this time the group states they “do not believe that VIPIT is more common in people who have had blood clots before, people with a family history of blood clots, people with low platelet counts or pregnant women because VIPIT does not develop through the same process as usual types of bleeding or clotting problems.”

A statement from the Public Health Agency of Canada (PHAC) said VIPIT can have serious outcomes, but early diagnosis and treatment can help prevent that.

“Based on current evidence, for those individuals who have already been vaccinated with AstraZeneca for more than 20 days there is no cause for concern,” PHAC said. “For those who have been vaccinated with AstraZeneca less than 20 days, and anyone vaccinated with the AstraZeneca vaccine going forward, you should seek immediate medical attention in the rare event that you develop symptoms starting four days or more after vaccination.”

Some doctors are sounding the alarm over the new data.

“These are not ordinary blood clots, they can cause very serious disease in the brain and they can be fatal,” infectious disease specialist Dr. Abdu Sharkawy told CTV News Channel’s Power Play on Monday.

“Even though they are extremely rare, they’re very serious and it begs an explanation, it begs an investigation to make sure that if you are going to roll it out potentially over a scale of millions and millions of people, you certainly don’t want to put them in harm’s way.”

Gorfinkel said it’s very difficult to track down the “why” of rare possible vaccine side effects like VIPIT.

“Was it just a certain population who is susceptible? Could it have been something in the shipment of those vaccines – a temperature deviation? Is it the genetic makeup of those people? Could it be related to something that’s going on in that immediate vicinity that causes a cross-reactivity with a vaccine or something they are exposed to in that area? This is what you’re talking about with rare side effects,” she said.

Gorfinkel also urged people to do research before panicking and said a lot of the answers for NACI’s decision making lies in the math.

“The numbers that we’re seeing [of VIPIT] are so far and few between that you will be very hard pressed to find a doctor who’s ever seen a case,” she said. “So consider that the World Health Organization estimates this to be one in a million. A regular doctor has maybe 1,500 patients – so how many doctors would it take to get to that million? The answer is way more doctors than I personally even know.”

Gorfinkel said that health agencies may be “worried” about the findings from the Paul Erlich Institute, but said what they “all agree on” is that blood clots are rare.

“It’s extremely rare after getting the shot…but the World Health Organization has landed squarely on the [fact that] benefits outweigh the risks, and the European Medicines Agency has said the benefits outweigh the risks, but why NACI is recommending a pause is a little more complicated and it has to do with math,” she said.

Gorfinkel said that “less than 30 per cent of all hospitalizations” and just over four per cent of COVID-19 related deaths in Canada were among those under the age of 55, which shows that is not the cohort typically dying from the disease.

Because health organizations can only give the vaccine at a certain rate due to supply chains and dosage schedules, Gorfinkel said that NACI is asking the question, “‘can we make do with the vaccines that we have for the population who is most risk right now and still get the information we need for the younger people?’”

But Gorfinkel added that the “numbers change completely” if the World Health Organization’s estimate of one in a million VIPIT cases is correct versus the Paul Erlich Institute’s one in 100,000.

“If it’s as high as one in one hundred thousand, this is where NACI is drawing the line in the sand, and saying they need to look more closely at it,” Gorfinkel said, adding that because cases of VIPIT are so few and Canada’s population so varied the question becomes: “Is that data necessarily even translatable to what’s happening here?…we cannot be sure of that.”

Gorfinkel said some of NACI’s decision making comes to down to the fact that Canada has alternatives to offer instead of the AstraZeneca vaccine.

“NACI’s thoughtfully asking the question, ‘could we not just vaccinate with these others options?’” Gorfinkel said. “This is ultimately why we have Health Canada, why we have NACI and you know, the way it works is Health Canada is a ‘yay or nay,’ is it ‘in or out,’ and NACI does the finer details on it. And generally speaking, the provinces and territories will follow exactly what NACI suggests.”

Despite Monday’s announcement, NACI has recommended the continued use of the AstraZeneca vaccine among people over the age of 55 with informed consent, due to the lower risk of developing of VIPIT in older populations and the increased risk of severe COVID-19 infections among that age group.

Canada is expected to receive 1.5 million doses of the AstraZeneca vaccine on Tuesday from the United States.

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With files from CTVNews.ca writer Ben Cousins and writer and producer Ryan Flanagan

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Telus prioritizing ‘most important customers,’ avoiding ‘unprofitable’ offers: CFO

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Telus Corp. says it is avoiding offering “unprofitable” discounts as fierce competition in the Canadian telecommunications sector shows no sign of slowing down.

The company said Friday it had fewer net new customers during its third quarter compared with the same time last year, as it copes with increasingly “aggressive marketing and promotional pricing” that is prompting more customers to switch providers.

Telus said it added 347,000 net new customers, down around 14.5 per cent compared with last year. The figure includes 130,000 mobile phone subscribers and 34,000 internet customers, down 30,000 and 3,000, respectively, year-over-year.

The company reported its mobile phone churn rate — a metric measuring subscribers who cancelled their services — was 1.09 per cent in the third quarter, up from 1.03 per cent in the third quarter of 2023. That included a postpaid mobile phone churn rate of 0.90 per cent in its latest quarter.

Telus said its focus is on customer retention through its “industry-leading service and network quality, along with successful promotions and bundled offerings.”

“The customers we have are the most important customers we can get,” said chief financial officer Doug French in an interview.

“We’ve, again, just continued to focus on what matters most to our customers, from a product and customer service perspective, while not loading unprofitable customers.”

Meanwhile, Telus reported its net income attributable to common shares more than doubled during its third quarter.

The telecommunications company said it earned $280 million, up 105.9 per cent from the same three-month period in 2023. Earnings per diluted share for the quarter ended Sept. 30 was 19 cents compared with nine cents a year earlier.

It reported adjusted net income was $413 million, up 10.7 per cent year-over-year from $373 million in the same quarter last year. Operating revenue and other income for the quarter was $5.1 billion, up 1.8 per cent from the previous year.

Mobile phone average revenue per user was $58.85 in the third quarter, a decrease of $2.09 or 3.4 per cent from a year ago. Telus said the drop was attributable to customers signing up for base rate plans with lower prices, along with a decline in overage and roaming revenues.

It said customers are increasingly adopting unlimited data and Canada-U.S. plans which provide higher and more stable ARPU on a monthly basis.

“In a tough operating environment and relative to peers, we view Q3 results that were in line to slightly better than forecast as the best of the bunch,” said RBC analyst Drew McReynolds in a note.

Scotiabank analyst Maher Yaghi added that “the telecom industry in Canada remains very challenging for all players, however, Telus has been able to face these pressures” and still deliver growth.

The Big 3 telecom providers — which also include Rogers Communications Inc. and BCE Inc. — have frequently stressed that the market has grown more competitive in recent years, especially after the closing of Quebecor Inc.’s purchase of Freedom Mobile in April 2023.

Hailed as a fourth national carrier, Quebecor has invested in enhancements to Freedom’s network while offering more affordable plans as part of a set of commitments it was mandated by Ottawa to agree to.

The cost of telephone services in September was down eight per cent compared with a year earlier, according to Statistics Canada’s most recent inflation report last month.

“I think competition has been and continues to be, I’d say, quite intense in Canada, and we’ve obviously had to just manage our business the way we see fit,” said French.

Asked how long that environment could last, he said that’s out of Telus’ hands.

“What I can control, though, is how we go to market and how we lead with our products,” he said.

“I think the conditions within the market will have to adjust accordingly over time. We’ve continued to focus on digitization, continued to bring our cost structure down to compete, irrespective of the price and the current market conditions.”

Still, Canada’s telecom regulator continues to warn providers about customers facing more charges on their cellphone and internet bills.

On Tuesday, CRTC vice-president of consumer, analytics and strategy Scott Hutton called on providers to ensure they clearly inform their customers of charges such as early cancellation fees.

That followed statements from the regulator in recent weeks cautioning against rising international roaming fees and “surprise” price increases being found on their bills.

Hutton said the CRTC plans to launch public consultations in the coming weeks that will focus “on ensuring that information is clear and consistent, making it easier to compare offers and switch services or providers.”

“The CRTC is concerned with recent trends, which suggest that Canadians may not be benefiting from the full protections of our codes,” he said.

“We will continue to monitor developments and will take further action if our codes are not being followed.”

French said any initiative to boost transparency is a step in the right direction.

“I can’t say we are perfect across the board, but what I can say is we are absolutely taking it under consideration and trying to be the best at communicating with our customers,” he said.

“I think everyone looking in the mirror would say there’s room for improvement.”

This report by The Canadian Press was first published Nov. 8, 2024.

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TC Energy cuts cost estimate for Southeast Gateway pipeline project in Mexico

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CALGARY – TC Energy Corp. has lowered the estimated cost of its Southeast Gateway pipeline project in Mexico.

It says it now expects the project to cost between US$3.9 billion and US$4.1 billion compared with its original estimate of US$4.5 billion.

The change came as the company reported a third-quarter profit attributable to common shareholders of C$1.46 billion or $1.40 per share compared with a loss of C$197 million or 19 cents per share in the same quarter last year.

Revenue for the quarter ended Sept. 30 totalled C$4.08 billion, up from C$3.94 billion in the third quarter of 2023.

TC Energy says its comparable earnings for its latest quarter amounted to C$1.03 per share compared with C$1.00 per share a year earlier.

The average analyst estimate had been for a profit of 95 cents per share, according to LSEG Data & Analytics.

This report by The Canadian Press was first published Nov. 7, 2024.

Companies in this story: (TSX:TRP)

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BCE reports Q3 loss on asset impairment charge, cuts revenue guidance

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BCE Inc. reported a loss in its latest quarter as it recorded $2.11 billion in asset impairment charges, mainly related to Bell Media’s TV and radio properties.

The company says its net loss attributable to common shareholders amounted to $1.24 billion or $1.36 per share for the quarter ended Sept. 30 compared with a profit of $640 million or 70 cents per share a year earlier.

On an adjusted basis, BCE says it earned 75 cents per share in its latest quarter compared with an adjusted profit of 81 cents per share in the same quarter last year.

“Bell’s results for the third quarter demonstrate that we are disciplined in our pursuit of profitable growth in an intensely competitive environment,” BCE chief executive Mirko Bibic said in a statement.

“Our focus this quarter, and throughout 2024, has been to attract higher-margin subscribers and reduce costs to help offset short-term revenue impacts from sustained competitive pricing pressures, slow economic growth and a media advertising market that is in transition.”

Operating revenue for the quarter totalled $5.97 billion, down from $6.08 billion in its third quarter of 2023.

BCE also said it now expects its revenue for 2024 to fall about 1.5 per cent compared with earlier guidance for an increase of zero to four per cent.

The company says the change comes as it faces lower-than-anticipated wireless product revenue and sustained pressure on wireless prices.

BCE added 33,111 net postpaid mobile phone subscribers, down 76.8 per cent from the same period last year, which was the company’s second-best performance on the metric since 2010.

It says the drop was driven by higher customer churn — a measure of subscribers who cancelled their service — amid greater competitive activity and promotional offer intensity. BCE’s monthly churn rate for the category was 1.28 per cent, up from 1.1 per cent during its previous third quarter.

The company also saw 11.6 per cent fewer gross subscriber activations “due to more targeted promotional offers and mobile device discounting compared to last year.”

Bell’s wireless mobile phone average revenue per user was $58.26, down 3.4 per cent from $60.28 in the third quarter of the prior year.

This report by The Canadian Press was first published Nov. 7, 2024.

Companies in this story: (TSX:BCE)

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