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One in five deaths around the world is caused by sepsis, also known as blood poisoning, shows the most comprehensive analysis of the condition.
The report estimates 11 million people a year are dying from sepsis – more than are killed by cancer.
The researchers at the University of Washington said the “alarming” figures were double previous estimates.
Most cases were in poor and middle income countries, but even wealthier nations are dealing with sepsis.
What is sepsis?
Sepsis is also known as the “hidden killer” because it can be so hard to detect.
It is caused by the immune system going into over-drive. Instead of just fighting an infection, it starts attacking other parts of the body too.
Ultimately it causes organ failure. Even survivors can be left with long-term damage and disability.
Bacteria and viruses that cause diarrhoeal infections or lung diseases are the leading triggers of sepsis.
Why the jump in numbers?
Previous global estimates, which came up with a figure of 19 million cases and 5 million deaths, were based on just a handful of western countries.
This analysis, published in the Lancet and based on medical records from 195 nations, shows there are 49 million cases a year.
The 11 million deaths from sepsis account for one in five of all deaths around the world.
“I’ve worked in rural Uganda, and sepsis is what we saw every single day,” said researcher, assistant professor Kristina Rudd.
“My colleagues treating patients on the ground in low- and middle-income countries every day have been saying this for years, that sepsis is a major problem.
“So in a way I wasn’t actually that surprised – on the other hand I didn’t expect it to be double the previous estimate.”
The good news in this analysis is that cases and deaths have fallen since 1990.
The hope is understanding the true scale of the problem will raise awareness and save more lives.
Who is affected?
The overwhelming majority of cases (85%) are in low- and middle- income countries.
Children were most at risk with four in 10 cases in children under the age of five.
But even in the UK, sepsis is a challenge. The death rate is higher than in countries such as Spain, France and Canada.
There are around 48,000 deaths from sepsis in the UK each year, the report shows.
There has been a big push within the health service to identify the signs of sepsis more quickly and to begin treatment.
What can be done about it?
Reducing the number of infections can reduce the number of cases of sepsis.
For many countries, this means good sanitation, clean water and access to vaccines.
The other challenge is to get better at identifying patients with sepsis in order to treat them before it is too late.
Early treatment with antibiotics or anti-virals to clear an infection can make a massive difference.
Prof Mohsen Naghavi said: “We are alarmed to find sepsis deaths are much higher than previously estimated, especially as the condition is both preventable and treatable.
“We need renewed focus on sepsis prevention among newborns and on tackling antimicrobial resistance, an important driver of the condition.”
What are the symptoms of sepsis?
- slurred speech
- extreme shivering or muscle pain
- passing no urine in a day
- severe breathlessness
- high heart rate and high or low body temperature
- skin mottled or discoloured
- a mottled, bluish or pale appearance
- very lethargic or difficult to wake
- abnormally cold to touch
- breathing very fast
- a rash that does not fade when you press it
- a seizure or convulsion
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Study suggests Pfizer COVID-19 vaccine only partially protects against Omicron – Toronto Sun
The Omicron variant can partially evade protection from two doses of Pfizer and partner BioNTech’s COVID-19 vaccine, the research head of a laboratory at the Africa Health Research Institute in South Africa said on Tuesday.
But the study showed that blood from people who had received two doses of the vaccine and had a prior infection was mostly able to neutralize the variant, suggesting that booster doses of the vaccine could help to fend off infection.
The Omicron variant, first detected in southern Africa last month, has triggered alarms globally of another surge in infections, with more than two dozen countries from Japan to the United States reporting cases.
The World Health Organization classified it on Nov. 26 as a “variant of concern,” but said there was no evidence to support the need for new vaccines specifically designed to tackle the Omicron variant with its many mutations.
Alex Sigal, a professor at the research institute, said on Twitter there was “a very large drop” in neutralization of the Omicron variant relative to an earlier strain of COVID-19.
A separate lab test by virologist Sandra Ciesek of the University Hospital Frankfurt painted a somewhat bleaker picture.
Exposing the blood of vaccinated individuals to different virus variants, she found that the ability to mount an antibody response to Omicron in people who had three shots of BioNTech/Pfizer was up to 37 times lower than the response to Delta.
An antibody response to Omicron half a year after a two-shot regimen of Pfizer/BioNTech, Moderna or a mixed course of AstraZeneca/BioNTech was not even measurable, Ciesek added.
She posted only selected findings on Twitter, not including the number of samples, and the university said the paper had not yet been published.
“The set of data underscores that it makes sense to develop a vaccine that is adapted to Omicron,” Chiesek tweeted, adding that no conclusion could be drawn about protection against severe disease.
WHO’s chief scientist, Soumya Swaminathan, said a large drop in the antibody response of vaccinated people to Omicron had been expected.
“This does not mean the vaccine will not work – T-cell immunity (is) likely to persist,” she said on Twitter, referring to a cellular immune response that is believed to prevent severe disease as a second line of immune defence.
Researchers including Carsten Watzl of the German Society of Immunology and Penny Ward, visiting professor at King’s College London, said the findings underscored the need to get booster shots because a three-shot course would likely continue to protect against severe disease.
Sigal’s lab tested blood from 12 people who had been vaccinated with two doses of the Pfizer/BioNTech vaccine, according to a manuscript posted on the website for his lab. The preliminary data in the manuscript has not yet been peer reviewed.
Blood from five out of six people who had been vaccinated as well as previously infected with COVID-19 still neutralized the Omicron variant, the manuscript said.
“These results are better than I expected. The more antibodies you got, the more chance you’ll be protected from Omicron,” Sigal said on Twitter.
He said the lab had not tested the variant against blood from people who had received a booster dose, because they are not available in South Africa yet.
According to the manuscript, the lab observed a 41-fold decline in levels of neutralizing antibodies against the Omicron variant.
Sigal said on Twitter that figure is likely to be adjusted after his lab does more experiments.
While neutralizing antibodies are an indicator of the body’s immune response, scientists believe other kinds of cells such as B-cells and T-cells are also stimulated by the vaccines and help protect against the effects of the coronavirus.
The preliminary data does not indicate that the vaccine is less able to prevent severe illness or death. While lab tests are under way, BioNTech CEO Ugur Sahin said last week “we think it’s likely that people will have substantial protection against severe disease caused by Omicron.”
There is not significant data yet on how vaccines from Moderna, Johnson & Johnson and other drugmakers hold up against the new variant. All the manufacturers, including Pfizer and BioNTech, are expected to release their own data within weeks.
BioNTech’s Sahin told NBC News on Tuesday that the drugmaker has data coming on Wednesday or Thursday.
Seven Omicron variant cases in Simcoe County linked to travellers from Nigeria – BayToday.ca
The Simcoe Muskoka District Health Unit says it is investigating a household cluster in Simcoe County with seven confirmed COVID-19 cases that have a strong probability of being the Omicron variant of concern. All the cases are currently isolating at home.
“The cluster is linked to travellers who arrived in Simcoe County from Nigeria in late November,” says a news release.
“Although the health unit is awaiting whole genomic sequencing of the samples which should be available in the next 7 to 14 days, given the travel history and the preliminary laboratory screening results, the likelihood of an Omicron cluster is very high.”
The Unit’s case and contact management team is currently following up with each case to identify close contacts regarding isolation and testing.
“Scientific data about the Omicron variant is still emerging,” said Dr. Charles Gardner, Medical Officer of Health. “Early evidence suggests that the variant might be more transmissible. While we continue to closely monitor this local situation, I urge all residents to remain vigilant about following public health measures, to monitor themselves for symptoms of COVID-19 and seek testing immediately if any should develop, and get vaccinated if they have not already done so.”
The rate of COVID-19 infection among the unvaccinated vaccine-eligible Simcoe Muskoka population is seven times higher than it is for the fully vaccinated population and the rate of COVID-19 hospitalizations is 15 times higher says Gardner. Getting the vaccine can lower the risk of serious illness, hospitalization, and death.
Eating disorder symptoms and self-harm linked to higher levels of depression and anxiety during COVID-19 pandemic – Medical Xpress
Young adults with previous self-harm or eating disorders reported higher levels of depression and anxiety during the pandemic, even when restrictions had eased, according to new research.
The study, led by the University of Bristol and funded by Elizabeth Blackwell Institute, Medical Research Council and Medical Research Foundation, has been published in the Journal of Eating Disorders. It looked at questionnaire information for 2,657 individuals from world-renowned health study Children of the 90s (also known as the Avon Longitudinal Study of Parents and Children) before and during the COVID-19 pandemic.
Researchers analyzed the relationship between previous reports of eating disorder symptoms and self-harm before the pandemic, and mental health problems (symptoms of depression and anxiety) and mental wellbeing during the COVID-19 pandemic. The study also assessed whether lifestyle changes, such as more sleep, relaxation techniques, or visiting green space, could be linked to mental health and wellbeing in young adults with and without previous eating disorder symptoms or self-harm.
Researchers studied questionnaire data from 2017, when the participants were then aged 25 years, as well as data taken during the pandemic in 2020.
At age 25, 32 percent of the 2,657 young adults reported at least one eating disorder symptom, 9 percent reported self-harm, and 5.5 percent reported both an eating disorder symptom and self-harm in the last year.
During the pandemic, those with previously reported eating disorder symptoms and/or self-harm had more symptoms of depression and anxiety, and worse mental wellbeing, compared to individuals without previous symptoms. This remained the case after adjusting for their pre-pandemic levels of depression, anxiety and mental wellbeing.
Lifestyle changes appeared to have little effect on the increased risk for mental health problems in those with prior eating disorder symptoms or self-harm.
Lead author Dr. Naomi Warne, Senior Research Associate at the University’s Centre for Academic Mental Health, said: “Eating disorders and self-harm are common and troubling mental health problems among young adults. In the UK, approximately 1.25 million people are living with an eating disorder and almost 1 in 15 adults report self-harm.
“Our research has highlighted individuals with prior self-harm and eating disorder symptoms are key risk groups and further longitudinal research is needed to understand their ongoing mental health as well as risk and protective factors.
“Individuals with previous eating disorder symptoms and self-harm should be considered vulnerable to depression and anxiety throughout the pandemic and beyond. Funding for rapid and responsive service provision is essential to reduce the impact of the pandemic on those with mental health problems.”
Naomi Warne et al, Disordered eating and self-harm as risk factors for poorer mental health during the COVID-19 pandemic: a UK-based birth cohort study, Journal of Eating Disorders (2021). DOI: 10.1186/s40337-021-00510-9
University of Bristol
Eating disorder symptoms and self-harm linked to higher levels of depression and anxiety during COVID-19 pandemic (2021, December 8)
retrieved 8 December 2021
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