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BioNTech founders warn of vaccine supply gaps as it works to boost production – CTV News

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BERLIN —
BioNTech is working flat out with partner Pfizer to boost production of their COVID-19 vaccine, its founders said, warning there would be gaps in supply until other vaccines were rolled out.

The German biotech startup has led the vaccine race but its shot has been slow to arrive in the European Union because of relatively late approval from the bloc’s health regulator and the small size of the order placed by Brussels.

The delays in rolling out the home-grown vaccine have caused consternation in Germany, where some regions had to halt vaccinations within days of starting an inoculation drive.

“At the moment it doesn’t look good – a hole is appearing because there’s a lack of other approved vaccines and we have to fill the gap with our own vaccine,” BioNTech CEO Ugur Sahin told news weekly Spiegel.

Sahin founded BioNTech with his wife, Oezlem Tuereci, who is the company’s chief medical officer. Both faulted the EU’s decision to spread orders in the expectation that more vaccines would be approved quickly.

The United States ordered 600 million doses of the BioNTech/Pfizer shot in July, while the EU waited until November to place an order half that size.

“At some point it became clear that it would not be possible to deliver so quickly,” Tuereci told Spiegel. “By then it was already too late to place follow-on orders.”

After publication of the interview, BioNTech said it was in talks with Brussels on boosting output

“We are in productive discussions with the European Commission on how to make more of our vaccine in Europe, for Europe,” a spokeswoman said.

 

NEW PRODUCTION

BioNTech hopes to launch a new production line in Marburg, Germany, ahead of schedule in February, with the potential to produce 250 million doses in the first half of 2021, said Sahin.

Talks are also under way with contract manufacturers and there should be greater clarity by the end of January, he added.

Health Minister Jens Spahn said on Twitter that German authorities would do everything possible to enable a swift start in Marburg.

The federal government, which has backed BioNTech with 375 million euros (US$458 million) in funding, has resisted calls from opposition leaders to speed production of its vaccine by issuing compulsory licenses to other drugmakers.

Another vaccine from Moderna is expected to be cleared by the European Medicines Agency (EMA) on Jan. 6.

Spahn has also urged the EMA to quickly approve the Oxford University-AstraZeneca shot cleared by Britain. The EU timeline for that treatment remains uncertain.

That vaccine was approved by India’s drug regulator on Friday for emergency use, two sources with knowledge of the matter told Reuters.

 

VIRAL VARIANT

Sahin said the BioNTech/Pfizer vaccine, which uses messenger RNA to instruct the human immune system to fight the coronavirus, should be able to cope with a new, more contagious variant first detected in Britain.

“We are testing whether our vaccine can also neutralize this variant and will soon know more,” he said.

Asked about coping with a strong mutation, he said it would be possible to tweak the vaccine as required within six weeks – though such new treatments might require additional regulatory approvals.

Sahin also said BioNTech would make its vaccine, which requires storage at about minus 70 degrees Celsius (minus 94 Fahrenheit), easier to handle, adding that a next-generation vaccine could be ready by late summer.

(Reporting by Douglas Busvine Editing by John Stonestreet and David Goodman)

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Quebec high school students back in classroom after month-long break – CP24 Toronto's Breaking News

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Sidhartha Banerjee, The Canadian Press


Published Monday, January 18, 2021 10:32PM EST

MONTREAL – Quebec high school students returned to classrooms on Monday following a month-long, extended winter break imposed by the government to reduce the spread of COVID-19.

The return of high schoolers came one week after primary schools reopened last Monday. High school students are required to wear procedural masks at all times inside school buildings, and the province is providing each student two masks per day.

Quebec is reopening schools despite imposing a provincewide curfew between 8 p.m. and 5 a.m. until at least Feb. 8. and despite ordering most businesses deemed non-essential closed.

Premier Francois Legault has said schools aren’t primary drivers of COVID-19 transmission and that the benefits to children of keeping them open outweigh the risks of contagion.

A recent study by a group of researchers, including some from the Universite de Montreal, indicated schools were, in fact, a significant vector of transmission. Government figures indicate that schools have accounted for about 22.5 per cent of all completed outbreaks in the province – second only to workplaces.

Monday’s return to class coincided with a sharp decrease in the number of reported COVID-19 infections. The province reported 1,634 new COVID-19 cases – including about 200 that were left out of Sunday’s tally due to a reporting delay. Quebec had been recently reporting more than 1,900 cases a day.

Benoit Masse, public health expert at the Universite de Montreal, said it’s too soon to know which way the numbers are trending.

“I would be very careful before we declare victory because I think everybody realized, especially in the last 10 days, that we are in a very, very difficult situation,” Masse said. “I think everybody is making their effort and following the rules.”

He said it’ll take another 10 days to two weeks to determine the epidemiological impact of reopening schools.

“We have to see for a week or two that the early trend that we’re seeing (currently) keeps going down and has an effect on hospitalizations,” Masse said in an interview Monday.

“It’s not going to be tomorrow . . . but we should be able to reach Feb. 8 and see whether we’re going to be in a good position,” he said, referring to the date when the curfew is scheduled to be lifted.

Despite a drop in new infections, authorities reported a rise in hospitalizations Monday after reporting decreases during the previous three days. The number of patients rose by 31, to 1,491, and the number of patients in intensive care rose by two, to 217.

“Before you see a reduction of hospitalizations, you have to see a reduction in the cases,” Masse said.

Quebec announced Monday it has vaccinated three-quarters of long-term care residents with a first dose of COVID-19 vaccine.

“Vaccination continues to give a first dose to the entire group,” Health Minister Christian Dube wrote on Twitter. Quebec administered 6,845 vaccine doses Sunday, for a total 153,539.

Vaccinations won’t help bring down Quebec numbers in the short term, but Masse said the protection will be needed should cases begin to rise in the spring.

Masse said it’s too early to say whether the curfew is having a direct impact on case numbers. On Monday, Quebec’s Public Security Department reported that 1,429 tickets had been handed out by Quebec police forces relating to the curfew between Jan. 11 and Jan. 17.

Montreal police said they handed out 353 curfew-related tickets and another 583 tickets for contravening public health rules.

Quebec has reported 244,348 infections and 9,087 deaths since the beginning of the pandemic, with 215,325 people deemed recovered.

This report by The Canadian Press was first published Jan. 18, 2021.

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Survey offers glimpse of what could reopen in Manitoba – Winnipeg Free Press

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The Manitoba government’s online survey on the easing of COVID-19 restrictions is mostly a public relations exercise. But it does provide insight into what the province may reopen this week — and what is off the table.

The Pallister government is expected to announce as early as Tuesday what changes are in store for public health orders when regulations expire Friday. The easing of restrictions are expected to be minor. Provincial officials have made it clear they don’t want a “yo-yo” approach, where measures are loosened and reinstated every few weeks.

The online survey, which went live Friday, is mostly about optics; an attempt to convince the public they have a real say over public health orders. It may have some impact on government decision-making. Not all low-risk businesses, services or activities can reopen at once. Decisions to open some and not others will be arbitrary. Knowing the priorities of the public could act as a tie-breaker in some cases.

JOHN WOODS CANADIAN PRESS FILES

Much to the chagrin of some protesters, the doffing of masks in indoor public places is also not on the table.

For the most part, though, public health officials will make those decisions on their own.

In the meantime, the survey acts as a short list for what could reopen. It shows what is under consideration and asks respondents to rank options in order of importance. If it’s not listed, it’s probably not on the table.

“Not all activities and services are immediately listed as not all are being considered in the current round of services and activities due to the higher risk of activity,” the survey says.

Bars, city libraries, movie theatres and tattoo parlours are not listed. Presumably, those are not up for consideration. Much to the chagrin of some protesters, the doffing of masks in indoor public places is also not on the table.

Bars are not one of the activities listed in the survey.

JESSE BOILY / FREE PRESS FILES

Bars are not one of the activities listed in the survey.

Reducing restrictions for places of worship is being considered. In-person services are banned under code-red restrictions. Given the high level of transmission reported in those settings, it seems doubtful those would reopen, even with capacity limits. Respondents were also asked about increasing the five-person limit for funerals and weddings. Those seem more likely.

Expanding retail has a good shot. It will probably be the most significant part of this week’s announcement. Respondents were asked whether they should be allowed to shop without limiting the products they can buy. Right now, stores can only sell essential items, as prescribed by regulation. Considering the low-risk nature of retail and what’s at stake economically for small business owners, eliminating the essential-items list (or at least broadening it) seems likely. With the help of face coverings and capacity restrictions, retail can operate relatively safely.

Barber shops and hairstylists are up for consideration, as are gyms and fitness studios. Those are possibilities.

Greater access to recreation opportunities, including resuming organized sports (such as amateur hockey and indoor soccer) are also on the list. I wouldn’t hold my breath on those. Most organized sports are volunteer-driven and don’t have the resources of public schools to enforce public health measures. Sports for adults, such as beer league hockey and indoor soccer, will probably have to wait.

Considering the low-risk nature of retail and what’s at stake economically for small business owners, eliminating the essential-items list seems likely.

MALAK ABAS / FREE PRESS FILES

Considering the low-risk nature of retail and what’s at stake economically for small business owners, eliminating the essential-items list seems likely.

The most concerning set of questions in the survey is around household gatherings. Once government finally agreed in late November to prohibit people from having visitors in their homes (with some exceptions), COVID-19 cases began to fall. It wasn’t the only reason for the decline, but it was a significant factor. People gathering indoors for prolonged periods without masks is a major source of transmission.

The survey asks respondents for their views on expanding the list of exemptions for household gatherings, returning to a limit of five visitors per home, or maintaining the status quo.

Loosening those measures when Manitoba still has over 100 cases of COVID-19 a day would be a big mistake.

If infection rates and hospital numbers continue to fall, Manitoba could ease restrictions further in late February. For now, baby steps are the name of the game.

tom.brodbeck@freepress.mb.ca

Tom Brodbeck

Tom Brodbeck
Columnist

Tom has been covering Manitoba politics since the early 1990s and joined the Winnipeg Free Press news team in 2019.

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Some provinces see positive signs in COVID fight, but hospitalizations a concern – Red Deer Advocate

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Some provincial authorities saw encouraging signs in the fight against COVID-19 on Monday, even as experts warned that it’s too soon to draw conclusions from the data and provinces scrambled to deal with a looming shortage of Pfizer vaccines.

Officials in both Quebec and Manitoba noted that case numbers have dropped slightly in recent days and suggested that their populations’ efforts to control the virus could be paying off.

Dr. Brent Roussin, Manitoba’s chief public health officer, said case numbers in his province appeared to be dipping.

“We’re definitely not out of the woods,” he told a news conference as the province reported 118 cases. “We certainly still have a long way to go before we can return to normal.”

Roussin said the province is looking at easing some restrictions in the coming days, but that any changes would be gradual.

Quebec reported 1,634 new COVID-19 cases, which included about 200 from the previous day that weren’t noted because of a delay. The province had broken the 3,000-case mark in early January and has a seven-day rolling average of more than 1,900 cases a day.

Health Minister Christian Dube noted on Twitter that the Quebec City region in particular had seen a decline in the number of new infections recently, which he saw as a sign that “the sacrifices that we’re asking of Quebecers are bearing fruit.” However, he asked Quebecers to continue their efforts in order to reduce the number of hospitalizations, which rose Monday after three straight days of decline.

Universite de Montreal public health professor Benoit Masse said it will take another week or two to know whether the downward trend will be sustained and to gauge the impact of the recently imposed curfew. He said the province should know more by Feb. 8, when curfew restrictions are set to lift.

Ontario also reported its lowest number of COVID-19 cases since early January, with 2,578 new infections, but the province completed a little more than 40,000 tests Sunday, compared with more than 60,000 the day before.

Nova Scotia also reported no new cases for the second time this month.

The news was less positive in New Brunswick, where the Edmundston region entered the province’s highest pandemic-alert level, ushering in new restrictions on businesses in the region after a record-breaking number of new cases on Sunday. The province reported 26 new cases of COVID-19 on Monday after recording 36 the day before.

Provinces were also reviewing their vaccine programs to contend with a reduced supply of Pfizer-BioNTech doses after the company said last week it was cutting back on promised deliveries over the next month as it works to expand production.

Alberta Premier Jason Kenney said Monday that his province was pausing appointments for people to get their first dose of the COVID-19 vaccine due to the supply shortage.

“Even with a new shipment of Pfizer expected later this week, we won’t have enough supply to continue with new first-dose appointments,” he said, adding that the province had set aside vaccines for people who were due for their second doses, and those appointments would continue.

Manitoba stopped booking new appointments over the weekend, but health officials announced Monday that those bookings would resume, with room for about 4,000 new appointments this week and next.

Ontario also acknowledged it was working with a supply crunch that would see its next two shipments of Pfizer vaccine reduced by 20 per cent and 80 per cent respectively.

Health Minister Christine Elliott said the situation would last until late February or early March when larger shipments begin to arrive.

Ontario announced that a new hospital set to open in Vaughan, Ont. would be used to relieve a capacity crunch because of rising COVID-19 admissions. Elliott and Premier Doug Ford said the Cortellucci Vaughan Hospital would add 35 new critical care beds and 150 medical beds to the province’s bed capacity.

Hospital capacity has been a concern in many provinces, with doctors in Ontario and Quebec being told to prepare for the possibility of implementing protocols to decide which patients get access to life-saving care in the case of extreme intensive care unit overcrowding.

Nationally, COVID-19 hospitalizations and deaths are still increasing, according to Canada’s chief public health officer. Dr. Theresa Tam noted that hospitalizations tend to lag one or more weeks behind a surge in cases.

“These impacts affect everyone, as the health-care workforce and health system bear a heavy strain, important elective medical procedures are delayed or postponed, adding to pre-existing backlogs,” she wrote in a statement.

She said an average of 4,705 COVID-19 patients a day were being treated in Canadian hospitals during the last seven days, including an average of 875 in ICUs.

This report by The Canadian Press was first published Jan. 18, 2021

— With files from Steve Lambert, Shawn Jeffords and Sidhartha Banerjee

Morgan Lowrie, The Canadian Press

Coronavirus

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