Connect with us

Health

Coronavirus Update: Shilla closes in Seoul and Jeju; Confirmed case numbers surpass SARS; death toll reaches 361; Lotte Duty Free shuts Jeju – The Moodie Davitt Report – The Moodie Davitt Report

Published

 on


South Korea

The Shilla Duty Free has temporarily closed its downtown stores in Seoul and Jeju in response to the worsening coronavirus situation, The Moodie Davitt Report can confirm. Local reports say that a coronavirus-infected person was confirmed to have visited the Seoul flagship twice last month. [Source: Yonhap News].

“Sales have slumped in recent days as the situation has worsened,” a Korean travel retail veteran told The Moodie Davitt Report from Seoul this morning. “Over 70% of sales have gone from downtown duty free.”

Genius Dog 336 x 280 - Animated

This startling picture tells the story of a mounting crisis. Against the backdrop of a Louis Vuitton boutique inside one of Asia’s most important travel retail stores, health officials prepare to carry out protective measures against the coronavirus.

Fellow Korean media Newsis carries similar dramatic imagery.

China

2,829 new cases of coronavirus were reported in China yesterday (2 February), bringing the total number of infected case to 17,205.The death toll hit 361.

Philippines

The Philippines today reported its first death from the novel coronavirus, the first fatality outside China.

International

Hotels, luxury shops and other attractions and destinations that are heavily reliant on Chinese tourists face an even bigger crisis than during the SARS outbreak of 2003, according to a Bloomberg report.

“From Tokyo to London, hotels, casinos, airlines and retailers are already recording a downturn and are bracing for weeks, if not months, of plummeting spending after China curbed outbound travel and governments tightened border controls,” the news agency reported.

 “The benchmark everyone is comparing this to is SARS in 2003” –Luya You, Bocom International Analyst

In fact the impact could be much greater. As reported by The Moodie Davitt Senior Retail and Commercial Analyst Min Yong Jung, total air passenger traffic by Chinese has grown exponentially since 2002, the year before the SARS crisis peaked. Since then the Chinese spend has become the engine room of growth for travel retail worldwide, generating over 70% of sales in the world’s biggest duty free market, South Korea, alone.

Total (domestic and international) Chinese passenger figures in millions; Source: National Bureau of Statistics China; Moodie Davitt Business Intelligence Unit

“It’s a triple whammy – Chinese travel more, they spend more and they spend more on beauty products,” Jefferies LLC consumer analyst Stephanie Wissink told Bloomberg. “Chinese travellers are the most significant and most important customers for growth in the travel retail industry.”

“The benchmark everyone is comparing this to is SARS in 2003,” said Luya You, a Hong Kong-based transportation analyst at Bocom International. “The actual cost and negative impact of this virus could be greater because more Chinese are travelling than before. The cost of preventing travel, grounding flights is magnitudes higher than what it was in 2003.”

How long will this crisis last? What will be its impact on global travel retail? How long will the recovery take? Those are the questions on everyone’s lips in the travel retail sector. [Chart: Generation Research; TFWA]

China

As of midnight Saturday Beijing time, the coronavirus death toll had reached 304. Encouragingly, 328 people have been cured and discharged from hospital. The number of suspected cases in China stood at 19,544  with 14,380 cases confirmed.

South Korea

Lotte Duty Free has today announced the temporary closure of its Jeju downtown duty free store from tomorrow in order to prevent the spread of the coronavirus domestically.

The measure is necessary “for the safety of customers and employees”, Lotte said.

Lotte Duty Free confirmed that a Chinese customer who visited the store on 23 January and later returned to Yangzhou, China, had been confirmed subsequently with the coronavirus.

A Chinese customer who entered the store on 23 January was later diagnosed with the coronavirus

Until the closure, no new customers are being allowed into the store today and customers already in the store are being asked to leave.

Lotte Duty Free Jeju will carry out additional quarantine work after the store is closed. The retailer will decide when to reopen after consultation with the health authorities and Jeju Special Self-Governing Province.

A company spokesperson said: “We decided to close the business quickly on a temporary basis to prevent the spread of the new coronavirus in Korea.”

As reported, Lotte Duty Free formed an emergency response committee on 24 January with CEO Kap Lee as Chairman. The retailer is conducting thorough health inspections at stores, implementing a self-disinfecting policy at least six times a day; obliging all employees to wear masks and providing customers with masks.

China

Song Guoyou, Deputy Director of the Center for American Studies at Fudan University, has slammed US Secretary of Commerce Wilbur Ross’s claim, made Thursday, that the coronavirus would help accelerate the return of jobs to the US.

“It’s hard to believe that such immoral remarks were made by a US Commerce Secretary,” Song wrote in a hard-hitting opinion piece in state-controlled Chinese state media Global Times.

“There is no boundary for this epidemic. The novel coronavirus is the common enemy of mankind.”

“Basic compassion and morality are the yardsticks of human behaviour,” he wrote. “But Ross’s comments show that extreme selfishness seems to have dominated his mindset and values. He is so cold-blooded that he has ignored diplomatic etiquette, taking the public health epidemic that a country with 1.4 billion people is grappling with as an opportunity to realize American interests.”

Hard-hitting editorial: A leading Chinese commentator slams perceived American opportunish

He continued: “The H1N1 influenza pandemic, known as swine flu, that first broke out in the US in 2009, was also declared by the World Health Organization (WHO) as a public health emergency of international concern. Scientists estimated that the flu pandemic that swept more than 200 countries and regions killed about 280,000 people worldwide.

“In the US, the influenza virus led to the deaths of an estimated 10,000 people. Imagine if a Chinese senior official had said the swine flu would hit the US economy and accelerate the flow of global investment into China when the US was combating the virus, what would Americans and international society have thought? The only thing Ross cares about amid the novel coronavirus outbreak is the return of manufacturing to the US. He is too narrow-minded.

“There is no boundary for this epidemic. The novel coronavirus is the common enemy of mankind. As the commerce secretary of the world’s most powerful economy, instead of exploiting China’s crisis, Ross should fairly appraise the efforts made by the Chinese government in fighting the coronavirus.”

China

Chinese authorities confirm 11,791 cases of novel coronavirus in the country, with 259 deaths and importantly, 243 people confirmed to have recovered. [Source: Global Times]

“The WHO declaration is understandable. How China’s battle against the novel coronavirus goes and what trajectory the Chinese economy will head this year are determined by China’s own efforts. As long as we can put the epidemic under control, many problems will be solved. The WHO’s declaration will not become a major hurdle for China to make up for its current losses.

“It is possible that some countries would use the WHO declaration as a lever to overreact to the current virus outbreak in China. But still, as long as China contains the epidemic, the situation will improve. Most countries and world organizations have no reason to find fault with China over the epidemic after it is effectively contained, because they will only end up suffering losses if they do so.

“We have to concentrate on fighting the epidemic. While China has left a lot of room for improvement, from an outside perspective, China’s public health battle this time has been resolute and orderly. It is hoped that our efforts can effectively curb the epidemic so that China can hold more initiatives in world affairs this year.”

– Edited highlights from an editorial in Chinese state media Global Times, 31 January

[embedded content]

International

As part of our continuing service to update the travel retail community on the novel coronavirus outbreak and its impact on business, we are pleased to announce a phone-in audience with Dr David Heymann on Wednesday (5 February) at 9am (GMT).

From 2012 to March 2017, Dr Heymann was chairman of Public Health England. Earlier in his distinguished career, he was Executive Director of the Communicable Diseases Cluster, and headed the global response to SARS in 2003.

For more information on how to get involved with the free event, click here.

Russia

Russia today reported its first two cases of the coronavirus, report Reuters and official Russian news agencies. Both are Chinese citizens, who were diagnosed in the Siberian regions of Tyumen and Zabaikalsky Krai respectively.

Deputy Prime Minister Tatiana Golikova said that Russian airlines will halt flights to China from midnight tonight, although the national carrier Aeroflot plans to continue. It has offered passengers the option of rebooking or a refund, but has not yet cancelled flights.

Russia has closed its 4,300km land border with China to try to protect against the spread of the outbreak.

China (Macau)

Following our earlier report that arrivals in Macau had dropped -69% in the first four days of the Lunar New Year period, we can now confirm that total arrivals for the Lunar New Year week plummeted -78.3%.

Overall arrivals in Macau for the Lunar New Year week; Source: Macao Tourism Data Plus

During the Lunar New Year week (24 January to 30 January inclusive), arrivals from Mainland China were down -83.3% compared to the equivalent period in 2019 (4 February to 10 February inclusive).

The drop off in arrivals was particularly pronounced over recent days. Arrivals in Macau from Mainland China declined by over -90% on each of the last three days of the Lunar New Year week compared to the equivalent period a year earlier.

Arrivals in Macau from Mainland China for the Lunar New Year week; Source: Macao Tourism Data Plus

Macau Daily Times reports that the novel coronavirus will particularly impact the cash flow of Macau’s gaming industry, a sector inextricably linked to the special administrative region’s duty free operations.

China

Authorities say 9,692 cases of the new coronavirus pneumonia have been confirmed, leading to 213 deaths. The number of confirmed cases is now higher than the 8,098 seen during the SARS outbreak in 2003.

China is “confident in and capable of” effectively containing the novel coronavirus epidemic, and eventually defeating it, the National Health Commission of the People’s Republic of China said in a statement today.

The Commission was speaking after the World Health Organization (WHO) declared last night that the novel coronavirus outbreak has become a Public Health Emergency of International Concern (PHEIC).

WHO Director-General Tedros Adhanom Ghebreyesus had stressed that the WHO did not favour imposing travel or trade restrictions on China, the Commission noted. As reported, however, the U.S. Department of State last night issued a Level 4 (‘Do not travel’) Travel Advisory relating to China.

Image: National Health Commission of the People’s Republic of China

International

As countries and airlines globally restrict travel to Wuhan and China, the Reuters news agency has compiled an extensive summary of steps taken by airlines in response to the coronavirus outbreak. Read the full list here

Click to read the full summary from Reuters

China (Hong Kong)

Cathay Pacific and Cathay Dragon have suspended inflight duty free sales on flights to and from Mainland China with immediate effect.

The Cathay Pacific Group added that the meal service in first and business class will comprise a single tray with appetiser, main course and dessert served together, with trolley services suspended after the meal. Passengers in economy class will be served a disposable snack bag including a hot handheld snack and other items.

Amenities including hot towels, pillows, blankets and magazines will also not be offered to any passengers.

“This modified service offering is strictly a temporary measure designed to further strengthen our health and safety protocols in light of the evolving situation regarding coronavirus cases in Mainland China. These changes will enable us to provide enhanced protection for our customers and crew while at the same time continuing to deliver a satisfactory inflight experience for passengers,” the airline said in a statement.

UK

The first two cases have been confirmed in the UK. In a statement, England’s Chief Medical Officer Chris Whitty said: “We can confirm that two patients in England, who are members of the same family, have tested positive for coronavirus. The patients are receiving specialist NHS care, and we are using tried and tested infection control procedures to prevent further spread of the virus.”

US

The US Department of State last night issued a Level 4 (‘Do not travel’) Travel Advisory relating to China.

“Do not travel to China due to novel coronavirus first identified in Wuhan, China. On January 30, the World Health Organization has determined the rapidly spreading outbreak constitutes a Public Health Emergency of International Concern. Travellers should be prepared for travel restrictions to be put into effect with little or no advance notice. Commercial carriers have reduced or suspended routes to and from China,” the advisory read.

The US action seems to fly in the face of the World Health Organization’s (WHO) recommendations, contained in its statement last night. The WHO said: “The Committee acknowledged that, in general, evidence has shown that restricting the movement of people and goods during public health emergencies may be ineffective and may divert resources from other interventions. Further, restrictions may interrupt needed aid and technical support, may disrupt businesses, and may have negative effects on the economies of countries affected by the emergencies.

“However, in certain specific circumstances, measures that restrict the movement of people may prove temporarily useful, such as in settings with limited response capacities and capabilities, or where there is high intensity of transmission among vulnerable populations.

“In such situations, countries should perform risk and cost-benefit analyses before implementing such restrictions to assess whether the benefits would outweigh the drawbacks. Countries must inform WHO about any travel measures taken, as required by the IHR. Countries are cautioned against actions that promote stigma or discrimination, in line with the principles of Article 3 of the IHR.”

The scale of the outbreak at 9.30pm (EST) on 30 January, according to John Hopkins University (click to enlarge)

International

The Emergency Committee of the World Health Organization held today agreed that the novel coronavirus outbreak now meets the criteria for a Public Health Emergency of International Concern (PHEIC).

The Committee emphasised that the declaration of a PHEIC “should be seen in the spirit of support and appreciation for China, its people, and the actions China has taken on the frontlines of this outbreak, with transparency, and, it is to be hoped, with success”.

In line with the need for global solidarity, the committee felt that a global coordinated effort is needed to enhance preparedness in other regions of the world that may need additional support for that.

China/International

The offshore renminbi dropped below the 7 RMB to the dollar mark for the first time this year today, returning to similar levels witnessed in early to mid-December, writes The Moodie Davitt Report Senior Retail and Commercial Analyst Min Yong Jung.

Investors are positioning themselves ahead of the World Health Organization’s likely decision (expected tonight Switzerland time) to declare the latest outbreak an international public health emergency. News of the fast-paced spread of the virus has deterred investors from buying the Chinese Yuan.

Meanwhile, Taiwanese traders have returned to action following time off from the Chinese New Year holiday. Financial markets in Taiwan have been closed since 20 January and traders were actively selling in today’s trading session, resulting in the steepest one-day fall of the benchmark index, which slumped -5.75%.

The electronics sector underperformed the index, declining -5.99%, with investors anticipating production disruption as a result of the coronavirus.

International

Tax Free World Association President Alain Maingreaud says the coronavirus outbreak is having a “significant short-term impact” but he is hopeful of a rapid return to normal trading conditions once it is contained.

In a statement, Maingreaud also highlighted the resilience of the travel retail industry when presented with such challenges, and said that preparations for upcoming events – including TFWA Asia Pacific, which was cancelled in 2003 as the SARS crisis deepened – continue as normal.

Maingreaud’s full statement reads: “The situation in China is a cause for great concern, both at a business level, but of course most importantly on a personal level for those who have been affected by the coronavirus outbreak.

“Preparations for our future events, including TFWA Asia Pacific Exhibition & Conference, continue”

“An issue that affects China, one of the most important markets in our industry, will clearly have an impact across the business. Our colleagues in China and those catering for Chinese travellers around the world are trading in very difficult circumstances and we stand with our industry colleagues.

How global duty free sales from 1984-2017 have been impacted by – and rebounded from – external crises; Chart from a TFWA presentation in Cannes, October 2018; figures courtesy of Generation Research; Click to enlarge

“The resilience of our industry has been tested many times, and while this outbreak is clearly having a significant short-term impact, we remain hopeful of a rapid return to normal trading conditions once the outbreak is under control. We must be optimistic that, given the resources available, the relevant authorities will find ways to contain the virus.

“We are working closely with other trade bodies and our business partners to review the situation on a daily basis, and in the meantime preparations for our future events, including TFWA Asia Pacific Exhibition & Conference, continue.”

Italy

Local media Wanted in Rome reports the cruiseship incident

Over 6,000 passengers and 1,000 crew members are being held in port onboard the Costa Smeralda on fears that a 54-year-old woman from Macau and her travelling companion have the coronavirus. The vessel and its passengers are in Civitavecchia port, a coastal town northwest of Rome.

International

The World Health Organization (WHO) is once again meeting to decide whether to declare the outbreak an emergency of international concern. After a two-day deliberation last week, the WHO stopped short of making the declaration but emphasised the fluidity of the situation.

Philippines

The first case in the Philippines has been announced by the World Health Organization.

India

The country’s first confirmed case of novel coronavirus has been reported. The patient, a student of the Wuhan University, is stable and in isolation at a hospital in Kerala, the Health Ministry said. [Source: Economic Times]

China

While China has over 7,700 confirmed cases,  there are only 68 cases in other countries, less than 1 percent of the total reported worldwide, Global Times noted, citing an expert from government agency, the Centers for Disease Control and Prevention.

In an encouraging development, the Wuhan Institute of Virology under the Chinese Academy of Science has listed some medicines that can effectively curb the novel coronavirus at cellular level. Results have been provided to the Hubei provincial headquarters, which is leading the battle against the virus.

Any medical breakthroughs can’t come soon enough. As of 07:47 Beijing time, 7,711 cases of novel coronavirus had been confirmed in China, with 170 deaths. 124 patients have recovered. [Source: Global Times]

This real-time tracking map from Johns Hopkins University’s Center for Systems Science and Engineering shows the spread of novel coronavirus across the world

Finland

The coronavirus outbreak has spread to Finland with the first confirmed case. Finnish media Uutiset said that the individual is a Chinese tourist from Wuhan. The 32-year-old woman is being treated in Lapland Central Hospital in Rovaniemi.

China

The number of confirmed cases of novel coronavirus had reached 6,078 nationwide as at 18:00. Among those, 132 have died and 115 have been discharged from hospitals. [Source: Global Times, Xinhua]

International

LVMH Moët Hennessy Louis Vuitton CFO Jean-Jacques Guiony was asked about the impact of the coronavirus outbreak on the company during the earnings call for the luxury products group’s financial results for 2019.

Guiony emphasised that, while it is too early to assess the outbreak’s impact on business, it was important to “analyse the situation calmly” and “not panic”.

LVMH’s teams in China, Guiony continued, have reported that the virus does not appear to be as aggressive as SARS and that the Chinese government has reacted “very strongly” to the outbreak. He added that the LVMH teams in China were predicting the situation to be partially resolved during March or towards the end of March.

“If it lasts a couple of months, or if it’s resolved over the next two, two and a half months, then it won’t be that bad… if it were to last two years, it would be a totally different matter,” Guiony added.

South Korea

There has been a quiet atmosphere in South Korean duty free stores today – a world away from the usual scenes of hustle and bustle in the industry’s largest market. However, on this occasion at least, the coronavirus was not to blame; it is the Lunar New Year.

The Lunar New Year festive period typically results in a -20% week-on-week decline in sales in South Korea’s duty free market with resellers back in China to enjoy time off with family and relatives. Lotte Duty Free confirmed that the Lunar New Year period is yielding a similar performance this year.

The decision to extend the holiday period to 3 February is keeping resellers away from Korean duty free stores for longer.

The continued suspension of packaged tours to Korea will also affect the duty free market and the impact will be felt more severely than before, according to The Moodie Davitt Report’s Senior Retail and Commercial Analyst Min Yong Jung. Read his analysis here.

International

GlobalData has added a note of caution to its estimate for airport sales in 2020.

The data analytics company has estimated global airport retail sales will reach US$48.2 billion in 2020, a +6.1% year-on-year increase.

Adding a note of caution, GlobalData Principal Analyst Honor Strachan said: “The prevention of travel for Chinese consumers will impact the performance of airport retail worldwide. Over the last few years airport retailers, especially those in Europe, have tailored their propositions, integrated Chinese payment solutions and invested in Mandarin-speaking staff to target Chinese passengers and maximise sales growth opportunities.”

GlobalData is forecasting Asia Pacific will contribute 45.1% of global airport sales this year, with sales in the region rising +8.4% year-on-year to US$21.7 billion.

“If outbound tourism from China suffers as a result of the coronavirus, airport operators and retailers must adapt their strategies to target other passengers,” Strachan added.

China (Macau)

Visitor numbers have collapsed, plummeting -69% in the first four days of the Lunar New Year festive period. Arrivals from the Mainland were down by over -75%.  Travel retailers, such as DFS, and the closely related gaming, hotel and restaurant sectors, are all reeling from the downturn [Source: Macau Daily Times]

DFS declined to comment but it is understood that its stores are still open, in close discussion with the respective landlords. Like all affected travel retailers, DFS will be working hard to protect its staff and customers.

China yesterday announced a temporary suspension of the Individual Visitor Scheme (IVS) to Macau. Sources say that 47% of Mainland visitors to Macau arrived on IVS last year. With the group tour business already suspended, that has immediate and stark repercussions for Macau’s economy.

Source: Macau Government Tourism Office

With China Duty Free Group forced to close its doors at the CDF Mall in Haitang Bay last Sunday; and DFS Group’s modern-day commercial heartland of Macau set to grind to a near or actual halt, these are grim days for the travel retail community. Hong Kong, already suffering from the effect of sustained social unrest, will be further affected by the closure of the main borders with Mainland China from tomorrow.

The home page of Macau Daily Times (and the photograph of empty streets) tells a stark tale

UAE

The first cases in the Middle East have been confirmed, with the Ministry of Health & Protection in the UAE announcing that a family of four has been infected. The statement added that the general health situation “is not a cause for concern” and that the Ministry advises “all citizens and residents to adhere to the general health guidelines”.

International

The next few weeks will be critical in determining the extent of the spread of the coronavirus from heightened travel during Lunar New Year.

The Moodie Davitt Report’s Senior Retail and Commercial Analyst Min Yong Jung has written an insightful analysis of the potential impact of holiday travel, using South Korea as a case study, in an article you can read here.

India

The Ministry of Health is advising travellers to refrain from travelling to China.

UK

British Airways has suspended flights to and from Mainland China as the coronavirus outbreak worsens. This comes as the UK Foreign & Commonwealth Office advised against all travel to Hubei Province and all but essential travel to the rest of Mainland China.

China

China is likely to have a vaccine for the novel coronavirus for public use within three months. That will include a month and a half of development and a similar period of testing, according to Li Lanjuan, an academician of the Chinese Academy of Engineering, Global Times reports.

1,459 new cases of coronavirus and 3,248 suspected cases, including one in Tibet, were reported across China yesterday alone as the spread of the virus accelerates. The total number of confirmed infections reached 5,974, with 1,239 patients in critical condition. The death toll has reached 132 while 103 patients have recovered. [Source: Global Times]

China/International

As Chinese shoppers alter their travel plans and stay at home to avoid infection, many luxury market players — including luxury groups, Chinese brands, and ecommerce companies — have decided to make generous contributions, writes The Moodie Davitt Report business information partner Jing Daily.

International luxury group LVMH announced on 27 January 27 that it would donate nearly US$2.3 million (RMB16 million)to the Chinese Red Cross Foundation to help with a medical supplies shortage in Wuhan. The group also helped to gather much-needed supplies for China from France and throughout Europe with the assistance of the Red Cross. This news was shared by many LVMH employees in China and garnered positive reactions from fashion insiders.

LVMH’s rival luxury group Kering posted a donation of US$1.1 million to the Red Cross in the heavily impacted province of Hubei. The donation will be used for front-line prevention and control work (including care for hospital medical staff and patients) as well as training and public health education. International beauty groups L’Oréal and The Estée Lauder Companies pledged US$720,000 and US$300,000 respectively to help China  fight the virus.

Beauty brand Perfect Diary is broadcasting safety recommendations, and intimate wear company Neiwai posted a message reminding its fans to stay healthy and strong on WeChat.

From big donations to small messages, brands chose to be sensitive to their consumers during this crisis rather than push out promotional messages. “I personally find it tone-deaf to push coupons or remain silent during these times of crisis,” said Dao Nguyen, founder of Essenzia, a consultancy for beauty and fragrance marketing strategy in China. “I am not sure if this is a lack of awareness or reactivity?”

In return, fans responded positively to brands’ heartfelt messages. “What Perfect Diary did is quite moving, they are the first brand I saw publish any safety guide for their fans,” commented one WeChat user named Aaliyah. “No wonder Estée Lauder is my favourite brand,” wrote Annabelle Du under the group’s donation announcement.

These are the kinds of organic, positive impressions that can’t be bought with a marketing budget or advertising money.

International

A scientific race to find a vaccine for the virus is underway, writes The Moodie Davitt Report Senior Research & Commercial Analyst Min Jon Jung. Here is a roundup of key breakthroughs so far.

January 10: Chinese scientists posted a complete genome of the coronavirus.

January 28: Hong Kong University Professor Yuen Kwok-yung was successful in producing a vaccine but testing on animals will take months and clinical trials at least another year.

January 29: Peter Doherty Institute for Infection and Immunity in Australia successful in recreating virus outside of China.

The joint global effort may help to shorten the time required to develop a successful vaccine, but the development is both expensive and time-consuming. The vaccine for the SARS virus was developed 20 months after the viral genome was released and the outbreak was contained with public health measures before the vaccine was ready.

Dr Paul Stoffels, Johnson & Johnson’s chief scientific officer, estimated it could take eight to 12 months before his company’s vaccines reach human clinical trials.

The scale of the outbreak at 11pm (EST) on 28 January, according to John Hopkins University (click to enlarge)

China (Macau)

In a big blow to travel retailers, the government today announced a temporary suspension of the Individual Visitor Scheme (IVS) to Macau. Sources say that 47% of Mainland visitors to Macau arrived on IVS last year.  The FIT business is crucial to both the gaming and travel retail sectors.

China

The Director-General of the World Health Organization (WHO), Dr Tedros Adhanom Ghebreyesus, today met President Xi Jinping of the People’s Republic of China in Beijing. They shared the latest information on the novel coronavirus 2019 (2019-nCoV) outbreak and reiterated their commitment to bring it under control.

The death toll in China has risen to 106, with 4,535 reported cases of the virus.

An historic picture, albeit for the wrong reasons, as Director-General of the World Health Organization (WHO), Dr Tedros Adhanom Ghebreyesus (left), meets President Xi Jinping of the People’s Republic of China in Beijing to discuss the novel coronavirus 2019 crisis

UK

The Foreign Office has warned Britons not to travel to Mainland China, unless their journey is essential.

Thailand

King Power International has taken steps to reassure customers that it is minimising the risk of infection from the coronavirus.

With so many Chinese tourists at the retailer’s airport and downtown stores, some shoppers have expressed concern at the risk of infection. But King Power has taken to Twitter to explain that it has been spraying its stores to kill virus particles. In addition, all public-facing staff are required to wear masks, principally to protect them from exposure. The retailer is also encouraging all customers to wear masks.

King Power has added service points where customers can use hand-washing gels and is ensuring that beauty testers are being regularly sprayed with alcohol and wiped with clean tissue paper.

Click here to read the full story.

International

In the wake of the coronavirus outbreak, our Senior Editor Liam Coleman has looked at the travel retail industry’s traditional strength in dealing with global crises,

“There’s no doubt that travel retail will be hit hard – in terms of passenger numbers, sales and investor confidence – over the coming weeks. Yet if history offers us consolation, it is this: once the worst is over, the bounce back is likely to be swift, strong and sustained,” he says.

Read the full piece with supporting analysis by Generation Research here.

China (Hong Kong)

A number of Hong Kong’s borders with Mainland China will close temporarily from 30 January, Reuters is reporting.

The four land border crossings between the city and the mainland will be suspended, Hong Kong Chief Executive Carrie Lam said. That includes the West Kowloon Station, where Dufry recently secured a concession to operate stores.

Lam added that flights from the mainland to Hong Kong will decrease by -50%, all cross-border ferry services will be stopped and that cross-boundary coach services on the Hong Kong-Zhuhai-Macau Bridge will be suspended.

China (Hainan Island)

China Duty Free Group (CDFG) staff in Hainan are safe and well, a company spokesperson told The Moodie Davitt Report today. As reported, China’s travel retail giant closed its acclaimed CDF Mall in Haitang Bay in Sanya, Hainan Island on Sunday in response to the worsening Wuhan coronavirus outbreak.

CDF Mall is one of Asia’s and the world’s most important duty free locations, generating the lion’s share of the CNY13.61 billion (US$1.98 billion) in sales on the island last year – a whopping +35% year-on-year increase. CDFG has also closed its airport stores at Xi’an Xianyang International and Hangzhou Xiaoshan International airports.

“In order to protect the safety of passengers and staff, the Haitang Bay store and some domestic duty free shops have been closed,” the spokesman said. “The personnel of CDFG are safe at present, please rest assured.”

Japan

Over 20,000 of tour company Kamone’s Chinese package tour customers have so far pulled the plug on all trips to Japan up to 10 February, CNN reported.

China announced a ban on outbound group travel on Sunday.

CNN reports the growing commercial impact from the health crisis

China

China’s death toll from the coronavirus outbreak has soared to 106. The number of confirmed cases in the country has climbed to around 4,500. 26 new deaths were reported on Tuesday. [Source: South China Morning Post]

South Korea

Leading travel retailer Lotte Duty Free, whose business is hugely reliant on Chinese visitors, has taken action to ensure the safety of customers and staff in the face of the coronavirus threat with a series of emergency measures at its stores.

The company has set up an emergency response committee, chaired by CEO Lee Kap, to minimise the risk of the outbreak spreading.

Lotte Duty Free will check all employees for fever daily; it will make masks mandatory for store staff and available for customers; ensure regular disinfection of the stores; and expand the number of hand sanitisers available in its stores. Special leave is also permitted for staff who are pregnant or have underlying illness conditions.

Lotte employees wearing masks on the 12th floor of the retailer’s store in Myeong-dong

Lee Kap said: “Lotte Duty Free plans to take prompt and additional countermeasures, with the highest priority on customer and employee safety.

“We will continue our response through close cooperation with relevant organisations such as the Korea Centers for Disease Control and Prevention, Incheon International Airport Corporation and Korea Airports Corporation.”

Lotte Duty Free staff at the information desk on the tenth floor of the Seoul Myeong-dong store, as increased protections against the virus are introduced

The scale of the outbreak at 8.30pm (EST) on 27 January, according to John Hopkins University (click to enlarge)

Turkey

Turkey has become the latest country to advise its citizens against non-compulsory travel to China. “It is highly recommended that our citizens do not travel to China unless it is compulsory, and if they travel to China, they should stay away from the regions where the incidents are intense, especially in Hubei Province,” a statement from the Turkish Ministry of Foreign Affairs said.

China (Hainan Island)

China Duty Free Group (CDFG) has closed its acclaimed CDF Mall in Haitang Bay in Sanya, Hainan Island in response to the worsening Wuhan coronavirus outbreak.

The popular resort island, birthplace of China’s ‘offshore duty free’ sector, has so far reported 33 confirmed cases, 11 of them in Sanya.

The CDF Mall is one of Asia’s and the world’s most important duty free locations, generating the lion’s share of the CNY13.61 billion (US$1.98 billion) in sales on the island last year – a whopping +35% year-on-year increase.

CDFG said: “Due to epidemic prevention and control, and the need to reduce the concentration of the population and its risk of pathogen transmission, China Duty Free Sanya Duty Free Shop will temporarily close from 4pm today [Sunday 26 January]. The re-opening of the store will be notified in due course, according to the government’s requirements in terms of epidemic prevention and control.”

CDFG pledged to “fully support customers with product refunds” where necessary due to any changes in travel arrangements. It recommended that customers use the official CDFG Sanya Mall online shop during the main store’s closure.

Click here for more analysis on the store closure

CDFG announces the store closure

For our earlier updates, click here.

Let’s block ads! (Why?)



Source link

Continue Reading

Health

Health officials in B.C. urge flu vaccination for young children as hospitalization rates surge – The Globe and Mail

Published

 on


Provincial health officer Dr. Bonnie Henry speaks in the press theatre at the legislature in Victoria, B.C., on March 10.CHAD HIPOLITO/The Canadian Press

Prime Minister Justin Trudeau is urging parents to get their children vaccinated against the flu, as provincial governments across the country scramble to deal with hospitals overflowing with sick children.

Hospitalizations of children with flu have skyrocketed across the country, with more children admitted with influenza than at any other time in at least a decade, according to surveillance data.

Mr. Trudeau said Monday he is alarmed about the rise in respiratory illnesses, and called on Canadians to “step up again” to get vaccinated against both COVID-19 and the flu to keep their families and communities safe.

Genius Dog 336 x 280 - Animated

“I’m extremely worried about what Canadian kids are facing right now. Families are really worried about whether they are going to be able to get their kids to hospital,” he told reporters at an unrelated news conference.

Flu surges on heels of RSV, COVID-19 to overwhelm children’s hospitals in Canada

British Columbia is heading to a record year for flu vaccines, but a push to protect seniors has left the most vulnerable group – children under the age of 5 – behind. This weekend, public-health officials are launching an influenza vaccination blitz for young children who are most at-risk of severe illness.

More than half of B.C.’s seniors have been vaccinated for the flu this year, but only 20 per cent of children between the ages of six months and 4 years have had a flu shot. With the holiday season approaching, health officials are hoping to boost that rate in the coming week.

Dr. Bonnie Henry, Provincial Health Officer, told a news conference on Monday that the annual flu season arrived early, in mid-November. At that time, BC Children’s Hospital was already cancelling dozens of surgeries owing to staff shortages and a surge in respiratory infections. It is influenza, not COVID-19, that is driving the patient load, and the virus has not yet peaked, according to Dr. Henry.

“We’re still early on in this trajectory of influenza. We’re starting to see the impact of a large number of children who haven’t been exposed to influenza for a few years, and a small proportion of them are getting severely ill,” she said. “But we still have time to blunt the impact.”

Pediatric emergency services at major hospitals have already been reorganized to deal with the surge in cases in the province, however, BC Children’s Hospital briefly activated a “Code Orange” alert on Saturday morning because it did not have the resources to manage demand.

B.C. Health Minister Adrian Dix told reporters the province has taken a number of steps to mitigate the pressure, such as bringing in pediatricians to treat patients in the emergency department at Victoria General Hospital, and creating an emergency satellite clinic at BC Children’s. Starting next week, Surrey Memorial Hospital will place emergency room physicians at the Surrey Urgent and Primary Care Centre so that it can redirect some patients, and Peace Arch Hospital will offer pediatric services at its rapid care clinic.

In Ontario, the government of Premier Doug Ford faced questions on Monday over how it could have allowed a surge in patients to force one of its premiere pediatric institutions, the Children’s Hospital of Eastern Ontario in Ottawa, to call in the Red Cross to help.

The local MPP for CHEO in the riding of Ottawa South, Liberal interim leader John Fraser, said this shows the government had failed to plan properly for the fall surge in illness.

“It is absolutely incredible to me that we’re calling in an organization that deals in humanitarian disasters to help out,” Mr. Fraser said.

In Question Period, Ontario Opposition NDP Leader Peter Tabuns said the move shows the government was caught flat-footed by the situation in children’s hospitals. Progressive Conservative MPP Robin Martin, the parliamentary assistant to the province’s Health Minister, responded by saying that bringing in the Red Cross “was certainly part of our planning to make sure we had the care we need for pediatric patients at CHEO and other pediatric hospitals.” However, Hannah Jensen, a spokesperson for Ontario Health Minister Sylvia Jones, later said that calling in the Red Cross to help hospitals was not part of the government’s surge plan.

Mr. Ford, alongside the Prime Minister for an unrelated announcement at a GM plant in Ingersoll, Ont., praised the chief executive officer of CHEO, Alex Munter, for “thinking outside the box” in dealing with the situation at his hospital. But he did not answer a question about whether using the Red Cross was part of the government’s plans, instead listing its pledges to increase health care funding and the number of nurses.

In Alberta, 65 staff have been redeployed from the Rotary Flames House and five outpatient clinics to help with the surge in respiratory illnesses. Some medical staff have also stepped down from corporate positions to work the front lines, said Margaret Fullerton, senior operating officer of the Alberta Children’s Hospital.

At the affected clinics, Ms. Fullerton said there is a 30-to-50-per-cent reduction in services related to orthopedics, nephrology, gastrointestinal, pulmonary and surgical services. She said patients with urgent needs will continue to be prioritized in those clinics, but other appointments will be postponed.

Ms. Fullerton said there are contingency plans in place at the hospital should respiratory care needs grow, but she did not provide details. Kerry Williamson, a spokesperson for Alberta Health Services, said there are no plans at this time to bring in support from outside agencies, such as the Red Cross in Ottawa.

Alberta Health Minister Jason Copping said Monday there are indications that a spike in flu cases may subside soon but acknowledged that there are likely to be future bouts of respiratory infections in the coming months. He said the government is finding ways to move people through the system quicker, but in the long-term is focused on building capacity.

Adblock test (Why?)



Source link

Continue Reading

Health

Serial cross-sectional estimation of vaccine-and infection-induced SARS-CoV-2 seroprevalence in British Columbia, Canada

Published

 on

Abstract

Background: The evolving proportion of the population considered immunologically naive versus primed for more efficient immune memory response to SARS-CoV-2 has implications for risk assessment. We sought to chronicle vaccine- and infection-induced seroprevalence across the first 7 waves of the COVID-19 pandemic in British Columbia, Canada.

Methods: During 8 cross-sectional serosurveys conducted between March 2020 and August 2022, we obtained anonymized residual sera from children and adults who attended an outpatient laboratory network in the Lower Mainland (Greater Vancouver and Fraser Valley). We used at least 3 immunoassays per serosurvey to detect SARS-CoV-2 spike and nucleocapsid antibodies. We assessed any seroprevalence (vaccineor infection-induced, or both), defined by positivity on any 2 assays, and infection-induced seroprevalence, also defined by dual-assay positivity but requiring both antinucleocapsid and antispike detection. We used estimates of infection-induced seroprevalence to explore underascertainment of infections by surveillance case reports.

Results: By January 2021, we estimated that any seroprevalence remained less than 5%, increasing with vaccine rollout to 56% by May–June 2021, 83% by September–October 2021 and 95% by March 2022. Infection-induced seroprevalence remained less than 15% through September–October 2021, increasing across Omicron waves to 42% by March 2022 and 61% by July–August 2022. By August 2022, 70%–80% of children younger than 20 years and 60%–70% of adults aged 20–59 years had been infected, but fewer than half of adults aged 60 years and older had been infected. Compared with estimates of infection-induced seroprevalence, surveillance case reports underestimated infections 12-fold between September 2021 and March 2022 and 92-fold between March 2022 and August 2022.

Interpretation: By August 2022, most children and adults younger than 60 years had evidence of both SARS-CoV-2 vaccination and infection. As previous evidence suggests that a history of both exposures may induce stronger, more durable hybrid immunity than either exposure alone, older adults — who have the lowest infection rates but highest risk of severe outcomes — continue to warrant prioritized vaccination.

Genius Dog 336 x 280 - Animated

The British Columbia Centre for Disease Control (BCCDC) has a long-established serosurvey protocol to monitor population susceptibility to emerging or re-emerging respiratory viruses. The approach was first deployed during the influenza A (H1N1) pandemic in 2009 to monitor changes in seroprevalence across successive pandemic waves and the mass vaccination campaign.17 The methodology is predicated upon serial cross-sectional convenience sampling of anonymized residual sera from children and adults of all ages in the most populated Lower Mainland region of BC.8,9

Adapting this protocol, the BCCDC launched its first SARS-CoV-2 serosurvey in March 2020, just before the World Health Organization’s declaration of the COVID-19 pandemic. 10 Baseline assessment was followed by additional serosurveys that spanned the time from mRNA vaccine availability in mid-December 2020, through 7 pandemic waves associated with multiple variants of concern to August 2022 (Figure 1).1113 Using these serosurveys, we sought to track the evolving proportion of the population that remained immunologically naive and, thus, fully susceptible to COVID-19, versus the evolving proportion that was immunologically primed (through vaccination or infection) and, thus, poised for more efficient memory response in mitigating the risk of SARS-CoV-2. Recognizing the spectrum of illness, including asymptomatic or mild infections, and variable diagnostic access, case identification and reporting, we also used estimates of infection-induced seroprevalence to explore the potential underascertainment of infections by surveillance case reports.

50 people prohibited. Provincial state of emergency declared. †Interactions limited to households or “core bubble” (immediate family or those in same dwelling) or to a maximum of 2 other people if living alone. ‡Dine-in food services and indoor fitness activities banned, only essential travel permitted. §Gradual return to gatherings, recreational travel, in-person work, which was interrupted by the fourth wave. ¶Indoor and personal gatherings limited, 50% capacity limit at venues of > 1000 people, sports tournaments paused. Social restrictions lifted during epidemiological week 7, 2022. **Mask mandates lifted during epidemiological week 10, 2022. ††The first 2 spike-based mRNA vaccine formulations were authorized during epidemiological weeks 50 and 52, 2020, respectively, with mRNA vaccines comprising most doses (> 90%) administered in BC and Canada across the pandemic. In epidemiological week 8, 2021, a chimpanzee adenoviral-vectored (ChAdOx1) vaccine was also authorized. ‡‡Vaccines (mRNA) initially deployed to high-risk individuals, including residents and staff of long-term care and assisted-living facilities, essential visitors within those settings and health care workers. §§Community-based vaccine roll-out, prioritized by age, beginning with the oldest adults in mid-March 2021. Access to booster doses followed similar prioritization sequence, inclusive of clinically extremely vulnerable individuals of any age. ¶¶Single-dose vaccine card required for entry into social and recreational settings starting in epidemiological week 37, 2021; 2-dose cards were required beginning in epidemiological week 43, 2021. Vaccine cards were ultimately repealed in epidemiological week 14, 2022.” class=”highwire-fragment fragment-images colorbox-load” rel=”gallery-fragment-images-1567424728″ data-figure-caption=”

Provincial surveillance case reports to the British Columbia Centre for Disease Control (BCCDC) by epidemiological week from January 2020 to September 2022, with timing of serosurveys and select public health measures, in BC, Canada. We group case tallies by epidemiological week (7-d period) as per standard surveillance methods for comparing data by period from year to year. Epidemic waves are enumerated sequentially and are displayed with the predominant variant of concern (VOC). Publicly funded access to nucleic acid amplification tests (NAATs) or rapid antigen tests (RATs) is displayed below the X-axis. For details on public health measures, vaccines, schedules and coverage estimates, see Appendix 1, Supplementary Material 1, available at www.cmaj.ca/lookup/doi/10.1503/cmaj.221335/tab-related-content. *Nonessential travel discouraged, health care service delivery adjusted, public gatherings > 50 people prohibited. Provincial state of emergency declared. †Interactions limited to households or “core bubble” (immediate family or those in same dwelling) or to a maximum of 2 other people if living alone. ‡Dine-in food services and indoor fitness activities banned, only essential travel permitted. §Gradual return to gatherings, recreational travel, in-person work, which was interrupted by the fourth wave. ¶Indoor and personal gatherings limited, 50% capacity limit at venues of > 1000 people, sports tournaments paused. Social restrictions lifted during epidemiological week 7, 2022. **Mask mandates lifted during epidemiological week 10, 2022. ††The first 2 spike-based mRNA vaccine formulations were authorized during epidemiological weeks 50 and 52, 2020, respectively, with mRNA vaccines comprising most doses (> 90%) administered in BC and Canada across the pandemic. In epidemiological week 8, 2021, a chimpanzee adenoviral-vectored (ChAdOx1) vaccine was also authorized. ‡‡Vaccines (mRNA) initially deployed to high-risk individuals, including residents and staff of long-term care and assisted-living facilities, essential visitors within those settings and health care workers. §§Community-based vaccine roll-out, prioritized by age, beginning with the oldest adults in mid-March 2021. Access to booster doses followed similar prioritization sequence, inclusive of clinically extremely vulnerable individuals of any age. ¶¶Single-dose vaccine card required for entry into social and recreational settings starting in epidemiological week 37, 2021; 2-dose cards were required beginning in epidemiological week 43, 2021. Vaccine cards were ultimately repealed in epidemiological week 14, 2022.

” data-icon-position data-hide-link-title=”0″>Figure 1:

Figure 1:

Provincial surveillance case reports to the British Columbia Centre for Disease Control (BCCDC) by epidemiological week from January 2020 to September 2022, with timing of serosurveys and select public health measures, in BC, Canada. We group case tallies by epidemiological week (7-d period) as per standard surveillance methods for comparing data by period from year to year. Epidemic waves are enumerated sequentially and are displayed with the predominant variant of concern (VOC). Publicly funded access to nucleic acid amplification tests (NAATs) or rapid antigen tests (RATs) is displayed below the X-axis. For details on public health measures, vaccines, schedules and coverage estimates, see Appendix 1, Supplementary Material 1, available at www.cmaj.ca/lookup/doi/10.1503/cmaj.221335/tab-related-content. *Nonessential travel discouraged, health care service delivery adjusted, public gatherings > 50 people prohibited. Provincial state of emergency declared. †Interactions limited to households or “core bubble” (immediate family or those in same dwelling) or to a maximum of 2 other people if living alone. ‡Dine-in food services and indoor fitness activities banned, only essential travel permitted. §Gradual return to gatherings, recreational travel, in-person work, which was interrupted by the fourth wave. ¶Indoor and personal gatherings limited, 50% capacity limit at venues of > 1000 people, sports tournaments paused. Social restrictions lifted during epidemiological week 7, 2022. **Mask mandates lifted during epidemiological week 10, 2022. ††The first 2 spike-based mRNA vaccine formulations were authorized during epidemiological weeks 50 and 52, 2020, respectively, with mRNA vaccines comprising most doses (> 90%) administered in BC and Canada across the pandemic. In epidemiological week 8, 2021, a chimpanzee adenoviral-vectored (ChAdOx1) vaccine was also authorized. ‡‡Vaccines (mRNA) initially deployed to high-risk individuals, including residents and staff of long-term care and assisted-living facilities, essential visitors within those settings and health care workers. §§Community-based vaccine roll-out, prioritized by age, beginning with the oldest adults in mid-March 2021. Access to booster doses followed similar prioritization sequence, inclusive of clinically extremely vulnerable individuals of any age. ¶¶Single-dose vaccine card required for entry into social and recreational settings starting in epidemiological week 37, 2021; 2-dose cards were required beginning in epidemiological week 43, 2021. Vaccine cards were ultimately repealed in epidemiological week 14, 2022.

Methods

Study design and setting

Eight cross-sectional serosurveys were undertaken between March 2020 and July–August 2022 in the Lower Mainland (Greater Vancouver and Fraser Valley) region of BC, where about 60% of the provincial population (of about 5 million) resides.8,9 The timeline of SARS-CoV-2 serosurveys in relation to pandemic waves, publicly funded nucleic acid amplification testing, vaccine roll-out and other mitigation measures are shown in Figure 1, with additional details provided in Appendix 1, Supplementary Material 1, available at www.cmaj.ca/lookup/doi/10.1503/cmaj.221335/tab-related-content.1113

Sampling approach

We obtained anonymized residual sera from children and adults visiting LifeLabs, the only outpatient laboratory network in the Lower Mainland. Two health authorities are responsible for surveillance in the Lower Mainland, namely the Fraser Health Authority (population 1.9 million) and Vancouver Coastal Health Authority (population 1.2 million).8,9 Residents of either health authority could participate, with eligible municipalities shown in Appendix 1, Supplementary Figure 1. At each serosurvey, a convenience sample of sera was selected by age group, equally by sex, from the LifeLabs central processing centre. For the first 2 serosurveys, we sampled 100 sera per age group, but thereafter, sampling increased to 200 per age group (< 5 yr, 5–9 yr, 10–19 yr, 20–29 yr, 30–39 yr, 40–49 yr, 50–59 yr, 60–69 yr, 70–79 yr, ≥ 80 yr).14 We excluded people who were specifically seeking SARS-CoV-2 antibody testing (which was limited in BC) and residents of long-term care, assisted-living or correctional facilities because of different pre-test likelihood of positivity.

Serological testing

At each serosurvey, we used at least 3 commercially available chemiluminescent immunoassays that targeted spike (S1) or nucleocapsid (NP) proteins.15,16 For seroprevalence estimation, we defined seropositivity as a signal above the manufacturer’s cut-off threshold on at least 2 chemiluminescent immunoassays (i.e., dual-assay positivity). Before the availability of S1-based vaccines,13 we assumed any dual-assay seropositivity to be from infection. From January 2021, infection-induced seropositivity required that at least 1 of the 2 positive assays included anti-NP detection.

We undertook serological testing in real time, with adjustment based on evolving understanding of assay characteristics and their local availability. For the first 3 serosurveys in 2020, we screened sera with Ortho (S1 total antibody) and Abbott (NP immunoglobulin [Ig] G) assays at the BCCDC Public Health Laboratory. For specimens positive on either of these assays, we also tested with the Siemens (S1 receptor-binding domain IgG/IgM) assay. With vaccine roll-out, anti-NP detection became more important, but concerns related to waning antibody levels and reduced anti-NP sensitivity also arose, particularly for the Abbott assay.1721 For the fourth and fifth serosurveys, we supplemented testing with the Roche (NP total antibody) assay at the Providence Health Care Special Chemistry Laboratory, as volume permitted. In the event a specimen returned discordant results on the Abbott and Roche NP assays, we accepted anti-NP positivity on either assay (in conjunction with anti-S1) as evidence of infection. For the sixth and seventh serosurveys, all sera were tested by Ortho, Siemens and Roche assays. By the eighth serosurvey, BCCDC no longer offered Ortho testing, replacing it instead with the Abbott (S1 receptor-binding domain IgG) assay.15,16,22

Statistical analysis

Seroprevalence estimation

We assessed 2 seroprevalence categories: any seroprevalence (induced by vaccine, infection or both), defined by any dual-assay positivity, and infection-induced seroprevalence, also defined by dual-assay positivity but requiring both anti-NP and anti-S1 detection. Detection of anti-NP indicated infection-induced antibody as no vaccines used in Canada contained NP antigen. Primary seroprevalence estimates with 95% credible intervals (CrIs) were based on Bayesian analysis,2325 standardizing for age, sex and health authority. We derived cumulative and period-specific estimates, the latter conservatively reflecting the rate of new infections between specified serosurveys under the assumption of no meaningful waning of antibody levels and no reinfections. Bayesian methods are detailed in Appendix 1, Supplementary Material 2. High assay sensitivities and specificities have been reported for each chemiluminescent immunoassay, 15,16,22,26 but typically without addressing potential variation by vaccination status, time since exposure, severity or age.2729 Like others,30,31 we did not adjust for sensitivity or specificity in the primary analyses but explored their effects as outlined in Appendix 1, Supplementary Material 2, based on assumptions detailed in Appendix 1, Supplementary Material 3.

Surveillance underascertainment ratios

All cases of SARS-CoV-2 confirmed by nucleic acid amplification testing were laboratory-reportable to local public health authorities and to BCCDC. Provincial surveillance reporting excluded reinfections and those positive only by rapid antigen test.11 We used infection-induced seroprevalence estimates and health authority–specific population census statistics to derive the estimated number of infections in the Lower Mainland. We derived surveillance underascertainment ratios with 95% CrIs by dividing estimated infections by surveillance reports from both health authorities, including cumulative and period-specific surveillance underascertainment ratios, the latter assuming no reinfections as per surveillance reporting. Additional methodological details are provided in Appendix 1, Supplementary Material 4, including exploratory investigation that included reinfections as 10% or 25% of all infections.

Ethics approval

Sera were provided to BCCDC under legal order of the Provincial Health Officer (B.H.), and the study was approved by the University of British Columbia Clinical Research Ethics Board (H20–00653).

Results

Of 14 000 sera collected, 13 765 (98.3%) contributed to the study. Of 235 sera excluded owing to insufficient volume, 215 (91.5%) were collected during the earliest 2 serosurveys, mostly (n = 189, 80.4%) from children younger than 10 years (Table 1 and Appendix 1, Supplementary Table 1).

Table 1:

SARS-CoV-2 seroprevalence survey and participant characteristics

Age and sex distributions reflected the Lower Mainland source population (Table 1 and Appendix 1, Supplementary Table 2). Sera disproportionately came from the Fraser Health Authority (59%–74% by serosurvey) compared with the proportion of this health authority’s population in the Lower Mainland (61%), notably among children younger than 10 years (Appendix 1, Supplementary Table 3). The Fraser Health Authority also reported disproportionately more cases of SARS-CoV-2 (about two-thirds) of Lower Mainland SARS-CoV-2 cases (Figure 1).

Seroprevalence

Any seroprevalence

Overall vaccine- and infection-induced seroprevalence remained 1% or lower through the first 3 serosurveys to September 2020, and was less than 5% by the fourth serosurvey in January 2021 (Figure 2, Table 2 and Appendix 1, Supplementary Table 4). Seroprevalence rose to 56.2% by May–June 2021 (fifth serosurvey) and was higher with increasing age, consistent with age-prioritized vaccination, except among the oldest adults (≤ 70 yr) who were the earliest vaccinated by age (Appendix 1, Supplementary Material 1). By September–October 2021 (sixth serosurvey), overall seroprevalence reached 82.7%, reflecting increased vaccination of younger adults and adolescents, as well as delivery of second doses (Appendix 1, Supplementary Material 1). By March 2022 (seventh serosurvey) and July–August 2022 (eighth serosurvey), seroprevalence reached 95% or more, reflecting both higher vaccination (including third doses) and infection rates.

<a href=”https://www.cmaj.ca/content/cmaj/194/47/E1599/F2.large.jpg?width=800&height=600&carousel=1″ title=”Seroprevalence (any and infection-induced) by age group and serosurvey (serosurvey 4 in January 2021, serosurvey 5 in May–June 2021, serosurvey 6 in September–October 2021, serosurvey 7 in March 2022, serosurvey 8 in July–August 2022). Darker bars represent the infection-induced seroprevalence, which may or may not include vaccinated individuals. Lighter plus darker bars together provide a combined estimate of “any” seroprevalence (vaccine-induced, infection-induced or both). Displayed seroprevalence estimates are based on Bayesian analysis, standardized for age, sex and health authority within the Lower Mainland, British Columbia, Canada. Analysis details are in Appendix 1, Supplementary Material 2, available at www.cmaj.ca/lookup/doi/10.1503/cmaj.221335/tab-related-content. Full results are in Table 2 and Appendix 1, Supplementary Table 4 (any seroprevalence) and Appendix 1, Supplementary Table 5 (infection-induced seroprevalence). Note: CrI = credible interval.” class=”highwire-fragment fragment-images colorbox-load” rel=”gallery-fragment-images-1567424728″ data-figure-caption=”

Seroprevalence (any and infection-induced) by age group and serosurvey (serosurvey 4 in January 2021, serosurvey 5 in May–June 2021, serosurvey 6 in September–October 2021, serosurvey 7 in March 2022, serosurvey 8 in July–August 2022). Darker bars represent the infection-induced seroprevalence, which may or may not include vaccinated individuals. Lighter plus darker bars together provide a combined estimate of “any” seroprevalence (vaccine-induced, infection-induced or both). Displayed seroprevalence estimates are based on Bayesian analysis, standardized for age, sex and health authority within the Lower Mainland, British Columbia, Canada. Analysis details are in Appendix 1, Supplementary Material 2, available at www.cmaj.ca/lookup/doi/10.1503/cmaj.221335/tab-related-content. Full results are in Table 2 and Appendix 1, Supplementary Table 4 (any seroprevalence) and Appendix 1, Supplementary Table 5 (infection-induced seroprevalence). Note: CrI = credible interval.

” data-icon-position data-hide-link-title=”0″>Figure 2:Figure 2:

Figure 2:

Seroprevalence (any and infection-induced) by age group and serosurvey (serosurvey 4 in January 2021, serosurvey 5 in May–June 2021, serosurvey 6 in September–October 2021, serosurvey 7 in March 2022, serosurvey 8 in July–August 2022). Darker bars represent the infection-induced seroprevalence, which may or may not include vaccinated individuals. Lighter plus darker bars together provide a combined estimate of “any” seroprevalence (vaccine-induced, infection-induced or both). Displayed seroprevalence estimates are based on Bayesian analysis, standardized for age, sex and health authority within the Lower Mainland, British Columbia, Canada. Analysis details are in Appendix 1, Supplementary Material 2, available at www.cmaj.ca/lookup/doi/10.1503/cmaj.221335/tab-related-content. Full results are in Table 2 and Appendix 1, Supplementary Table 4 (any seroprevalence) and Appendix 1, Supplementary Table 5 (infection-induced seroprevalence). Note: CrI = credible interval.

Table 2:

SARS-CoV-2 seroprevalence by serosurvey and category (any or infection-induced), by age group

Infection-induced seroprevalence

Cumulative infection-induced seroprevalence remained less than 15% overall through September–October 2021 (sixth serosurvey) (Figure 2, Table 2 and Appendix 1, Supplementary Table 5). At least one-third were newly infected between the sixth and seventh serosurveys (Figure 3 and Table 3), with cumulative infection-induced seroprevalence reaching 42.5% by March 2022. Thereafter, one-fifth were newly infected between the seventh and eighth serosurveys, with 61.1% having evidence of previous infection by the July–August 2022 serosurvey.

<a href=”https://www.cmaj.ca/content/cmaj/194/47/E1599/F3.large.jpg?width=800&height=600&carousel=1″ title=”Difference in infection-induced seroprevalence by age group between the sixth and seventh (September–October 2021 to March 2022), and the seventh and eighth (March to July–August 2022) serosurveys. Displayed seroprevalence estimates are based on Bayesian analysis — standardized for age, sex and health authority within the Lower Mainland, British Columbia, Canada — and are predicated on the assumption of no reinfections and no antibody waning. In that context, estimates represent the rate of new infections between specified serosurveys, stratified by age group. Analysis details are in Appendix 1, Supplementary Material 4, available at www.cmaj.ca/lookup/doi/10.1503/cmaj.221335/tab-related-content. Full results are in Table 3 and Appendix 1, Supplementary Table 9. Note: CrI = credible interval.” class=”highwire-fragment fragment-images colorbox-load” rel=”gallery-fragment-images-1567424728″ data-figure-caption=”

Difference in infection-induced seroprevalence by age group between the sixth and seventh (September–October 2021 to March 2022), and the seventh and eighth (March to July–August 2022) serosurveys. Displayed seroprevalence estimates are based on Bayesian analysis — standardized for age, sex and health authority within the Lower Mainland, British Columbia, Canada — and are predicated on the assumption of no reinfections and no antibody waning. In that context, estimates represent the rate of new infections between specified serosurveys, stratified by age group. Analysis details are in Appendix 1, Supplementary Material 4, available at www.cmaj.ca/lookup/doi/10.1503/cmaj.221335/tab-related-content. Full results are in Table 3 and Appendix 1, Supplementary Table 9. Note: CrI = credible interval.

” data-icon-position data-hide-link-title=”0″>Figure 3:Figure 3:

Figure 3:

Difference in infection-induced seroprevalence by age group between the sixth and seventh (September–October 2021 to March 2022), and the seventh and eighth (March to July–August 2022) serosurveys. Displayed seroprevalence estimates are based on Bayesian analysis — standardized for age, sex and health authority within the Lower Mainland, British Columbia, Canada — and are predicated on the assumption of no reinfections and no antibody waning. In that context, estimates represent the rate of new infections between specified serosurveys, stratified by age group. Analysis details are in Appendix 1, Supplementary Material 4, available at www.cmaj.ca/lookup/doi/10.1503/cmaj.221335/tab-related-content. Full results are in Table 3 and Appendix 1, Supplementary Table 9. Note: CrI = credible interval.

Table 3:

Period-specific seroprevalence and surveillance underascertainment ratio estimates between the sixth and seventh and the seventh and eighth serosurveys

Infection-induced seroprevalence decreased with increasing age. In general, age groups with the highest period-specific infection rates between the sixth and seventh serosurveys had the lowest rates between the seventh and eighth serosurveys. The highest rate of new infections was between the sixth and seventh serosurveys for all age categories younger than 50 years, whereas adults aged 70 years and older had their highest rates of new infections between the seventh and eighth serosurveys. Adults aged 50–59 and 60–69 years had comparable rates of new infection during both periods.

About half (45%–55%) of children aged 0–4, 5–9 and 10–19 years were newly infected between the sixth and seventh serosurveys (Figure 3 and Table 3). Rates of new infections were slightly lower (34%–44%) but with overlapping 95% CrIs among young adults aged 20–29, 30–39 and 40–49 years. Cumulatively, more than half of children were already infected by March 2022, reaching about three-quarters (70%–76%) by August 2022; rates were comparable or slightly lower (64%–70%), with overlapping 95% CrIs, among young adults (Figure 2 and Table 2). By March 2022, less than one-quarter (14%–25%) of older adults aged 60–69, 70–79 or 80 years and older had been infected. With their highest period-specific infection rates between the seventh and eighth serosurveys, still fewer than half (38%–43%) of these older adults were infected by July–August 2022.

Estimates of any seroprevalence were comparable by health authority, but infection-induced estimates were consistently higher for the Fraser Health Authority (Appendix 1, Supplementary Tables 4 and 5). Seroprevalence estimates did not differ meaningfully when stratified by sex (Appendix 1, Supplementary Tables 4–7). Crude and Bayesian-adjusted estimates were similar (Appendix 1, Supplementary Tables 4–7), and are also shown by individual assay in Appendix 1, Supplementary Table 8.

Surveillance underascertainment ratios

Surveillance case reports underestimated infections by 12-fold between the sixth and seventh and 92-fold between the seventh and eighth serosurveys, more than in previous periods (Table 3, Figure 4 and Appendix 1, Supplementary Table 9). Surveillance underascertainment ratios were highest among children aged 10–19 years and lowest among adults aged 80 years and older, with overlapping 95% CrIs between most other pediatric and adult age groups. Cumulative surveillance underascertainment ratios by serosurvey are also shown in Appendix 1, Supplementary Table 10.

<a href=”https://www.cmaj.ca/content/cmaj/194/47/E1599/F4.large.jpg?width=800&height=600&carousel=1″ title=”Period-specific surveillance underascertainment ratios (SUARs), overall and by age group between (A) the sixth and seventh (September– October 2021 to March 2022) serosurveys, and (B) the seventh and eighth (March 2022 to July–August 2022) serosurveys, Lower Mainland, British Columbia, Canada. Precise values, including period-specific surveillance case report tallies, new infection rates and SUARs, are in Table 3 and Appendix 1, Supplementary Table 9, available at www.cmaj.ca/lookup/doi/10.1503/cmaj.221335/tab-related-content. Note: CrI = credible interval.” class=”highwire-fragment fragment-images colorbox-load” rel=”gallery-fragment-images-1567424728″ data-figure-caption=”

Period-specific surveillance underascertainment ratios (SUARs), overall and by age group between (A) the sixth and seventh (September– October 2021 to March 2022) serosurveys, and (B) the seventh and eighth (March 2022 to July–August 2022) serosurveys, Lower Mainland, British Columbia, Canada. Precise values, including period-specific surveillance case report tallies, new infection rates and SUARs, are in Table 3 and Appendix 1, Supplementary Table 9, available at www.cmaj.ca/lookup/doi/10.1503/cmaj.221335/tab-related-content. Note: CrI = credible interval.

” data-icon-position data-hide-link-title=”0″>Figure 4:Figure 4:

Figure 4:

Period-specific surveillance underascertainment ratios (SUARs), overall and by age group between (A) the sixth and seventh (September– October 2021 to March 2022) serosurveys, and (B) the seventh and eighth (March 2022 to July–August 2022) serosurveys, Lower Mainland, British Columbia, Canada. Precise values, including period-specific surveillance case report tallies, new infection rates and SUARs, are in Table 3 and Appendix 1, Supplementary Table 9, available at www.cmaj.ca/lookup/doi/10.1503/cmaj.221335/tab-related-content. Note: CrI = credible interval.

Exploratory sensitivity analysis

Adjustment for assay sensitivity and specificity had little impact on estimates of seroprevalence or surveillance underascertainment ratios (Appendix 1, Supplementary Table 11 and Table 12). Assuming reinfections constituted as much as one-quarter of all period-specific infections did not affect the order of magnitude of estimates of surveillance underascertainment ratios between the sixth and seventh (16-fold), or the seventh and eighth serosurveys (123-fold) (Appendix 1, Supplementary Table 13).

Interpretation

Through 8 serosurveys spanning the first 2.5 years of the COVID-19 pandemic, we chronicled evolution of pediatric and adult seroprevalence in the Lower Mainland, BC. During the first year of the pandemic, when extraordinary measures were in place to curtail transmission, virtually everyone remained immunologically naive. Thereafter, age-based vaccine roll-out dramatically changed the immunoepidemiological landscape such that, by September 2021, more than 80% of the study population had antibody evidence of immunological priming, while more than 85% remained uninfected. By August 2022, after a series of Omicron waves, overall vaccine and infection-induced seroprevalence exceeded 95%, with 60% having been infected, including at least three-quarters of children but less than half of older adults.

Multiple immunological, epidemiological and modelling studies suggest that having had both vaccination and infection exposures contributes to stronger, broader and more durable hybrid immunity than with either exposure alone, especially against severe outcomes.3247 The extent to which such exposure history should guide recommendations regarding booster doses depends on several factors, recognizing that a large proportion may not even be aware of their previous infection status.48 Moreover, the antigenic relatedness and immunological interactions between previously infecting viruses, the original monovalent vaccines, more recently updated bivalent vaccine strains, and currently circulating or emerging variants are complex and dynamic. Overall, our age-related findings to date are consistent with children being the least vaccinated and most infected subgroup, whereas older adults are the most vaccinated and least infected. Although everyone may benefit somewhat from additional vaccine doses, the relative incremental value of boosting by age depends on individual- and population-level risk assessment, notably related to severe outcomes. Over the longer horizon, the determinants and potential impact of post-COVID-19 conditions may further add to the complexity of risk assessment.4953 Amidst this uncertainty, however, the prioritization of older adults, who are still at greatest risk of severe outcomes, remains most consistent with immunization goals to prevent serious morbidity and preserve health care capacity as the 2022–23 respiratory virus season begins.11,13

A strength of our serosurveillance approach is our sampling all age groups and both sexes simultaneously, enabling their direct comparison and extending the information available from more restricted population subsets (e.g., prenatal sera from women of childbearing age, or blood donors who are mostly younger adults). We found the highest infection rates among children, closely followed by young adults, which may reflect their greater interconnectedness, including between siblings and parents in the household, as well as with peers in schools and the community.5456 The lowest cumulative infection rates were among older adults, which may reflect their greater vaccination rates and social isolation. Their increased rate of new infections between March and August 2022, after relaxation of public health measures and societal reopening, may reflect their lower likelihood of having previously acquired hybrid (vaccine-plus infection-induced) immunity.

In the United States, similar age-related gradation in accumulated infection rates (highest in children and lowest in older adults) has been reported.57 Pediatric seroprevalence estimates elsewhere in Canada are limited. Among children aged 17 years and younger who attended emergency departments in the Greater Montreal Area, 50%–60% had detectable anti-NP by June 1, 2022,58 similar to what we observed in March 2022, but lower than what we observed in July–August 2022. Differences may reflect provincial variation in the implementation of public health measures such as school closures or masking requirements. 59 Among Canadian adult blood donors 17 years of age and older, 54% had serological evidence of infection by the end of July 2022; estimates were highest among younger adults aged 17–24 years (71%) and lowest among adults aged 60 years and older (38%), which is also similar to our own findings.60,61

Our serosurveillance findings showed substantial underestimation of infections by standard case-based surveillance reporting, notably during the post-Omicron period. More restricted access to nucleic acid amplification testing and abundant community access to nonreportable rapid antigen testing likely contributed to underascertainment. Although other surveillance indicators may be warranted, including those for which access to testing is more consistent (e.g., among patients admitted to hospital) or sustainable (e.g., wastewater sampling), the derivation of severe outcome risks per SARS-CoV-2 case still requires accurate case tallies. In that regard, ongoing serosurveillance and associated estimates of surveillance underascertainment ratios are needed to inform the magnitude of increase in case denominators (and commensurate fold-decrease in severe outcome risks per case) required for accurate risk assessment and the optimal targeting of interventions.

Limitations

By assuming no antibody waning or reinfection, our cumulative and period-specific infection-induced seroprevalences are likely underestimates and may best be summarized as “at least” that percentage infected. Among children younger than 5 years, discrepancy between our estimates of any and infection-induced seroprevalence by August 2022 may be a measure of such underestimation, given their very recent vaccine eligibility and negligible vaccine coverage. As vaccination may reduce viral loads, underestimation of infection-induced antibody may be greater among more highly vaccinated individuals.62,63 To improve upon anti-NP detection, we used both Abbott and Roche assays beginning in January 2021 (as described in Appendix 1, Supplementary Table 1), switching to the latter (with its improved sensitivity) for the final 2 serosurveys, when waning antibody levels may have been a greater concern.1721 Convenience sampling is inherently subject to bias, but we show good concordance in the age and sex profiles of our participants with our source population, which we further standardized in Bayesian analyses. We cannot comment on discrete ethnic or socioeconomic groups who, although not specifically excluded, were also not specifically evaluated. Residual clinical specimens are more likely to come from people with underlying comorbidities who may differ in their exposure risk and immune responses, which could contribute to an underestimation of infection-induced seroprevalence, as would our exclusion of individuals who were specifically seeking SARS-CoV-2 antibody testing. In the other direction, sera collected in the follow-up of post-COVID-19 sequelae may have contributed to some overestimation. All surveillance data, as used here in estimation of surveillance underascertainment ratios, are subject to incomplete or missing information. Given our assumption of no reinfections, the higher the actual rate of reinfection, the greater the extent to which our surveillance underascertainment ratios may be conservative underestimates; however, in exploratory analyses in which we allowed reinfections to comprise as much as 25% of all infections, period-specific estimates were of similar order of magnitude. Finally, extrapolation to other geographic areas should take into account the specific context we provide here, such as in-person school attendance, mask mandates, vaccination program adjustments and other mitigation measures that may differ elsewhere.

Conclusion

By August 2022, most children and adults younger than 60 years in the Lower Mainland, BC, had acquired evidence of both SARS-CoV-2 vaccination and infection, which likely provides stronger, broader and more durable hybrid immunity than either exposure alone, especially against severe outcomes. With the lowest infection rates but highest risk of severe outcomes, older adults continue to warrant prioritized vaccination.

Acknowledgments

The authors acknowledge the serological testing oversight and contribution of the British Columbia Centre for Disease Control (BCCDC) Public Health Laboratory and Providence Health Care Special Chemistry Laboratory, including Tamara Pidduck, Jesse Kustra, Laura Burns, Gahyun Cheon and Bonny So. They thank Rhonda Creswell and Iva Tong of LifeLabs for diligent supervision of serum collection; Dr. Manish Sadarangani for his co-leadership of the SARS-CoV-2 Immunity Study referenced in Supplementary Material 3; and Dr. May Ahmed, Hannah Caird and Macy Zou for their supportive surveillance analyses at the BCCDC, as well as the many other frontline, regional and provincial practitioners, including clinical and public health providers, epidemiologists, medical health offficers and others for their significant contributions to surveillance case reporting and COVID-19 control measures in British Columbia.

Footnotes

  • Competing interests: Danuta Skowronski reports grants from the Canadian Institutes of Health Research and the British Columbia Centre for Disease Control Foundation for Public Health, paid to her institution, for other SARS-CoV-2 work. Romina Reyes is chair of the BC Diagnostic Accreditation Program committee. Mel Krajden reports grants paid to his institution from Roche, Hologic and Siemens. No other competing interests were declared.

  • This article has been peer reviewed.

  • Contributors: Danuta Skowronski, Samantha Kaweski and Suzana Sabaiduc contributed to the conception and design of the work. Samantha Kaweski, Shinhye Kim, Suzana Sabaiduc, Bonnie Henry and Romina Reyes contributed to data acquisition. Samantha Kaweski, Michael Irvine, Erica Chuang, Mieke Fraser, Suzana Sabaiduc, Paul Levett, Martin Petric, Mel Krajden and Inna Sekirov contributed to data analysis. Danuta Skowronski, Samantha Kaweski, Michael Irvine and Bonnie Henry contributed to data interpretation. Danuta Skowronski drafted the manuscript. All of the authors revised it critically for important intellectual content, gave final approval of the version to be published and agreed to be accountable for all aspects of the work.

  • Funding: Funding was provided in part by the Public Health Agency of Canada (Grant number: 2021-HQ-000067) and the Michael Smith Foundation for Health Research (Grant number 18934). The views expressed herein do not necessarily represent the views of the Public Health Agency of Canada.

  • Data sharing: Data sharing will be considered upon reasonable request to the corresponding author with appropriate review and aggregation, as required to comply with the provincial legislation under which the data were assembled, and respecting privacy and confidentiality requirements.

  • Accepted October 27, 2022.

This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY-NC-ND 4.0) licence, which permits use, distribution and reproduction in any medium, provided that the original publication is properly cited, the use is noncommercial (i.e., research or educational use), and no modifications or adaptations are made. See: https://creativecommons.org/licenses/by-nc-nd/4.0/

 

Source link

Continue Reading

Health

Banned in the U.S., not approved for breastfeeding — why are so many moms taking this drug?

Published

 on

WARNING: The story contains details about suicidal thoughts and attempts.

For Jamie Robinson, the changes were subtle at first.

She found herself playing with her hair and bumping into things. But soon, she was having six or seven panic attacks a day. Things then escalated to intrusive thoughts to take her own life and punch herself in the face. Robinson, 39, knew at that point something was terribly wrong.

“I’m looking at my own baby,” the Montreal woman recalled, “this warmth that floods me had just died completely.”

Genius Dog 336 x 280 - Animated

“This reoccurring thought that she had been replaced, that this was not my baby, that this was maybe even a robot baby because there was no emotional engagement from my side… And the emotions are rushing to that space. The guilt, the feeling of panic. Like, am I a bad mom? Am I losing my mind?”

When her psychologist saw the distress she was in, she zeroed in on a breastfeeding medication Robinson had recently stopped taking. The medication was domperidone, a gastrointestinal drug that can also induce lactation.

But domperidone also acts as an antipsychotic, and psychologist Karen White believes Robinson was suffering withdrawal symptoms.

“[It] kind of clicked because I’ve seen people have very extreme reactions to stopping different medications,” White recalled. “And we kind of went, ‘oh, that could be it.'”

Jamie Robinson and her daughter Emma read on the couch of their Montreal home. Robinson says she suffered debilitating side effects from a medication she was taking to breastfeed. (Esteban Cuevas Gonzalez/CBC News)

Drug prescribed off-label

Domperidone, which blocks dopamine in the brain, is approved in Canada as an aid to speed up digestion, but it also has a side effect: lactation. Doctors and midwives routinely prescribe it off-label for this purpose. More than 120 million prescriptions for domperidone were filled in 2020, according to Health Canada.

Thousands of mothers describe it in online forums as a wonder drug that helped them produce enough milk to breastfeed their babies.

“It kind of sounded like a miracle drug,” said Emily Matreal, 29, who lives just outside Detroit and took domperidone in 2021 to help her breastfeed her son, Conner.

Emily Matreal, who lives just outside Detroit, took domperidone when her breastmilk supply dropped off suddenly, three months after her son Conner was born. (Emily Matreal)

Health Canada told CBC that although the agency is aware the drug is routinely prescribed to stimulate lactation, it is not approved for that purpose.

CBC spoke with nine women in Canada, the U.S. and Australia who say they had debilitating psychological side effects when they tried to come off the drug. They described extreme anxiety, panic attacks, insomnia and intrusive thoughts so severe they were left unable to function or care for their children, often for months. Some were forced to stop working or move in with family. At least one attempted to take her own life. They all say no one warned them these things could happen.

Multiple experts interviewed by CBC said they believe such side-effects are rare.

“It’s very unpredictable,” said researcher Janet Currie, who wrote her doctoral thesis on postpartum domperidone prescriptions in British Columbia. She says she’s helped between 15 and 20 postpartum women with severe psychological side effects slowly taper off the drug in the last year.

“No one can tell you exactly in advance whether you’ll have these symptoms and how intense they will be.”

Domperidone is not approved as a lactation aid anywhere in the world and there are no large-scale clinical trials that shed any light on how often these side effects occur.

 

 

Domperidone Warning

 

Health Canada has issued a safety alert about a drug that’s popular with nursing mothers.

Canadian data does not give the reason a person was prescribed a drug. But a CBC analysis of partial data from B.C., Saskatchewan, Manitoba and publicly-insured residents of Quebec found that of the nearly two million people prescribed domperidone between 2000 and 2021, more than three-quarters were women in their childbearing years.

The only published accounts of severe psychological withdrawal symptoms are case studies, including three published last month in the Journal of Breastfeeding Medicine.

Health Canada has issued several warnings about domperidone, but for cardiac side effects, not withdrawal symptoms. In 2012, 2015, and 2022,  the agency noted it can cause irregular heart rates and sudden cardiac death.

Health Canada’s warnings about domperidone, which echo those from the manufacturer in the product monograph, say it should be prescribed at doses no higher than 30 milligrams per day for the shortest possible period. The European Medicines Agency has similar guidelines.

Banned in the U.S.

In the United States, domperidone is banned, for any purpose, by the Food and Drug Administration (FDA) due to cardiac risks. But the FDA ban hasn’t stopped Americans desperate to breastfeed, like Matreal outside Detroit, from seeking it out.

When Matreal’s breast milk supply dropped off at three months postpartum, she posted in a Facebook mom’s group asking for advice. That was where she learned about domperidone — and how to get it in the U.S., through a well-known Canadian doctor.

“I thought, ‘well, that sounds safe. I will reach out to the doctor and kind of see how this goes’,” Matreal said.

Dr. Jack Newman is a pediatrician and expert on breastfeeding based in Toronto. He says he has been prescribing domperidone for decades to help with lactation. (CBC)

That doctor is Jack Newman, a pediatrician who runs the International Breastfeeding Centre in Toronto and is one of the best-known physicians in the field. Newman’s books and online reference materials on using domperidone to stimulate lactation are widely cited as evidence the medication is safe for this purpose in breastfeeding support groups with members around the world.

In an interview with CBC, Newman emphasized that if women were well supported by the health-care system to breastfeed from the beginning, domperidone wouldn’t be needed. Lactation consultants at his clinic watch mothers nurse and recommend other techniques, such as correcting a latch or breast compression, before turning to medication, he added.

He says the risks identified by regulators are overblown.

“We’ve never had a mother have a cardiac arrest. And I’m talking about thousands of mothers that we’ve treated over the years,” Newman said.

“The dose of domperidone that Health Canada recommends —  it’s not a ‘you must do this’ — is useless, it’s not going to work. And so we with experience know that three tablets three times a day, and sometimes we go higher than that, actually helps, and it helps in the majority of mothers.”

Newman starts patients at 90 milligrams per day — three times Health’s Canada’s maximum daily recommendation — and sometimes goes as high as 160 milligrams.

‘Our lives kind of started to unravel’

Matreal paid $100 and was able to get a virtual appointment with a lactation consultant at Newman’s International Breastfeeding Centre in Toronto the next day.

The consultant presented her case to Newman, who prescribed domperidone at 90 milligrams per day. The clinic sent the prescription to a pharmacy in Vancouver, which shipped the medication to Matreal’s doorstep.

When her breast milk supply didn’t increase, Matreal got in touch with the lactation consultant at the clinic, who recommended increasing the dose to 120 milligrams.

At this dose, Matreal said she started producing “a good amount of milk.” Three months later, she decided to stop taking the drug.

Matreal says she was warned by the Newman clinic to wean slowly so her milk supply was not disrupted, and that there could be some anxiety. She tapered slowly at first, but then, in her eagerness to be done with pumping and freezing milk, decided to stop altogether.

Emily Matreal says she started to experience symptoms such as dry eyes and hot flashes within days of going off domperidone. (Emily Matreal)

Two days after going off the drug, Matreal noticed changes: dry eyes, hot flashes and sweating.

“There was just a deep feeling of panic. I didn’t have an appetite, I couldn’t eat, I couldn’t unwind, I couldn’t sleep…. And then our lives kind of started to unravel from there.”

Matreal tried to get answers from the medical community, including from Newman. In an email dated Oct. 10, 2021, viewed by CBC, she wrote to Newman, saying she was “suffering horrible, horrible anxiety” trying to come off the drug.

In an email response the next day, also viewed by CBC, Newman suggested she either take an anti-anxiety medication her doctor had recommended, or go back on domperidone and wean “very slowly, over six months, say.”

“Your situation is very unusual, by the way, since I have not heard of anyone having symptoms like you describe after only three months of taking it,” he added.

Matreal tried going back on domperidone, she said, but her symptoms persisted. She said she found some comfort when she went back to the online mom’s forums and found dozens of other women who said they experienced the same symptoms when they stopped taking the drug.

Emily Matreal says she lost the ability to care for her son Conner after she stopped taking domperidone. (Emily Matreal)

‘Heartbreaking’

It’s a familiar story to Dr. Kaitlyn Krutsch, an assistant professor at the InfantRisk Center at the Texas Tech University Health Sciences Center School of Medicine, and author of three recently published case studies on domperidone withdrawal.

The Center, which studies the amounts of drugs that get into breastmilk, gets about half a dozen calls a week from American women in crisis trying to come off domperidone and unable to find answers from their doctors, Krutsch said. Women are reluctant to disclose they’ve been taking a banned drug, Krutsch explained. And even when they do, she said, American doctors don’t know what it is.

Many of the women, she added, get the drug from Canada.

“It’s heartbreaking,” she said. “A lot of times we’ll hear from the same moms over and over that they’re really struggling, that they’re having a lot of trouble with depression, that they’re having trouble functioning in their daily lives, that they don’t want to get out of bed. We even hear that they are suicidal.”

Krutsch said domperidone withdrawal can look a lot like postpartum depression, which can lead some health-care providers to assume that’s what’s wrong.

But there are important differences, Krutsch noted. In the case studies she published, women would experience symptoms within days of stopping the drug. When they went back on, symptoms would wane, she explained. In addition, one of the women in her case study was an adoptive mother who used domperidone to induce lactation. She was never pregnant.

Montreal psychologist Karen White suspects domperidone withdrawal was responsible for the sudden appearance of extreme anxiety in one of her patients. (Esteban Cuevas Gonzalez/CBC News)

In Montreal, Robinson’s psychologist Karen White also had her doubts that what she was seeing was postpartum depression. White, who has Robinson’s permission to discuss her case with CBC, said Robinson had what she considered to be a normal amount of anxiety for a first-time parent after the birth.

But when White saw Robinson several months later, Robinson’s level of distress alarmed her.

“I’ve seen very severe postpartum depression and anxiety, and this looks similar, but occurring so long after the birth and when she had been doing very well, didn’t make sense to me.”

Robinson says a lactation consultant at the Herzl-Goldfarb Breastfeeding Clinic in Montreal suggested she try domperidone. A doctor working at the clinic prescribed it.

The Herzl-Goldfarb clinic did not respond to a request for comment.

 

 

Addressing gaps in the system for perinatal mental health

 

A Manitoba mother with postpartum depression says she was dismissed by an emergency room physician last month when she sought help after having suicidal thoughts. Instead, she left the hospital feel ashamed and judged.

‘It would be better for everybody’

Matreal eventually stopped getting out of bed. She and her husband sold their house and moved in with Matreal’s parents so her mother could help take care of the baby. Unable to function, Matreal says she started to feel like a burden.

She tried to take her own life shortly after Conner turned one, and again around Mother’s Day.

“I 100 per cent felt like if I wasn’t here anymore, causing all of this, it would be better for everybody,” she said.

When CBC discussed Matreal’s case with Newman, he said anyone prescribed through his clinic gets comprehensive information about how to wean off domperidone slowly and is welcome to get in touch with the lactation consultants at the clinic if they run into problems.

Around the time she took this photo, Emily Matreal’s mental health deteriorated to the point where she stopped leaving the house or getting out of bed. (Emily Matreal)

He said such side effects are rare in his patients, and what’s more likely is the drug was masking symptoms of postpartum depression or anxiety that were already there.

“What is common in our patients, or anybody’s patients, is postpartum depression or anxiety. These mothers have been on the domperidone for several months and then small amounts of domperidone enter into the brain and act as an antidepressant. And when they go off it, especially if they go off it quickly, [they have] symptoms of maybe what is really the postpartum depression rather than the effect of the domperidone,” he said.

He said he prescribes the drug to American women about five or six times every few weeks, and that the FDA’s reasons for banning the drug are baseless.

“The FDA has said a lot of rubbish in the years …and they’re wrong about domperidone, to say it’s a particularly dangerous drug.”

Newman added that in the U.S., domperidone “isn’t actually banned because veterinarians can use it. So, you know, a million-dollar race horse is much more important than a mother.”

Asked if he’s ever advised American women to get the drug from a veterinarian, Newman replied: “Yes, but they don’t do it.”

Newman also said the clinic’s patients are warned about psychological withdrawal effects if they don’t taper off slowly, but CBC found no evidence of such warnings in reviewing the documentation Matreal received from his clinic.

The website of Newman’s International Breastfeeding Centre notes some women can experience anxiety and depression if they stop taking the drug too quickly, but says it is unlikely domperidone is responsible and that the same thing can happen to women who abruptly stop breastfeeding.

The College of Physicians and Surgeons of Ontario says doctors who provide care in other jurisdictions must do so in compliance with the college’s drug prescription guidelines  — “as well as any relevant legal or professional obligations in their patient’s jurisdiction,” the college said in a statement.

Sharing the stories

A year after she stopped taking domperidone, Matreal laughs as she lunges for a toy Conner tosses in her direction as he toddles by. The family has moved into their own apartment and life is starting to feel normal again, she said.

“When I hear music, it kind of feels good again, and I’m spending time with my son.”

Matreal said she wants to share her story because hearing from other women who had been through the same thing was what helped her when she was at her lowest.

Emily Matreal, pictured here with husband Tyler and son Conner, says life is starting to feel normal again a year after she stopped taking domperidone. (Chelsea Gomez/CBC News)

“It was displayed as an overall pretty safe drug, but then it’s so powerful that it can flip your life upside down,” she reflected.

“I guess that’s been the biggest thing, is just wanting to get my story out there and try to help people and kind of make them more aware that it might not just be a drop in breast milk and some anxiety. It could be a lot more.”

Back in Montreal, Robinson has created a website where she posts stories of other mothers who have had traumatic withdrawals from domperidone.

She said she’s doing it so other women have the information she was never given.

“I think that if women knew what the potential risk was … I don’t think almost any mother would take this risk of not being able to care for their child. It’s a nightmare.”


If you or someone you know is struggling, here’s where to get help:

CBC obtained data on the number of domperidone prescriptions from B.C., Saskatchewan and Manitoba, broken down by age range and gender, from the Canadian Institute for Health Information. Data from B.C. and Saskatchewan was from 2006-2021. Data from Manitoba was from 2015-2021. CBC designated “childbearing years” for these provinces as 15-54 (the 15-24 through 45-54 age buckets).

Data for Quebec came from the Régie de l’assurance maladie du Québec and included prescriptions for domperidone between 2000 and 2021 for publicly insured residents, which constitutes just under half the province. CBC designated “childbearing years” for Québec as 11-50 (the 11-20 through 41-50 age brackets). In total, the data included prescriptions for 1,974,475 unique individuals. The data did not include the reason the person was prescribed domperidone.

Source link

Continue Reading

Trending