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Made-in-Canada coronavirus vaccine starts human clinical trials – CBC.ca

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A made-in-Canada vaccine to protect against COVID-19 began human clinical trials Tuesday in Toronto, says the biotechnology company that developed the vaccine.

Toronto-based Providence Therapeutics said three shots will be given to 60 adult volunteers at a clinical trial site in Toronto in the first phase of the trial on Tuesday. 

Fifteen of those volunteers will receive a placebo, and 45 will get the vaccine, called PTX-COVID19-B.

Brad Sorenson, the company’s CEO, said it’s the first time a vaccine designed and manufactured in Canada has begun clinical trials. The company has purchased a site in Calgary to mass produce the vaccine. 

Vaccines are designed to trigger an immune response in the body. Providence’s product is an mRNA vaccine and is similar to the Moderna coronavirus shot being given to people across Canada.

Quebec-based pharmaceutical Medicago began clinical trials last July of its coronavirus vaccine that is based on another technology. Unlike Providence, a large portion of Medicago’s vaccine doses will be manufactured outside the country, in North Carolina.

A vial is shown in this handout image provided by Providence Therapeutics. The company says it is the first fully made-in-Canada coronavirus vaccine to reach clinical trials in this country. (Providence Therapeutics/The Canadian Press)

Medicago’s vaccine is currently in Phase 3 clinical trials — the last stage before it can apply for approval from Health Canada and other regulators to market the product. 

Sorenson said Providence designed and built its vaccine last March.

“We reached out to the Canadian government in April and said, ‘Hey, you’ve heard of Moderna. We’re doing the exact same thing,'” Sorenson said in an interview.

“We went from concept into the clinic in under a year without the same level of support as our peers had.”

Purchased Calgary site

The federal government provided financial sponsorship and support for the early phase clinical trial through the National Research Council of Canada’s Industrial Research Assistance Program. 

Currently, Canada lacks the capacity to manufacture the millions of doses of coronavirus vaccines needed to immunize people outside of a clinical trial setting. It’s why the federal government struck deals with Pfizer and Moderna — both manufactured abroad — to obtain the vaccines being rolled out across Canada.

While the company was developing the vaccine in pre-clinical studies, Sorenson said it also started to build the infrastructure to manufacture the vaccine in Canada as well.

A typical vaccination station is seen at the COVID-19 vaccination clinic at the Health Sciences Centre in Winnipeg on Dec. 14. Currently, Canada lacks the capacity to manufacture the millions of doses of coronavirus vaccines needed to immunize people outside of a clinical trial setting. (John Woods/The Canadian Press)

The company purchased a 20,000-square-foot facility in Calgary that includes 12,000 square feet of lab space to mass produce the vaccine. The facility will be up and running in two months, Sorensen said. 

Pending regulatory approval, a larger Phase 2 trial with adults over 65, youths under 18 and pregnant people could start in May, Sorenson said.

Initial focus was cancer research

If the vaccine proves safe and effective in clinical trials and Health Canada approves it, the goal is to have it ready for the global market by January 2022.

Sorenson founded Providence Therapeutics in 2013 to focus on cancer vaccines.

Several scientists contributed to the pre-clinical research on Providence’s vaccine, including those at the lab of Dr. Mario Ostrowski, a scientist at the Keenan Research Centre for Biomedical Science and an infectious disease clinician at St. Michael’s Hospital, Dr. Anne-Claude Gingras at Mt. Sinai Hospital, Dr. Samira Mubareka and Dr. Rob Kozak at Sunnybrook Research Institute, as well as Dr. Michael Pollanen, Ontario’s chief forensic pathologist.

In August, Ostrowski, whose laboratory performed the animal trials, said results were on par with tests of vaccines from Moderna and Pfizer-BioNTech at that stage.

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Medical assistance in dying given to 10K Canadians in 2021 – CTV News

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More Canadians are ending their lives with a medically-assisted death, says the third federal annual report on medical assistance in dying (MAID). Data shows that 10,064 people died in 2021 with medical aid, an increase of 32 per cent over 2020.

The report says that 3.3 per cent of all deaths in Canada in 2021 were assisted deaths. On a provincial level, the rate was higher in provinces such as Quebec, at 4.7 per cent, and British Columbia, at 4.8 per cent.

“It is rising remarkably fast,” University of Toronto law professor Trudo Lemmens, who was a member of the Council of Canadian Academies Expert Panel on Medical Assistance in Dying, wrote in an email to CTV News. He noted that some regions in the country have quickly matched or surpassed rates in Belgium and the Netherlands, where the practice has been in place for over two decades.

Advocates say it isn’t surprising because Canadians are growing more comfortable with MAID and some expect the rising rates may level off.

“The…. expectation has always been it (the rate) will be something around four to five per cent, (as in) Europe. We will probably, in the end, saw off at around the same rate,” said Dr. Jean Marmoreo, a family physician and MAID provider in Toronto.

The report uses data collected from files submitted by doctors, nurse practitioners and pharmacists across the country involving written requests for MAID.

Among the findings:

  • All provinces saw increases in MAID deaths, ranging from 1.2 per cent (Newfoundland & Labrador) to a high of 4.8 per cent (British Columbia);
  • More men (52.3 per cent) than women (47.7 per cent) received MAID;
  • The average age was 76.3 years;
  • Sixty-five per cent of those provided with assisted death had cancer. Heart disease or strokes were cited in 19 per cent of cases, followed by chronic lung diseases (12 per cent) and neurological conditions like ALS (12 per cent);
  • Just over two per cent of assisted deaths were offered to a newer group of patients: those with chronic illnesses but who were not dying of their condition, with new legislation in 2021 allowing expanded access to MAID.

Documents show that 81 per cent of written applications for MAID were approved.

Thirteen per cent of patients died before MAID could be provided, with almost two per cent withdrawing their application before the procedure was offered.

Four per cent of people who made written applications for medical assistance were rejected. The report says some were deemed ineligible because assessors felt the patient was not voluntarily applying for MAID. The majority of requests were denied because patients were deemed not mentally capable of making the decision.

But other countries with long-established programs reject far more assisted death requests, said Lemmens, citing data that shows 12 to 16 per cent of applicants in the Netherlands are told no.

“It ….may be an indication that restrictions (in my view safeguards) are weaker here than in the most liberal euthanasia regimes,” he wrote in his email to CTV News.

But Marmoreo, who has offered MAID since 2016, sees Canada’s low rejection rate differently.

“It is more like that the right cases are put forward,” she said.

“We have a very good screening process right from the get-go. So before people actually even make a formal request to have assisted dying, they have a lot of information that’s been given to them by the intake….here’s what’s involved in seeking an assisted death, you must meet these eligibility criteria.”

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B.C. ‘clear’ there’s not enough housing as Vancouver encampment ordered dismantled

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VANCOUVER — British Columbia’s acting attorney general says the province was “clear” with Vancouver officials that the Crown corporation responsible for subsidized housing does not have enough spaces available for people who are being told to dismantle their tents along a street in the city’s Downtown Eastside.

Murray Rankin, who is also the minister responsible for housing, says housing is a human right, and the “deeply concerning scenes from Hastings Street demonstrate how much more work we have to do to make that a reality for everyone in our communities.”

Rankin in a statement Friday says BC Housing has accelerated efforts to secure new housing for encampment residents including pursuing new sites to lease or buy and expediting renovations on single-room occupancy units as they become vacant.

He says BC Housing is aiming to make a “limited number” of renovated units available next week, with more opening later in the fall.

Vancouver fire Chief Karen Fry ordered tents set up along Hastings Street sidewalks dismantled last month, saying there was an extreme fire and safety risk.

Police blocked traffic Tuesday as city staff began what’s expected to be a weeks-long process of dismantling the encampment but little had changed by the end of the week with most residents staying put, saying they have nowhere to go.

The city has said staff plan to approach encampment residents with “respect and sensitivity” to encourage the voluntary removal of their tents and belongings.

Community advocacy groups, including the Vancouver Area of Drug Users and Pivot Legal Society, have said clearing the encampment violates a memorandum of understanding between the city, the B.C. government and Vancouver’s park board, because people are being told to move without being offered suitable housing.

The stated aim of the agreement struck last March is to connect unsheltered people to housing and preserve their dignity when dismantling encampments.

The City of Vancouver may enforce bylaws that prohibit structures on sidewalks “when suitable spaces are available for people to move indoors,” it reads.

The province is not involved in the fire chief’s order or the enforcement of local bylaws, which prohibit structures on sidewalks, but it is “bringing all of BC Housing’s resources to bear to do what we can to secure housing for people, Rankin said.

“I recognize the profound uncertainty and upheaval people impacted by the fire order are facing, and we will provide updates on this work as we have news to share,” he said.

Rankin, who had been serving as minister of Indigenous relations, was appointed acting attorney general after David Eby stepped down to run for leadership of the B.C. NDP.

This report by The Canadian Press was first published Aug. 12, 2022.

 

The Canadian Press

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N.W.T. RCMP deploy controversial roadside cannabis screening devices

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YELLOWKNIFE — RCMP in the Northwest Territories have begun using roadside cannabis-screening technology that has faced criticism from defence lawyers elsewhere in Canada.

Mounties in the territory announced late last month that they had deployed devices designed to take a saliva sample and test for the presence of tetrahydrocannabinol, also known as THC, the main psychoactive substance in cannabis. They said the technology would help them detect impaired drivers and make roads safer.

But some criminal defence lawyers have raised concerns about these devices’ ability to deliver reliable test results, particularly in cold temperatures. They argue the technology isn’t effective at determining whether someone is impaired.

“It can lead to people being arrested who are actually innocent,” said Kyla Lee, a lawyer based in Vancouver.

Lee said research has shown the devices may be more likely to deliver false results in extreme cold temperatures, and movement during analysis could also affect outcomes. She added that while the devices can deliver either a positive or negative test result, they do not indicate how much THC may be in a person’s bloodstream.

Lee recently represented a Nova Scotia woman in a constitutional challenge of the law that allows for roadside drug testing technology in Canada.

Michelle Gray, who uses cannabis for multiple sclerosis, had her car impounded and her licence suspended for a week after she failed a cannabis saliva test at a roadside checkpoint in 2019, even though she passed a sobriety test that same night.

“The technology just doesn’t exist yet to allow police to make a determination of impairment via drugs using physical equipment,” Lee said.

Lee is awaiting a decision on the constitutional challenge in Nova Scotia. She said she expects there will be further court challenges in other Canadian jurisdictions where these devices are used, including the Northwest Territories.

There are two devices approved for roadside cannabis screening in Canada: the Drager DrugTest 5000 and the Abbott SoToxa mobile test system. The companies that manufacture the devices recommend they be used in temperatures no lower than 4 C and 5 C, respectively.

Cpl. Andree Sieber of the Regina Police Service, which began using roadside devices to detect cannabis use in early 2020, said officers bring drivers to their vehicles for testing to prevent issues with weather conditions or temperatures.

“We’ve used it throughout all seasons here in Regina,” she said. “We have very cold winters and some pretty nasty, snowy cold days and you have the person attend back to your vehicle with you where it’s heated and it’s not an issue.”

Sieber said the more THC a person has consumed, the more likely they are to show signs of impairment and to test positive.

The RCMP said roadside screening devices are just one tool they use to detect and investigate drug-impaired drivers alongside officers’ observations. They said field sobriety testing and drug recognition experts remain the primary enforcement tools.

“Police officers rely on what they see and hear, as well as what they smell when investigating impaired drivers,” the RCMP said in a written statement. “Regardless of how a drug is consumed, there are signs of that consumption and police are trained to recognized them.”

This report by The Canadian Press was first published Aug. 13, 2022.

This story was produced with the financial assistance of the Meta and Canadian Press News Fellowship.

 

Emily Blake, The Canadian Press

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