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Nova Scotia researchers to evaluate treatments for moderate, severe COVID-19 – The Telegram

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A Nova Scotia study will look into the effectiveness of treatments for hospital patients suffering from moderate to severe COVID-19. 

The study, called CO-VIC for COVID victory, will involve about 600 patients from Nova Scotia Health Authority sites across the province, an NSHA news release said Monday. 

The study, which the authority is doing in conjunction with Dalhousie University, will test out potential therapies and their impact on COVID-19 symptoms. 

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“When additional cutting-edge therapies become available, they will also be assessed,” the release said. “Personalized measurements of immune response will help develop future therapies and predict when and how severe COVID-19 happens.”

The work, which is being led by infectious disease clinician and researcher Dr. Lisa Barrett, aims to advance our understanding of how the immune system responds to COVID and help develop future treatments and second-wave vaccines.

 “We need the best knowledge of treatments and immunity, to save lives now and in the future as we continue to fight COVID-19.”

– CO-VIC study leader Dr. Lisa Barrett

CO-VIC is partially funded by the Nova Scotia COVID-19 Health Research Coalition.

 “As COVID-19 related deaths increase in the older population, in the young who didn’t ever expect to be ill, and in health care workers, our research community feels the overwhelming urgency to protect Nova Scotians with research that tests treatments, predicts disease, and promotes understanding of immunity,” Barrett said in the release.

 “We need the best knowledge of treatments and immunity, to save lives now and in the future as we continue to fight COVID-19.”

The NSHA called the treatment study an integral part of Nova Scotia’s pandemic response. Compared with other provinces, Nova Scotia’s population includes a high proportion of vulnerable people who are older, have underlying respiratory conditions or are immunosuppressed.

“These are all people at higher risk of severe COVID-19 disease and this work may aid in protecting our population.”

Most Nova Scotians will be eligible to take part at hospitals outside traditional research facilities to ensure fair access to research and potential therapies, the release said. 

“While data will be gathered from Nova Scotians, for Nova Scotians, the study is designed to mirror larger international trials to promote the comparison of global data. This will allow the research team to leverage international information so it can be applied here in Nova Scotia.”

For more information, visit the study website

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RCMP warn about benzodiazepine-laced fentanyl tied to overdose in Alberta – Edmonton Journal

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Grande Prairie RCMP issued a warning Friday after it was revealed fentanyl linked to a deadly overdose was mixed with a chemical that doesn’t respond to naloxone treatment.

The drugs were initially seized on Feb. 28 after a fatal overdose, and this week, Health Canada reported back to Mounties that the fentanyl had been mixed with Bromazolam, which is a benzodiazepine.

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Mounties say this is the first recorded instance of Bromazolam in Alberta. The drug has previously been linked to nine fatal overdoses in New Brunswick in 2022.

The pills seized in Alberta were oval-shaped and stamped with “20” and “SS,” though Mounties say it can come in other forms.

Naloxone treatment, given in many cases of opioid toxicity, is not effective in reversing the effects of Bromazalam, Mounties said, and therefore, any fentanyl mixed with the benzodiazepine “would see a reduced effectiveness of naloxone, requiring the use of additional doses and may still result in a fatality.”

Photo of benzodiazepine-laced fentanyl seized earlier this year by Grande Prairie RCMP after a fatal overdose. edm

From January to November of last year, there were 1,706 opioid-related deaths in Alberta, and 57 linked to benzodiazepine, up from 1,375 and 43, respectively, in 2022.

Mounties say officers responded to about 1,100 opioid-related calls for service, last year with a third of those proving fatal. RCMP officers also used naloxone 67 times while in the field, a jump of nearly a third over the previous year.

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CFIA continues surveillance for HPAI in cattle, while sticking with original name for disease – RealAgriculture

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The Canada Food Inspection Agency will continue to refer to highly pathogenic avian influenza in cattle as HPAI in cattle, and not refer to it as bovine influenza A virus (BIAV), as suggested by the American Association of Bovine Practitioners earlier this month.

Dr. Martin Appelt, senior director for the Canadian Food Inspection Agency, in the interview below, says at this time Canada will stick with “HPAI in cattle” when referencing the disease that’s been confirmed in dairy cattle in multiple states in the U.S.

The CFIA’s naming policy is consistent with the agency’s U.S. counterparts’, as the U.S. Animal and Plant Health Inspection Service has also said it will continue referring to it as HPAI or H5N1.

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Appelt explains how the CFIA is learning from the U.S. experience to-date, and how it is working with veterinarians across Canada to stay vigilant for signs of the disease in dairy and beef cattle.

As of April 19, there has not been a confirmed case of HPAI in cattle in Canada. Appelt says it’s too soon to say if an eventual positive case will significantly restrict animal movement, as is the case with positive poultry cases.

This is a major concern for the cattle industry, as beef cattle especially move north and south across the U.S. border by the thousands. Appelt says that CFIA will address an infection in each species differently in conjunction with how the disease is spread and the threat to neighbouring farms or livestock.

Currently, provincial dairy organizations have advised producers to postpone any non-essential tours of dairy barns, as a precaution, in addition to other biosecurity measures to reduce the risk of cattle contracting HPAI.

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Toronto reports 2 more measles cases. Use our tool to check the spread in Canada – Toronto Star

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Canada has seen a concerning rise in measles cases in the first months of 2024.

By the third week of March, the country had already recorded more than three times the number of cases as all of last year. Canada had just 12 cases of measles in 2023, up from three in 2022.

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