Health
Alzheimers can be predicted BEFORE symptoms show as new test detects spread in brain – Express.co.uk
Alzheimer’s disease is the most common type of dementia and currently scientists are unable to diagnose it until serious symptoms occur – and as yet no cure has been found. But a new study carried out by the University of California in San Francisco could change that, as scientists identify “key driver” of Alzheimers. Cutting-edge brain scans enable experts to track a protein found inside brain cells, which has been found to predict how the disease will develop years before patients show serious symptoms.
Scientists have used imaging techniques to track the extent of the protein, called tau, of those with early signs of Alzheimer’s, revealing that levels of the protein predict not only how much brain shrinkage will subsequently occur, but where.
The research suggests the protein drives the death of brain cells and could lead to better drugs and a screening programme for those most at risks.
The study, published on Wednesday in Science Translational Medicine, used PET (positive emission tomography) scans to study the brains of 32 people aged between 49 and 84 who were in the early stages of showing Alzheimer’s symptoms.
PET imaging in this case involved injecting patients with a substance that attached to tau tangles, allowing clusters to show up in subsequent scans.
Scientists took a PET scan at the start of the study, as well as an MRI, which reveals the structure of the brain.
A second MRI was taken 15 months later to track brain atrophy and the results revealed the amounts of tau at the outset predicted how much degeneration would occur – on average 15 months later.
The findings also showed the level and location of tau tangles shown in the PET scan were closely linked to shrinkage of grey matter in the brain, both in terms of the degree of shrinkage and its location.
Gill Rabinovici, a co-author of the study, said: “These predictions were much more powerful than anything we’ve been able to do with other imaging tools, and add evidence that tau is a major driver of the disease.”
READ MORE: Alzheimer’s charity demands £320m spent on research to stop condition
But Mr La Joie said the results does not mean amyloid is not harmful.
He said: “It is extremely rare to see significant amounts of tau tangles across the brain in patients with no amyloid: for some reason, amyloid seems almost necessary for tau to build up in the cortex.”
Alzheimer’s Research UK welcomed the results of the study and suggested it tracking tau could be an important tool for future clinical trials.
Dr Laura Phipps said: “The ability to track tau in the brain will be critical for testing treatments designed to prevent the protein causing damage, and the scans used in this study could be an important tool for future clinical trials.”
She continued: “This relatively small study adds to evidence that tau may drive the death of brain cells, and could explain why symptoms get worse as tau spreads through the brain.
“While the majority of volunteers in the study were under the age of 65, making it harder to generalise the findings to everyone with the disease, the study highlights the importance of focusing future research efforts on the tau protein.”
Health
CFIA continues surveillance for HPAI in cattle, while sticking with original name for disease – RealAgriculture
The Canada Food Inspection Agency will continue to refer to highly pathogenic avian influenza in cattle as HPAI in cattle, and not refer to it as bovine influenza A virus (BIAV), as suggested by the American Association of Bovine Practitioners earlier this month.
Dr. Martin Appelt, senior director for the Canadian Food Inspection Agency, in the interview below, says at this time Canada will stick with “HPAI in cattle” when referencing the disease that’s been confirmed in dairy cattle in multiple states in the U.S.
The CFIA’s naming policy is consistent with the agency’s U.S. counterparts’, as the U.S. Animal and Plant Health Inspection Service has also said it will continue referring to it as HPAI or H5N1.
Appelt explains how the CFIA is learning from the U.S. experience to-date, and how it is working with veterinarians across Canada to stay vigilant for signs of the disease in dairy and beef cattle.
As of April 19, there has not been a confirmed case of HPAI in cattle in Canada. Appelt says it’s too soon to say if an eventual positive case will significantly restrict animal movement, as is the case with positive poultry cases.
This is a major concern for the cattle industry, as beef cattle especially move north and south across the U.S. border by the thousands. Appelt says that CFIA will address an infection in each species differently in conjunction with how the disease is spread and the threat to neighbouring farms or livestock.
Currently, provincial dairy organizations have advised producers to postpone any non-essential tours of dairy barns, as a precaution, in addition to other biosecurity measures to reduce the risk of cattle contracting HPAI.
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Health
Toronto reports 2 more measles cases. Use our tool to check the spread in Canada – Toronto Star
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Canada has seen a concerning rise in measles cases in the first months of 2024.
By the third week of March, the country had already recorded more than three times the number of cases as all of last year. Canada had just 12 cases of measles in 2023, up from three in 2022.
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Cancer Awareness Month
Posted on: Apr 18, 2024
April is Cancer Awareness Month
As we recognize Cancer Awareness Month, we stand together to raise awareness, support those affected, advocate for prevention, early detection, and continued research towards a cure. Cancer is the leading cause of death for Métis women and the second leading cause of death for Métis men. The Otipemisiwak Métis Government of the Métis Nation Within Alberta is working hard to ensure that available supports for Métis Citizens battling cancer are culturally appropriate, comprehensive, and accessible by Métis Albertans at all stages of their cancer journey.
Receiving a cancer diagnosis, whether for yourself or a loved one, can feel overwhelming, leaving you unsure of where to turn for support. In June, our government will be launching the Cancer Supports and Navigation Program which will further support Métis Albertans and their families experiencing cancer by connecting them to OMG-specific cancer resources, external resources, and providing navigation support through the health care system. This program will also include Métis-specific peer support groups for those affected by cancer.
With funding from the Canadian Partnership Against Cancer (CPAC) we have also developed the Métis Cancer Care Course to ensure that Métis Albertans have access to culturally safe and appropriate cancer services. This course is available to cancer care professionals across the country and provides an overview of who Métis people are, our culture, our approaches to health and wellbeing, our experiences with cancer care, and our cancer journey.
Together, we can make a difference in the fight against cancer and ensure equitable access to culturally safe and appropriate care for all Métis Albertans. Please click on the links below to learn more about the supports available for Métis Albertans, including our Compassionate Care: Cancer Transportation program.
I wish you all good health and happiness!
Bobbi Paul-Alook
Secretary of Health & Seniors
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