VANCOUVER — Researchers at the University of British Columbia have discovered what they are calling a “weak spot” in the virus that causes COVID-19.
A study published in the peer-reviewed scientific journal Nature Communications says the “key vulnerability” is found in all major variants of the SARS-CoV-2 virus.
Researchers say exploiting that weakness could pave the way for new treatments that would be effective against all strains of the illness that has killed almost 6.5-million people across the globe since it was identified more than two years ago.
The study’s senior author, Dr. Sriram Subramaniam, a professor in UBC’s faculty of medicine, says the team studied the virus at an atomic level, found the weak spot and identified an antibody fragment that can attach to it and all other variants, including the surging Omicron subvariants.
Antibodies counteract viruses by attaching like a key in a lock and are no longer effective when the virus mutates quickly, but Subramaniam says the weak spot is constant in all seven major variants of the SARS-CoV-2 virus, allowing one antibody to act as a “master key” capable of overcoming extensive mutations.
Subramaniam says the weak spot and master key identified in the study “unlock a whole new realm of treatment possibilities” that have the potential to be effective against current or future variants of the virus that causes COVID-19.
This report by The Canadian Press was first published Aug. 18, 2022.
The Canadian Press
Hastings & Prince Edward Public Health expecting surge in respiratory illnesses – mybancroftnow.com
Hastings & Prince Edward Public Health is encouraging people to get both a flu vaccine and a COVID-19 booster shot this fall, ahead of what could be a rough winter.
A report that followed a recent board meeting, said that Ontario is expecting a spike in acute respiratory illnesses this season. The projected increase is big enough to pose a burden on the health care system.
The health unit urges people to use the same strategies they’ve used throughout the pandemic. That includes being vaccinated, washing hands frequently and knowing how to get tested and treated for COVID-19.
Officials also encourage people to stay home when feeling sick. And they ask you to wear a mask if you’re recovering or in a high-risk setting.
UM Today the Magazine | Outsmarting a Brain Tumour – UM Today
The little girl with the pink glasses and blue sweatshirt smiles back from a photo on the wall. It’s hung in Tamra Werbowetski-Ogilvie’s sixth-floor office, overlooking the treetops of the neighbourhood surrounding UM’s Bannatyne campus.
Alongside the framed photo are images of her own two children, including her daughter. She’s around the same age as this tween who was undergoing cancer treatment and who was connected to a foundation that funded Werbowetski-Ogilvie’s work in pediatric brain tumours—the deadliest of childhood cancers.
The Rady Faculty of Health Sciences researcher recalls chatting with the inquisitive girl on a Zoom call a year ago.
“Those are emotional meetings, you know? And I can’t get through them without crying. She was so thankful when I met her and just so happy that people were doing work,” says Werbowetski-Ogilvie. “It hits you. See? Already, I’m getting emotional.”
That’s why she opted for life as a stem cell biologist instead of a physician. Pediatric brain cancer became an obvious choice; it’s a discipline starving for discovery. This cancer is surprisingly rare in kids; it’s only been in the last decade that research in this specialized field has gained momentum, with advances in gene sequencing technology. But still, children’s cancers in general are “ridiculously underfunded,” Werbowetski-Ogilvie is quick to point out. “In the States, they account for less than four per cent of all funded research in cancer. And it’s the same everywhere.”
Roughly 1,000 kids are diagnosed with cancer in Canada every year, including about 50 in Manitoba. Around 10 of these children will learn they have a malignant tumour in their still-developing brain. A few of them will be diagnosed with a medulloblastoma tumour—the type Werbowetski-Ogilvie investigates.
“Parents don’t care how rare it is. They want to look for better treatments.”
She’s saying this just weeks before the prestigious journal Nature publishes what is possibly her team’s biggest findings to date. With collaborators in Toronto, Seattle and Tokyo, they pinpointed how and where aggressive types of medulloblastoma first appear—in pre-malignant form—during a child’s brain development, while still in the womb. Kids aren’t usually diagnosed with this type of tumour, known as group 4, until age seven, which suggests there’s a window of several years to prevent the cancer from ever happening.
Until now, group 4 tumours were the least understood, yet they require some of the most intense treatment. Up to 40 per cent of kids don’t survive.
Parents don’t care how rare it is. They want to look for better treatments.
With new clarity of which genes go awry and grow into tumours, clinicians could potentially detect these problematic cells before they turn into cancer—it’s the first time scientists have suggested medulloblastoma is preventable. They can also now develop better human cell models to test potential drugs to slow or stop its spread.
“With better models, we’ll actually be able to make some headway,” says Werbowetski-Ogilvie.
Brain cancer, she reiterates, doesn’t always get its moment in the spotlight. Greater attention tends to go toward unravelling the mysteries of leukemia, which affects the blood and is the most common cancer among children.
“In the leukemias it seems that there’s been better strides made in terms of survival rates. Whereas with brain tumours—especially for these really, really bad cases—current therapies are really not extending life beyond an extra couple of months and are so toxic,” she says. “We need to do better for brain tumours. And I think we are definitely moving in that direction.”
The search for new treatments finds fuel in cancer stem cell biology, where scientists identify a tumour’s “cellular fingerprint.”
“We’re looking for the proteins on the surface of a cell as well as inside the cell that make those tumours unique,” says Werbowetski-Ogilvie. “And then we look for drugs that will target that unique signature.” That way oncologists can go after diseased cells while leaving surrounding healthy cells intact.
This shift in approach will redefine the future of cancer care by offering alternatives to radiation and chemotherapy, which simply goes after all dividing cells, healthy or not, she explains. A more tailored approach is especially overdue for kids since they suffer worse long-term side effects from conventional options.
“Trials and drugs for children cannot be lumped into what is given to adults. They’re not the same. Everything we know about childhood cancer is different: the mutations, the drugs they’ll respond to, how they will respond. We’re dealing with developing bodies, right? And so we have to think about how we treat these diseases in very different ways.”
She and her mostly female team—many of whom are mothers of young children—have spent years investigating another type of medulloblastoma—the sonic hedgehog brain tumour—which originates in the cerebellum. It was a postdoctoral fellow at Harvard Medical School, Robert Riddle, who first identified the protein behind the tumour’s growth. The protein belongs to the hedgehog genes. (Riddle raised eyebrows when he named it “sonic hedgehog” after the 1990s Sega videogame character.)
Werbowetski-Ogilvie set out to uncover a drug that would target this cancer and, in 2018, found that selumetinib slowed the tumour’s growth, as their hypothesis had hoped. But stopping the study there, Werbowetski-Ogilvie notes, would have been like plucking a dandelion from the surface rather than removing its root. So they pursued the possibility of a second drug—and serendipity stepped in.
Had COVID-19 closures in 2020 not shut down her lab, these experiments wouldn’t have been cut short, and her team wouldn’t have gathered data at the precise point that alerted them to just how fast not one, but a combination of drugs—selumetinib, along with pacritinib—was shrinking these tumours. “One model showed an almost 90 per cent reduction in the tumour’s growth. Over time, this translated to a greater than 40 per cent increase in survival,” she says. “You can just feel the excitement in the lab when a story is coming together and it’s all sort of clicking.”
Postdoctoral student Jamie Zagozewski [BSc(Hons)/09, MSc/12] remembers that moment well. “We were just blown away when we saw how much we could shrink the overall size of these tumours,” says Zagozewski, 37. “These parents are going through what I imagine is the worst thing in their entire life, and if I can have something to do with helping to ease that, that’s just incredible.”
Up until then, neither of these drugs had been tried on medulloblastoma—but since they have been used on other childhood cancers, approvals can come quicker, says Werbowetski-Ogilvie.
“I don’t like hearing the term, ‘It’s good enough,’” she says. “You have to stick with it and you have to keep putting in effort. Maximum effort.”
Finding new ways to treat brain cancer is especially complex since drug candidates must effectively reach tumours in this delicate organ. Many drugs are designed to not affect the brain, to not cross our blood-brain barrier, which protects toxins from getting in. Finding new, tailored treatments is made even more complicated since there are so many different types of tumours: 120 to be exact, according to the Brain Tumour Foundation of Canada.
Thankfully, in recent years, more affordable sequencing technology and an effort by the international research community to catalogue genetic differences among these tumours means scientists have a breakdown of genes involved in all forms of medulloblastoma. While this is extremely helpful, the data doesn’t speak to the behaviour of those genes and how they affect individual cells. It can be overwhelming to try to figure out which to narrow in on, admits Werbowetski-Ogilvie.
“When we get these large data sets, it’s our job to figure out which of these genes or proteins end up being functionally relevant. Not everything is,” she says. “It takes years to prioritize what to work on and figure out what our genes of interest actually do.”
In Werbowetski-Ogilvie’s office, on her whiteboard, are old doodles by her son that have been there so long they won’t erase. On her shelf is an anatomical model of a brain, and a ‘science lab’ her daughter made out of a milk cartoon, along with a drawing she did depicting Mom as Wonder Woman—something her team placed prominently during a surprise makeover of the space.
“What I teach in my lab, and what I teach my kids, is perseverance,” she says. “With science, sometimes experiments don’t work, but you have to stick with it.”
That’s not lost on Zagozewski, who says it’s no small thing to be part of a predominantly female team in a STEM field, led by a researcher who’s both tenacious and nurturing. “Not only are we scientists but we’re friends and mothers, all supporting each other,” she says. “It’s not just a job—it’s more than that.”
DID YOU KNOW? Pediatric oncologist Dr. Norma Ramsay [MD/68], a 2021 recipient of a UM Distinguished Alumni Award and mentor to dozens of female researchers, also found her calling in the emotionally charged field of childhood cancer. A leader in stem cell biology, she headed the acclaimed Pediatric and Blood Marrow Transplant Program at the University of Minnesota, improving mortality rates. And if treatments failed, she’d often drive to hospitals, no matter the time of day, to be with children in their last moments.
Peak BioBoost Reviews – What To Know Before Buying Peak Biome Prebiotics – Abbotsford News
Infrequent bowel movements and inadequate intake of fiber-rich foods lead to constipation and other gut health issues. Colon inflammation syndrome, Crohn’s disease, and ulcerative colitis, among other gut health issues, affect many people globally. People with irritable bowel and constipation face other digestive health issues, but there are various treatment options to suppress the effects.
Numerous probiotics and prebiotic-made supplements claim to aid in digestive health but aren’t effective. Peak BioBoost is a prebiotic fiber-containing supplement that delivers gut-friendly bacteria to provide myriad digestive health benefits. This review will evaluate various facts about the Peak BioBoost supplement.
What Is Peak BioBoost?
Peak BioBoost is a prebiotic fiber blend dietary supplement manufactured by Peak Biome Inc-a reputable brand in producing digestive health supplements. The innovative, science-proven, and plant extract-based formula treats the root cause of the digestive health issue by delivering good bacteria in the digestive tract. According to the manufacturer, the supplement contains oat fiber-rich ingredients that are ideal for digestion.
The product is made of natural and powerful ingredients that revitalize the body. In addition, the potent ingredients lower insulin sensitivity and enable one to feel refreshed. Peak BioBoost ingredients primarily support gut health and restore quality of life. The manufacturer recommends consumers take one sachet of the formula daily to find positive outcomes. The supplement restores healthy and regular bowel movements and prevents painful straining or uncomfortable gas caused by constipation.
How Does Peak BioBoost Work?
The prebiotic fiber-rich formulation works in various approaches. It allegedly works in several different ways to achieve positive results. First, the product purportedly relaxes the intestinal nerves and muscles to allow for easy bowel movements. Slight damage to the intestinal muscles can easily lead to irritable bowel and constipation. Once the intestinal lining is loose, it leads to digestive tract issues. In addition, the stress experienced in the gut lining results in constipation. Peal BioBoost formula alleviates stress and thus lowers constipation.
Secondly, fiber deficiency leads to difficulty in bowel movements and stool gliding processes. The revolutionary supplement enables smoother movement of bowels since it contains oat fiber ingredients that nourish the gut system. The latter eventually eliminates chronic constipation. Prebiotic fiber softens the stool and alleviates the strain caused by constipation.
Finally, the prebiotic-made formula provides the gut system with good bacteria (probiotics). Probiotics are vital in eliminating toxins in the digestive tract and supporting metabolism. The presence of bad bacteria in the digestive tract leads to a rise in infections, prolonged digestion periods, and excess fat deposition, which leads to adverse gut health issues. Peak BioBoost formula provides good bacteria to alleviate such complications.
What Are the Ingredients Contained in the Peak BioBoost Formula?
The prebiotic fiber-rich supplement is manufactured under a GMP-certified facility. Each batch of production undergoes quality checks, and some of the high-quality ingredients used in the formula include:
Xylooligosaccharides contain prebiotics that deliver good bacteria and support healthy bowel movements. The ingredient also supports the digestive system and alleviates intestinal lining stress and pain. The ingredient is used in the Peak BioBoost formula to aid in the relaxation of intestinal nerves, strengthen the gut lining and enhance efficient bowel movements.
Peak BioBoost has a blend of active ingredients, including oat fiber and tapioca fiber. Tapioca Fiber supports healthy bowel movements and weight loss. Consumers can benefit from Tapioca fiber since it alleviates stomach pain that occurs due to irritable bowel syndrome. Consumers of Peak BioBoost benefit from the ingredient since it soothes the intestinal nerves and eases bowel movements.
Besides its vital role in weight loss, the ingredient is used in the Peak BioBoost supplement to aid in bowel movements. Consumers can benefit from the ingredient since it aids in resolving irregular bowel movements and offsetting gas in the digestive tract.
Being one of the Peak BioBoost ingredients, Acacia gum extract aids in restoring a healthy digestive system. The element gets rid of bad bacteria to enhance healthy bowel movements. The ingredient also alleviates discomfort or restraint during excretion.
Peak BioBoost formula contains FOS due to its significant role in alleviating stomach pain that’s caused by poor digestive functions. In addition, the ingredient aids in bowel movements and the prevention of constipation. The element also introduces probiotics to the gut system to aid in smooth excretion.
Magnesium citrate is contained in the Peak BioBoost formula for consumers to soothe damaged intestinal nerves and muscles. The ingredient supports healthy bowel movement and restores the ideal ratio of good bacteria. Healthy bacteria improve overall health.
The above ingredients make Peak BioBoost a viable dietary supplement for targeting the root cause of one’s digestive system issues and addressing them momentarily.
Peak BioBoost Benefits
Besides addressing digestion issues, the Peak BioBoost supplement by Peak Biome has additional benefits. The supplement is viable for people of all ages. The manufacturer has provided various benefits of the product as follows:
Helps Improve Digestive System
The Peak BioBoost formula enables the consumer to have a well-functioning digestive tract. The supplement improves the quality of life by getting rid of all bowel-related problems, including constipation and extreme acidity. Peak BioBoost formula is suitable for one’s metabolism and overall digestive health since it aids in reducing constipation, acidity, and more digestion-related issues.
Frees up Rancid Acid Formation from the Body
The supplement ensures consumers undergo smooth digestion and inhibits the formation of rancid acid. The formula is used to lower acidity for people struggling with intense acidity. The presence of acid on the intestinal lining can be detrimental, and the supplement aids in reversing the action of damage.
Support Bowel Movements
Peak BioBoost ideally eases bowel movements. The supplement relaxes the intestinal nerves and muscles, ensuring effortless toilet gliding. Achieving efficient bowel movement enables one to feel refreshed and revitalized all day. Consumers who use the supplement regularly notice that all their digestive-related issues vanish momentarily.
Improves the Immune System
Besides targeting the digestive system, Peak BioBoost also improves the immune system. Upon achieving a good immune system, consumers have healthy and disease-free lives. The new formula can enable consumers to manage chronic digestive health issues. The supplement also contains potent and active ingredients that strengthen the immune system and enables the body fight pathogens.
Delivers the Good Bacteria and Aids in Gut Health and Weight Loss
The Peak BioBoost formula supercharges the gut with good bacteria enabling consumers to feel refreshed, revitalized, and without bloating. Dietary supplements also support weight loss. The good bacteria in the digestive system support weight loss. Probiotics prevent excessive deposition of fat and boost the metabolic rate. Regular consumption of the supplement enables consumers to achieve weight loss.
Peak BioBoost Usage
The manufacturer recommends ingesting one scoop or sachet of the prebiotic supplement with a morning beverage. The product is also recommended with smoothies, oatmeal, pancakes, or basically any breakfast you like. Coffee is ideal for kickstarting the bowels, and it’s recommended while one is using the product.
Peak BioBoost prebiotic formula easily dissolves in beverages and has low carbs. In addition, the dietary supplement is not addictive, and it’s recommended to use it regularly to find significant improvement, a revitalized body, and overall wellness.
Unlike other products that cause allergies, the formula is safe for consumption. It’s free from gluten, preservatives, flavors, and other harmful substances. However, consumers with underlying health issues should liaise with their physicians to ensure the product doesn’t have any reactions.
Peak BioBoost Formula Pricing and Refund Policy
Peak BioBoost is productive and affordable, and consumers can get the product by ordering it from the official website. The GMO-free and keto-friendly supplement has the following discounted packages on the website:
- Starter Pack: 1 Bottle of Peak BioBoost supplement is offered at $44.95
- Most Popular Package: 6-Bottles of the prebiotic supplement are selling at $33.33 per bottle saving $150
- Family Pack: 3-bottle of the supplement are selling at $39.95
All the packages are inclusive of “The Dessert Cookbook” and free US shipping and handling fee. Consumers who reside in the US or Canada can get the product shipped within 5-7 business days. However, the product is shipped internationally within 15 business days.
In addition, consumers have a 365-day money-back guarantee. The refund policy is issued with a 100% satisfaction guarantee. Consumers who feel the product doesn’t satisfy their needs can get their money back without hassle.
Besides the discounted offers by ordering the product from the official website, consumers get an additional bonus. “The Perfect Poops Desserts Cookbook Bonus Guide” provides consumers with 50+ dessert recipes that aid gut health.
Irritable bowels, chronic constipation, and other digestive health issues can be detrimental to the overall health. People who take digestive health issues lightly are likely to face severe underlying health complications in the future.
Some dietary supplements are viable solutions for most digestive health problems. The supplements contain potent ingredients that ingest the body with fiber that supports bowel movements.
Peak BioBoost formula may help improve bowel movements by providing the gut system with prebiotics. The manufacturer highlights myriad benefits associated with the product. Prebiotics enhance sustainable good bacteria in the gut system to eliminate toxins. Consumers can benefit from Peak BioBoost and improve their digestive system’s health, among other benefits.
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