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Canadians may need COVID-19 boosters by Christmas, Moderna president says – Global News

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Moderna’s president is warning that Canada could see a rise in so-called “breakthrough” infections of COVID-19 among fully vaccinated people by Christmas time, prompting the need for a booster shot for the broader public.

“In December and January, when flu season comes back and when respiratory viruses really take off around the holidays, it could become a very bad moment because you’ll see high forces of infection and breakthroughs,” president Stephen Hoge said in an exclusive interview with Global News’ current affairs show The New Reality.

Moderna has been studying the immune response to its vaccine since the summer of 2020, when 30,000 participants received two doses, 28 days apart. Moderna says data from that trial shows antibodies start to wane about six months after the second shot.

WATCH: Antibodies only half the story of immune protection: experts


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Antibodies only half the story of vaccine protection: experts


Antibodies only half the story of vaccine protection: experts

While antibodies are expected to decrease over time, Hoge said alarm bells started going off over the summer as outbreaks fuelled by the Delta variant surged worldwide. Moderna researchers began to see a spike in breakthrough cases of symptomatic COVID-19, among those fully vaccinated clinical trial participants.

This is prompting Moderna to call for a booster for fully vaccinated adults.

“None of us want to be in a situation where we’re showing up six months or three months late … where we’re seeing breakthrough infections, severe disease, hospitalization, and even death.”

Canadian data shows vaccine effectiveness is still remarkably robust at preventing severe outcomes, like hospitalization, from COVID-19.  Hoge said that could be, in part, because some Canadian provinces delayed the interval between the first and second doses by up to four months, prolonging immunity.

Read more:
An exclusive look inside Moderna

The decision to stretch the interval between doses was a controversial move as health officials weighed the benefits of getting people fully vaccinated versus giving more people partial immunity with one dose.

“In retrospect, we will probably say that time between the doses extended the durability,” Hoge said.


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“The more recently you were boosted with your second dose, the less likely you’re going to need a third dose booster. And that’s good news,” he said. “The challenge for all of us is you also don’t want to wait too long.”

WATCH: Boosters could be needed annually says Moderna’s president


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TNR Extra: Boosters could be needed annually says Moderna’s president


TNR Extra: Boosters could be needed annually says Moderna’s president

But fast-forward six months from summer – after many Canadians received their second doses – and the number of breakthrough infections could change, Moderna’s internal trial data suggests.

“Do we expect there to be waning immunity in populations like Canada that had separated booster doses? I think the answer is yes,” Hoge said.

“That’s the concern, that by Christmas things could look very different.”


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The concerning forecast comes as health officials in the U.S. are launching campaigns to provide booster shots for millions of vulnerable people who received the Pfizer-BioNTech vaccine. The Centres for Disease Control (CDC) formally approved plans for additional shots for people who work in high-risk jobs like teachers and health care workers, as well as anyone over 65.

Canada’s National Advisory Committee on Immunization (NACI), meanwhile, has only recommended additional shots for people with compromised immune systems and those living in congregate care settings, like long-term care homes.

Read more:
COVID-19 booster shots could rake in billions for some vaccine makers

The booster debate has divided the international scientific community, with some saying there is no current need for additional doses for healthy adults, while others say there is mounting evidence showing immunity is declining.

Studies from Pfizer and the CDC have also suggested evidence of waning vaccine effectiveness.

One CDC study evaluated data from New York State from May 3 to July 25, when the Delta variant represented more than 80 per cent of new cases. The effectiveness of vaccines in preventing infection in adults declined from 91.7 percent to 79.8 percent during that time, the study found.


Click to play video: 'Pfizer vaccine efficacy drops'



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Pfizer vaccine efficacy drops


Pfizer vaccine efficacy drops – Aug 1, 2021

During those weeks, New York recorded 9,675 breakthrough infections and 1,271 hospitalizations in vaccinated people, roughly 15 per cent of all COVID-19 hospitalizations.

However, a series of contrasting studies released by the CDC have shown the vaccines are working well at preventing severe disease.

A pair of analyses released last month showed that vaccines are still holding up in the fight against COVID-19. One study indicated unvaccinated people were about 4.5 times more likely to become infected, and were more than 10 times more likely to need hospitalization or die from COVID-19 than people who are fully vaccinated.

Read more:
Unvaccinated 60 times more likely to end up in ICU with COVID-19, Ontario data shows

Canadian public health officials, meanwhile, say they are evaluating data from other countries before making any further recommendations on booster doses.

“(NACI) continues to review evidence on the effectiveness of COVID-19 vaccines in key populations and the general population, including the duration of protection that will inform decisions regarding booster doses,” a spokesperson with the Public Health Agency of Canada said in an email.

Moderna has asked regulators in the U.S. to greenlight a half-dose (50mcg) of its original vaccine for use six months after the second shot. Hoge says its data shows the booster brings antibody levels even higher than after the initial shots across all age groups.

They have yet to make a formal submission to Health Canada for approval but are planning to do so imminently, Hoge said.

“Our clinical trials – which are the longest exposures to the vaccine and the virus that we have – are starting to suggest to us that it’s time to get concerned and get ready,” he said.

“We’ll present that data to Health Canada and to recommending bodies globally, but they then need to decide ‘OK, does that cause them to take action for their people?’”

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My Boy Prince to race against older horses in $1-million Woodbine Mile

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TORONTO – He’s firmly among Canada’s top three-year-olds but My Boy Prince faces a stiff test Saturday at Woodbine Racetrack.

The ’24 King’s Plate runner-up will be part of a global field in the $1-million Woodbine Mile turf event. Not only will it be My Boy Prince’s first race against older competition but among the seven other starters will be such horses as Naval Power (Great Britain), Big Rock (France) and Filo Di Arianna (Brazil).

My Boy Prince will race for the first time since finishing second to filly Caitlinhergrtness in the Plate on Aug. 23.

“It’s his first try against older horses and it’s hard to say where he fits in,” said trainer Mark Casse. “This time of year running a three-year-old against older horses, it’s like running a teenager against college athletes.

“We’re doing it because we believe a mile on the turf is his preferred surface … we wanted to give him a shot at this. (American owner Gary Barber) is someone who likes to think outside the box and take calculated risks so we’re going to see where he fits in.”

Casse, 16 times Canada’s top trainer, is a Hall of Famer both here and in the U.S. He’s also a two-time Woodbine Mile winner with filly Tepin (2016) and World Approval (2017).

Sahin Civaci will again ride My Boy Prince, Canada’s top two-year-old male who has six wins and 10 money finishes (6-3-1) in 11 career starts. The horse will be one of three Casse trainees in the race with Filo Di Arianna (ridden by Sovereign Award winner Kazushi Kimura) and Win for the Money (veteran Woodbine jockey Patrick Husbands aboard).

Naval Power, a four-year-old, has finished in the money in eight of nine starts (six wins, twice second) and will race in Canada for the first time. He comes to Woodbine with second-place finishes in two Grade 1 turf races.

Big Rock, another four-year-old, makes his North American debut Saturday. The horse has five wins and five second-place finishes in 14 starts but has struggled in ’24, finishing sixth, 10th and fifth in three races.

Filo Di Arianna is a four-time graded stakes winner with nine victories, three seconds and a third from 17 starts. It was Canada’s ’22 top male sprinter and champion male turf horse.

Other starters include Playmea Tune, Niagara Skyline and Secret Reserve.

Playmea Tune, a four-year-old, is trained by Josie Carrol. The gelding has made three starts, winning twice and finishing second in the Grade 3 Bold Venture on Aug. 23.

Woodbine-based Niagara Skyline is a six-year-old with 13 money finishes (six wins, five seconds, twice third) in 24-lifetime starts. The John Charlambous trainee has reached the podium (1-1-1) in all three races this year.

Secret Reserve, also a six-year-old, has finished in the money in 15-of-26 starts (six wins, one second, eight thirds). The horse, at 44-1, was third in the Grade 2 King Edward Stakes over a mile on the E.P. Taylor turf course.

The Mile highlights a stellar card featuring six graded stakes races. Also on tap are the $750,000 E.P. Taylor Stakes (fillies and mares), $500,000 bet365 Summer Stakes (two-year-olds) and $500,000 Johnnie Walker Natalma Stakes (two-year-old fillies), all Grade 1 turf events.

The Mile, Natalma and Summer winners earn automatic entries into the Breeders’ Cup at Del Mar in November.

Casse has won all four races, earning his first E.P. Taylor title last year with filly Fev Rover, Canada’s horse of the year and champion female turf horse. Fev Rover will defend her title Saturday against a field that includes Moira, the ’22 King’s Plate winner and Canada’s horse of the year trained by Woodbine’s Kevin Attard.

“It (E.P. Taylor) was definitely on my bucket list because it had eluded us,” Casse said. “But I honestly hadn’t realized I’d won all four of them, hadn’t really thought about it.”

Casse will have horses in all four turf races Saturday. Arguably the most intriguing matchup will be between Moira and Fev Rover, who ran 1-2, respectively, in a photo finish Aug. 11 in the Grade 2 Beverly D. Stakes, a 1 3/16-mile turf race, at Virginia’s Colonial Downs.

“What’s funny is the two of them went all the way to Virginia and she beat us by a nose,” Casse said. “We could’ve done that at Woodbine.

“There’s two of the best fillies in the world both from Toronto and they’re going to be competing Saturday.”

Some question having so many solid races on a single card but Casse likes the strategy.

“I think it’s a good thing,” he said. “On Saturday, the main focus on horse racing in the world will be on Woodbine and that’s because it’s such a great card.

“It’s an international day, there’s horses coming from everywhere and we’re going to do our best to represent Canada.”

This report by The Canadian Press was first published Sept. 13, 2024.



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Former world No. 1 Sharapova wins fan vote for International Tennis Hall of Fame

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NEWPORT, R.I. (AP) — Maria Sharapova, a five-time Grand Slam singles champion, led the International Tennis Hall of Fame’s fan vote her first year on the ballot — an important part to possible selection to the hall’s next class.

The organization released the voting results Friday. American doubles team Bob and Mike Bryan finished second with Canada’s Daniel Nestor third.

The Hall of Fame said tens of thousands of fans from 120 countries cast ballots. Fan voting is one of two steps in the hall’s selection process. The second is an official group of journalists, historians, and Hall of Famers from the sport who vote on the ballot for the hall’s class of 2025.

“I am incredibly grateful to the fans all around the world who supported me during the International Tennis Hall of Fame’s fan votes,” Sharapova said in a statement. “It is a tremendous honor to be considered for the Hall of Fame, and having the fans’ support makes it all the more special.”

Sharapova became the first Russian woman to reach No. 1 in the world. She won Wimbledon in 2004, the U.S. Open in 2006 and the Australian Open in 2008. She also won the French Open twice, in 2012 and 2014.

Sharapova was also part of Russia’s championship Fed Cup team in 2008 and won a silver medal at the London Olympics in 2012.

To make the hall, candidates must receive 75% or higher on combined results of the official voting group and additional percentage from the fan vote. Sharapova will have an additional three percentage points from winning the fan vote.

The Bryans, who won 16 Grand Slam doubles titles, will have two additional percentage points and Nestor, who won eight Grand Slam doubles titles, will get one extra percentage point.

The hall’s next class will be announced late next month.

___

AP tennis:

The Canadian Press. All rights reserved.



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Roots sees room for expansion in activewear, reports $5.2M Q2 loss and sales drop

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TORONTO – Roots Corp. may have built its brand on all things comfy and cosy, but its CEO says activewear is now “really becoming a core part” of the brand.

The category, which at Roots spans leggings, tracksuits, sports bras and bike shorts, has seen such sustained double-digit growth that Meghan Roach plans to make it a key part of the business’ future.

“It’s an area … you will see us continue to expand upon,” she told analysts on a Friday call.

The Toronto-based retailer’s push into activewear has taken shape over many years and included several turns as the official designer and supplier of Team Canada’s Olympic uniform.

But consumers have had plenty of choice when it comes to workout gear and other apparel suited to their sporting needs. On top of the slew of athletic brands like Nike and Adidas, shoppers have also gravitated toward Lululemon Athletica Inc., Alo and Vuori, ramping up competition in the activewear category.

Roach feels Roots’ toehold in the category stems from the fit, feel and following its merchandise has cultivated.

“Our product really resonates with (shoppers) because you can wear it through multiple different use cases and occasions,” she said.

“We’ve been seeing customers come back again and again for some of these core products in our activewear collection.”

Her remarks came the same day as Roots revealed it lost $5.2 million in its latest quarter compared with a loss of $5.3 million in the same quarter last year.

The company said the second-quarter loss amounted to 13 cents per diluted share for the quarter ended Aug. 3, the same as a year earlier.

In presenting the results, Roach reminded analysts that the first half of the year is usually “seasonally small,” representing just 30 per cent of the company’s annual sales.

Sales for the second quarter totalled $47.7 million, down from $49.4 million in the same quarter last year.

The move lower came as direct-to-consumer sales amounted to $36.4 million, down from $37.1 million a year earlier, as comparable sales edged down 0.2 per cent.

The numbers reflect the fact that Roots continued to grapple with inventory challenges in the company’s Cooper fleece line that first cropped up in its previous quarter.

Roots recently began to use artificial intelligence to assist with daily inventory replenishments and said more tools helping with allocation will go live in the next quarter.

Beyond that time period, the company intends to keep exploring AI and renovate more of its stores.

It will also re-evaluate its design ranks.

Roots announced Friday that chief product officer Karuna Scheinfeld has stepped down.

Rather than fill the role, the company plans to hire senior level design talent with international experience in the outdoor and activewear sectors who will take on tasks previously done by the chief product officer.

This report by The Canadian Press was first published Sept. 13, 2024.

Companies in this story: (TSX:ROOT)

The Canadian Press. All rights reserved.



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