NFL odds, lines, picks, spreads, best bets, predictions for Week 15, 2021: Model backing Saints, Steelers - CBS Sports

No team has more wins than Arizona and no team has fewer than Detroit. Oddsmakers are expecting these trends to continue when these two get together as part of the Week 15 NFL schedule. The Cardinals are 13.5-point favorites at Caesars Sportsbook in the latest Week 15 NFL odds. At almost two touchdowns, it’s one of the largest NFL spreads of the entire season.

Detroit is 8-5 against the spread this year, so the team has been much more competitive than its record indicates. Is that enough for you to back the Lions in a matchup of former No. 1 overall picks as Jared Goff takes on Kyler Murray? All of the Week 15 NFL lines are listed below, and SportsLine’s advanced computer model has all the NFL betting advice and predictions you need to make the best Week 15 NFL picks now.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 15 of the 2021 season on an incredible 132-96 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, it has turned its attention to the latest Week 15 NFL odds and locked in picks for every NFL matchup. Head here to see every pick.

Top Week 15 NFL predictions

One of the model’s strongest Week 15 NFL picks is that the Saints (+11) cover the spread against the Buccaneers. The Saints have won six of their last seven meetings against Tampa Bay and are 7-3 against the spread in their last 10 games against the Buccaneers.

New Orleans knocked off Tampa Bay 36-27 earlier this season, and New Orleans will try to keep its playoff hopes alive after dominating the Jets last week. In the Saints’ 30-9 victory over New York, quarterback Taysom Hill had a field day with his legs, rushing for 73 yards and two touchdowns while also throwing for 175 yards.

The model is predicting that Hill has another big day against a Tampa Bay defense that just allowed Josh Allen to eclipse 300 passing and 100 rushing yards. Hill is projected to average 5.8 yards per carry while also throwing for 162 yards and two touchdowns. Meanwhile, Alvin Kamara is projected to rack-up 99 all-purpose yards, helping the Saints cover the double-digit spread in 60 percent of simulations.

Another one of its Week 15 NFL predictions: The Steelers (+1.5) cover against the Titans at home. Pittsburgh will surely enjoy the mini-bye that came with playing on Thursday in Week 14. The Steelers are 2-0 against the spread this year when they have more than eight days of rest.

Tennessee is averaging nine fewer points per game since running back Derrick Henry was injured as well as under 300 yards of total offense. Its second-best playmaker, A.J. Brown, is also out with a chest injury, while Julio Jones has only topped 59 receiving yards once this season. With limited options, the model has quarterback Ryan Tannehill barely cracking 200 yards through the air, while Ben Roethlisberger has over 250.

Receivers Diontae Johnson and Chase Claypool are Roethlisberger’s primary targets and are expected to total nearly 150 receiving yards. With running back Najee Harris coming close to 100 scrimmage yards himself, the Steelers are projected to cover in well over 50 percent of simulations. The model also projects 47 combined points, so it has the Over (41.5) hitting almost 60 percent of the time.

How to make Week 15 NFL picks

The model has also made the call on who wins and covers in every other game on the Week 15 NFL schedule, and it’s calling for a Super Bowl contender to go down hard. You can only get every pick for every game at SportsLine.

So which NFL picks can you make with confidence, and which Super Bowl contender goes down hard? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $7,200 since its inception, and find out.