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Canadian company announces COVID-19 vaccine candidate

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A Canadian company says it has made a breakthrough in the fight against the coronavirus outbreak, claiming to have developed a COVID-19 vaccine candidate that could begin human testing as early as this summer.

Quebec City-based Medicago said it has produced a virus-like particle of the novel coronavirus, a first step towards producing a vaccine, which will now undergo pre-clinical testing for safety and efficacy.

Medicago said it could begin human trials as soon as July or August if approved by Health Canada and other agencies.

Company CEO Bruce Clark told Global News that if the vaccine is successful it could be available to the wider public by November 2021. Other media reports erroneously said the vaccine could be ready by November of this year.

“These timelines are heavily reliant on what will give the regulators enough comfort to say this product is ready to go into human testing and then, secondly, for use in the broader public,” he said. “Our best guess right now is 18 months.”

Clark said Medicago researchers were able to produce a candidate vaccine within just 20 days of obtaining the gene of the virus.

If they are given the green light, they could produce as many as 10 million doses a month out of their plant in North Carolina, according to Clark. The company currently has the resources to create about two million doses a month out of its plant in Quebec.

The biopharmaceutical company said it was able to create a vaccine candidate quickly as it used a plant-based platform, not chicken embryos, to help grow vaccine proteins.

“We have a [seasonal flu vaccine] that is currently under review with Health Canada, and the [technology] we are using for this COVID vaccine is exactly the same, which has proven to be efficacious,” Clark said.

Dawn Bowdish, Canada Research Chair in aging and immunity at McMaster University, said the company’s ability to grow virus-like particles in plants has helped it produce vaccines in the past against influenza, including a vaccine candidate against H1N1 in 2009.

“A virus-like particle looks like the outside of a virus but doesn’t have any of the genetic material on the inside,” said Bowdish, who also sits on the scientific advisory board of Medicago. “It doesn’t cause infection but looks really similar from your immune system’s perspective.”

Medical researchers around the world have been racing to develop a vaccine for COVID-19, which has sickened more than 127,000 people and killed roughly 5,000. As of Friday morning, there were 159 confirmed cases in Canada, including the prime minister’s wife Sophie Gregoire Trudeau.

Medicago said it’s also working to develop antibodies against SARS-CoV-2, the pathogen that causes COVID-19, in collaboration with the Laval University’s Infectious Disease Research Centre headed by Dr. Gary Kobinger, who helped develop a vaccine and treatment for Ebola. The research is being partly funded by the Canadian Institutes for Health Research (CIHR).

“The hope is that we’ll be able to create antibodies that as soon as the virus gets into us, it covers it so it can no longer infect cells,” Bowdish said.

Although this was “good news,” Bowdish cautioned that most vaccine trials fail and in 17 years there was never a vaccine fully developed for the SARS outbreak.

“It’s unlikely there will be a miracle drug,” she said. “But Canada has had some incredible successes creating vaccines very quickly. We had huge success with the Ebola virus.”

Other vaccine candidates to be tested

Globally, there are roughly 20 coronavirus vaccine candidates being developed by research institutes and drugmakers, including America’s Johnson & Johnson and France’s Sanofi SA, according to Reuters.

In China, dozens of clinical trials are underway, according to the World Health Organization, as medical researchers work to evaluate everything from HIV drugs to stem cells and even traditional medicines to treat COVID-19.

Two pharmaceutical companies in the U.S. are getting close to human testing.

Biotechnology company Moderna Inc. — working with the U.S.-funded National Institutes of Health (NIH) — has announced plans to start a trial of a vaccine candidate on 45 people in Seattle this month. Testing on animals will proceed simultaneously with human trials, the NIH told Reuters.

Inovio Pharmaceuticals Inc., an immunotherapy company, is working with a company in China to develop a vaccine and expects to start human clinical trials in 30 U.S. volunteers in April.

Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, told the U.S. House Oversight and Reform Committee on Thursday that human trials for a vaccine would be possible “within a few weeks.”

“We said … it would take two to three months to have it in the first human,” Fauci said. “I think we’re going to do better than that. I hope within a few weeks we may be able to make an announcement to you all that we’ve given the first shot to the first person.”

However, he tempered expectations, stating a vaccine would not be widely available for another 12 to 18 months. The World Health Organization has also made similar projections.

“I want to make sure people understand, and I’ve said that over and over again, that does not mean we have a vaccine that we can use,” he said. “We mean it’s record time to get it tested. It’s going to take a year to a year and a half to really know if it works.”

The WHO has said that there’s currently no vaccine and no specific antiviral medicine to prevent or treat COVID-19, but that possible vaccines and some specific drug treatments are currently under investigation.

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Statistics Canada reports wholesale sales higher in July

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OTTAWA – Statistics Canada says wholesale sales, excluding petroleum, petroleum products, and other hydrocarbons and excluding oilseed and grain, rose 0.4 per cent to $82.7 billion in July.

The increase came as sales in the miscellaneous subsector gained three per cent to reach $10.5 billion in July, helped by strength in the agriculture supplies industry group, which rose 9.2 per cent.

The food, beverage and tobacco subsector added 1.7 per cent to total $15 billion in July.

The personal and household goods subsector fell 2.5 per cent to $12.1 billion.

In volume terms, overall wholesale sales rose 0.5 per cent in July.

Statistics Canada started including oilseed and grain as well as the petroleum and petroleum products subsector as part of wholesale trade last year, but is excluding the data from monthly analysis until there is enough historical data.

This report by The Canadian Press was first published Sept. 13, 2024.

The Canadian Press. All rights reserved.



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Dolphins’ Tua Tagovailoa sustains third concussion of his career after hitting head on turf

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MIAMI GARDENS, Fla. (AP) — Miami Dolphins quarterback Tua Tagovailoa sustained a concussion for the third time in his NFL career, leaving his team’s game Thursday night against Buffalo after running into defensive back Damar Hamlin and hitting the back of his head against the turf.

Tagovailoa remained down for about two minutes before getting to his feet and walking to the sideline after the play in the third quarter. He made his way to the tunnel not long afterward, looking into the stands before smiling and departing toward the locker room.

The Dolphins needed almost no time before announcing it was a concussion. The team said he had two during the 2022 season, and Tagovailoa was diagnosed with another concussion when he was a college player at Alabama.

Dolphins coach Mike McDaniel said Tagovailoa would get “proper procedural evaluation” and “appropriate care” on Friday.

“The furthest thing from my mind is, ‘What is the timeline?’ We just need to evaluate and just worry about my teammate, like the rest of the guys are,” McDaniel said. “We’ll get more information tomorrow and take it day by day from here.”

Some players saw Tagovailoa in the locker room after the game and said they were encouraged. Tagovailoa spoke with some players and then went home after the game, McDaniel said.

“I have a lot of love for Tua, built a great relationship with him,” said quarterback Skylar Thompson, who replaced Tagovailoa after the injury. “You care about the person more than the player and everybody in the organization would say the same thing. Just really praying for Tua and hopefully everything will come out all right.”

Tagovailoa signed a four-year, $212 million extension before this season — a deal that makes him one of the highest-paid players in the NFL — and was the NFL’s leading passer in Week 1 this season. Tagovailoa left with the Dolphins trailing 31-10, and that was the final score.

“If you know Tua outside of football, you can’t help but feel for him,” Bills quarterback Josh Allen said on Amazon following the game. “He’s a great football player but he’s an even greater human being. He’s one of the best humans on the planet. I’ve got a lot of love for him and I’m just praying for him and his family, hoping everything’s OK. But it’s tough, man. This game of football that we play, it’s got its highs and it’s got its lows — and this is one of the lows.”

Tagovailoa’s college years and first three NFL seasons were marred by injury, though he positioned himself for a big pay bump with an injury-free and productive 2023 as he led the Dolphins into the playoffs. He threw for 29 touchdowns and a league-best 4,624 yards last year.

When, or if, he can come back this season is anyone’s guess. Tagovailoa said in April 2023 that the concussions he had in the 2022 season left him contemplating his playing future. “I think I considered it for a time,” he said then, when asked if he considered stepping away from the game to protect himself.

McDaniel said it’s not his place to say if Tagovailoa should return to football. “He’ll be evaluated and we’ll have conversations and progress as appropriate,” McDaniel said.

Tagovailoa was hurt Thursday on a fourth-down keeper with about 4:30 left in the third. He went straight ahead into Hamlin and did not slide, leading with his right shoulder instead.

Hamlin was the player who suffered a cardiac arrest after making a tackle during a Monday night game in January 2023 at Cincinnati, causing the NFL to suspend a pivotal game that quickly lost significance in the aftermath of a scary scene that unfolded in front of a national television audience.

Tagovailoa wound up on his back, both his hands in the air and Bills players immediately pointed at him as if to suggest there was an injury. Dolphins center Aaron Brewer quickly did the same, waving to the sideline.

Tagovailoa appeared to be making a fist with his right hand as he lay on the ground. It was movement consistent with something that is referred to as the “fencing response,” which can be common after a traumatic brain injury.

Tagovailoa eventually got to his feet. McDaniel grabbed the side of his quarterback’s head and gave him a kiss on the cheek as Tagovailoa departed. Thompson came into the game to take Tagovailoa’s spot.

“I love Tua on and off the football field,” Bills edge Von Miller said. “I’m a huge fan of him. I can empathize and sympathize with him because I’ve been there. I wish him the best.”

Tagovailoa’s history with concussions — and how he has since worked to avoid them — is a huge part of the story of his career, and now comes to the forefront once again.

He had at least two concussions during the 2022 season. He was hurt in a Week 3 game against Buffalo and cleared concussion protocol, though he appeared disoriented on that play but returned to the game.

The NFL later changed its concussion protocol to mandate that if a player shows possible concussion symptoms — including a lack of balance or stability — he must sit out the rest of the game.

Less than a week later, in a Thursday night game at Cincinnati, Tagovailoa was concussed on a scary hit that briefly knocked him unconscious and led to him being taken off the field on a stretcher.

His second known concussion of that season came in a December game against Green Bay, and he didn’t play for the rest of the 2022 season. After that, Tagovailoa began studying ways where he may be able to fall more safely and protect himself against further injury — including studying jiu-jitsu.

“I’m not worried about anything that’s out of my hands,” McDaniel said. “I’m just worried about the human being.”

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David Beckham among soccer dignitaries attending ex-England coach Sven-Goran Eriksson’s funeral

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TORSBY, Sweden (AP) — David Beckham and former England coach Roy Hodgson were among the soccer dignitaries who attended the funeral of Sven-Goran Eriksson on Friday in the Swedish manager’s small hometown of Torsby.

Eriksson’s wooden coffin was covered in white flowers and surrounded by six tall candles and other floral wreaths as the ceremony began inside the 600-seat Fryksande church.

“It is a day of grief but also a day of thankfulness,” the priest, Ingela Älvskog, told those in attendance.

Beckham, who arrived by private jet on Thursday, greeted Eriksson’s 95-year-old father Sven and other family members with hugs inside the church before the funeral started.

Eriksson became England’s first foreign-born coach when he led the national team from 2001-06, and made Beckham his captain.

Eriksson, who also won trophies at club level in Italy, Portugal and Sweden, died on Aug. 26 at the age of 76, eight months after he revealed he had been diagnosed with pancreatic cancer and had at most one year to live.

Some 200 seats in the neo-Gothic church from 1898 were reserved for his family, friends and players from his career in the football world, according to his agent. The remaining seats were open for the public, according to Eriksson’s wish, with a big screen set up outside the church where hundreds more gathered to watch the ceremony. The funeral was also broadcast live on some Swedish media websites.

The wooden coffin was wheeled in by pallbearers at the church Friday morning as fog wrapped Torsby — a town of about 4,000 people located about 310 kilometers (193 miles) west of Stockholm. Next to the casket was a photo of Eriksson on a small table. The floral wreaths included ones sent by FIFA and Lazio, the Italian team that Eriksson led to the Serie A title in 2000.

The ceremony began with somber piano and organ music, but later took on a more upbeat note with Swedish singer Charlotta Birgersson performing Elton John’s song “Candle In The Wind” and then “My Way” in a duet with Johan Birgersson, who later intoned the popular Italian song “Volare” after the family had gathered around the casket to lay flowers.

Beckham also visited Eriksson in Sweden in June to say goodbye. Others attending the funeral included the Swedish coach’s longtime partner Nancy Dell’Olio. Eriksson’s agent had said that guests from England, Italy and Spain were expected.

After the funeral, the casket was carried out of the church by eight men to the hearse. The guests then walked in a procession accompanying the coffin to a nearby museum where speeches and eulogies to the coach fondly known as “Svennis” were planned on an outdoor stage. A brass band played during the procession through Torsby, including the tune “You never walk alone” from the musical “Carousel” which has become the anthem of Liverpool, the club Eriksson supported since childhood.

The local soccer club Torsby IF, where Eriksson started his career in the 1960s, wrote on its webpage that “you also showed your greatness by always being yourself, the caring Svennis who talked to everyone and took the time, for big and small, asking how things were and how the football was going. We will miss you.”

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AP soccer:

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