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Calgary researchers zero in on gut bacteria as potent cancer fighter – The Province

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FILE – Dr. Kathy McCoy, director of the Western Canadian Microbiome Centre, explains the purpose of the facility on a tour prior to it opening in Calgary in this 2017 file photo.

Jeff McIntosh / CP

Employing intestinal bacteria could boost the effectiveness of some cancer treatment four-fold, say researchers at the University of Calgary.

Employing intestinal bacteria could boost the effectiveness of some cancer treatment four-fold, say researchers at the University of Calgary.

A lead scientist in an ongoing study said Thursday her team has made huge strides in understanding how such microbiomes supercharge the potency of immunotherapy in targeting cancer cells.

“We think the impact is huge,” said Dr. Kathy McCoy of the Snyder Institute for Chronic Diseases at the U of C’s Cumming School of Medicine.

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“With cancers (normally) susceptible to immunotherapy 20 per cent of the time, and it responds at 80 per cent, that’s a major increase in efficacy.”

A series of published studies on the approach dating back to 2015 hinted strongly at the potential of combining some forms of gut bacteria with immunotherapy in treating diseases like melanoma and colorectal cancer.

But scientists weren’t able to pinpoint how it worked, said McCoy, who set about using germ-free mice as research subjects.

“We’d have to identify a mechanism…we identified three bacteria that were in an animal model of colorectal cancer and we wondered if we could tease apart the differences in the microbiomes,” she said.

Her team noted immunotherapy by itself was conspicuously ineffective.

But the bacteria that worked, she said, activated a T-cell which ultimately takes on cancerous tumours, shrinking them significantly.

“The three specific bacteria by themselves turn on a first switch on the T-cells within the intestine,” said McCoy.

That bacteria generates a tiny molecule called inosine that interacts with the T-cells to boost the immunotherapy that in turn eradicates cancer cells.

Another bacteria, akkermansia, has also been found to be an effective tumour fighter, said the scientist, and like the other three bacteria, is one present in humans who have been the subject of some study.

“We actually found there was an increase in bacterium in the patients responding, but the studies were too small,” said McCoy.

The U of C studies using humans remain preliminary for now with researchers seeking grants to further and broaden that work, to focus on lung cancer and melanoma over several years, she said.

“We’re going to see if we can find this metabolite in the serum, or blood, and in feces and see if they’re working with the same mechanism,” said McCoy.

And there’s a strong likelihood that approach could be applied to a much wider variety of cancers, she added.

That latest work is set to be published in the magazine Science, which has highlighted earlier discoveries using gut bacteria to enhance the immune system.

Efforts that have pushed the envelope on the treatment, said McCoy, are “a purely Calgary” achievement and one that should help undermine public skepticism over the effectiveness of cancer research funding that’s often led to conspiracy theories.

“I don’t know what people expect – research has made amazing strides in developing cancer therapies,” she said.

BKaufmann@postmedia.com

On Twitter:

@BillKaufmannjrn

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NASA hears from Voyager 1, the most distant spacecraft from Earth, after months of quiet

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CAPE CANAVERAL, Fla. (AP) – NASA has finally heard back from Voyager 1 again in a way that makes sense.

The most distant spacecraft from Earth stopped sending back understandable data last November. Flight controllers traced the blank communication to a bad computer chip and rearranged the spacecraft’s coding to work around the trouble.

NASA’s Jet Propulsion Laboratory in Southern California declared success after receiving good engineering updates late last week. The team is still working to restore transmission of the science data.

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It takes 22 1/2 hours to send a signal to Voyager 1, more than 15 billion miles (24 billion kilometers) away in interstellar space. The signal travel time is double that for a round trip.

Contact was never lost, rather it was like making a phone call where you can’t hear the person on the other end, a JPL spokeswoman said Tuesday.

Launched in 1977 to study Jupiter and Saturn, Voyager 1 has been exploring interstellar space – the space between star systems – since 2012. Its twin, Voyager 2, is 12.6 billion miles (20 billion kilometers) away and still working fine.

 

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SpaceX launches 23 Starlink satellites from Florida (photos)

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SpaceX sent yet another batch of its Starlink internet satellites skyward today (April 23).

A Falcon 9 rocket topped with 23 Starlink spacecraft lifted off from Florida’s Cape Canaveral Space Force Station today at 6:17 p.m. EDT (2217 GMT).

The Falcon 9’s first stage came back to Earth for a vertical landing about 8.5 minutes after launch as planned. It touched down on the SpaceX droneship Just Read the Instructions, which was stationed in the Atlantic Ocean.

It was the ninth launch and landing for this particular booster, according to a SpaceX mission description. Five of its previous eight liftoffs were Starlink missions.

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The Falcon 9’s upper stage will continue carrying the 23 Starlink satellites toward low Earth orbit (LEO) today, deploying them about 65 minutes after liftoff.

This evening’s launch was the 41st of the year for SpaceX, and the 28th of 2024 dedicated to building out the huge and ever-growing Starlink megaconstellation. There are nearly 5,800 operational Starlink satellites in LEO at the moment, according to astrophysicist and satellite tracker Jonathan McDowell.

The Starlink launch ended up being the first half of a spaceflight doubleheader: A Rocket Lab Electron vehicle launched two satellites, including a NASA solar-sailing technology demonstrator, from New Zealand today at 6:33 p.m. EDT (2233 GMT).

Editor’s note: This story was updated at 6:30 p.m. ET on April 23 with news of successful launch and first-stage landing.

 

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Exploring ecological networks in a digital world | News | Vancouver Island University | Canada – Vancouver Island University News

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Getting to know Samantha Letourneau

By day, Samantha Letourneau is Vancouver Island University’s Canada Learning Bond project lead and Volunteer Tutor Coordinator. She’s also a musician and dancer and for the past two years, she’s been collaborating with Swedish artist Mårten Spångberg, thanks to funding obtained through Crimson Coast Dance, to create a digital art installation that goes live on Friday, April 26. A launch event takes place at Black Rabbit restaurant in the Old City Quarter that night. Samantha is also hosting a creative process workshop on April 27 and 28.

Can you share a bit about your background as an artist and how you got into it?

I have been working in art for a very long time, as a musician and dancer as well as an art administrator and program coordinator. I started music at the age of 11 and dance came later in my life in my early 20s. I always wanted to do dance, but I grew up in a small community in Yellowknife and at that time the only dance classes available were highland dancing, which I was not very interested in. 

In my early 20s while living in Vancouver, I took classes in contemporary dance and was fortunate to land a small part in the Karen Jameison Dance company for a piece called The River. The River was about rivers and connection between the reality of a real and physical outdoor river and the different reality of “the river within.” It was both a piece of art and outreach for the community. It included working with the S’pak’wus Slu’lum Dancers of the Squamish Nation. Somewhat ground-breaking for 1998.

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From there I was hooked and wanted to do more in dance. I studied a lot and took many classes. Fast forward to now, I have been involved with productions and performances with Crimson Coast Dance for more than 15 years and greatly appreciate the talent and innovation that Artistic Director Holly Bright has brought to this community. She is amazing and very supportive of artists in Nanaimo.

How did this international exchange come about?

The Nordic/Nanaimo exchange is one of the innovative projects Holly created. At the height of the pandemic, funded by BC Arts Council and Made In BC, Crimson Coast Dance embarked on a project that explored the ways in which Nanaimo artists could participate in online exchanges. 

Two artists in Nanaimo – myself and Genevieve Johnson – were introduced to artists from Europe and supported through this international exchange. My collaborator, Mårten Spångberg, is a Swedish artist living and working in Berlin. An extension of that exchange is funded by Canada Council for the Arts – Digital Now.

What brought Mårten and myself together – and I quote Mårten here – is “questions around climate change, ecology and the influence contemporary society has on its environments. We are not interested in making art about the ecological crises or informing our audience about the urgency that climate change implies, but instead through our research develop work that in itself proposes, practices and engages in alternative ecologies.”

We share an understanding that art is a unique place, in the sense of practice, activation, performance and event, through which alternative ecologies can emerge and be probed and analyzed.

Tell us about the launch event.

We are launching the digital art installation that Mårten and I created on April 26 at The Attic at Black Rabbit Restaurant. The event is free to attend but people must sign up as seating is limited. I produced video art with soundscapes that I recorded mixing field recordings with voice and instrumentation. Marten explores text, imagery and AI.

My focus is on the evolving and ongoing process of how we communicate with each other and to nature within a digital context.

During our collaboration, Mårten and I talked about networks, though not just the expansive digital network of the internet but of nature. We shared thoughts on mycelium, a network of fungal threads or hyphae, that lately has received much attention on the importance of its function for the environment, including human beings.

Building off this concept, ideas of digital and ecological landscapes being connected emerged. From this we worked both collaboratively and individually to produce material for this digital project. Mårten will be there via Zoom as well and we will talk about this two-year process and the work we created together.

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