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Scientists closing in on why some people never get COVID. That could help with future vaccines

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A new study identified a specific gene in people who didn’t get infected

Early on in the pandemic, in 2021, Hugh Potter ate dinner and watched TV next to his wife while she coughed violently from COVID-19, yet he never even sniffled.

It’s been thought that some people may not have gotten COVID because they were careful to avoid exposure. Alternatively, some people may have been infected but showed no symptoms. Another possibility is that some people have a genetic advantage that makes them a super-dodger.

Bloody lucky, Potter, 68, said. Where I work, I think almost everyone has had it. A few didn’t believe the Pickering, Ont., resident has escaped it since the early years of the pandemic.

Now, experts peering into the genes of such rare people have gained some surprising insights.

Last week, scientists writing in the journal Nature (new window) described high activity of a specific gene in people who didn’t get infected. And in a complementary research project, Potter provided DNA from saliva samples to researchers at McGill University Health Centre looking for those with a golden armour against the virus.

Researchers hope by better understanding early immune responses, it could help with developing nasal spray forms of vaccines for the coronavirus, similar to the existing FluMist to prevent influenza.

As much as people may wish to forget the pandemic emergency, the virus is still with us (new window) and kills about 20 people a week in Canada. The World Health Organization (new window) reported more than 2,600 new fatalities in April, bringing total confirmed cases to over 775 million including more than seven million deaths globally.

Voluntary infection

To gain some leads into what makes people super-dodgers, in March 2021, investigators with the UK COVID-19 Human Challenge study administered a low dose of the original form of SARS-CoV-2 through the nose to 36 healthy adult volunteers and then closely tracked how long it took their immune cells to kick into gear. None were previously exposed to the virus or vaccinated.

The 16 participants with detailed monitoring of their blood and nose fell into three groups:

  • Six developed a sustained infection and fell ill.
  • Three became infected but quickly cleared the virus.
  • Seven never tested positive on the gold standard PCR test, which shows they successfully prevented infection.

Christopher Chiu, a professor of infectious diseases at Imperial College London, and his co-authors saw high levels of activity in a gene called HLA-DQA2. They think the gene helps flag invaders to the immune system so it can quickly destroy the virus.

For medical researchers, the study offers a step-by-step look at what happens in the immune responses to the virus in both the nose and blood and their interaction.

Location, location, location

Immunologists who weren’t involved in the U.K. study say they’re not sure why or how that specific gene offers protection.

If you had asked me to bet money on the genes involved in the protection, they’re not the ones I would have chosen, said professor Dawn Bowdish, who holds the Canada Research Chair in Aging and Immunity at McMaster University in Hamilton.

The realtor’s motto of location, location, location applies, Bowdish said, because our nose, blood and lungs all differ in the type and timing of immune responses.

For instance, the vaccines we get in the arm are designed to trigger our immune system to mount a response as part of adaptive immunity.

HLA genes take up the trigger and present it to fighter cells of the immune system.

While the particular HLA in the study was better at blocking infection in COVID, it isn’t necessarily better overall since it is also associated with some diseases like lupus and rheumatoid arthritis, said Dr. Lynora Saxinger, an infectious diseases specialist at the University of Alberta.

In people who got a sustained infection in the study, it took their immune systems a while to concentrate efforts in the nasal mucosa lining areas like the nose, Saxinger said. In contrast, findings from those who mounted the fastest immune response could invigorate the field of nasal vaccines.

Blocking infection

Teams of researchers at McMaster (new window) and the University of Ottawa (new window) are among those aiming to design nasal spray or puffer forms of inhaled vaccines to not only prevent the risk of severe illness requiring hospitalization and death from COVID — as current vaccines do — but to block infection altogether.

Bowdish said scientists used to think turning on immune cells in the nose would be enough to kill the virus. But in the new study from England, cells involved in recruiting immune reactions in the mouth, nose and lungs were all important.

We are hoping to move to a world where we use inhaled vaccines or nasal vaccines, and this gives us some hints about what specific … immune genes we want those vaccines to turn on to help protect us, Bowdish said.

WATCH | Vulnerability from age still holds:

 

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Age still best determines when to get COVID vaccines, new research suggests

It’s been four years since COVID-19 was declared a pandemic, and new research suggests your age may determine how often you should get a booster shot.

Saxinger called the opportunity to block infection really big, adding understanding how to clear the virus early is also important to prevent asymptomatic spread.

The pandemic landscape of variants and immunity from vaccinations is now very different than when the volunteers were exposed in the study. Some people come down with COVID repeatedly as variants evolve to dodge immune defences. And COVID illness continues to push some older, vulnerable individuals over the edge when hospitalized, doctors say.

Next, the British researchers plan to test the potential of several nasal spray vaccines against the family of coronaviruses that includes SARS-CoV-2, MERS and four seasonal common cold viruses in other human challenge trials (new window).

There might be some kind of common features that that would allow you to consider preventative or very early treatment, Saxinger said.

 

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What’s the greatest holiday gift: lips, hair, skin? Give the gift of great skin this holiday season

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Give the gift of great skin this holiday season

Skinstitut Holiday Gift Kits take the stress out of gifting

Toronto, October 31, 2024 – Beauty gifts are at the top of holiday wish lists this year, and Laser Clinics Canada, a leader in advanced beauty treatments and skincare, is taking the pressure out of seasonal shopping. Today, Laser Clincs Canada announces the arrival of its 2024 Holiday Gift Kits, courtesy of Skinstitut, the exclusive skincare line of Laser Clinics Group.

In time for the busy shopping season, the limited-edition Holiday Gifts Kits are available in Laser Clinics locations in the GTA and Ottawa. Clinics are conveniently located in popular shopping centers, including Hillcrest Mall, Square One, CF Sherway Gardens, Scarborough Town Centre, Rideau Centre, Union Station and CF Markville. These limited-edition Kits are available on a first come, first served basis.

“These kits combine our best-selling products, bundled to address the most relevant skin concerns we’re seeing among our clients,” says Christina Ho, Senior Brand & LAM Manager at Laser Clinics Canada. “With several price points available, the kits offer excellent value and suit a variety of gift-giving needs, from those new to cosmeceuticals to those looking to level up their skincare routine. What’s more, these kits are priced with a savings of up to 33 per cent so gift givers can save during the holiday season.

There are two kits to select from, each designed to address key skin concerns and each with a unique theme — Brightening Basics and Hydration Heroes.

Brightening Basics is a mix of everyday essentials for glowing skin for all skin types. The bundle comes in a sleek pink, reusable case and includes three full-sized products: 200ml gentle cleanser, 50ml Moisture Defence (normal skin) and 30ml1% Hyaluronic Complex Serum. The Brightening Basics kit is available at $129, a saving of 33 per cent.

Hydration Heroes is a mix of hydration essentials and active heroes that cater to a wide variety of clients. A perfect stocking stuffer, this bundle includes four deluxe products: Moisture 15 15 ml Defence for normal skin, 10 ml 1% Hyaluronic Complex Serum, 10 ml Retinol Serum and 50 ml Expert Squalane Cleansing Oil. The kit retails at $59.

In addition to the 2024 Holiday Gifts Kits, gift givers can easily add a Laser Clinic Canada gift card to the mix. Offering flexibility, recipients can choose from a wide range of treatments offered by Laser Clinics Canada, or they can expand their collection of exclusive Skinstitut products.

 

Brightening Basics 2024 Holiday Gift Kit by Skinstitut, available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

Hydration Heroes 2024 Holiday Gift Kit by Skinstitut – available exclusively at Laser Clincs Canada clinics and online at skinstitut.ca.

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Here is how to prepare your online accounts for when you die

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LONDON (AP) — Most people have accumulated a pile of data — selfies, emails, videos and more — on their social media and digital accounts over their lifetimes. What happens to it when we die?

It’s wise to draft a will spelling out who inherits your physical assets after you’re gone, but don’t forget to take care of your digital estate too. Friends and family might treasure files and posts you’ve left behind, but they could get lost in digital purgatory after you pass away unless you take some simple steps.

Here’s how you can prepare your digital life for your survivors:

Apple

The iPhone maker lets you nominate a “ legacy contact ” who can access your Apple account’s data after you die. The company says it’s a secure way to give trusted people access to photos, files and messages. To set it up you’ll need an Apple device with a fairly recent operating system — iPhones and iPads need iOS or iPadOS 15.2 and MacBooks needs macOS Monterey 12.1.

For iPhones, go to settings, tap Sign-in & Security and then Legacy Contact. You can name one or more people, and they don’t need an Apple ID or device.

You’ll have to share an access key with your contact. It can be a digital version sent electronically, or you can print a copy or save it as a screenshot or PDF.

Take note that there are some types of files you won’t be able to pass on — including digital rights-protected music, movies and passwords stored in Apple’s password manager. Legacy contacts can only access a deceased user’s account for three years before Apple deletes the account.

Google

Google takes a different approach with its Inactive Account Manager, which allows you to share your data with someone if it notices that you’ve stopped using your account.

When setting it up, you need to decide how long Google should wait — from three to 18 months — before considering your account inactive. Once that time is up, Google can notify up to 10 people.

You can write a message informing them you’ve stopped using the account, and, optionally, include a link to download your data. You can choose what types of data they can access — including emails, photos, calendar entries and YouTube videos.

There’s also an option to automatically delete your account after three months of inactivity, so your contacts will have to download any data before that deadline.

Facebook and Instagram

Some social media platforms can preserve accounts for people who have died so that friends and family can honor their memories.

When users of Facebook or Instagram die, parent company Meta says it can memorialize the account if it gets a “valid request” from a friend or family member. Requests can be submitted through an online form.

The social media company strongly recommends Facebook users add a legacy contact to look after their memorial accounts. Legacy contacts can do things like respond to new friend requests and update pinned posts, but they can’t read private messages or remove or alter previous posts. You can only choose one person, who also has to have a Facebook account.

You can also ask Facebook or Instagram to delete a deceased user’s account if you’re a close family member or an executor. You’ll need to send in documents like a death certificate.

TikTok

The video-sharing platform says that if a user has died, people can submit a request to memorialize the account through the settings menu. Go to the Report a Problem section, then Account and profile, then Manage account, where you can report a deceased user.

Once an account has been memorialized, it will be labeled “Remembering.” No one will be able to log into the account, which prevents anyone from editing the profile or using the account to post new content or send messages.

X

It’s not possible to nominate a legacy contact on Elon Musk’s social media site. But family members or an authorized person can submit a request to deactivate a deceased user’s account.

Passwords

Besides the major online services, you’ll probably have dozens if not hundreds of other digital accounts that your survivors might need to access. You could just write all your login credentials down in a notebook and put it somewhere safe. But making a physical copy presents its own vulnerabilities. What if you lose track of it? What if someone finds it?

Instead, consider a password manager that has an emergency access feature. Password managers are digital vaults that you can use to store all your credentials. Some, like Keeper,Bitwarden and NordPass, allow users to nominate one or more trusted contacts who can access their keys in case of an emergency such as a death.

But there are a few catches: Those contacts also need to use the same password manager and you might have to pay for the service.

___

Is there a tech challenge you need help figuring out? Write to us at onetechtip@ap.org with your questions.

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Pediatric group says doctors should regularly screen kids for reading difficulties

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The Canadian Paediatric Society says doctors should regularly screen children for reading difficulties and dyslexia, calling low literacy a “serious public health concern” that can increase the risk of other problems including anxiety, low self-esteem and behavioural issues, with lifelong consequences.

New guidance issued Wednesday says family doctors, nurses, pediatricians and other medical professionals who care for school-aged kids are in a unique position to help struggling readers access educational and specialty supports, noting that identifying problems early couldhelp kids sooner — when it’s more effective — as well as reveal other possible learning or developmental issues.

The 10 recommendations include regular screening for kids aged four to seven, especially if they belong to groups at higher risk of low literacy, including newcomers to Canada, racialized Canadians and Indigenous Peoples. The society says this can be done in a two-to-three-minute office-based assessment.

Other tips encourage doctors to look for conditions often seen among poor readers such as attention-deficit hyperactivity disorder; to advocate for early literacy training for pediatric and family medicine residents; to liaise with schools on behalf of families seeking help; and to push provincial and territorial education ministries to integrate evidence-based phonics instruction into curriculums, starting in kindergarten.

Dr. Scott McLeod, one of the authors and chair of the society’s mental health and developmental disabilities committee, said a key goal is to catch kids who may be falling through the cracks and to better connect families to resources, including quicker targeted help from schools.

“Collaboration in this area is so key because we need to move away from the silos of: everything educational must exist within the educational portfolio,” McLeod said in an interview from Calgary, where he is a developmental pediatrician at Alberta Children’s Hospital.

“Reading, yes, it’s education, but it’s also health because we know that literacy impacts health. So I think that a statement like this opens the window to say: Yes, parents can come to their health-care provider to get advice, get recommendations, hopefully start a collaboration with school teachers.”

McLeod noted that pediatricians already look for signs of low literacy in young children by way of a commonly used tool known as the Rourke Baby Record, which offers a checklist of key topics, such as nutrition and developmental benchmarks, to cover in a well-child appointment.

But he said questions about reading could be “a standing item” in checkups and he hoped the society’s statement to medical professionals who care for children “enhances their confidence in being a strong advocate for the child” while spurring partnerships with others involved in a child’s life such as teachers and psychologists.

The guidance said pediatricians also play a key role in detecting and monitoring conditions that often coexist with difficulty reading such as attention-deficit hyperactivity disorder, but McLeod noted that getting such specific diagnoses typically involves a referral to a specialist, during which time a child continues to struggle.

He also acknowledged that some schools can be slow to act without a specific diagnosis from a specialist, and even then a child may end up on a wait list for school interventions.

“Evidence-based reading instruction shouldn’t have to wait for some of that access to specialized assessments to occur,” he said.

“My hope is that (by) having an existing statement or document written by the Canadian Paediatric Society … we’re able to skip a few steps or have some of the early interventions present,” he said.

McLeod added that obtaining specific assessments from medical specialists is “definitely beneficial and advantageous” to know where a child is at, “but having that sort of clear, thorough assessment shouldn’t be a barrier to intervention starting.”

McLeod said the society was partly spurred to act by 2022’s “Right to Read Inquiry Report” from the Ontario Human Rights Commission, which made 157 recommendations to address inequities related to reading instruction in that province.

He called the new guidelines “a big reminder” to pediatric providers, family doctors, school teachers and psychologists of the importance of literacy.

“Early identification of reading difficulty can truly change the trajectory of a child’s life.”

This report by The Canadian Press was first published Oct. 23, 2024.

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